NR1H2 (nuclear receptor subfamily 1 group H member 2)

2003-02-01  

Identity

HGNC
NR1H2
LOCATION
19q13.33
LOCUSID
7376
ALIAS
LXR-b,LXRB,NER,NER-I,RIP15,UNR
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 7376
MIM: 600380
HGNC: 7965
Ensembl: ENSG00000131408

Variants:

dbSNP: 7376
ClinVar: 7376
TCGA: ENSG00000131408
COSMIC: NR1H2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000131408ENST00000253727P55055
ENSG00000131408ENST00000593532M0R229
ENSG00000131408ENST00000593926P55055
ENSG00000131408ENST00000597130M0R1V8
ENSG00000131408ENST00000597157M0QYE6
ENSG00000131408ENST00000597790M0QZF5
ENSG00000131408ENST00000598168M0R0K3
ENSG00000131408ENST00000599105M0R2F9
ENSG00000131408ENST00000600355M0R3A7
ENSG00000131408ENST00000652203P55055

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Nuclear Receptor transcription pathwayREACTOMER-HSA-383280
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Lipid digestion, mobilization, and transportREACTOMER-HSA-73923
Lipoprotein metabolismREACTOMER-HSA-174824
Insulin resistanceKEGGhsa04931
VLDL interactionsREACTOMER-HSA-8855121
VLDLR internalisation and degradationREACTOMER-HSA-8866427

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA131301952gefitinibChemicalClinicalAnnotationassociatedPD31664190
PA443622Carcinoma, Non-Small-Cell LungDiseaseClinicalAnnotationassociatedPD31664190
PA443899DiarrheaDiseaseClinicalAnnotationassociatedPD31664190

References

Pubmed IDYearTitleCitations
172182712007Parallel SUMOylation-dependent pathways mediate gene- and signal-specific transrepression by LXRs and PPARgamma.205
198377212010Liver X receptor in cholesterol metabolism.102
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
181826822008Thematic review series: skin lipids. Peroxisome proliferator-activated receptors and liver X receptors in epidermal biology.71
201599572010GPS2-dependent corepressor/SUMO pathways govern anti-inflammatory actions of LRH-1 and LXRbeta in the hepatic acute phase response.71
16524875200624(S)-hydroxycholesterol participates in a liver X receptor-controlled pathway in astrocytes that regulates apolipoprotein E-mediated cholesterol efflux.43
191052082009Liver X receptor mediates hepatitis B virus X protein-induced lipogenesis in hepatitis B virus-associated hepatocellular carcinoma.43
194815302009GPS2 is required for cholesterol efflux by triggering histone demethylation, LXR recruitment, and coregulator assembly at the ABCG1 locus.42
127362582003X-ray crystal structure of the liver X receptor beta ligand binding domain: regulation by a histidine-tryptophan switch.40
197966212009Liver X receptors and oxysterols promote ventral midbrain neurogenesis in vivo and in human embryonic stem cells.37

Citation

Dessen P

NR1H2 (nuclear receptor subfamily 1 group H member 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41570/nr1h2