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PLK4 (polo like kinase 4)

Identity

Alias_namesSTK18
serine/threonine kinase 18
polo-like kinase 4 (Drosophila)
polo-like kinase 4
Alias_symbol (synonym)Sak
Other aliasMCCRP2
SAK
HGNC (Hugo) PLK4
LocusID (NCBI) 10733
Atlas_Id 43733
Location 4q28.1  [Link to chromosome band 4q28]
Location_base_pair Starts at 127880861 and ends at 127899222 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PLK4   11397
Cards
Entrez_Gene (NCBI)PLK4  10733  polo like kinase 4
AliasesMCCRP2; SAK; STK18
GeneCards (Weizmann)PLK4
Ensembl hg19 (Hinxton)ENSG00000142731 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000142731 [Gene_View]  chr4:127880861-127899222 [Contig_View]  PLK4 [Vega]
ICGC DataPortalENSG00000142731
TCGA cBioPortalPLK4
AceView (NCBI)PLK4
Genatlas (Paris)PLK4
WikiGenes10733
SOURCE (Princeton)PLK4
Genetics Home Reference (NIH)PLK4
Genomic and cartography
GoldenPath hg38 (UCSC)PLK4  -     chr4:127880861-127899222 +  4q28.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PLK4  -     4q28.1   [Description]    (hg19-Feb_2009)
EnsemblPLK4 - 4q28.1 [CytoView hg19]  PLK4 - 4q28.1 [CytoView hg38]
Mapping of homologs : NCBIPLK4 [Mapview hg19]  PLK4 [Mapview hg38]
OMIM605031   616171   
Gene and transcription
Genbank (Entrez)AB006972 AB741646 AI088969 AK302858 AK303399
RefSeq transcript (Entrez)NM_001190799 NM_001190801 NM_014264
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PLK4
Cluster EST : UnigeneHs.172052 [ NCBI ]
CGAP (NCI)Hs.172052
Alternative Splicing GalleryENSG00000142731
Gene ExpressionPLK4 [ NCBI-GEO ]   PLK4 [ EBI - ARRAY_EXPRESS ]   PLK4 [ SEEK ]   PLK4 [ MEM ]
Gene Expression Viewer (FireBrowse)PLK4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10733
GTEX Portal (Tissue expression)PLK4
Protein : pattern, domain, 3D structure
UniProt/SwissProtO00444   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO00444  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO00444
Splice isoforms : SwissVarO00444
Catalytic activity : Enzyme2.7.11.21 [ Enzyme-Expasy ]   2.7.11.212.7.11.21 [ IntEnz-EBI ]   2.7.11.21 [ BRENDA ]   2.7.11.21 [ KEGG ]   
PhosPhoSitePlusO00444
Domaine pattern : Prosite (Expaxy)POLO_BOX (PS50078)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)   
Domains : Interpro (EBI)Kinase-like_dom    Plk4    POLO_box_dom    POLO_box_Plk4_1    POLO_box_Plk4_2    POLO_box_Plk4_C    Prot_kinase_dom    Protein_kinase_ATP_BS    Tyr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)    POLO_box (PF00659)   
Domain families : Pfam (NCBI)pfam00069    pfam00659   
Conserved Domain (NCBI)PLK4
DMDM Disease mutations10733
Blocks (Seattle)PLK4
PDB (SRS)2N19    3COK    4JXF    4N7V    4N7Z    4N9J    4YUR    4YYP   
PDB (PDBSum)2N19    3COK    4JXF    4N7V    4N7Z    4N9J    4YUR    4YYP   
PDB (IMB)2N19    3COK    4JXF    4N7V    4N7Z    4N9J    4YUR    4YYP   
PDB (RSDB)2N19    3COK    4JXF    4N7V    4N7Z    4N9J    4YUR    4YYP   
Structural Biology KnowledgeBase2N19    3COK    4JXF    4N7V    4N7Z    4N9J    4YUR    4YYP   
SCOP (Structural Classification of Proteins)2N19    3COK    4JXF    4N7V    4N7Z    4N9J    4YUR    4YYP   
CATH (Classification of proteins structures)2N19    3COK    4JXF    4N7V    4N7Z    4N9J    4YUR    4YYP   
SuperfamilyO00444
Human Protein AtlasENSG00000142731
Peptide AtlasO00444
HPRD10387
IPIIPI00410344   IPI00944477   IPI00944493   IPI00966955   IPI00966079   IPI00965030   
Protein Interaction databases
DIP (DOE-UCLA)O00444
IntAct (EBI)O00444
FunCoupENSG00000142731
BioGRIDPLK4
STRING (EMBL)PLK4
ZODIACPLK4
Ontologies - Pathways
QuickGOO00444
Ontology : AmiGOG2/M transition of mitotic cell cycle  XY body  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein binding  ATP binding  nucleolus  centrosome  centriole  cytosol  cytosol  protein phosphorylation  centriole replication  cleavage furrow  identical protein binding  positive regulation of centriole replication  positive regulation of centriole replication  trophoblast giant cell differentiation  ciliary basal body docking  de novo centriole assembly involved in multi-ciliated epithelial cell differentiation  deuterosome  
Ontology : EGO-EBIG2/M transition of mitotic cell cycle  XY body  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein binding  ATP binding  nucleolus  centrosome  centriole  cytosol  cytosol  protein phosphorylation  centriole replication  cleavage furrow  identical protein binding  positive regulation of centriole replication  positive regulation of centriole replication  trophoblast giant cell differentiation  ciliary basal body docking  de novo centriole assembly involved in multi-ciliated epithelial cell differentiation  deuterosome  
Pathways : KEGGFoxO signaling pathway   
NDEx NetworkPLK4
Atlas of Cancer Signalling NetworkPLK4
Wikipedia pathwaysPLK4
Orthology - Evolution
OrthoDB10733
GeneTree (enSembl)ENSG00000142731
Phylogenetic Trees/Animal Genes : TreeFamPLK4
HOVERGENO00444
HOGENOMO00444
Homologs : HomoloGenePLK4
Homology/Alignments : Family Browser (UCSC)PLK4
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPLK4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PLK4
dbVarPLK4
ClinVarPLK4
1000_GenomesPLK4 
Exome Variant ServerPLK4
ExAC (Exome Aggregation Consortium)PLK4 (select the gene name)
Genetic variants : HAPMAP10733
Genomic Variants (DGV)PLK4 [DGVbeta]
DECIPHERPLK4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPLK4 
Mutations
ICGC Data PortalPLK4 
TCGA Data PortalPLK4 
Broad Tumor PortalPLK4
OASIS PortalPLK4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPLK4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPLK4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PLK4
DgiDB (Drug Gene Interaction Database)PLK4
DoCM (Curated mutations)PLK4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PLK4 (select a term)
intoGenPLK4
Cancer3DPLK4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605031    616171   
Orphanet954   
MedgenPLK4
Genetic Testing Registry PLK4
NextProtO00444 [Medical]
TSGene10733
GENETestsPLK4
Huge Navigator PLK4 [HugePedia]
snp3D : Map Gene to Disease10733
BioCentury BCIQPLK4
ClinGenPLK4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10733
Chemical/Pharm GKB GenePA36205
Clinical trialPLK4
Miscellaneous
canSAR (ICR)PLK4 (select the gene name)
Probes
Litterature
PubMed77 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePLK4
EVEXPLK4
GoPubMedPLK4
iHOPPLK4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 12:31:40 CEST 2017

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