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PIK3R4 (phosphoinositide-3-kinase, regulatory subunit 4)

Identity

Other namesVPS15
p150
HGNC (Hugo) PIK3R4
LocusID (NCBI) 30849
Location 3q22.1
Location_base_pair Starts at 130397778 and ends at 130465696 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)PIK3R4   8982
Cards
Entrez_Gene (NCBI)PIK3R4  30849  phosphoinositide-3-kinase, regulatory subunit 4
GeneCards (Weizmann)PIK3R4
Ensembl (Hinxton)ENSG00000196455 [Gene_View]  chr3:130397778-130465696 [Contig_View]  PIK3R4 [Vega]
AceView (NCBI)PIK3R4
Genatlas (Paris)PIK3R4
WikiGenes30849
SOURCE (Princeton)NM_014602
Genomic and cartography
GoldenPath (UCSC)PIK3R4  -  3q22.1   chr3:130397778-130465696 -  3q22.1   [Description]    (hg19-Feb_2009)
EnsemblPIK3R4 - 3q22.1 [CytoView]
Mapping of homologs : NCBIPIK3R4 [Mapview]
OMIM602610   
Gene and transcription
Genbank (Entrez)AK314219 BC009899 BC017332 BC057239 BC069191
RefSeq transcript (Entrez)NM_014602
RefSeq genomic (Entrez)AC_000135 NC_000003 NC_018914 NT_005612 NW_001838884 NW_004929311
Consensus coding sequences : CCDS (NCBI)PIK3R4
Cluster EST : UnigeneHs.149032 [ NCBI ]
CGAP (NCI)Hs.149032
Alternative Splicing : Fast-db (Paris)GSHG0022060
Alternative Splicing GalleryENSG00000196455
Gene ExpressionPIK3R4 [ NCBI-GEO ]     PIK3R4 [ SEEK ]   PIK3R4 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ99570 (Uniprot)
NextProtQ99570  [Medical]
With graphics : InterProQ99570
Splice isoforms : SwissVarQ99570 (Swissvar)
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   
Domaine pattern : Prosite (Expaxy)HEAT_REPEAT (PS50077)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)    WD_REPEATS_1 (PS00678)    WD_REPEATS_2 (PS50082)    WD_REPEATS_REGION (PS50294)   
Domains : Interpro (EBI)ARM-like    ARM-type_fold    HEAT_type_2    Kinase-like_dom    Prot_kinase_dom    Ser/Thr_kinase_AS    WD40/YVTN_repeat-like_dom    WD40_repeat    WD40_repeat_CS    WD40_repeat_dom   
Related proteins : CluSTrQ99570
Domain families : Pfam (Sanger)Pkinase (PF00069)    WD40 (PF00400)   
Domain families : Pfam (NCBI)pfam00069    pfam00400   
Domain families : Smart (EMBL)WD40 (SM00320)  
DMDM Disease mutations30849
Blocks (Seattle)Q99570
Human Protein AtlasENSG00000196455
Peptide AtlasQ99570
HPRD04010
IPIIPI00024006   IPI00967377   IPI00968183   IPI00967677   
Protein Interaction databases
DIP (DOE-UCLA)Q99570
IntAct (EBI)Q99570
FunCoupENSG00000196455
BioGRIDPIK3R4
InParanoidQ99570
Interologous Interaction database Q99570
IntegromeDBPIK3R4
STRING (EMBL)PIK3R4
Ontologies - Pathways
Ontology : AmiGOtoll-like receptor signaling pathway  protein kinase activity  protein serine/threonine kinase activity  protein binding  ATP binding  late endosome  cytosol  protein phosphorylation  phospholipid metabolic process  phosphatidylinositol biosynthetic process  insulin receptor signaling pathway  toll-like receptor 9 signaling pathway  small molecule metabolic process  innate immune response  
Ontology : EGO-EBItoll-like receptor signaling pathway  protein kinase activity  protein serine/threonine kinase activity  protein binding  ATP binding  late endosome  cytosol  protein phosphorylation  phospholipid metabolic process  phosphatidylinositol biosynthetic process  insulin receptor signaling pathway  toll-like receptor 9 signaling pathway  small molecule metabolic process  innate immune response  
Pathways : KEGGRegulation of autophagy   
REACTOMEPIK3R4
Protein Interaction DatabasePIK3R4
Wikipedia pathwaysPIK3R4
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)PIK3R4
SNP (GeneSNP Utah)PIK3R4
SNP : HGBasePIK3R4
Genetic variants : HAPMAPPIK3R4
1000_GenomesPIK3R4 
ICGC programENSG00000196455 
Somatic Mutations in Cancer : COSMICPIK3R4 
CONAN: Copy Number AnalysisPIK3R4 
Mutations and Diseases : HGMDPIK3R4
OMIM602610   
GENETestsPIK3R4
Disease Genetic AssociationPIK3R4
Huge Navigator PIK3R4 [HugePedia]  PIK3R4 [HugeCancerGEM]
Genomic VariantsPIK3R4  PIK3R4 [DGVbeta]
Exome VariantPIK3R4
dbVarPIK3R4
ClinVarPIK3R4
snp3D : Map Gene to Disease30849
General knowledge
Homologs : HomoloGenePIK3R4
Homology/Alignments : Family Browser (UCSC)PIK3R4
Phylogenetic Trees/Animal Genes : TreeFamPIK3R4
Chemical/Protein Interactions : CTD30849
Chemical/Pharm GKB GenePA33315
Clinical trialPIK3R4
Cancer Resource (Charite)ENSG00000196455
Other databases
Probes
Litterature
PubMed21 Pubmed reference(s) in Entrez
CoreMinePIK3R4
iHOPPIK3R4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Apr 18 17:14:40 CEST 2014

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