PANX2 (pannexin 2)

2008-03-01  

Identity

HGNC
PANX2
LOCATION
22q13.33
LOCUSID
56666
ALIAS
PX2,hPANX2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 56666
MIM: 608421
HGNC: 8600
Ensembl: ENSG00000073150

Variants:

dbSNP: 56666
ClinVar: 56666
TCGA: ENSG00000073150
COSMIC: PANX2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000073150ENST00000159647Q96RD6
ENSG00000073150ENST00000395842Q96RD6
ENSG00000073150ENST00000402472F8W8Y4

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Neuronal SystemREACTOMER-HSA-112316
Transmission across Electrical SynapsesREACTOMER-HSA-112307
Electric Transmission Across Gap JunctionsREACTOMER-HSA-112303

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
205160702010Pannexin1 and Pannexin2 channels show quaternary similarities to connexons and different oligomerization numbers from each other.67
250089462014Pannexin channels and their links to human disease.46
197497892009Pannexin2 as a novel growth regulator in C6 glioma cells.26
169897242006What is hidden in the pannexin treasure trove: the sneak peek and the guesswork.20
201983152010Association of genetic variants with hemorrhagic stroke in Japanese individuals.11
241460912013Altered expression of pannexin proteins in patients with temporal lobe epilepsy.8
257734742015Pannexin-2 is expressed in the human colon with extensive localization in the enteric nervous system.4
198512962010Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals.3
280362892017Expression of pannexin 1 and 2 in cortical lesions from intractable epilepsy patients with focal cortical dysplasia.3
174270272007Gap junction coding genes and schizophrenia: a genetic association study.2

Citation

Dessen P

PANX2 (pannexin 2)

Atlas Genet Cytogenet Oncol Haematol. 2008-03-01

Online version: http://atlasgeneticsoncology.org/gene/50085/panx2