PIK3R5 (phosphoinositide-3-kinase regulatory subunit 5)

2007-12-01  

Identity

HGNC
PIK3R5
LOCATION
17p13.1
LOCUSID
23533
ALIAS
F730038I15Rik,FOAP-2,P101-PI3K,p101
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 23533
MIM: 611317
HGNC: 30035
Ensembl: ENSG00000141506

Variants:

dbSNP: 23533
ClinVar: 23533
TCGA: ENSG00000141506
COSMIC: PIK3R5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000141506ENST00000269300X6R3K3
ENSG00000141506ENST00000447110Q8WYR1
ENSG00000141506ENST00000447110L7RT34
ENSG00000141506ENST00000581552Q8WYR1
ENSG00000141506ENST00000581552L7RT34
ENSG00000141506ENST00000581895J3KRE9
ENSG00000141506ENST00000584803J3KSW1
ENSG00000141506ENST00000585260J3KT66
ENSG00000141506ENST00000611902Q8WYR1
ENSG00000141506ENST00000616147Q8WYR1
ENSG00000141506ENST00000623421Q8WYR1

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
ToxoplasmosisKEGGko05145
ToxoplasmosisKEGGhsa05145
Cholinergic synapseKEGGhsa04725
PI3K-Akt signaling pathwayKEGGhsa04151
PI3K-Akt signaling pathwayKEGGko04151
Adrenergic signaling in cardiomyocytesKEGGhsa04261
Adrenergic signaling in cardiomyocytesKEGGko04261
Platelet activationKEGGhsa04611
Oxytocin signaling pathwayKEGGhsa04921
Oxytocin signaling pathwayKEGGko04921
cGMP-PKG signaling pathwayKEGGhsa04022
cGMP-PKG signaling pathwayKEGGko04022
HemostasisREACTOMER-HSA-109582
Platelet activation, signaling and aggregationREACTOMER-HSA-76002
GPVI-mediated activation cascadeREACTOMER-HSA-114604
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR downstream signalingREACTOMER-HSA-388396
G-protein beta:gamma signallingREACTOMER-HSA-397795
G beta:gamma signalling through PI3KgammaREACTOMER-HSA-392451
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Phospholipid metabolismREACTOMER-HSA-1483257
PI MetabolismREACTOMER-HSA-1483255
Synthesis of PIPs at the plasma membraneREACTOMER-HSA-1660499
Phospholipase D signaling pathwayKEGGko04072
Phospholipase D signaling pathwayKEGGhsa04072
Apelin signaling pathwayKEGGhsa04371

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA24684AKT1GenePathwayassociated
PA24686AKT3GenePathwayassociated
PA29457HRH2GenePathwayassociated

References

Pubmed IDYearTitleCitations
125079952003Roles of G beta gamma in membrane recruitment and activation of p110 gamma/p101 phosphoinositide 3-kinase gamma.83
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
194532612009High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men.20
156110652005Assigning functional domains within the p101 regulatory subunit of phosphoinositide 3-kinase gamma.15
220655242012A missense mutation in PIK3R5 gene in a family with ataxia and oculomotor apraxia.10
240140272013p87 and p101 subunits are distinct regulators determining class IB phosphoinositide 3-kinase (PI3K) specificity.9
174860672007Overexpression of p101 activates PI3Kgamma signaling in T cells and contributes to cell survival.6
261732592015Different inhibition of Gβγ-stimulated class IB phosphoinositide 3-kinase (PI3K) variants by a monoclonal antibody. Specific function of p101 as a Gβγ-dependent regulator of PI3Kγ enzymatic activity.6
200561782010Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment.5
253742362014Screening of differential promoter hypermethylated genes in primary oral squamous cell carcinoma.2

Citation

Dessen P

PIK3R5 (phosphoinositide-3-kinase regulatory subunit 5)

Atlas Genet Cytogenet Oncol Haematol. 2007-12-01

Online version: http://atlasgeneticsoncology.org/gene/49880/pik3r5