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PIN1 (peptidylprolyl cis/trans isomerase, NIMA-interacting 1)

Identity

Other namesDOD
UBL5
HGNC (Hugo) PIN1
LocusID (NCBI) 5300
Atlas_Id 467
Location 19p13.2  [Link to chromosome band 19p13]
Location_base_pair Starts at 9945883 and ends at 9960365 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
DNM2 (19p13.2) / PIN1 (19p13.2)PTPRZ1 (7q31.32) / PIN1 (19p13.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PIN1   8988
Cards
Entrez_Gene (NCBI)PIN1  5300  peptidylprolyl cis/trans isomerase, NIMA-interacting 1
AliasesDOD; UBL5
GeneCards (Weizmann)PIN1
Ensembl hg19 (Hinxton)ENSG00000127445 [Gene_View]  chr19:9945883-9960365 [Contig_View]  PIN1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000127445 [Gene_View]  chr19:9945883-9960365 [Contig_View]  PIN1 [Vega]
ICGC DataPortalENSG00000127445
TCGA cBioPortalPIN1
AceView (NCBI)PIN1
Genatlas (Paris)PIN1
WikiGenes5300
SOURCE (Princeton)PIN1
Genomic and cartography
GoldenPath hg19 (UCSC)PIN1  -     chr19:9945883-9960365 +  19p13.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PIN1  -     19p13.2   [Description]    (hg38-Dec_2013)
EnsemblPIN1 - 19p13.2 [CytoView hg19]  PIN1 - 19p13.2 [CytoView hg38]
Mapping of homologs : NCBIPIN1 [Mapview hg19]  PIN1 [Mapview hg38]
OMIM601052   
Gene and transcription
Genbank (Entrez)AF086512 AK092970 AK097558 AK291074 BC002899
RefSeq transcript (Entrez)NM_006221
RefSeq genomic (Entrez)NC_000019 NC_018930 NG_029167 NT_011295 NW_004929414
Consensus coding sequences : CCDS (NCBI)PIN1
Cluster EST : UnigeneHs.465849 [ NCBI ]
CGAP (NCI)Hs.465849
Alternative Splicing GalleryENSG00000127445
Gene ExpressionPIN1 [ NCBI-GEO ]   PIN1 [ EBI - ARRAY_EXPRESS ]   PIN1 [ SEEK ]   PIN1 [ MEM ]
Gene Expression Viewer (FireBrowse)PIN1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5300
GTEX Portal (Tissue expression)PIN1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13526 (Uniprot)
NextProtQ13526  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ13526
Splice isoforms : SwissVarQ13526 (Swissvar)
Catalytic activity : Enzyme5.2.1.8 [ Enzyme-Expasy ]   5.2.1.85.2.1.8 [ IntEnz-EBI ]   5.2.1.8 [ BRENDA ]   5.2.1.8 [ KEGG ]   
PhosPhoSitePlusQ13526
Domaine pattern : Prosite (Expaxy)PPIC_PPIASE_1 (PS01096)    PPIC_PPIASE_2 (PS50198)    WW_DOMAIN_1 (PS01159)    WW_DOMAIN_2 (PS50020)   
Domains : Interpro (EBI)PPIase_PpiC    PPIase_PpiC_CS    WW_dom   
Domain families : Pfam (Sanger)Rotamase (PF00639)    WW (PF00397)   
Domain families : Pfam (NCBI)pfam00639    pfam00397   
Domain families : Smart (EMBL)WW (SM00456)  
DMDM Disease mutations5300
Blocks (Seattle)PIN1
PDB (SRS)1F8A    1I6C    1I8G    1I8H    1NMV    1NMW    1PIN    1ZCN    2F21    2ITK    2KBU    2KCF    2LB3    2M8I    2M8J    2M9E    2M9F    2M9I    2M9J    2N1O    2Q5A    2RUC    2RUD    2RUQ    2RUR    2XP3    2XP4    2XP5    2XP6    2XP7    2XP8    2XP9    2XPA    2XPB    2ZQS    2ZQT    2ZQU    2ZQV    2ZR4    2ZR5    2ZR6    3I6C    3IK8    3IKD    3IKG    3JYJ    3KAB    3KAC    3KAD    3KAF    3KAG    3KAH    3KAI    3KCE    3NTP    3ODK    3OOB    3TC5    3TCZ    3TDB    3WH0    4GWT    4GWV    4QIB    4TNS    4TYO    4U84    4U85    4U86   
PDB (PDBSum)1F8A    1I6C    1I8G    1I8H    1NMV    1NMW    1PIN    1ZCN    2F21    2ITK    2KBU    2KCF    2LB3    2M8I    2M8J    2M9E    2M9F    2M9I    2M9J    2N1O    2Q5A    2RUC    2RUD    2RUQ    2RUR    2XP3    2XP4    2XP5    2XP6    2XP7    2XP8    2XP9    2XPA    2XPB    2ZQS    2ZQT    2ZQU    2ZQV    2ZR4    2ZR5    2ZR6    3I6C    3IK8    3IKD    3IKG    3JYJ    3KAB    3KAC    3KAD    3KAF    3KAG    3KAH    3KAI    3KCE    3NTP    3ODK    3OOB    3TC5    3TCZ    3TDB    3WH0    4GWT    4GWV    4QIB    4TNS    4TYO    4U84    4U85    4U86   
PDB (IMB)1F8A    1I6C    1I8G    1I8H    1NMV    1NMW    1PIN    1ZCN    2F21    2ITK    2KBU    2KCF    2LB3    2M8I    2M8J    2M9E    2M9F    2M9I    2M9J    2N1O    2Q5A    2RUC    2RUD    2RUQ    2RUR    2XP3    2XP4    2XP5    2XP6    2XP7    2XP8    2XP9    2XPA    2XPB    2ZQS    2ZQT    2ZQU    2ZQV    2ZR4    2ZR5    2ZR6    3I6C    3IK8    3IKD    3IKG    3JYJ    3KAB    3KAC    3KAD    3KAF    3KAG    3KAH    3KAI    3KCE    3NTP    3ODK    3OOB    3TC5    3TCZ    3TDB    3WH0    4GWT    4GWV    4QIB    4TNS    4TYO    4U84    4U85    4U86   
PDB (RSDB)1F8A    1I6C    1I8G    1I8H    1NMV    1NMW    1PIN    1ZCN    2F21    2ITK    2KBU    2KCF    2LB3    2M8I    2M8J    2M9E    2M9F    2M9I    2M9J    2N1O    2Q5A    2RUC    2RUD    2RUQ    2RUR    2XP3    2XP4    2XP5    2XP6    2XP7    2XP8    2XP9    2XPA    2XPB    2ZQS    2ZQT    2ZQU    2ZQV    2ZR4    2ZR5    2ZR6    3I6C    3IK8    3IKD    3IKG    3JYJ    3KAB    3KAC    3KAD    3KAF    3KAG    3KAH    3KAI    3KCE    3NTP    3ODK    3OOB    3TC5    3TCZ    3TDB    3WH0    4GWT    4GWV    4QIB    4TNS    4TYO    4U84    4U85    4U86   
Structural Biology KnowledgeBase1F8A    1I6C    1I8G    1I8H    1NMV    1NMW    1PIN    1ZCN    2F21    2ITK    2KBU    2KCF    2LB3    2M8I    2M8J    2M9E    2M9F    2M9I    2M9J    2N1O    2Q5A    2RUC    2RUD    2RUQ    2RUR    2XP3    2XP4    2XP5    2XP6    2XP7    2XP8    2XP9    2XPA    2XPB    2ZQS    2ZQT    2ZQU    2ZQV    2ZR4    2ZR5    2ZR6    3I6C    3IK8    3IKD    3IKG    3JYJ    3KAB    3KAC    3KAD    3KAF    3KAG    3KAH    3KAI    3KCE    3NTP    3ODK    3OOB    3TC5    3TCZ    3TDB    3WH0    4GWT    4GWV    4QIB    4TNS    4TYO    4U84    4U85    4U86   
SCOP (Structural Classification of Proteins)1F8A    1I6C    1I8G    1I8H    1NMV    1NMW    1PIN    1ZCN    2F21    2ITK    2KBU    2KCF    2LB3    2M8I    2M8J    2M9E    2M9F    2M9I    2M9J    2N1O    2Q5A    2RUC    2RUD    2RUQ    2RUR    2XP3    2XP4    2XP5    2XP6    2XP7    2XP8    2XP9    2XPA    2XPB    2ZQS    2ZQT    2ZQU    2ZQV    2ZR4    2ZR5    2ZR6    3I6C    3IK8    3IKD    3IKG    3JYJ    3KAB    3KAC    3KAD    3KAF    3KAG    3KAH    3KAI    3KCE    3NTP    3ODK    3OOB    3TC5    3TCZ    3TDB    3WH0    4GWT    4GWV    4QIB    4TNS    4TYO    4U84    4U85    4U86   
CATH (Classification of proteins structures)1F8A    1I6C    1I8G    1I8H    1NMV    1NMW    1PIN    1ZCN    2F21    2ITK    2KBU    2KCF    2LB3    2M8I    2M8J    2M9E    2M9F    2M9I    2M9J    2N1O    2Q5A    2RUC    2RUD    2RUQ    2RUR    2XP3    2XP4    2XP5    2XP6    2XP7    2XP8    2XP9    2XPA    2XPB    2ZQS    2ZQT    2ZQU    2ZQV    2ZR4    2ZR5    2ZR6    3I6C    3IK8    3IKD    3IKG    3JYJ    3KAB    3KAC    3KAD    3KAF    3KAG    3KAH    3KAI    3KCE    3NTP    3ODK    3OOB    3TC5    3TCZ    3TDB    3WH0    4GWT    4GWV    4QIB    4TNS    4TYO    4U84    4U85    4U86   
SuperfamilyQ13526
Human Protein AtlasENSG00000127445
Peptide AtlasQ13526
HPRD03031
IPIIPI00013723   IPI00903344   IPI00644298   
Protein Interaction databases
DIP (DOE-UCLA)Q13526
IntAct (EBI)Q13526
FunCoupENSG00000127445
BioGRIDPIN1
STRING (EMBL)PIN1
ZODIACPIN1
Ontologies - Pathways
QuickGOQ13526
Ontology : AmiGOprotein peptidyl-prolyl isomerization  positive regulation of protein phosphorylation  peptidyl-prolyl cis-trans isomerase activity  peptidyl-prolyl cis-trans isomerase activity  motor activity  protein binding  nucleus  nucleoplasm  mitochondrion  cytosol  cell cycle  regulation of mitotic nuclear division  beta-catenin binding  beta-catenin binding  nuclear speck  neuron differentiation  midbody  negative regulation of transforming growth factor beta receptor signaling pathway  mitogen-activated protein kinase kinase binding  negative regulation of protein binding  regulation of cytokinesis  regulation of cytokinesis  negative regulation of type I interferon production  GTPase activating protein binding  positive regulation of protein dephosphorylation  negative regulation of protein catabolic process  neuron projection  negative regulation of neuron apoptotic process  positive regulation of neuron apoptotic process  positive regulation of GTPase activity  positive regulation of transcription from RNA polymerase II promoter  synapse organization  phosphoserine binding  phosphothreonine binding  phosphothreonine binding  protein stabilization  protein stabilization  positive regulation of ubiquitin-protein transferase activity  regulation of pathway-restricted SMAD protein phosphorylation  positive regulation of cell growth involved in cardiac muscle cell development  negative regulation of ERK1 and ERK2 cascade  positive regulation of canonical Wnt signaling pathway  regulation of protein localization to nucleus  regulation of signal transduction by p53 class mediator  negative regulation of cell motility  
Ontology : EGO-EBIprotein peptidyl-prolyl isomerization  positive regulation of protein phosphorylation  peptidyl-prolyl cis-trans isomerase activity  peptidyl-prolyl cis-trans isomerase activity  motor activity  protein binding  nucleus  nucleoplasm  mitochondrion  cytosol  cell cycle  regulation of mitotic nuclear division  beta-catenin binding  beta-catenin binding  nuclear speck  neuron differentiation  midbody  negative regulation of transforming growth factor beta receptor signaling pathway  mitogen-activated protein kinase kinase binding  negative regulation of protein binding  regulation of cytokinesis  regulation of cytokinesis  negative regulation of type I interferon production  GTPase activating protein binding  positive regulation of protein dephosphorylation  negative regulation of protein catabolic process  neuron projection  negative regulation of neuron apoptotic process  positive regulation of neuron apoptotic process  positive regulation of GTPase activity  positive regulation of transcription from RNA polymerase II promoter  synapse organization  phosphoserine binding  phosphothreonine binding  phosphothreonine binding  protein stabilization  protein stabilization  positive regulation of ubiquitin-protein transferase activity  regulation of pathway-restricted SMAD protein phosphorylation  positive regulation of cell growth involved in cardiac muscle cell development  negative regulation of ERK1 and ERK2 cascade  positive regulation of canonical Wnt signaling pathway  regulation of protein localization to nucleus  regulation of signal transduction by p53 class mediator  negative regulation of cell motility  
Pathways : BIOCARTAHow Progesterone Initiates the Oocyte Maturation [Genes]   
Pathways : KEGGRIG-I-like receptor signaling pathway   
NDEx NetworkPIN1
Atlas of Cancer Signalling NetworkPIN1
Wikipedia pathwaysPIN1
Orthology - Evolution
OrthoDB5300
GeneTree (enSembl)ENSG00000127445
Phylogenetic Trees/Animal Genes : TreeFamPIN1
Homologs : HomoloGenePIN1
Homology/Alignments : Family Browser (UCSC)PIN1
Gene fusions - Rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerPIN1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PIN1
dbVarPIN1
ClinVarPIN1
1000_GenomesPIN1 
Exome Variant ServerPIN1
ExAC (Exome Aggregation Consortium)PIN1 (select the gene name)
Genetic variants : HAPMAP5300
Genomic Variants (DGV)PIN1 [DGVbeta]
Mutations
ICGC Data PortalPIN1 
TCGA Data PortalPIN1 
Broad Tumor PortalPIN1
OASIS PortalPIN1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPIN1 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)Mendelian genes
BioMutasearch PIN1
DgiDB (Drug Gene Interaction Database)PIN1
DoCM (Curated mutations)PIN1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PIN1 (select a term)
intoGenPIN1
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)19:9945883-9960365  ENSG00000127445
CONAN: Copy Number AnalysisPIN1 
Mutations and Diseases : HGMDPIN1
OMIM601052   
MedgenPIN1
Genetic Testing Registry PIN1
NextProtQ13526 [Medical]
TSGene5300
GENETestsPIN1
Huge Navigator PIN1 [HugePedia]
snp3D : Map Gene to Disease5300
BioCentury BCIQPIN1
ClinGenPIN1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5300
Chemical/Pharm GKB GenePA33320
Clinical trialPIN1
Miscellaneous
canSAR (ICR)PIN1 (select the gene name)
Probes
Litterature
PubMed326 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePIN1
EVEXPIN1
GoPubMedPIN1
iHOPPIN1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 19 19:07:10 CEST 2016

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