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PLA2G6 (phospholipase A2, group VI (cytosolic, calcium-independent))

Identity

Other namesCaI-PLA2
GVI
INAD1
IPLA2-VIA
NBIA2
NBIA2A
NBIA2B
PARK14
PLA2
PNPLA9
iPLA2
iPLA2beta
HGNC (Hugo) PLA2G6
LocusID (NCBI) 8398
Location 22q13.1
Location_base_pair Starts at 38507502 and ends at 38577761 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)PLA2G6   9039
Cards
Entrez_Gene (NCBI)PLA2G6  8398  phospholipase A2, group VI (cytosolic, calcium-independent)
GeneCards (Weizmann)PLA2G6
Ensembl (Hinxton)ENSG00000184381 [Gene_View]  chr22:38507502-38577761 [Contig_View]  PLA2G6 [Vega]
ICGC DataPortalENSG00000184381
cBioPortalPLA2G6
AceView (NCBI)PLA2G6
Genatlas (Paris)PLA2G6
WikiGenes8398
SOURCE (Princeton)NM_001004426 NM_001199562 NM_003560
Genomic and cartography
GoldenPath (UCSC)PLA2G6  -  22q13.1   chr22:38507502-38577761 -  22q13.1   [Description]    (hg19-Feb_2009)
EnsemblPLA2G6 - 22q13.1 [CytoView]
Mapping of homologs : NCBIPLA2G6 [Mapview]
OMIM256600   603604   610217   612953   
Gene and transcription
Genbank (Entrez)AF064594 AF102988 AF102989 AK001290 AK096521
RefSeq transcript (Entrez)NM_001004426 NM_001199562 NM_003560
RefSeq genomic (Entrez)AC_000154 NC_000022 NC_018933 NG_007094 NT_011520 NW_001838745 NW_004929430
Consensus coding sequences : CCDS (NCBI)PLA2G6
Cluster EST : UnigeneHs.170479 [ NCBI ]
CGAP (NCI)Hs.170479
Alternative Splicing : Fast-db (Paris)GSHG0020386
Alternative Splicing GalleryENSG00000184381
Gene ExpressionPLA2G6 [ NCBI-GEO ]     PLA2G6 [ SEEK ]   PLA2G6 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO60733 (Uniprot)
NextProtO60733  [Medical]
With graphics : InterProO60733
Splice isoforms : SwissVarO60733 (Swissvar)
Catalytic activity : Enzyme3.1.1.4 [ Enzyme-Expasy ]   3.1.1.43.1.1.4 [ IntEnz-EBI ]   3.1.1.4 [ BRENDA ]   3.1.1.4 [ KEGG ]   
Domaine pattern : Prosite (Expaxy)ANK_REP_REGION (PS50297)    ANK_REPEAT (PS50088)   
Domains : Interpro (EBI)Acyl_Trfase/lysoPLipase [organisation]   Ankyrin_rpt [organisation]   Ankyrin_rpt-contain_dom [organisation]   Patatin/PLipase_A2-rel [organisation]  
Related proteins : CluSTrO60733
Domain families : Pfam (Sanger)Ank (PF00023)    Patatin (PF01734)   
Domain families : Pfam (NCBI)pfam00023    pfam01734   
Domain families : Smart (EMBL)ANK (SM00248)  
DMDM Disease mutations8398
Blocks (Seattle)O60733
Human Protein AtlasENSG00000184381 [gene] [tissue] [antibody] [cell] [cancer]
Peptide AtlasO60733
HPRD04675
IPIIPI00031476   IPI00220207   IPI00375455   IPI00220209   IPI00889582   IPI00902720   IPI00889707   IPI00983579   IPI00889638   IPI01025500   IPI00894402   IPI00894303   IPI00893667   IPI00893281   IPI00893043   IPI00980784   IPI00893213   
Protein Interaction databases
DIP (DOE-UCLA)O60733
IntAct (EBI)O60733
FunCoupENSG00000184381
BioGRIDPLA2G6
InParanoidO60733
Interologous Interaction database O60733
IntegromeDBPLA2G6
STRING (EMBL)PLA2G6
Ontologies - Pathways
Ontology : AmiGOpositive regulation of protein phosphorylation  phospholipase A2 activity  calmodulin binding  mitochondrion  cytosol  phospholipid metabolic process  chemotaxis  positive regulation of cytosolic calcium ion concentration  memory  cell death  urinary bladder smooth muscle contraction  membrane  lipid catabolic process  cardiolipin biosynthetic process  response to endoplasmic reticulum stress  positive regulation of insulin secretion involved in cellular response to glucose stimulus  cardiolipin acyl-chain remodeling  phosphatidylcholine acyl-chain remodeling  phosphatidylethanolamine acyl-chain remodeling  Fc-gamma receptor signaling pathway involved in phagocytosis  ATP-dependent protein binding  small molecule metabolic process  innate immune response  positive regulation of vasodilation  positive regulation of exocytosis  glycerophospholipid biosynthetic process  calcium-independent phospholipase A2 activity  negative regulation of synaptic transmission, glutamatergic  maternal process involved in female pregnancy  positive regulation of protein kinase C signaling  positive regulation of release of cytochrome c from mitochondria  positive regulation of arachidonic acid secretion  regulation of store-operated calcium channel activity  positive regulation of ceramide biosynthetic process  
Ontology : EGO-EBIpositive regulation of protein phosphorylation  phospholipase A2 activity  calmodulin binding  mitochondrion  cytosol  phospholipid metabolic process  chemotaxis  positive regulation of cytosolic calcium ion concentration  memory  cell death  urinary bladder smooth muscle contraction  membrane  lipid catabolic process  cardiolipin biosynthetic process  response to endoplasmic reticulum stress  positive regulation of insulin secretion involved in cellular response to glucose stimulus  cardiolipin acyl-chain remodeling  phosphatidylcholine acyl-chain remodeling  phosphatidylethanolamine acyl-chain remodeling  Fc-gamma receptor signaling pathway involved in phagocytosis  ATP-dependent protein binding  small molecule metabolic process  innate immune response  positive regulation of vasodilation  positive regulation of exocytosis  glycerophospholipid biosynthetic process  calcium-independent phospholipase A2 activity  negative regulation of synaptic transmission, glutamatergic  maternal process involved in female pregnancy  positive regulation of protein kinase C signaling  positive regulation of release of cytochrome c from mitochondria  positive regulation of arachidonic acid secretion  regulation of store-operated calcium channel activity  positive regulation of ceramide biosynthetic process  
Pathways : KEGGGlycerophospholipid metabolism    Ether lipid metabolism    Arachidonic acid metabolism    Linoleic acid metabolism    alpha-Linolenic acid metabolism    Ras signaling pathway    Vascular smooth muscle contraction    Fc gamma R-mediated phagocytosis   
Protein Interaction DatabasePLA2G6
Wikipedia pathwaysPLA2G6
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)PLA2G6
snp3D : Map Gene to Disease8398
SNP (GeneSNP Utah)PLA2G6
SNP : HGBasePLA2G6
Genetic variants : HAPMAPPLA2G6
Exome VariantPLA2G6
1000_GenomesPLA2G6 
ICGC programENSG00000184381 
Somatic Mutations in Cancer : COSMICPLA2G6 
CONAN: Copy Number AnalysisPLA2G6 
Mutations and Diseases : HGMDPLA2G6
Genomic VariantsPLA2G6  PLA2G6 [DGVbeta]
dbVarPLA2G6
ClinVarPLA2G6
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM256600    603604    610217    612953   
MedgenPLA2G6
GENETestsPLA2G6
Disease Genetic AssociationPLA2G6
Huge Navigator PLA2G6 [HugePedia]  PLA2G6 [HugeCancerGEM]
General knowledge
Homologs : HomoloGenePLA2G6
Homology/Alignments : Family Browser (UCSC)PLA2G6
Phylogenetic Trees/Animal Genes : TreeFamPLA2G6
Chemical/Protein Interactions : CTD8398
Chemical/Pharm GKB GenePA33367
Clinical trialPLA2G6
Cancer Resource (Charite)ENSG00000184381
Other databases
Probes
Litterature
PubMed101 Pubmed reference(s) in Entrez
CoreMinePLA2G6
iHOPPLA2G6
OncoSearchPLA2G6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jul 30 14:10:09 CEST 2014

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