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PIN1 (peptidylprolyl cis/trans isomerase, NIMA-interacting 1)

Identity

Other namesDOD
UBL5
HGNC (Hugo) PIN1
LocusID (NCBI) 5300
Location 19p13.2
Location_base_pair Starts at 9945883 and ends at 9960365 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)PIN1   8988
Cards
Entrez_Gene (NCBI)PIN1  5300  peptidylprolyl cis/trans isomerase, NIMA-interacting 1
GeneCards (Weizmann)PIN1
Ensembl (Hinxton)ENSG00000127445 [Gene_View]  chr19:9945883-9960365 [Contig_View]  PIN1 [Vega]
ICGC DataPortalENSG00000127445
AceView (NCBI)PIN1
Genatlas (Paris)PIN1
WikiGenes5300
SOURCE (Princeton)NM_006221
Genomic and cartography
GoldenPath (UCSC)PIN1  -  19p13.2   chr19:9945883-9960365 +  19p13.2   [Description]    (hg19-Feb_2009)
EnsemblPIN1 - 19p13.2 [CytoView]
Mapping of homologs : NCBIPIN1 [Mapview]
OMIM601052   
Gene and transcription
Genbank (Entrez)AF086512 AK092970 AK097558 AK291074 BC002899
RefSeq transcript (Entrez)NM_006221
RefSeq genomic (Entrez)AC_000151 NC_000019 NC_018930 NG_029167 NT_011295 NW_001838483 NW_004929414
Consensus coding sequences : CCDS (NCBI)PIN1
Cluster EST : UnigeneHs.465849 [ NCBI ]
CGAP (NCI)Hs.465849
Alternative Splicing : Fast-db (Paris)GSHG0014561
Alternative Splicing GalleryENSG00000127445
Gene ExpressionPIN1 [ NCBI-GEO ]     PIN1 [ SEEK ]   PIN1 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13526 (Uniprot)
NextProtQ13526  [Medical]
With graphics : InterProQ13526
Splice isoforms : SwissVarQ13526 (Swissvar)
Catalytic activity : Enzyme5.2.1.8 [ Enzyme-Expasy ]   5.2.1.85.2.1.8 [ IntEnz-EBI ]   5.2.1.8 [ BRENDA ]   5.2.1.8 [ KEGG ]   
Domaine pattern : Prosite (Expaxy)PPIC_PPIASE_1 (PS01096)    PPIC_PPIASE_2 (PS50198)    WW_DOMAIN_1 (PS01159)    WW_DOMAIN_2 (PS50020)   
Domains : Interpro (EBI)PPIase_PpiC    PPIase_PpiC_CS    WW_dom   
Related proteins : CluSTrQ13526
Domain families : Pfam (Sanger)Rotamase (PF00639)    WW (PF00397)   
Domain families : Pfam (NCBI)pfam00639    pfam00397   
Domain families : Smart (EMBL)WW (SM00456)  
DMDM Disease mutations5300
Blocks (Seattle)Q13526
PDB (SRS)1F8A    1I6C    1I8G    1I8H    1NMV    1NMW    1PIN    1ZCN    2F21    2ITK    2KBU    2KCF    2LB3    2M8I    2M8J    2M9E    2M9F    2M9I    2M9J    2Q5A    2XP3    2XP4    2XP5    2XP6    2XP7    2XP8    2XP9    2XPA    2XPB    2ZQS    2ZQT    2ZQU    2ZQV    2ZR4    2ZR5    2ZR6    3I6C    3IK8    3IKD    3IKG    3JYJ    3KAB    3KAC    3KAD    3KAF    3KAG    3KAH    3KAI    3KCE    3NTP    3ODK    3OOB    3TC5    3TCZ    3TDB    4GWT    4GWV   
PDB (PDBSum)1F8A    1I6C    1I8G    1I8H    1NMV    1NMW    1PIN    1ZCN    2F21    2ITK    2KBU    2KCF    2LB3    2M8I    2M8J    2M9E    2M9F    2M9I    2M9J    2Q5A    2XP3    2XP4    2XP5    2XP6    2XP7    2XP8    2XP9    2XPA    2XPB    2ZQS    2ZQT    2ZQU    2ZQV    2ZR4    2ZR5    2ZR6    3I6C    3IK8    3IKD    3IKG    3JYJ    3KAB    3KAC    3KAD    3KAF    3KAG    3KAH    3KAI    3KCE    3NTP    3ODK    3OOB    3TC5    3TCZ    3TDB    4GWT    4GWV   
PDB (IMB)1F8A    1I6C    1I8G    1I8H    1NMV    1NMW    1PIN    1ZCN    2F21    2ITK    2KBU    2KCF    2LB3    2M8I    2M8J    2M9E    2M9F    2M9I    2M9J    2Q5A    2XP3    2XP4    2XP5    2XP6    2XP7    2XP8    2XP9    2XPA    2XPB    2ZQS    2ZQT    2ZQU    2ZQV    2ZR4    2ZR5    2ZR6    3I6C    3IK8    3IKD    3IKG    3JYJ    3KAB    3KAC    3KAD    3KAF    3KAG    3KAH    3KAI    3KCE    3NTP    3ODK    3OOB    3TC5    3TCZ    3TDB    4GWT    4GWV   
PDB (RSDB)1F8A    1I6C    1I8G    1I8H    1NMV    1NMW    1PIN    1ZCN    2F21    2ITK    2KBU    2KCF    2LB3    2M8I    2M8J    2M9E    2M9F    2M9I    2M9J    2Q5A    2XP3    2XP4    2XP5    2XP6    2XP7    2XP8    2XP9    2XPA    2XPB    2ZQS    2ZQT    2ZQU    2ZQV    2ZR4    2ZR5    2ZR6    3I6C    3IK8    3IKD    3IKG    3JYJ    3KAB    3KAC    3KAD    3KAF    3KAG    3KAH    3KAI    3KCE    3NTP    3ODK    3OOB    3TC5    3TCZ    3TDB    4GWT    4GWV   
Human Protein AtlasENSG00000127445
Peptide AtlasQ13526
HPRD03031
IPIIPI00013723   IPI00903344   IPI00644298   
Protein Interaction databases
DIP (DOE-UCLA)Q13526
IntAct (EBI)Q13526
FunCoupENSG00000127445
BioGRIDPIN1
InParanoidQ13526
Interologous Interaction database Q13526
IntegromeDBPIN1
STRING (EMBL)PIN1
Ontologies - Pathways
Ontology : AmiGOprotein peptidyl-prolyl isomerization  protein peptidyl-prolyl isomerization  positive regulation of protein phosphorylation  peptidyl-prolyl cis-trans isomerase activity  protein binding  nucleus  nucleoplasm  cytoplasm  protein folding  cell cycle  regulation of mitosis  nuclear speck  cytokine-mediated signaling pathway  midbody  negative regulation of transforming growth factor beta receptor signaling pathway  mitogen-activated protein kinase kinase binding  positive regulation of Rho GTPase activity  regulation of cytokinesis  regulation of cytokinesis  negative regulation of type I interferon production  GTPase activating protein binding  innate immune response  phosphoserine binding  phosphothreonine binding  phosphothreonine binding  positive regulation of ubiquitin-protein transferase activity  regulation of pathway-restricted SMAD protein phosphorylation  negative regulation of ERK1 and ERK2 cascade  negative regulation of cell motility  
Ontology : EGO-EBIprotein peptidyl-prolyl isomerization  protein peptidyl-prolyl isomerization  positive regulation of protein phosphorylation  peptidyl-prolyl cis-trans isomerase activity  protein binding  nucleus  nucleoplasm  cytoplasm  protein folding  cell cycle  regulation of mitosis  nuclear speck  cytokine-mediated signaling pathway  midbody  negative regulation of transforming growth factor beta receptor signaling pathway  mitogen-activated protein kinase kinase binding  positive regulation of Rho GTPase activity  regulation of cytokinesis  regulation of cytokinesis  negative regulation of type I interferon production  GTPase activating protein binding  innate immune response  phosphoserine binding  phosphothreonine binding  phosphothreonine binding  positive regulation of ubiquitin-protein transferase activity  regulation of pathway-restricted SMAD protein phosphorylation  negative regulation of ERK1 and ERK2 cascade  negative regulation of cell motility  
Pathways : BIOCARTAHow Progesterone Initiates the Oocyte Maturation [Genes]   
Pathways : KEGGRIG-I-like receptor signaling pathway   
Protein Interaction DatabasePIN1
Wikipedia pathwaysPIN1
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)PIN1
SNP (GeneSNP Utah)PIN1
SNP : HGBasePIN1
Genetic variants : HAPMAPPIN1
1000_GenomesPIN1 
ICGC programENSG00000127445 
CONAN: Copy Number AnalysisPIN1 
Somatic Mutations in Cancer : COSMICPIN1 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)Mendelian genes
Mutations and Diseases : HGMDPIN1
OMIM601052   
MedgenPIN1
GENETestsPIN1
Disease Genetic AssociationPIN1
Huge Navigator PIN1 [HugePedia]  PIN1 [HugeCancerGEM]
Genomic VariantsPIN1  PIN1 [DGVbeta]
Exome VariantPIN1
dbVarPIN1
ClinVarPIN1
snp3D : Map Gene to Disease5300
General knowledge
Homologs : HomoloGenePIN1
Homology/Alignments : Family Browser (UCSC)PIN1
Phylogenetic Trees/Animal Genes : TreeFamPIN1
Chemical/Protein Interactions : CTD5300
Chemical/Pharm GKB GenePA33320
Clinical trialPIN1
Cancer Resource (Charite)ENSG00000127445
Other databases
Probes
Litterature
PubMed270 Pubmed reference(s) in Entrez
CoreMinePIN1
iHOPPIN1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 13 13:08:18 CEST 2014

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