PABPN1 (poly(A) binding protein nuclear 1)

2003-05-01  

Identity

HGNC
PABPN1
LOCATION
14q11.2
LOCUSID
8106
ALIAS
OPMD,PAB2,PABII,PABP-2,PABP2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 8106
MIM: 602279
HGNC: 8565
Ensembl: ENSG00000100836

Variants:

dbSNP: 8106
ClinVar: 8106
TCGA: ENSG00000100836
COSMIC: PABPN1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000100836ENST00000216727Q86U42
ENSG00000100836ENST00000397276Q86U42
ENSG00000100836ENST00000555295H0YJH9
ENSG00000100836ENST00000556821G3V4T2
ENSG00000100836ENST00000557702B4DEH8

Expression (GTEx)

0
50
100
150
200
250
300
350
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
mRNA surveillance pathwayKEGGko03015
mRNA surveillance pathwayKEGGhsa03015
Influenza AKEGGko05164
Influenza AKEGGhsa05164
DiseaseREACTOMER-HSA-1643685
Infectious diseaseREACTOMER-HSA-5663205
Influenza InfectionREACTOMER-HSA-168254
Host Interactions with Influenza FactorsREACTOMER-HSA-168253
NS1 Mediated Effects on Host PathwaysREACTOMER-HSA-168276
Inhibition of Host mRNA Processing and RNA SilencingREACTOMER-HSA-168315
Gene ExpressionREACTOMER-HSA-74160
RNA Polymerase II TranscriptionREACTOMER-HSA-73857
RNA Polymerase II Transcription TerminationREACTOMER-HSA-73856
Cleavage of Growing Transcript in the Termination RegionREACTOMER-HSA-109688
Processing of Capped Intron-Containing Pre-mRNAREACTOMER-HSA-72203
mRNA SplicingREACTOMER-HSA-72172
mRNA Splicing - Major PathwayREACTOMER-HSA-72163
mRNA 3'-end processingREACTOMER-HSA-72187
Processing of Capped Intronless Pre-mRNAREACTOMER-HSA-75067
Processing of Intronless Pre-mRNAsREACTOMER-HSA-77595

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
225028662012The poly(A)-binding protein nuclear 1 suppresses alternative cleavage and polyadenylation sites.143
280802042017Identification of HuR target circular RNAs uncovers suppression of PABPN1 translation by CircPABPN1.128
259061882015Systematic profiling of poly(A)+ transcripts modulated by core 3' end processing and splicing factors reveals regulatory rules of alternative cleavage and polyadenylation.80
278714842016Identification of a Nuclear Exosome Decay Pathway for Processed Transcripts.66
231665212012Polyadenylation-dependent control of long noncoding RNA expression by the poly(A)-binding protein nuclear 1.63
266283682015A Polyadenylation-Dependent 3' End Maturation Pathway Is Required for the Synthesis of the Human Telomerase RNA.48
183978762008Sirtuin inhibition protects from the polyalanine muscular dystrophy protein PABPN1.30
264847602015Canonical Poly(A) Polymerase Activity Promotes the Decay of a Wide Variety of Mammalian Nuclear RNAs.29
116894812001Oligomerization of polyalanine expanded PABPN1 facilitates nuclear protein aggregation that is associated with cell death.27
259636582015Regulated Intron Retention and Nuclear Pre-mRNA Decay Contribute to PABPN1 Autoregulation.27

Citation

Dessen P

PABPN1 (poly(A) binding protein nuclear 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/41629/pabpn1