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PDIA2 (protein disulfide isomerase family A member 2)

Identity

Alias_namesPDIP
protein disulfide isomerase, pancreatic
protein disulfide isomerase-associated 2
protein disulfide isomerase family A, member 2
Alias_symbol (synonym)PDA2
PDI
PDIR
Other alias
HGNC (Hugo) PDIA2
LocusID (NCBI) 64714
Atlas_Id 51536
Location 16p13.3  [Link to chromosome band 16p13]
Location_base_pair Starts at 283118 and ends at 287209 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ASTN2 (9q33.1) / PDIA2 (16p13.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PDIA2   14180
Cards
Entrez_Gene (NCBI)PDIA2  64714  protein disulfide isomerase family A member 2
AliasesPDA2; PDI; PDIP; PDIR
GeneCards (Weizmann)PDIA2
Ensembl hg19 (Hinxton)ENSG00000185615 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000185615 [Gene_View]  chr16:283118-287209 [Contig_View]  PDIA2 [Vega]
ICGC DataPortalENSG00000185615
TCGA cBioPortalPDIA2
AceView (NCBI)PDIA2
Genatlas (Paris)PDIA2
WikiGenes64714
SOURCE (Princeton)PDIA2
Genetics Home Reference (NIH)PDIA2
Genomic and cartography
GoldenPath hg38 (UCSC)PDIA2  -     chr16:283118-287209 +  16p13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PDIA2  -     16p13.3   [Description]    (hg19-Feb_2009)
EnsemblPDIA2 - 16p13.3 [CytoView hg19]  PDIA2 - 16p13.3 [CytoView hg38]
Mapping of homologs : NCBIPDIA2 [Mapview hg19]  PDIA2 [Mapview hg38]
OMIM608012   
Gene and transcription
Genbank (Entrez)AK075485 AK124931 AK295383 AK308516 BC000537
RefSeq transcript (Entrez)NM_006849
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PDIA2
Cluster EST : UnigeneHs.66581 [ NCBI ]
CGAP (NCI)Hs.66581
Alternative Splicing GalleryENSG00000185615
Gene ExpressionPDIA2 [ NCBI-GEO ]   PDIA2 [ EBI - ARRAY_EXPRESS ]   PDIA2 [ SEEK ]   PDIA2 [ MEM ]
Gene Expression Viewer (FireBrowse)PDIA2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)64714
GTEX Portal (Tissue expression)PDIA2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13087   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ13087  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ13087
Splice isoforms : SwissVarQ13087
Catalytic activity : Enzyme5.3.4.1 [ Enzyme-Expasy ]   5.3.4.15.3.4.1 [ IntEnz-EBI ]   5.3.4.1 [ BRENDA ]   5.3.4.1 [ KEGG ]   
PhosPhoSitePlusQ13087
Domaine pattern : Prosite (Expaxy)ER_TARGET (PS00014)    THIOREDOXIN_1 (PS00194)    THIOREDOXIN_2 (PS51352)   
Domains : Interpro (EBI)Prot_disulphide_isomerase    Thioredoxin-like_fold    Thioredoxin_CS    Thioredoxin_domain   
Domain families : Pfam (Sanger)Thioredoxin (PF00085)   
Domain families : Pfam (NCBI)pfam00085   
Conserved Domain (NCBI)PDIA2
DMDM Disease mutations64714
Blocks (Seattle)PDIA2
SuperfamilyQ13087
Human Protein AtlasENSG00000185615
Peptide AtlasQ13087
HPRD07617
IPIIPI00011571   IPI00878546   IPI00845275   IPI00789094   IPI00657644   IPI00640718   
Protein Interaction databases
DIP (DOE-UCLA)Q13087
IntAct (EBI)Q13087
FunCoupENSG00000185615
BioGRIDPDIA2
STRING (EMBL)PDIA2
ZODIACPDIA2
Ontologies - Pathways
QuickGOQ13087
Ontology : AmiGOprotein disulfide isomerase activity  steroid binding  protein binding  endoplasmic reticulum  endoplasmic reticulum lumen  protein folding  protein retention in ER lumen  disulfide oxidoreductase activity  peptide disulfide oxidoreductase activity  peptidyl-proline hydroxylation  peptidyl-proline 4-dioxygenase activity  protein folding in endoplasmic reticulum  response to endoplasmic reticulum stress  cell redox homeostasis  oxidation-reduction process  regulation of oxidative stress-induced intrinsic apoptotic signaling pathway  
Ontology : EGO-EBIprotein disulfide isomerase activity  steroid binding  protein binding  endoplasmic reticulum  endoplasmic reticulum lumen  protein folding  protein retention in ER lumen  disulfide oxidoreductase activity  peptide disulfide oxidoreductase activity  peptidyl-proline hydroxylation  peptidyl-proline 4-dioxygenase activity  protein folding in endoplasmic reticulum  response to endoplasmic reticulum stress  cell redox homeostasis  oxidation-reduction process  regulation of oxidative stress-induced intrinsic apoptotic signaling pathway  
NDEx NetworkPDIA2
Atlas of Cancer Signalling NetworkPDIA2
Wikipedia pathwaysPDIA2
Orthology - Evolution
OrthoDB64714
GeneTree (enSembl)ENSG00000185615
Phylogenetic Trees/Animal Genes : TreeFamPDIA2
HOVERGENQ13087
HOGENOMQ13087
Homologs : HomoloGenePDIA2
Homology/Alignments : Family Browser (UCSC)PDIA2
Gene fusions - Rearrangements
Fusion : MitelmanASTN2/PDIA2 [9q33.1/16p13.3]  [t(9;16)(q33;p13)]  
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPDIA2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PDIA2
dbVarPDIA2
ClinVarPDIA2
1000_GenomesPDIA2 
Exome Variant ServerPDIA2
ExAC (Exome Aggregation Consortium)PDIA2 (select the gene name)
Genetic variants : HAPMAP64714
Genomic Variants (DGV)PDIA2 [DGVbeta]
DECIPHERPDIA2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPDIA2 
Mutations
ICGC Data PortalPDIA2 
TCGA Data PortalPDIA2 
Broad Tumor PortalPDIA2
OASIS PortalPDIA2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPDIA2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPDIA2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PDIA2
DgiDB (Drug Gene Interaction Database)PDIA2
DoCM (Curated mutations)PDIA2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PDIA2 (select a term)
intoGenPDIA2
Cancer3DPDIA2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608012   
Orphanet
MedgenPDIA2
Genetic Testing Registry PDIA2
NextProtQ13087 [Medical]
TSGene64714
GENETestsPDIA2
Target ValidationPDIA2
Huge Navigator PDIA2 [HugePedia]
snp3D : Map Gene to Disease64714
BioCentury BCIQPDIA2
ClinGenPDIA2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD64714
Chemical/Pharm GKB GenePA33153
Clinical trialPDIA2
Miscellaneous
canSAR (ICR)PDIA2 (select the gene name)
Probes
Litterature
PubMed87 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePDIA2
EVEXPDIA2
GoPubMedPDIA2
iHOPPDIA2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:24:15 CEST 2017

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