Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

PIK3R2 (phosphoinositide-3-kinase regulatory subunit 2)

Identity

Alias_namesphosphoinositide-3-kinase
Alias_symbol (synonym)P85B
p85
Other aliasMPPH
MPPH1
p85-BETA
HGNC (Hugo) PIK3R2
LocusID (NCBI) 5296
Atlas_Id 52814
Location 19p13.11  [Link to chromosome band 19p13]
Location_base_pair Starts at 18153178 and ends at 18170533 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
PIK3R2 (19p13.11) / ARIH1 (15q24.1)PIK3R2 (19p13.11) / CRYBA2 (2q35)PIK3R2 (19p13.11) / PIK3R2 (19p13.11)
PIK3R2 (19p13.11) / SETX (9q34.13)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PIK3R2   8980
Cards
Entrez_Gene (NCBI)PIK3R2  5296  phosphoinositide-3-kinase regulatory subunit 2
AliasesMPPH; MPPH1; P85B; p85; 
p85-BETA
GeneCards (Weizmann)PIK3R2
Ensembl hg19 (Hinxton)ENSG00000105647 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000105647 [Gene_View]  chr19:18153178-18170533 [Contig_View]  PIK3R2 [Vega]
ICGC DataPortalENSG00000105647
TCGA cBioPortalPIK3R2
AceView (NCBI)PIK3R2
Genatlas (Paris)PIK3R2
WikiGenes5296
SOURCE (Princeton)PIK3R2
Genetics Home Reference (NIH)PIK3R2
Genomic and cartography
GoldenPath hg38 (UCSC)PIK3R2  -     chr19:18153178-18170533 +  19p13.11   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PIK3R2  -     19p13.11   [Description]    (hg19-Feb_2009)
EnsemblPIK3R2 - 19p13.11 [CytoView hg19]  PIK3R2 - 19p13.11 [CytoView hg38]
Mapping of homologs : NCBIPIK3R2 [Mapview hg19]  PIK3R2 [Mapview hg38]
OMIM603157   603387   
Gene and transcription
Genbank (Entrez)BC011917 BC014170 BC032647 BC070082 BC090249
RefSeq transcript (Entrez)NM_005027
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PIK3R2
Cluster EST : UnigeneHs.371344 [ NCBI ]
CGAP (NCI)Hs.371344
Alternative Splicing GalleryENSG00000105647
Gene ExpressionPIK3R2 [ NCBI-GEO ]   PIK3R2 [ EBI - ARRAY_EXPRESS ]   PIK3R2 [ SEEK ]   PIK3R2 [ MEM ]
Gene Expression Viewer (FireBrowse)PIK3R2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5296
GTEX Portal (Tissue expression)PIK3R2
Protein : pattern, domain, 3D structure
UniProt/SwissProtO00459   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO00459  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO00459
Splice isoforms : SwissVarO00459
PhosPhoSitePlusO00459
Domaine pattern : Prosite (Expaxy)RHOGAP (PS50238)    SH2 (PS50001)    SH3 (PS50002)   
Domains : Interpro (EBI)PI3K_P85_iSH2    PI3kinase_P85    Rho_GTPase_activation_prot    RhoGAP_dom    SH2    SH3_domain   
Domain families : Pfam (Sanger)PI3K_P85_iSH2 (PF16454)    RhoGAP (PF00620)    SH2 (PF00017)   
Domain families : Pfam (NCBI)pfam16454    pfam00620    pfam00017   
Domain families : Smart (EMBL)RhoGAP (SM00324)  SH2 (SM00252)  SH3 (SM00326)  
Conserved Domain (NCBI)PIK3R2
DMDM Disease mutations5296
Blocks (Seattle)PIK3R2
PDB (SRS)2KT1    2XS6    3MTT    3O5Z   
PDB (PDBSum)2KT1    2XS6    3MTT    3O5Z   
PDB (IMB)2KT1    2XS6    3MTT    3O5Z   
PDB (RSDB)2KT1    2XS6    3MTT    3O5Z   
Structural Biology KnowledgeBase2KT1    2XS6    3MTT    3O5Z   
SCOP (Structural Classification of Proteins)2KT1    2XS6    3MTT    3O5Z   
CATH (Classification of proteins structures)2KT1    2XS6    3MTT    3O5Z   
SuperfamilyO00459
Human Protein AtlasENSG00000105647
Peptide AtlasO00459
HPRD04404
IPIIPI00011736   IPI00796770   
Protein Interaction databases
DIP (DOE-UCLA)O00459
IntAct (EBI)O00459
FunCoupENSG00000105647
BioGRIDPIK3R2
STRING (EMBL)PIK3R2
ZODIACPIK3R2
Ontologies - Pathways
QuickGOO00459
Ontology : AmiGOcellular glucose homeostasis  phosphotyrosine binding  GTPase activator activity  protein binding  nucleus  cytosol  phosphatidylinositol 3-kinase complex  phosphatidylinositol biosynthetic process  insulin receptor signaling pathway  regulation of autophagy  phosphatidylinositol 3-kinase signaling  regulation of phosphatidylinositol 3-kinase signaling  protein transport  1-phosphatidylinositol-3-kinase activity  1-phosphatidylinositol-3-kinase activity  protein phosphatase binding  receptor tyrosine kinase binding  cellular response to insulin stimulus  response to endoplasmic reticulum stress  phosphatidylinositol-3-phosphate biosynthetic process  Fc-epsilon receptor signaling pathway  Fc-gamma receptor signaling pathway involved in phagocytosis  positive regulation of transcription factor import into nucleus  positive regulation of apoptotic process  positive regulation of GTPase activity  regulation of phosphatidylinositol 3-kinase activity  positive regulation of transcription from RNA polymerase II promoter  phosphatidylinositol phosphorylation  phosphatidylinositol-4,5-bisphosphate 3-kinase activity  1-phosphatidylinositol-3-kinase regulator activity  protein heterodimerization activity  vascular endothelial growth factor receptor signaling pathway  phosphatidylinositol-mediated signaling  T cell receptor signaling pathway  leukocyte migration  regulation of small GTPase mediated signal transduction  positive regulation of glucose import in response to insulin stimulus  
Ontology : EGO-EBIcellular glucose homeostasis  phosphotyrosine binding  GTPase activator activity  protein binding  nucleus  cytosol  phosphatidylinositol 3-kinase complex  phosphatidylinositol biosynthetic process  insulin receptor signaling pathway  regulation of autophagy  phosphatidylinositol 3-kinase signaling  regulation of phosphatidylinositol 3-kinase signaling  protein transport  1-phosphatidylinositol-3-kinase activity  1-phosphatidylinositol-3-kinase activity  protein phosphatase binding  receptor tyrosine kinase binding  cellular response to insulin stimulus  response to endoplasmic reticulum stress  phosphatidylinositol-3-phosphate biosynthetic process  Fc-epsilon receptor signaling pathway  Fc-gamma receptor signaling pathway involved in phagocytosis  positive regulation of transcription factor import into nucleus  positive regulation of apoptotic process  positive regulation of GTPase activity  regulation of phosphatidylinositol 3-kinase activity  positive regulation of transcription from RNA polymerase II promoter  phosphatidylinositol phosphorylation  phosphatidylinositol-4,5-bisphosphate 3-kinase activity  1-phosphatidylinositol-3-kinase regulator activity  protein heterodimerization activity  vascular endothelial growth factor receptor signaling pathway  phosphatidylinositol-mediated signaling  T cell receptor signaling pathway  leukocyte migration  regulation of small GTPase mediated signal transduction  positive regulation of glucose import in response to insulin stimulus  
Pathways : KEGG   
NDEx NetworkPIK3R2
Atlas of Cancer Signalling NetworkPIK3R2
Wikipedia pathwaysPIK3R2
Orthology - Evolution
OrthoDB5296
GeneTree (enSembl)ENSG00000105647
Phylogenetic Trees/Animal Genes : TreeFamPIK3R2
HOVERGENO00459
HOGENOMO00459
Homologs : HomoloGenePIK3R2
Homology/Alignments : Family Browser (UCSC)PIK3R2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPIK3R2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PIK3R2
dbVarPIK3R2
ClinVarPIK3R2
1000_GenomesPIK3R2 
Exome Variant ServerPIK3R2
ExAC (Exome Aggregation Consortium)PIK3R2 (select the gene name)
Genetic variants : HAPMAP5296
Genomic Variants (DGV)PIK3R2 [DGVbeta]
DECIPHERPIK3R2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPIK3R2 
Mutations
ICGC Data PortalPIK3R2 
TCGA Data PortalPIK3R2 
Broad Tumor PortalPIK3R2
OASIS PortalPIK3R2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPIK3R2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPIK3R2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PIK3R2
DgiDB (Drug Gene Interaction Database)PIK3R2
DoCM (Curated mutations)PIK3R2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PIK3R2 (select a term)
intoGenPIK3R2
Cancer3DPIK3R2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603157    603387   
Orphanet11582    11582   
MedgenPIK3R2
Genetic Testing Registry PIK3R2
NextProtO00459 [Medical]
TSGene5296
GENETestsPIK3R2
Target ValidationPIK3R2
Huge Navigator PIK3R2 [HugePedia]
snp3D : Map Gene to Disease5296
BioCentury BCIQPIK3R2
ClinGenPIK3R2 (curated)
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5296
Chemical/Pharm GKB GenePA33313
Clinical trialPIK3R2
Miscellaneous
canSAR (ICR)PIK3R2 (select the gene name)
Probes
Litterature
PubMed162 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePIK3R2
EVEXPIK3R2
GoPubMedPIK3R2
iHOPPIK3R2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Sep 25 19:24:50 CEST 2017

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.