PHF2 (PHD finger protein 2)

2009-04-01  

Identity

HGNC
LOCATION
9q22.31
LOCUSID
ALIAS
CENP-35,GRC5,JHDM1E,KDM7C
FUSION GENES

Other Information

Locus ID:

NCBI: 5253
MIM: 604351
HGNC: 8920
Ensembl: ENSG00000197724

Variants:

dbSNP: 5253
ClinVar: 5253
TCGA: ENSG00000197724
COSMIC: PHF2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000197724ENST00000359246O75151
ENSG00000197724ENST00000375376E7ET14
ENSG00000197724ENST00000610682A0A087WW48

Expression (GTEx)

0
10
20
30
40
50
60
70

Pathways

PathwaySourceExternal ID
Chromatin organizationREACTOMER-HSA-4839726
Chromatin modifying enzymesREACTOMER-HSA-3247509
HDMs demethylate histonesREACTOMER-HSA-3214842

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
189902332008Alterations in candidate genes PHF2, FANCC, PTCH1 and XPA at chromosomal 9q22.3 region: pathological significance in early- and late-onset breast carcinoma.22
250433062015PHF2 histone demethylase acts as a tumor suppressor in association with p53 in cancer.20
211671742011Structural basis for human PHF2 Jumonji domain interaction with metal ions.15
225344672013Overexpression of Jumonji AT-rich interactive domain 1B and PHD finger protein 2 is involved in the progression of esophageal squamous cell carcinoma.14
252046602014PHD finger protein 2 (PHF2) represses ribosomal RNA gene transcription by antagonizing PHF finger protein 8 (PHF8) and recruiting methyltransferase SUV39H1.8
289943052018Plant homeodomain finger protein 2 as a novel IKAROS target in acute lymphoblastic leukemia.5
312146162019MiR-221 Promotes Hepatocellular Carcinoma Cells Migration via Targeting PHF2.4
277446262017Histone Demethylase Gene PHF2 Is Mutated in Gastric and Colorectal Cancers.2
293364842018Epigenetic regulation of megakaryocytic and erythroid differentiation by PHF2 histone demethylase.2

Citation

Dessen P

PHF2 (PHD finger protein 2)

Atlas Genet Cytogenet Oncol Haematol. 2009-04-01

Online version: http://atlasgeneticsoncology.org/gene/50847/phf2