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NR1H2 (nuclear receptor subfamily 1 group H member 2)

Identity

Alias (NCBI)LXR-b
LXRB
NER
NER-I
RIP15
UNR
HGNC (Hugo) NR1H2
HGNC Alias symbNER
NER-I
RIP15
LXR-b
LXRb
HGNC Alias nameliver X receptor-beta
HGNC Previous nameUNR
HGNC Previous nameubiquitously-expressed nuclear receptor
 nuclear receptor subfamily 1, group H, member 2
LocusID (NCBI) 7376
Atlas_Id 41570
Location 19q13.33  [Link to chromosome band 19q13]
Location_base_pair Starts at 50376457 and ends at 50383388 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
HHIPL2 (1q41)::NR1H2 (19q13.33)MRPS26 (20p13)::NR1H2 (19q13.33)NR1H2 (19q13.33)::NR1H2 (19q13.33)
NR1H2 (19q13.33)::SMARCD1 (12q13.12)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)NR1H2   7965
Cards
Entrez_Gene (NCBI)NR1H2    nuclear receptor subfamily 1 group H member 2
AliasesLXR-b; LXRB; NER; NER-I; 
RIP15; UNR
GeneCards (Weizmann)NR1H2
Ensembl hg19 (Hinxton)ENSG00000131408 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000131408 [Gene_View]  ENSG00000131408 [Sequence]  chr19:50376457-50383388 [Contig_View]  NR1H2 [Vega]
ICGC DataPortalENSG00000131408
TCGA cBioPortalNR1H2
AceView (NCBI)NR1H2
Genatlas (Paris)NR1H2
SOURCE (Princeton)NR1H2
Genetics Home Reference (NIH)NR1H2
Genomic and cartography
GoldenPath hg38 (UCSC)NR1H2  -     chr19:50376457-50383388 +  19q13.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NR1H2  -     19q13.33   [Description]    (hg19-Feb_2009)
GoldenPathNR1H2 - 19q13.33 [CytoView hg19]  NR1H2 - 19q13.33 [CytoView hg38]
ImmunoBaseENSG00000131408
Genome Data Viewer NCBINR1H2 [Mapview hg19]  
OMIM600380   
Gene and transcription
Genbank (Entrez)AB307697 AI252503 AK091535 AK290855 AK297978
RefSeq transcript (Entrez)NM_001256647 NM_007121
Consensus coding sequences : CCDS (NCBI)NR1H2
Gene ExpressionNR1H2 [ NCBI-GEO ]   NR1H2 [ EBI - ARRAY_EXPRESS ]   NR1H2 [ SEEK ]   NR1H2 [ MEM ]
Gene Expression Viewer (FireBrowse)NR1H2 [ Firebrowse - Broad ]
GenevisibleExpression of NR1H2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7376
GTEX Portal (Tissue expression)NR1H2
Human Protein AtlasENSG00000131408-NR1H2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP55055   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP55055  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP55055
PhosPhoSitePlusP55055
Domaine pattern : Prosite (Expaxy)NR_LBD (PS51843)    NUCLEAR_REC_DBD_1 (PS00031)    NUCLEAR_REC_DBD_2 (PS51030)   
Domains : Interpro (EBI)Liver_X_rcpt    NHR-like_dom_sf    Nucl_hrmn_rcpt_lig-bd    Nuclear_hrmn_rcpt    Znf_hrmn_rcpt    Znf_NHR/GATA   
Domain families : Pfam (Sanger)Hormone_recep (PF00104)    zf-C4 (PF00105)   
Domain families : Pfam (NCBI)pfam00104    pfam00105   
Domain families : Smart (EMBL)HOLI (SM00430)  ZnF_C4 (SM00399)  
Conserved Domain (NCBI)NR1H2
PDB (RSDB)1P8D    1PQ6    1PQ9    1PQC    1UPV    1UPW    3KFC    3L0E    4DK7    4DK8    4NQA    4RAK    5HJP    5I4V    5JY3    5KYA    5KYJ    6JIO    6K9G    6K9H    6K9M    6S4N    6S4T    6S4U    6S5K   
PDB Europe1P8D    1PQ6    1PQ9    1PQC    1UPV    1UPW    3KFC    3L0E    4DK7    4DK8    4NQA    4RAK    5HJP    5I4V    5JY3    5KYA    5KYJ    6JIO    6K9G    6K9H    6K9M    6S4N    6S4T    6S4U    6S5K   
PDB (PDBSum)1P8D    1PQ6    1PQ9    1PQC    1UPV    1UPW    3KFC    3L0E    4DK7    4DK8    4NQA    4RAK    5HJP    5I4V    5JY3    5KYA    5KYJ    6JIO    6K9G    6K9H    6K9M    6S4N    6S4T    6S4U    6S5K   
PDB (IMB)1P8D    1PQ6    1PQ9    1PQC    1UPV    1UPW    3KFC    3L0E    4DK7    4DK8    4NQA    4RAK    5HJP    5I4V    5JY3    5KYA    5KYJ    6JIO    6K9G    6K9H    6K9M    6S4N    6S4T    6S4U    6S5K   
Structural Biology KnowledgeBase1P8D    1PQ6    1PQ9    1PQC    1UPV    1UPW    3KFC    3L0E    4DK7    4DK8    4NQA    4RAK    5HJP    5I4V    5JY3    5KYA    5KYJ    6JIO    6K9G    6K9H    6K9M    6S4N    6S4T    6S4U    6S5K   
SCOP (Structural Classification of Proteins)1P8D    1PQ6    1PQ9    1PQC    1UPV    1UPW    3KFC    3L0E    4DK7    4DK8    4NQA    4RAK    5HJP    5I4V    5JY3    5KYA    5KYJ    6JIO    6K9G    6K9H    6K9M    6S4N    6S4T    6S4U    6S5K   
CATH (Classification of proteins structures)1P8D    1PQ6    1PQ9    1PQC    1UPV    1UPW    3KFC    3L0E    4DK7    4DK8    4NQA    4RAK    5HJP    5I4V    5JY3    5KYA    5KYJ    6JIO    6K9G    6K9H    6K9M    6S4N    6S4T    6S4U    6S5K   
SuperfamilyP55055
AlphaFold pdb e-kbP55055   
Human Protein Atlas [tissue]ENSG00000131408-NR1H2 [tissue]
HPRD02660
Protein Interaction databases
DIP (DOE-UCLA)P55055
IntAct (EBI)P55055
BioGRIDNR1H2
STRING (EMBL)NR1H2
ZODIACNR1H2
Ontologies - Pathways
QuickGOP55055
Ontology : AmiGOnegative regulation of transcription by RNA polymerase II  chromatin  RNA polymerase II cis-regulatory region sequence-specific DNA binding  RNA polymerase II cis-regulatory region sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription activator activity, RNA polymerase II-specific  DNA binding  nuclear receptor activity  protein binding  nucleus  nucleoplasm  cytoplasm  cytosol  zinc ion binding  positive regulation of gene expression  negative regulation of gene expression  negative regulation of macrophage derived foam cell differentiation  positive regulation of triglyceride biosynthetic process  positive regulation of cholesterol efflux  positive regulation of lipid storage  negative regulation of cholesterol storage  cell differentiation  response to nutrient levels  positive regulation of cellular protein metabolic process  negative regulation of lipid transport  positive regulation of cholesterol transport  apolipoprotein A-I receptor binding  phosphatidylcholine acyl-chain remodeling  cholesterol homeostasis  positive regulation of fatty acid biosynthetic process  negative regulation of proteolysis  negative regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription by RNA polymerase II  positive regulation of transcription by RNA polymerase II  positive regulation of transcription by RNA polymerase II  retinoid X receptor binding  retinoic acid receptor signaling pathway  negative regulation of pinocytosis  positive regulation of lipoprotein lipase activity  ATPase binding  negative regulation of interferon-gamma-mediated signaling pathway  positive regulation of high-density lipoprotein particle assembly  positive regulation of pancreatic juice secretion  positive regulation of secretion of lysosomal enzymes  RNA polymerase II transcription regulator complex  negative regulation of cold-induced thermogenesis  positive regulation of miRNA transcription  negative regulation of response to endoplasmic reticulum stress  
Ontology : EGO-EBInegative regulation of transcription by RNA polymerase II  chromatin  RNA polymerase II cis-regulatory region sequence-specific DNA binding  RNA polymerase II cis-regulatory region sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription activator activity, RNA polymerase II-specific  DNA binding  nuclear receptor activity  protein binding  nucleus  nucleoplasm  cytoplasm  cytosol  zinc ion binding  positive regulation of gene expression  negative regulation of gene expression  negative regulation of macrophage derived foam cell differentiation  positive regulation of triglyceride biosynthetic process  positive regulation of cholesterol efflux  positive regulation of lipid storage  negative regulation of cholesterol storage  cell differentiation  response to nutrient levels  positive regulation of cellular protein metabolic process  negative regulation of lipid transport  positive regulation of cholesterol transport  apolipoprotein A-I receptor binding  phosphatidylcholine acyl-chain remodeling  cholesterol homeostasis  positive regulation of fatty acid biosynthetic process  negative regulation of proteolysis  negative regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription by RNA polymerase II  positive regulation of transcription by RNA polymerase II  positive regulation of transcription by RNA polymerase II  retinoid X receptor binding  retinoic acid receptor signaling pathway  negative regulation of pinocytosis  positive regulation of lipoprotein lipase activity  ATPase binding  negative regulation of interferon-gamma-mediated signaling pathway  positive regulation of high-density lipoprotein particle assembly  positive regulation of pancreatic juice secretion  positive regulation of secretion of lysosomal enzymes  RNA polymerase II transcription regulator complex  negative regulation of cold-induced thermogenesis  positive regulation of miRNA transcription  negative regulation of response to endoplasmic reticulum stress  
NDEx NetworkNR1H2
Atlas of Cancer Signalling NetworkNR1H2
Wikipedia pathwaysNR1H2
Orthology - Evolution
OrthoDB7376
GeneTree (enSembl)ENSG00000131408
Phylogenetic Trees/Animal Genes : TreeFamNR1H2
Homologs : HomoloGeneNR1H2
Homology/Alignments : Family Browser (UCSC)NR1H2
Gene fusions - Rearrangements
Fusion : QuiverNR1H2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNR1H2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NR1H2
dbVarNR1H2
ClinVarNR1H2
MonarchNR1H2
1000_GenomesNR1H2 
Exome Variant ServerNR1H2
GNOMAD BrowserENSG00000131408
Varsome BrowserNR1H2
ACMGNR1H2 variants
VarityP55055
Genomic Variants (DGV)NR1H2 [DGVbeta]
DECIPHERNR1H2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNR1H2 
Mutations
ICGC Data PortalNR1H2 
TCGA Data PortalNR1H2 
Broad Tumor PortalNR1H2
OASIS PortalNR1H2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNR1H2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DNR1H2
Mutations and Diseases : HGMDNR1H2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaNR1H2
DgiDB (Drug Gene Interaction Database)NR1H2
DoCM (Curated mutations)NR1H2
CIViC (Clinical Interpretations of Variants in Cancer)NR1H2
Cancer3DNR1H2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600380   
Orphanet
DisGeNETNR1H2
MedgenNR1H2
Genetic Testing Registry NR1H2
NextProtP55055 [Medical]
GENETestsNR1H2
Target ValidationNR1H2
Huge Navigator NR1H2 [HugePedia]
ClinGenNR1H2
Clinical trials, drugs, therapy
MyCancerGenomeNR1H2
Protein Interactions : CTDNR1H2
Pharm GKB GenePA31750
PharosP55055
Clinical trialNR1H2
Miscellaneous
canSAR (ICR)NR1H2
HarmonizomeNR1H2
ARCHS4NR1H2
DataMed IndexNR1H2
Probes
Litterature
PubMed182 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXNR1H2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Jan 20 12:49:57 CET 2022

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