Atlas of Genetics and Cytogenetics in Oncology and Haematology


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PIK3R5 (phosphoinositide-3-kinase regulatory subunit 5)

Identity

Alias_namesphosphoinositide-3-kinase
Alias_symbol (synonym)P101-PI3K
p101
Other aliasF730038I15Rik
FOAP-2
HGNC (Hugo) PIK3R5
LocusID (NCBI) 23533
Atlas_Id 49880
Location 17p13.1  [Link to chromosome band 17p13]
Location_base_pair Starts at 8878916 and ends at 8965712 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
GOLGA3 (12q24.33) / PIK3R5 (17p13.1)MS4A7 (11q12.2) / PIK3R5 (17p13.1)PIK3R5 (17p13.1) / INPP5D (2q37.1)
PIK3R5 (17p13.1) / RNF135 (17q11.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PIK3R5   30035
Cards
Entrez_Gene (NCBI)PIK3R5  23533  phosphoinositide-3-kinase regulatory subunit 5
AliasesF730038I15Rik; FOAP-2; P101-PI3K; p101
GeneCards (Weizmann)PIK3R5
Ensembl hg19 (Hinxton)ENSG00000141506 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000141506 [Gene_View]  chr17:8878916-8965712 [Contig_View]  PIK3R5 [Vega]
ICGC DataPortalENSG00000141506
TCGA cBioPortalPIK3R5
AceView (NCBI)PIK3R5
Genatlas (Paris)PIK3R5
WikiGenes23533
SOURCE (Princeton)PIK3R5
Genetics Home Reference (NIH)PIK3R5
Genomic and cartography
GoldenPath hg38 (UCSC)PIK3R5  -     chr17:8878916-8965712 -  17p13.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PIK3R5  -     17p13.1   [Description]    (hg19-Feb_2009)
EnsemblPIK3R5 - 17p13.1 [CytoView hg19]  PIK3R5 - 17p13.1 [CytoView hg38]
Mapping of homologs : NCBIPIK3R5 [Mapview hg19]  PIK3R5 [Mapview hg38]
OMIM611317   615217   
Gene and transcription
Genbank (Entrez)AB028925 AF128881 AK129627 AK309074 AK314186
RefSeq transcript (Entrez)NM_001142633 NM_001251851 NM_001251852 NM_001251853 NM_001251855 NM_014308
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PIK3R5
Cluster EST : UnigeneHs.738684 [ NCBI ]
CGAP (NCI)Hs.738684
Alternative Splicing GalleryENSG00000141506
Gene ExpressionPIK3R5 [ NCBI-GEO ]   PIK3R5 [ EBI - ARRAY_EXPRESS ]   PIK3R5 [ SEEK ]   PIK3R5 [ MEM ]
Gene Expression Viewer (FireBrowse)PIK3R5 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23533
GTEX Portal (Tissue expression)PIK3R5
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8WYR1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8WYR1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8WYR1
Splice isoforms : SwissVarQ8WYR1
PhosPhoSitePlusQ8WYR1
Domains : Interpro (EBI)PIK3R5/6   
Domain families : Pfam (Sanger)PI3K_1B_p101 (PF10486)   
Domain families : Pfam (NCBI)pfam10486   
Conserved Domain (NCBI)PIK3R5
DMDM Disease mutations23533
Blocks (Seattle)PIK3R5
SuperfamilyQ8WYR1
Human Protein AtlasENSG00000141506
Peptide AtlasQ8WYR1
HPRD11433
IPIIPI00292380   IPI00552269   
Protein Interaction databases
DIP (DOE-UCLA)Q8WYR1
IntAct (EBI)Q8WYR1
FunCoupENSG00000141506
BioGRIDPIK3R5
STRING (EMBL)PIK3R5
ZODIACPIK3R5
Ontologies - Pathways
QuickGOQ8WYR1
Ontology : AmiGOnucleus  cytoplasm  microtubule organizing center  cytosol  cytosol  plasma membrane  phosphatidylinositol 3-kinase complex  phosphatidylinositol 3-kinase complex, class IB  phosphatidylinositol biosynthetic process  G-protein coupled receptor signaling pathway  G-protein coupled receptor signaling pathway  phosphatidylinositol 3-kinase signaling  phosphatidylinositol 3-kinase signaling  membrane  platelet activation  G-protein beta/gamma-subunit complex binding  positive regulation of MAP kinase activity  positive regulation of MAP kinase activity  regulation of phosphatidylinositol 3-kinase activity  phosphatidylinositol phosphorylation  phosphatidylinositol-4,5-bisphosphate 3-kinase activity  1-phosphatidylinositol-3-kinase regulator activity  positive regulation of protein kinase B signaling  
Ontology : EGO-EBInucleus  cytoplasm  microtubule organizing center  cytosol  cytosol  plasma membrane  phosphatidylinositol 3-kinase complex  phosphatidylinositol 3-kinase complex, class IB  phosphatidylinositol biosynthetic process  G-protein coupled receptor signaling pathway  G-protein coupled receptor signaling pathway  phosphatidylinositol 3-kinase signaling  phosphatidylinositol 3-kinase signaling  membrane  platelet activation  G-protein beta/gamma-subunit complex binding  positive regulation of MAP kinase activity  positive regulation of MAP kinase activity  regulation of phosphatidylinositol 3-kinase activity  phosphatidylinositol phosphorylation  phosphatidylinositol-4,5-bisphosphate 3-kinase activity  1-phosphatidylinositol-3-kinase regulator activity  positive regulation of protein kinase B signaling  
Pathways : KEGG   
NDEx NetworkPIK3R5
Atlas of Cancer Signalling NetworkPIK3R5
Wikipedia pathwaysPIK3R5
Orthology - Evolution
OrthoDB23533
GeneTree (enSembl)ENSG00000141506
Phylogenetic Trees/Animal Genes : TreeFamPIK3R5
HOVERGENQ8WYR1
HOGENOMQ8WYR1
Homologs : HomoloGenePIK3R5
Homology/Alignments : Family Browser (UCSC)PIK3R5
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPIK3R5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PIK3R5
dbVarPIK3R5
ClinVarPIK3R5
1000_GenomesPIK3R5 
Exome Variant ServerPIK3R5
ExAC (Exome Aggregation Consortium)PIK3R5 (select the gene name)
Genetic variants : HAPMAP23533
Genomic Variants (DGV)PIK3R5 [DGVbeta]
DECIPHERPIK3R5 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPIK3R5 
Mutations
ICGC Data PortalPIK3R5 
TCGA Data PortalPIK3R5 
Broad Tumor PortalPIK3R5
OASIS PortalPIK3R5 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPIK3R5  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPIK3R5
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
BioMutasearch PIK3R5
DgiDB (Drug Gene Interaction Database)PIK3R5
DoCM (Curated mutations)PIK3R5 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PIK3R5 (select a term)
intoGenPIK3R5
Cancer3DPIK3R5(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM611317    615217   
Orphanet10857   
MedgenPIK3R5
Genetic Testing Registry PIK3R5
NextProtQ8WYR1 [Medical]
TSGene23533
GENETestsPIK3R5
Target ValidationPIK3R5
Huge Navigator PIK3R5 [HugePedia]
snp3D : Map Gene to Disease23533
BioCentury BCIQPIK3R5
ClinGenPIK3R5
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD23533
Chemical/Pharm GKB GenePA134890823
Clinical trialPIK3R5
Miscellaneous
canSAR (ICR)PIK3R5 (select the gene name)
Probes
Litterature
PubMed21 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePIK3R5
EVEXPIK3R5
GoPubMedPIK3R5
iHOPPIK3R5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Tue Aug 1 17:10:42 CEST 2017

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