ORC4 (origin recognition complex subunit 4)

2010-10-01  

Identity

HGNC
LOCATION
2q23.1
LOCUSID
ALIAS
ORC4L,ORC4P
FUSION GENES

Other Information

Locus ID:

NCBI: 5000
MIM: 603056
HGNC: 8490
Ensembl: ENSG00000115947

Variants:

dbSNP: 5000
ClinVar: 5000
TCGA: ENSG00000115947
COSMIC: ORC4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000115947ENST00000264169O43929
ENSG00000115947ENST00000392857O43929
ENSG00000115947ENST00000416719Q53SE3
ENSG00000115947ENST00000440042C9JGH7
ENSG00000115947ENST00000457954C9J2X8
ENSG00000115947ENST00000535373O43929
ENSG00000115947ENST00000536575O43929
ENSG00000115947ENST00000540442O43929

Expression (GTEx)

0
5
10
15
20
25

Pathways

PathwaySourceExternal ID
Cell cycleKEGGko04110
Cell cycleKEGGhsa04110
Origin recognition complexKEGGhsa_M00284
Origin recognition complexKEGGM00284
Cell CycleREACTOMER-HSA-1640170
Cell Cycle CheckpointsREACTOMER-HSA-69620
G2/M CheckpointsREACTOMER-HSA-69481
Activation of ATR in response to replication stressREACTOMER-HSA-176187
Cell Cycle, MitoticREACTOMER-HSA-69278
Mitotic G1-G1/S phasesREACTOMER-HSA-453279
G1/S TransitionREACTOMER-HSA-69206
Activation of the pre-replicative complexREACTOMER-HSA-68962
E2F mediated regulation of DNA replicationREACTOMER-HSA-113510
E2F-enabled inhibition of pre-replication complex formationREACTOMER-HSA-113507
S PhaseREACTOMER-HSA-69242
Synthesis of DNAREACTOMER-HSA-69239
Switching of origins to a post-replicative stateREACTOMER-HSA-69052
Orc1 removal from chromatinREACTOMER-HSA-68949
Regulation of DNA replicationREACTOMER-HSA-69304
Association of licensing factors with the pre-replicative complexREACTOMER-HSA-69298
Removal of licensing factors from originsREACTOMER-HSA-69300
M/G1 TransitionREACTOMER-HSA-68874
DNA Replication Pre-InitiationREACTOMER-HSA-69002
Assembly of the pre-replicative complexREACTOMER-HSA-68867
Assembly of the ORC complex at the origin of replicationREACTOMER-HSA-68616
CDC6 association with the ORC:origin complexREACTOMER-HSA-68689
CDT1 association with the CDC6:ORC:origin complexREACTOMER-HSA-68827
DNA ReplicationREACTOMER-HSA-69306

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
213586312011Mutations in origin recognition complex gene ORC4 cause Meier-Gorlin syndrome.72
223338972012Meier-Gorlin syndrome genotype-phenotype studies: 35 individuals with pre-replication complex gene mutations and 10 without molecular diagnosis.32
190748852008Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia.25
159100032005Ku80 binds to human replication origins prior to the assembly of the ORC complex.16
200101612009Novel ORC4L gene mutation in B-cell lymphoproliferative disorders.8
290362202017Defective replication initiation results in locus specific chromosome breakage and a ribosomal RNA deficiency in yeast.8
196909802010Human initiation protein Orc4 prefers triple stranded DNA.7
104604121999Identification and characterization of MmORC4 and MmORC5, two subunits of the mouse origin of replication recognition complex.3
261240522015HsOrc4-Dependent Dna Remodeling of the ori-β Dhfr Replicator.0

Citation

Dessen P

ORC4 (origin recognition complex subunit 4)

Atlas Genet Cytogenet Oncol Haematol. 2010-10-01

Online version: http://atlasgeneticsoncology.org/gene/51730/orc4