PLXND1 (plexin D1)

2008-12-01  

Identity

HGNC
LOCATION
3q22.1
LOCUSID
ALIAS
PLEXD1
FUSION GENES

Other Information

Locus ID:

NCBI: 23129
MIM: 604282
HGNC: 9107
Ensembl: ENSG00000004399

Variants:

dbSNP: 23129
ClinVar: 23129
TCGA: ENSG00000004399
COSMIC: PLXND1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000004399ENST00000324093Q9Y4D7
ENSG00000004399ENST00000504689D6RH25
ENSG00000004399ENST00000505237H0YA64
ENSG00000004399ENST00000505665H0Y9D1
ENSG00000004399ENST00000506979H0YAM9
ENSG00000004399ENST00000512744H0YAB2

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
Semaphorin interactionsREACTOMER-HSA-373755
Other semaphorin interactionsREACTOMER-HSA-416700

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
215052592011Sema3E-PlexinD1 signaling selectively suppresses disoriented angiogenesis in ischemic retinopathy in mice.70
206641712010Sema3E-Plexin D1 signaling drives human cancer cell invasiveness and metastatic spreading in mice.65
203857692010Semaphorin 3E initiates antiangiogenic signaling through plexin D1 by regulating Arf6 and R-Ras.63
241398592013Semaphorin 3E suppresses tumor cell death triggered by the plexin D1 dependence receptor in metastatic breast cancers.35
217957012011Phosphatidylinositol-4-phosphate 5-kinase and GEP100/Brag2 protein mediate antiangiogenic signaling by semaphorin 3E-plexin-D1 through Arf6 protein.26
258315052015Plexin D1 determines body fat distribution by regulating the type V collagen microenvironment in visceral adipose tissue.24
215593682011Sema3E/plexin-D1 mediated epithelial-to-mesenchymal transition in ovarian endometrioid cancer.23
197033162009Plexin D1 is ubiquitously expressed on tumor vessels and tumor cells in solid malignancies.19
189742982008Semaphorin 3E expression correlates inversely with Plexin D1 during tumor progression.18
260680672015De novo mutations in PLXND1 and REV3L cause Möbius syndrome.18

Citation

Dessen P

PLXND1 (plexin D1)

Atlas Genet Cytogenet Oncol Haematol. 2008-12-01

Online version: http://atlasgeneticsoncology.org/gene/50545/plxnd1