PIN1 (peptidylprolyl cis/trans isomerase, NIMA-interacting 1)

2003-02-01  

Identity

HGNC
LOCATION
19p13.2
LOCUSID
ALIAS
DOD,UBL5
FUSION GENES

Other Information

Locus ID:

NCBI: 5300
MIM: 601052
HGNC: 8988
Ensembl: ENSG00000127445

Variants:

dbSNP: 5300
ClinVar: 5300
TCGA: ENSG00000127445
COSMIC: PIN1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000127445ENST00000247970Q13526
ENSG00000127445ENST00000586352K7EP26
ENSG00000127445ENST00000587625K7EMU7
ENSG00000127445ENST00000588695Q13526
ENSG00000127445ENST00000591777K7EN45

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
RIG-I-like receptor signaling pathwayKEGGko04622
RIG-I-like receptor signaling pathwayKEGGhsa04622
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathwaysREACTOMER-HSA-168928
Negative regulators of RIG-I/MDA5 signalingREACTOMER-HSA-936440
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Interferon SignalingREACTOMER-HSA-913531
Antiviral mechanism by IFN-stimulated genesREACTOMER-HSA-1169410
ISG15 antiviral mechanismREACTOMER-HSA-1169408
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
Regulation of TP53 ActivityREACTOMER-HSA-5633007
Regulation of TP53 Activity through PhosphorylationREACTOMER-HSA-6804756
Regulation of TP53 Activity through AcetylationREACTOMER-HSA-6804758
PI5P Regulates TP53 AcetylationREACTOMER-HSA-6811555

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA131285527oxaliplatinChemicalClinicalAnnotationassociatedPD
PA166123026progression-free survivalDiseaseVariantAnnotationassociatedPD
PA446108Colorectal NeoplasmsDiseaseClinicalAnnotation, VariantAnnotationassociatedPD
PA450085irinotecanChemicalClinicalAnnotation, VariantAnnotationassociatedPD

References

Pubmed IDYearTitleCitations
146905962003Regulation of NF-kappaB signaling by Pin1-dependent prolyl isomerization and ubiquitin-mediated proteolysis of p65/RelA.228
218521382011Prolyl isomerase Pin1 as a molecular switch to determine the fate of phosphoproteins.129
151113192004Prevalent overexpression of prolyl isomerase Pin1 in human cancers.127
217415982011A Pin1/mutant p53 axis promotes aggressiveness in breast cancer.124
123973622002The prolyl isomerase Pin1 reveals a mechanism to control p53 functions after genotoxic insults.119
123973612002The prolyl isomerase Pin1 is a regulator of p53 in genotoxic response.116
119785352002Pinning down proline-directed phosphorylation signaling.108
121012252002PIN1 is an E2F target gene essential for Neu/Ras-induced transformation of mammary epithelial cells.96
158679232005Phosphorylation-specific prolyl isomerization: is there an underlying theme?95
159503212006Oxidative modification and down-regulation of Pin1 in Alzheimer's disease hippocampus: A redox proteomics analysis.74

Citation

Dessen P

PIN1 (peptidylprolyl cis/trans isomerase, NIMA-interacting 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/467/pin1