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PIK3R4 (phosphoinositide-3-kinase regulatory subunit 4)

Identity

Other namesVPS15
p150
HGNC (Hugo) PIK3R4
LocusID (NCBI) 30849
Atlas_Id 43410
Location 3q22.1  [Link to chromosome band 3q22]
Location_base_pair Starts at 130397778 and ends at 130465696 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
CASP4 (11q22.3) / PIK3R4 (3q22.1)PIK3R4 (3q22.1) / PIK3R4 (3q22.1)PUS10 (2p16.1) / PIK3R4 (3q22.1)
ZNF621 (3p22.1) / PIK3R4 (3q22.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PIK3R4   8982
Cards
Entrez_Gene (NCBI)PIK3R4  30849  phosphoinositide-3-kinase regulatory subunit 4
AliasesVPS15; p150
GeneCards (Weizmann)PIK3R4
Ensembl hg19 (Hinxton)ENSG00000196455 [Gene_View]  chr3:130397778-130465696 [Contig_View]  PIK3R4 [Vega]
Ensembl hg38 (Hinxton)ENSG00000196455 [Gene_View]  chr3:130397778-130465696 [Contig_View]  PIK3R4 [Vega]
ICGC DataPortalENSG00000196455
TCGA cBioPortalPIK3R4
AceView (NCBI)PIK3R4
Genatlas (Paris)PIK3R4
WikiGenes30849
SOURCE (Princeton)PIK3R4
Genomic and cartography
GoldenPath hg19 (UCSC)PIK3R4  -     chr3:130397778-130465696 -  3q22.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PIK3R4  -     3q22.1   [Description]    (hg38-Dec_2013)
EnsemblPIK3R4 - 3q22.1 [CytoView hg19]  PIK3R4 - 3q22.1 [CytoView hg38]
Mapping of homologs : NCBIPIK3R4 [Mapview hg19]  PIK3R4 [Mapview hg38]
OMIM602610   
Gene and transcription
Genbank (Entrez)AK314219 BC009899 BC017332 BC057239 BC069191
RefSeq transcript (Entrez)NM_014602
RefSeq genomic (Entrez)NC_000003 NC_018914 NT_005612 NW_004929311
Consensus coding sequences : CCDS (NCBI)PIK3R4
Cluster EST : UnigeneHs.149032 [ NCBI ]
CGAP (NCI)Hs.149032
Alternative Splicing GalleryENSG00000196455
Gene ExpressionPIK3R4 [ NCBI-GEO ]   PIK3R4 [ EBI - ARRAY_EXPRESS ]   PIK3R4 [ SEEK ]   PIK3R4 [ MEM ]
Gene Expression Viewer (FireBrowse)PIK3R4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)30849
GTEX Portal (Tissue expression)PIK3R4
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ99570 (Uniprot)
NextProtQ99570  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ99570
Splice isoforms : SwissVarQ99570 (Swissvar)
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   
PhosPhoSitePlusQ99570
Domaine pattern : Prosite (Expaxy)HEAT_REPEAT (PS50077)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)    WD_REPEATS_1 (PS00678)    WD_REPEATS_2 (PS50082)    WD_REPEATS_REGION (PS50294)   
Domains : Interpro (EBI)ARM-like    ARM-type_fold    HEAT_type_2    Kinase-like_dom    Prot_kinase_dom    Ser/Thr_kinase_AS    WD40/YVTN_repeat-like_dom    WD40_repeat    WD40_repeat_CS    WD40_repeat_dom   
Domain families : Pfam (Sanger)Pkinase (PF00069)    WD40 (PF00400)   
Domain families : Pfam (NCBI)pfam00069    pfam00400   
Domain families : Smart (EMBL)WD40 (SM00320)  
DMDM Disease mutations30849
Blocks (Seattle)PIK3R4
SuperfamilyQ99570
Human Protein AtlasENSG00000196455
Peptide AtlasQ99570
HPRD04010
IPIIPI00024006   IPI00967377   IPI00968183   IPI00967677   
Protein Interaction databases
DIP (DOE-UCLA)Q99570
IntAct (EBI)Q99570
FunCoupENSG00000196455
BioGRIDPIK3R4
STRING (EMBL)PIK3R4
ZODIACPIK3R4
Ontologies - Pathways
QuickGOQ99570
Ontology : AmiGOprotein kinase activity  protein serine/threonine kinase activity  protein binding  ATP binding  nuclear pore  late endosome  autophagosome  cytosol  axoneme  protein phosphorylation  protein phosphorylation  protein targeting to vacuole  phosphatidylinositol biosynthetic process  membrane  macroautophagy  macroautophagy  1-phosphatidylinositol-3-kinase activity  pexophagy  phagocytic vesicle membrane  regulation of cytokinesis  receptor catabolic process  toll-like receptor 9 signaling pathway  phosphatidylinositol 3-kinase complex, class III, type I  phosphatidylinositol 3-kinase complex, class III, type II  phosphatidylinositol 3-kinase complex, class III  phosphatidylinositol-3-phosphate biosynthetic process  cellular response to glucose starvation  positive regulation of phosphatidylinositol 3-kinase activity  late endosome to vacuole transport  nucleus-vacuole junction  
Ontology : EGO-EBIprotein kinase activity  protein serine/threonine kinase activity  protein binding  ATP binding  nuclear pore  late endosome  autophagosome  cytosol  axoneme  protein phosphorylation  protein phosphorylation  protein targeting to vacuole  phosphatidylinositol biosynthetic process  membrane  macroautophagy  macroautophagy  1-phosphatidylinositol-3-kinase activity  pexophagy  phagocytic vesicle membrane  regulation of cytokinesis  receptor catabolic process  toll-like receptor 9 signaling pathway  phosphatidylinositol 3-kinase complex, class III, type I  phosphatidylinositol 3-kinase complex, class III, type II  phosphatidylinositol 3-kinase complex, class III  phosphatidylinositol-3-phosphate biosynthetic process  cellular response to glucose starvation  positive regulation of phosphatidylinositol 3-kinase activity  late endosome to vacuole transport  nucleus-vacuole junction  
Pathways : KEGGRegulation of autophagy   
NDEx NetworkPIK3R4
Atlas of Cancer Signalling NetworkPIK3R4
Wikipedia pathwaysPIK3R4
Orthology - Evolution
OrthoDB30849
GeneTree (enSembl)ENSG00000196455
Phylogenetic Trees/Animal Genes : TreeFamPIK3R4
Homologs : HomoloGenePIK3R4
Homology/Alignments : Family Browser (UCSC)PIK3R4
Gene fusions - Rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerPIK3R4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PIK3R4
dbVarPIK3R4
ClinVarPIK3R4
1000_GenomesPIK3R4 
Exome Variant ServerPIK3R4
ExAC (Exome Aggregation Consortium)PIK3R4 (select the gene name)
Genetic variants : HAPMAP30849
Genomic Variants (DGV)PIK3R4 [DGVbeta]
Mutations
ICGC Data PortalPIK3R4 
TCGA Data PortalPIK3R4 
Broad Tumor PortalPIK3R4
OASIS PortalPIK3R4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPIK3R4 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PIK3R4
DgiDB (Drug Gene Interaction Database)PIK3R4
DoCM (Curated mutations)PIK3R4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PIK3R4 (select a term)
intoGenPIK3R4
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)3:130397778-130465696  ENSG00000196455
CONAN: Copy Number AnalysisPIK3R4 
Mutations and Diseases : HGMDPIK3R4
OMIM602610   
MedgenPIK3R4
Genetic Testing Registry PIK3R4
NextProtQ99570 [Medical]
TSGene30849
GENETestsPIK3R4
Huge Navigator PIK3R4 [HugePedia]
snp3D : Map Gene to Disease30849
BioCentury BCIQPIK3R4
ClinGenPIK3R4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD30849
Chemical/Pharm GKB GenePA33315
Clinical trialPIK3R4
Miscellaneous
canSAR (ICR)PIK3R4 (select the gene name)
Probes
Litterature
PubMed32 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePIK3R4
EVEXPIK3R4
GoPubMedPIK3R4
iHOPPIK3R4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Sep 19 19:07:09 CEST 2016

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