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ORC4 (origin recognition complex subunit 4)

Identity

Alias_namesORC4L
origin recognition complex, subunit 4 (yeast homolog)-like
origin recognition complex, subunit 4-like (yeast)
origin recognition complex, subunit 4-like (S. cerevisiae)
origin recognition complex, subunit 4 homolog (S. cerevisiae)
origin recognition complex, subunit 4
Alias_symbol (synonym)HsORC4
Orc4p
Other aliasORC4P
HGNC (Hugo) ORC4
LocusID (NCBI) 5000
Atlas_Id 51730
Location 2q22.3  [Link to chromosome band 2q22]
Location_base_pair Starts at 148687966 and ends at 148778316 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
GALNT7 (4q34.1) / ORC4 (2q22.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ORC4   8490
Cards
Entrez_Gene (NCBI)ORC4  5000  origin recognition complex subunit 4
AliasesORC4L; ORC4P
GeneCards (Weizmann)ORC4
Ensembl hg19 (Hinxton)ENSG00000115947 [Gene_View]  chr2:148687966-148778316 [Contig_View]  ORC4 [Vega]
Ensembl hg38 (Hinxton)ENSG00000115947 [Gene_View]  chr2:148687966-148778316 [Contig_View]  ORC4 [Vega]
ICGC DataPortalENSG00000115947
TCGA cBioPortalORC4
AceView (NCBI)ORC4
Genatlas (Paris)ORC4
WikiGenes5000
SOURCE (Princeton)ORC4
Genetics Home Reference (NIH)ORC4
Genomic and cartography
GoldenPath hg19 (UCSC)ORC4  -     chr2:148687966-148778316 -  2q22.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)ORC4  -     2q22.3   [Description]    (hg38-Dec_2013)
EnsemblORC4 - 2q22.3 [CytoView hg19]  ORC4 - 2q22.3 [CytoView hg38]
Mapping of homologs : NCBIORC4 [Mapview hg19]  ORC4 [Mapview hg38]
OMIM603056   613800   
Gene and transcription
Genbank (Entrez)AF022108 AF047598 AF132596 AK055257 AK128860
RefSeq transcript (Entrez)NM_001190879 NM_001190881 NM_001190882 NM_002552 NM_181741 NM_181742
RefSeq genomic (Entrez)NC_000002 NC_018913 NG_028252 NT_005403 NW_004929304
Consensus coding sequences : CCDS (NCBI)ORC4
Cluster EST : UnigeneHs.558364 [ NCBI ]
CGAP (NCI)Hs.558364
Alternative Splicing GalleryENSG00000115947
Gene ExpressionORC4 [ NCBI-GEO ]   ORC4 [ EBI - ARRAY_EXPRESS ]   ORC4 [ SEEK ]   ORC4 [ MEM ]
Gene Expression Viewer (FireBrowse)ORC4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5000
GTEX Portal (Tissue expression)ORC4
Protein : pattern, domain, 3D structure
UniProt/SwissProtO43929   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO43929  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO43929
Splice isoforms : SwissVarO43929
PhosPhoSitePlusO43929
Domains : Interpro (EBI)AAA+_ATPase    ORC4    ORC4_C    P-loop_NTPase   
Domain families : Pfam (Sanger)ORC4_C (PF14629)   
Domain families : Pfam (NCBI)pfam14629   
Domain families : Smart (EMBL)AAA (SM00382)  
Conserved Domain (NCBI)ORC4
DMDM Disease mutations5000
Blocks (Seattle)ORC4
SuperfamilyO43929
Human Protein AtlasENSG00000115947
Peptide AtlasO43929
HPRD09118
IPIIPI00015164   IPI01014957   IPI00983461   IPI00980783   IPI00917052   IPI00917179   IPI00917328   
Protein Interaction databases
DIP (DOE-UCLA)O43929
IntAct (EBI)O43929
FunCoupENSG00000115947
BioGRIDORC4
STRING (EMBL)ORC4
ZODIACORC4
Ontologies - Pathways
QuickGOO43929
Ontology : AmiGOG1/S transition of mitotic cell cycle  nucleotide binding  nuclear chromosome, telomeric region  nuclear chromosome, telomeric region  origin recognition complex  DNA replication origin binding  protein binding  ATP binding  nucleus  nucleoplasm  nucleoplasm  nuclear origin of replication recognition complex  nucleolus  cytoplasm  DNA replication  DNA replication initiation  actin cytoskeleton  
Ontology : EGO-EBIG1/S transition of mitotic cell cycle  nucleotide binding  nuclear chromosome, telomeric region  nuclear chromosome, telomeric region  origin recognition complex  DNA replication origin binding  protein binding  ATP binding  nucleus  nucleoplasm  nucleoplasm  nuclear origin of replication recognition complex  nucleolus  cytoplasm  DNA replication  DNA replication initiation  actin cytoskeleton  
Pathways : BIOCARTACDK Regulation of DNA Replication [Genes]   
Pathways : KEGGCell cycle   
NDEx NetworkORC4
Atlas of Cancer Signalling NetworkORC4
Wikipedia pathwaysORC4
Orthology - Evolution
OrthoDB5000
GeneTree (enSembl)ENSG00000115947
Phylogenetic Trees/Animal Genes : TreeFamORC4
HOVERGENO43929
HOGENOMO43929
Homologs : HomoloGeneORC4
Homology/Alignments : Family Browser (UCSC)ORC4
Gene fusions - Rearrangements
Fusion : MitelmanGALNT7/ORC4 [4q34.1/2q22.3]  [t(2;4)(q23;q34)]  
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerORC4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ORC4
dbVarORC4
ClinVarORC4
1000_GenomesORC4 
Exome Variant ServerORC4
ExAC (Exome Aggregation Consortium)ORC4 (select the gene name)
Genetic variants : HAPMAP5000
Genomic Variants (DGV)ORC4 [DGVbeta]
DECIPHER (Syndromes)2:148687966-148778316  ENSG00000115947
CONAN: Copy Number AnalysisORC4 
Mutations
ICGC Data PortalORC4 
TCGA Data PortalORC4 
Broad Tumor PortalORC4
OASIS PortalORC4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICORC4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDORC4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ORC4
DgiDB (Drug Gene Interaction Database)ORC4
DoCM (Curated mutations)ORC4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ORC4 (select a term)
intoGenORC4
Cancer3DORC4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603056    613800   
Orphanet2357   
MedgenORC4
Genetic Testing Registry ORC4
NextProtO43929 [Medical]
TSGene5000
GENETestsORC4
Huge Navigator ORC4 [HugePedia]
snp3D : Map Gene to Disease5000
BioCentury BCIQORC4
ClinGenORC4 (curated)
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5000
Chemical/Pharm GKB GenePA32811
Clinical trialORC4
Miscellaneous
canSAR (ICR)ORC4 (select the gene name)
Probes
Litterature
PubMed51 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineORC4
EVEXORC4
GoPubMedORC4
iHOPORC4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 15:13:09 CEST 2017

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