Atlas of Genetics and Cytogenetics in Oncology and Haematology

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PI4K2A (phosphatidylinositol 4-kinase type 2 alpha)

Identity

Alias_symbol (synonym)PI4KII
DKFZP761G1923
PIK42A
Other alias
HGNC (Hugo) PI4K2A
LocusID (NCBI) 55361
Atlas_Id 46830
Location 10q24.2  [Link to chromosome band 10q24]
Location_base_pair Starts at 97640686 and ends at 97676432 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
PI4K2A (10q24.2) / ALDH3B1 (11q13.2)PI4K2A (10q24.2) / PFDN5 (12q13.13)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)PI4K2A   30031
Cards
Entrez_Gene (NCBI)PI4K2A  55361  phosphatidylinositol 4-kinase type 2 alpha
AliasesPI4KII; PIK42A
GeneCards (Weizmann)PI4K2A
Ensembl hg19 (Hinxton)ENSG00000155252 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000155252 [Gene_View]  ENSG00000155252 [Sequence]  chr10:97640686-97676432 [Contig_View]  PI4K2A [Vega]
ICGC DataPortalENSG00000155252
TCGA cBioPortalPI4K2A
AceView (NCBI)PI4K2A
Genatlas (Paris)PI4K2A
WikiGenes55361
SOURCE (Princeton)PI4K2A
Genetics Home Reference (NIH)PI4K2A
Genomic and cartography
GoldenPath hg38 (UCSC)PI4K2A  -     chr10:97640686-97676432 +  10q24.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PI4K2A  -     10q24.2   [Description]    (hg19-Feb_2009)
EnsemblPI4K2A - 10q24.2 [CytoView hg19]  PI4K2A - 10q24.2 [CytoView hg38]
Mapping of homologs : NCBIPI4K2A [Mapview hg19]  PI4K2A [Mapview hg38]
OMIM609763   
Gene and transcription
Genbank (Entrez)AF070611 AJ303098 AK023236 AK024317 AK309343
RefSeq transcript (Entrez)NM_018425
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PI4K2A
Cluster EST : UnigeneHs.25300 [ NCBI ]
CGAP (NCI)Hs.25300
Alternative Splicing GalleryENSG00000155252
Gene ExpressionPI4K2A [ NCBI-GEO ]   PI4K2A [ EBI - ARRAY_EXPRESS ]   PI4K2A [ SEEK ]   PI4K2A [ MEM ]
Gene Expression Viewer (FireBrowse)PI4K2A [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)55361
GTEX Portal (Tissue expression)PI4K2A
Human Protein AtlasENSG00000155252-PI4K2A [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9BTU6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9BTU6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9BTU6
Splice isoforms : SwissVarQ9BTU6
PhosPhoSitePlusQ9BTU6
Domains : Interpro (EBI)PI3/4_kinase_cat_dom   
Domain families : Pfam (Sanger)PI3_PI4_kinase (PF00454)   
Domain families : Pfam (NCBI)pfam00454   
Conserved Domain (NCBI)PI4K2A
DMDM Disease mutations55361
Blocks (Seattle)PI4K2A
PDB (SRS)4HND    4HNE    4PLA    4YC4    5EUT    5I0N   
PDB (PDBSum)4HND    4HNE    4PLA    4YC4    5EUT    5I0N   
PDB (IMB)4HND    4HNE    4PLA    4YC4    5EUT    5I0N   
PDB (RSDB)4HND    4HNE    4PLA    4YC4    5EUT    5I0N   
Structural Biology KnowledgeBase4HND    4HNE    4PLA    4YC4    5EUT    5I0N   
SCOP (Structural Classification of Proteins)4HND    4HNE    4PLA    4YC4    5EUT    5I0N   
CATH (Classification of proteins structures)4HND    4HNE    4PLA    4YC4    5EUT    5I0N   
SuperfamilyQ9BTU6
Human Protein Atlas [tissue]ENSG00000155252-PI4K2A [tissue]
Peptide AtlasQ9BTU6
HPRD11431
IPIIPI00020124   IPI00329210   
Protein Interaction databases
DIP (DOE-UCLA)Q9BTU6
IntAct (EBI)Q9BTU6
FunCoupENSG00000155252
BioGRIDPI4K2A
STRING (EMBL)PI4K2A
ZODIACPI4K2A
Ontologies - Pathways
QuickGOQ9BTU6
Ontology : AmiGOmagnesium ion binding  basophil degranulation  1-phosphatidylinositol 4-kinase activity  1-phosphatidylinositol 4-kinase activity  1-phosphatidylinositol 4-kinase activity  protein binding  ATP binding  mitochondrion  lysosomal membrane  endosome  endosome  trans-Golgi network  cytosol  plasma membrane  integral component of plasma membrane  phosphatidylinositol biosynthetic process  phosphatidylinositol biosynthetic process  Golgi organization  endosome organization  membrane  cell junction  dendrite  synaptic vesicle membrane  BLOC-1 complex  intrinsic component of membrane  cytoplasmic vesicle  early endosome membrane  AP-3 adaptor complex binding  growing cell tip  presynaptic membrane  neuron projection  neuronal cell body  perikaryon  host cell presynaptic membrane  membrane raft  phosphatidylinositol phosphorylation  phosphatidylinositol phosphorylation  
Ontology : EGO-EBImagnesium ion binding  basophil degranulation  1-phosphatidylinositol 4-kinase activity  1-phosphatidylinositol 4-kinase activity  1-phosphatidylinositol 4-kinase activity  protein binding  ATP binding  mitochondrion  lysosomal membrane  endosome  endosome  trans-Golgi network  cytosol  plasma membrane  integral component of plasma membrane  phosphatidylinositol biosynthetic process  phosphatidylinositol biosynthetic process  Golgi organization  endosome organization  membrane  cell junction  dendrite  synaptic vesicle membrane  BLOC-1 complex  intrinsic component of membrane  cytoplasmic vesicle  early endosome membrane  AP-3 adaptor complex binding  growing cell tip  presynaptic membrane  neuron projection  neuronal cell body  perikaryon  host cell presynaptic membrane  membrane raft  phosphatidylinositol phosphorylation  phosphatidylinositol phosphorylation  
Pathways : KEGGInositol phosphate metabolism    Phosphatidylinositol signaling system   
NDEx NetworkPI4K2A
Atlas of Cancer Signalling NetworkPI4K2A
Wikipedia pathwaysPI4K2A
Orthology - Evolution
OrthoDB55361
GeneTree (enSembl)ENSG00000155252
Phylogenetic Trees/Animal Genes : TreeFamPI4K2A
HOGENOMQ9BTU6
Homologs : HomoloGenePI4K2A
Homology/Alignments : Family Browser (UCSC)PI4K2A
Gene fusions - Rearrangements
Fusion : QuiverPI4K2A
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPI4K2A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PI4K2A
dbVarPI4K2A
ClinVarPI4K2A
1000_GenomesPI4K2A 
Exome Variant ServerPI4K2A
ExAC (Exome Aggregation Consortium)ENSG00000155252
GNOMAD BrowserENSG00000155252
Varsome BrowserPI4K2A
Genetic variants : HAPMAP55361
Genomic Variants (DGV)PI4K2A [DGVbeta]
DECIPHERPI4K2A [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPI4K2A 
Mutations
ICGC Data PortalPI4K2A 
TCGA Data PortalPI4K2A 
Broad Tumor PortalPI4K2A
OASIS PortalPI4K2A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPI4K2A  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPI4K2A
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PI4K2A
DgiDB (Drug Gene Interaction Database)PI4K2A
DoCM (Curated mutations)PI4K2A (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PI4K2A (select a term)
intoGenPI4K2A
Cancer3DPI4K2A(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609763   
Orphanet
DisGeNETPI4K2A
MedgenPI4K2A
Genetic Testing Registry PI4K2A
NextProtQ9BTU6 [Medical]
TSGene55361
GENETestsPI4K2A
Target ValidationPI4K2A
Huge Navigator PI4K2A [HugePedia]
snp3D : Map Gene to Disease55361
BioCentury BCIQPI4K2A
ClinGenPI4K2A
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD55361
Chemical/Pharm GKB GenePA162399304
Clinical trialPI4K2A
Miscellaneous
canSAR (ICR)PI4K2A (select the gene name)
Probes
Litterature
PubMed50 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePI4K2A
EVEXPI4K2A
GoPubMedPI4K2A
iHOPPI4K2A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Dec 21 15:42:32 CET 2018
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