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OTUD7B (OTU deubiquitinase 7B)

Identity

Alias_namesZA20D1
zinc finger, A20 domain containing 1
OTU domain containing 7B
Alias_symbol (synonym)CEZANNE
Other alias
HGNC (Hugo) OTUD7B
LocusID (NCBI) 56957
Atlas_Id 42862
Location 1q21.2  [Link to chromosome band 1q21]
Location_base_pair Starts at 149940330 and ends at 150010737 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
HNRNPUL1 (19q13.2) / OTUD7B (1q21.2)NTM (11q25) / OTUD7B (1q21.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)OTUD7B   16683
Cards
Entrez_Gene (NCBI)OTUD7B  56957  OTU deubiquitinase 7B
AliasesCEZANNE; ZA20D1
GeneCards (Weizmann)OTUD7B
Ensembl hg19 (Hinxton)ENSG00000264522 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000264522 [Gene_View]  chr1:149940330-150010737 [Contig_View]  OTUD7B [Vega]
ICGC DataPortalENSG00000264522
TCGA cBioPortalOTUD7B
AceView (NCBI)OTUD7B
Genatlas (Paris)OTUD7B
WikiGenes56957
SOURCE (Princeton)OTUD7B
Genetics Home Reference (NIH)OTUD7B
Genomic and cartography
GoldenPath hg38 (UCSC)OTUD7B  -     chr1:149940330-150010737 -  1q21.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)OTUD7B  -     1q21.2   [Description]    (hg19-Feb_2009)
EnsemblOTUD7B - 1q21.2 [CytoView hg19]  OTUD7B - 1q21.2 [CytoView hg38]
Mapping of homologs : NCBIOTUD7B [Mapview hg19]  OTUD7B [Mapview hg38]
OMIM611748   
Gene and transcription
Genbank (Entrez)AJ293573 AK299790 AL122102 BC015719 BC020622
RefSeq transcript (Entrez)NM_020205
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)OTUD7B
Cluster EST : UnigeneHs.98322 [ NCBI ]
CGAP (NCI)Hs.98322
Alternative Splicing GalleryENSG00000264522
Gene ExpressionOTUD7B [ NCBI-GEO ]   OTUD7B [ EBI - ARRAY_EXPRESS ]   OTUD7B [ SEEK ]   OTUD7B [ MEM ]
Gene Expression Viewer (FireBrowse)OTUD7B [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)56957
GTEX Portal (Tissue expression)OTUD7B
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ6GQQ9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ6GQQ9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ6GQQ9
Splice isoforms : SwissVarQ6GQQ9
PhosPhoSitePlusQ6GQQ9
Domaine pattern : Prosite (Expaxy)OTU (PS50802)    ZF_A20 (PS51036)   
Domains : Interpro (EBI)OTU_dom    Znf_A20   
Domain families : Pfam (Sanger)OTU (PF02338)    zf-A20 (PF01754)   
Domain families : Pfam (NCBI)pfam02338    pfam01754   
Domain families : Smart (EMBL)ZnF_A20 (SM00259)  
Conserved Domain (NCBI)OTUD7B
DMDM Disease mutations56957
Blocks (Seattle)OTUD7B
PDB (SRS)5LRU    5LRV    5LRW   
PDB (PDBSum)5LRU    5LRV    5LRW   
PDB (IMB)5LRU    5LRV    5LRW   
PDB (RSDB)5LRU    5LRV    5LRW   
Structural Biology KnowledgeBase5LRU    5LRV    5LRW   
SCOP (Structural Classification of Proteins)5LRU    5LRV    5LRW   
CATH (Classification of proteins structures)5LRU    5LRV    5LRW   
SuperfamilyQ6GQQ9
Human Protein AtlasENSG00000264522
Peptide AtlasQ6GQQ9
HPRD10313
IPIIPI00024658   IPI00647752   
Protein Interaction databases
DIP (DOE-UCLA)Q6GQQ9
IntAct (EBI)Q6GQQ9
FunCoupENSG00000264522
BioGRIDOTUD7B
STRING (EMBL)OTUD7B
ZODIACOTUD7B
Ontologies - Pathways
QuickGOQ6GQQ9
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  adaptive immune response  mucosal immune response  DNA binding  thiol-dependent ubiquitin-specific protease activity  protein binding  nucleus  cytoplasm  cytosol  immune response  cysteine-type peptidase activity  zinc ion binding  protein deubiquitination  negative regulation of interleukin-8 production  protein K11-linked deubiquitination  negative regulation of I-kappaB kinase/NF-kappaB signaling  K63-linked polyubiquitin binding  protein K63-linked deubiquitination  protein K48-linked deubiquitination  protein K48-linked deubiquitination  protein deubiquitination involved in ubiquitin-dependent protein catabolic process  negative regulation of protein localization to nucleus  Lys48-specific deubiquitinase activity  Lys48-specific deubiquitinase activity  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  adaptive immune response  mucosal immune response  DNA binding  thiol-dependent ubiquitin-specific protease activity  protein binding  nucleus  cytoplasm  cytosol  immune response  cysteine-type peptidase activity  zinc ion binding  protein deubiquitination  negative regulation of interleukin-8 production  protein K11-linked deubiquitination  negative regulation of I-kappaB kinase/NF-kappaB signaling  K63-linked polyubiquitin binding  protein K63-linked deubiquitination  protein K48-linked deubiquitination  protein K48-linked deubiquitination  protein deubiquitination involved in ubiquitin-dependent protein catabolic process  negative regulation of protein localization to nucleus  Lys48-specific deubiquitinase activity  Lys48-specific deubiquitinase activity  
NDEx NetworkOTUD7B
Atlas of Cancer Signalling NetworkOTUD7B
Wikipedia pathwaysOTUD7B
Orthology - Evolution
OrthoDB56957
GeneTree (enSembl)ENSG00000264522
Phylogenetic Trees/Animal Genes : TreeFamOTUD7B
HOVERGENQ6GQQ9
HOGENOMQ6GQQ9
Homologs : HomoloGeneOTUD7B
Homology/Alignments : Family Browser (UCSC)OTUD7B
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerOTUD7B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)OTUD7B
dbVarOTUD7B
ClinVarOTUD7B
1000_GenomesOTUD7B 
Exome Variant ServerOTUD7B
ExAC (Exome Aggregation Consortium)OTUD7B (select the gene name)
Genetic variants : HAPMAP56957
Genomic Variants (DGV)OTUD7B [DGVbeta]
DECIPHEROTUD7B [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisOTUD7B 
Mutations
ICGC Data PortalOTUD7B 
TCGA Data PortalOTUD7B 
Broad Tumor PortalOTUD7B
OASIS PortalOTUD7B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICOTUD7B  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDOTUD7B
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch OTUD7B
DgiDB (Drug Gene Interaction Database)OTUD7B
DoCM (Curated mutations)OTUD7B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)OTUD7B (select a term)
intoGenOTUD7B
Cancer3DOTUD7B(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM611748   
Orphanet
MedgenOTUD7B
Genetic Testing Registry OTUD7B
NextProtQ6GQQ9 [Medical]
TSGene56957
GENETestsOTUD7B
Target ValidationOTUD7B
Huge Navigator OTUD7B [HugePedia]
snp3D : Map Gene to Disease56957
BioCentury BCIQOTUD7B
ClinGenOTUD7B
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD56957
Chemical/Pharm GKB GenePA134873802
Clinical trialOTUD7B
Miscellaneous
canSAR (ICR)OTUD7B (select the gene name)
Probes
Litterature
PubMed42 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineOTUD7B
EVEXOTUD7B
GoPubMedOTUD7B
iHOPOTUD7B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:23:24 CEST 2017

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