PECAM1 (platelet and endothelial cell adhesion molecule 1)

2003-08-01  

Identity

HGNC
PECAM1
LOCATION
17q23.3
LOCUSID
5175
ALIAS
CD31,CD31/EndoCAM,GPIIA,PECA1,PECAM-1,endoCAM
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 5175
MIM: 173445
HGNC: 8823
Ensembl: ENSG00000261371

Variants:

dbSNP: 5175
ClinVar: 5175
TCGA: ENSG00000261371
COSMIC: PECAM1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000261371ENST00000563523A0A075B728
ENSG00000261371ENST00000563924P16284
ENSG00000261371ENST00000564866A0A075B727
ENSG00000261371ENST00000569967A0A075B737

Expression (GTEx)

0
50
100
150
200
250
300
350
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cell adhesion molecules (CAMs)KEGGko04514
Leukocyte transendothelial migrationKEGGko04670
Cell adhesion molecules (CAMs)KEGGhsa04514
Leukocyte transendothelial migrationKEGGhsa04670
MalariaKEGGko05144
MalariaKEGGhsa05144
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
HemostasisREACTOMER-HSA-109582
Platelet homeostasisREACTOMER-HSA-418346
Platelet sensitization by LDLREACTOMER-HSA-432142
Platelet activation, signaling and aggregationREACTOMER-HSA-76002
Response to elevated platelet cytosolic Ca2+REACTOMER-HSA-76005
Platelet degranulationREACTOMER-HSA-114608
Cell surface interactions at the vascular wallREACTOMER-HSA-202733
PECAM1 interactionsREACTOMER-HSA-210990
Extracellular matrix organizationREACTOMER-HSA-1474244
Integrin cell surface interactionsREACTOMER-HSA-216083
Neutrophil degranulationREACTOMER-HSA-6798695
Fluid shear stress and atherosclerosisKEGGko05418
Fluid shear stress and atherosclerosisKEGGhsa05418

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
126899162003Signal transduction pathways mediated by PECAM-1: new roles for an old molecule in platelet and vascular cell biology.114
185835702009Life after the thymus: CD31+ and CD31- human naive CD4+ T-cell subsets.103
177034122007Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes.100
126106272003Targeted recycling of PECAM from endothelial surface-connected compartments during diapedesis.97
121108922002Apoptosis disables CD31-mediated cell detachment from phagocytes promoting binding and engulfment.91
175803082007The neutrophil-specific antigen CD177 is a counter-receptor for platelet endothelial cell adhesion molecule-1 (CD31).68
145193852003PECAM-1: old friend, new partners.64
206344892010CD31+ cells represent highly angiogenic and vasculogenic cells in bone marrow: novel role of nonendothelial CD31+ cells in neovascularization and their therapeutic effects on ischemic vascular disease.54
119405332002Involvement of human PECAM-1 in angiogenesis and in vitro endothelial cell migration.50
270550472016Endothelial functions of platelet/endothelial cell adhesion molecule-1 (CD31).50

Citation

Dessen P

PECAM1 (platelet and endothelial cell adhesion molecule 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/41689/pecam1