Identity
HGNC
LOCATION
19p13.11
LOCUSID
ALIAS
MPPH,MPPH1,P85B,p85,p85-BETA
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 5296
MIM: 603157
HGNC: 8980
Ensembl: ENSG00000105647
Variants:
dbSNP: 5296
ClinVar: 5296
TCGA: ENSG00000105647
COSMIC: PIK3R2
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA128406956 | fluorouracil | Chemical | ClinicalAnnotation, VariantAnnotation | associated | PD | ||
| PA24684 | AKT1 | Gene | Pathway | associated | 28362716 | ||
| PA27844 | ERBB2 | Gene | Pathway | associated | |||
| PA27846 | ERBB3 | Gene | Pathway | associated | |||
| PA27847 | ERBB4 | Gene | Pathway | associated | |||
| PA28180 | FLT1 | Gene | Pathway | associated | 28362716 | ||
| PA28183 | FLT4 | Gene | Pathway | associated | 28362716 | ||
| PA30086 | KDR | Gene | Pathway | associated | 28362716 | ||
| PA443560 | Breast Neoplasms | Disease | ClinicalAnnotation, VariantAnnotation | associated | PD | ||
| PA445113 | Neutropenia | Disease | ClinicalAnnotation, VariantAnnotation | associated | PD | ||
| PA449165 | cyclophosphamide | Chemical | ClinicalAnnotation, VariantAnnotation | associated | PD | ||
| PA449476 | epirubicin | Chemical | ClinicalAnnotation, VariantAnnotation | associated | PD | ||
| PA7360 | EGFR | Gene | Pathway | associated |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38411298 | 2024 | NSUN2 promotes lung adenocarcinoma progression through stabilizing PIK3R2 mRNA in an m(5)C-dependent manner. | 0 |
| 38411298 | 2024 | NSUN2 promotes lung adenocarcinoma progression through stabilizing PIK3R2 mRNA in an m(5)C-dependent manner. | 0 |
| 36528701 | 2023 | PIK3R2 predicts poor outcomes for patients with melanoma and contributes to the malignant progression via PI3K/AKT/NF-κB axis. | 3 |
| 36857183 | 2023 | FAK-mediated phosphorylation at Y464 regulates p85β nuclear translocation to promote tumorigenesis of ccRCC by repressing RB1 expression. | 2 |
| 37904709 | 2023 | LncRNA HOTAIR regulates the PI3K/AKT pathway via the miR-126-3p/PIK3R2 axis to participate in synovial angiogenesis in rheumatoid arthritis. | 2 |
| 36528701 | 2023 | PIK3R2 predicts poor outcomes for patients with melanoma and contributes to the malignant progression via PI3K/AKT/NF-κB axis. | 3 |
| 36857183 | 2023 | FAK-mediated phosphorylation at Y464 regulates p85β nuclear translocation to promote tumorigenesis of ccRCC by repressing RB1 expression. | 2 |
| 37904709 | 2023 | LncRNA HOTAIR regulates the PI3K/AKT pathway via the miR-126-3p/PIK3R2 axis to participate in synovial angiogenesis in rheumatoid arthritis. | 2 |
| 35395865 | 2022 | Pan-cancer analysis on the role of PIK3R1 and PIK3R2 in human tumors. | 20 |
| 35550247 | 2022 | FER-mediated phosphorylation and PIK3R2 recruitment on IRS4 promotes AKT activation and tumorigenesis in ovarian cancer cells. | 7 |
| 35637600 | 2022 | lncRNA XLOC013218 promotes cell proliferation and TMZ resistance by targeting the PIK3R2-mediated PI3K/AKT pathway in glioma. | 14 |
| 36444616 | 2022 | SPTBN1 attenuates rheumatoid arthritis synovial cell proliferation, invasion, migration and inflammatory response by binding to PIK3R2. | 1 |
| 35395865 | 2022 | Pan-cancer analysis on the role of PIK3R1 and PIK3R2 in human tumors. | 20 |
| 35550247 | 2022 | FER-mediated phosphorylation and PIK3R2 recruitment on IRS4 promotes AKT activation and tumorigenesis in ovarian cancer cells. | 7 |
| 35637600 | 2022 | lncRNA XLOC013218 promotes cell proliferation and TMZ resistance by targeting the PIK3R2-mediated PI3K/AKT pathway in glioma. | 14 |
Citation
Dessen P
PIK3R2 (phosphoinositide-3-kinase regulatory subunit 2)
Atlas Genet Cytogenet Oncol Haematol. 2010-03-01
Online version: http://atlasgeneticsoncology.org/gene/52814/pik3r2
