Atlas of Genetics and Cytogenetics in Oncology and Haematology


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PLXND1 (plexin D1)

Identity

Alias_symbol (synonym)KIAA0620
Other aliasPLEXD1
HGNC (Hugo) PLXND1
LocusID (NCBI) 23129
Atlas_Id 50545
Location 3q22.1  [Link to chromosome band 3q22]
Location_base_pair Starts at 129555213 and ends at 129606739 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
PLXND1 (3q22.1) / AACS (12q24.31)PLXND1 (3q22.1) / CYBRD1 (2q31.1)PLXND1 (3q22.1) / RDX (11q22.3)
PLXND1 (3q22.1) / TMCC1 (3q22.1)PLXND1 3q22.1 / TMCC1 3q22.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PLXND1   9107
Cards
Entrez_Gene (NCBI)PLXND1  23129  plexin D1
AliasesPLEXD1
GeneCards (Weizmann)PLXND1
Ensembl hg19 (Hinxton)ENSG00000004399 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000004399 [Gene_View]  chr3:129555213-129606739 [Contig_View]  PLXND1 [Vega]
ICGC DataPortalENSG00000004399
TCGA cBioPortalPLXND1
AceView (NCBI)PLXND1
Genatlas (Paris)PLXND1
WikiGenes23129
SOURCE (Princeton)PLXND1
Genetics Home Reference (NIH)PLXND1
Genomic and cartography
GoldenPath hg38 (UCSC)PLXND1  -     chr3:129555213-129606739 -  3q22.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PLXND1  -     3q22.1   [Description]    (hg19-Feb_2009)
EnsemblPLXND1 - 3q22.1 [CytoView hg19]  PLXND1 - 3q22.1 [CytoView hg38]
Mapping of homologs : NCBIPLXND1 [Mapview hg19]  PLXND1 [Mapview hg38]
OMIM604282   
Gene and transcription
Genbank (Entrez)AB014520 AK026388 AK299425 AY116661 BC003526
RefSeq transcript (Entrez)NM_015103
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PLXND1
Cluster EST : UnigeneHs.301685 [ NCBI ]
CGAP (NCI)Hs.301685
Alternative Splicing GalleryENSG00000004399
Gene ExpressionPLXND1 [ NCBI-GEO ]   PLXND1 [ EBI - ARRAY_EXPRESS ]   PLXND1 [ SEEK ]   PLXND1 [ MEM ]
Gene Expression Viewer (FireBrowse)PLXND1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23129
GTEX Portal (Tissue expression)PLXND1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y4D7   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y4D7  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y4D7
Splice isoforms : SwissVarQ9Y4D7
PhosPhoSitePlusQ9Y4D7
Domaine pattern : Prosite (Expaxy)SEMA (PS51004)   
Domains : Interpro (EBI)Ig-like_fold    Ig_E-set    IPT    Plexin    Plexin_cytoplasmic_RasGAP_dom    Plexin_repeat    PSI    Rho_GTPase_activation_prot    Semap_dom    WD40/YVTN_repeat-like_dom   
Domain families : Pfam (Sanger)Plexin_cytopl (PF08337)    PSI (PF01437)    Sema (PF01403)    TIG (PF01833)   
Domain families : Pfam (NCBI)pfam08337    pfam01437    pfam01403    pfam01833   
Domain families : Smart (EMBL)IPT (SM00429)  PSI (SM00423)  Sema (SM00630)  
Conserved Domain (NCBI)PLXND1
DMDM Disease mutations23129
Blocks (Seattle)PLXND1
PDB (SRS)3H6N   
PDB (PDBSum)3H6N   
PDB (IMB)3H6N   
PDB (RSDB)3H6N   
Structural Biology KnowledgeBase3H6N   
SCOP (Structural Classification of Proteins)3H6N   
CATH (Classification of proteins structures)3H6N   
SuperfamilyQ9Y4D7
Human Protein AtlasENSG00000004399
Peptide AtlasQ9Y4D7
HPRD05046
IPIIPI00412492   IPI00472139   IPI00967371   IPI00966464   IPI00967690   IPI00967912   
Protein Interaction databases
DIP (DOE-UCLA)Q9Y4D7
IntAct (EBI)Q9Y4D7
FunCoupENSG00000004399
BioGRIDPLXND1
STRING (EMBL)PLXND1
ZODIACPLXND1
Ontologies - Pathways
QuickGOQ9Y4D7
Ontology : AmiGOangiogenesis  branching involved in blood vessel morphogenesis  outflow tract morphogenesis  cardiac septum development  protein binding  plasma membrane  integral component of plasma membrane  negative regulation of cell adhesion  synapse assembly  regulation of cell shape  semaphorin receptor activity  protein domain specific binding  lamellipodium  regulation of cell migration  positive regulation of protein binding  aorta development  regulation of GTPase activity  endothelial cell migration  endothelial cell migration  regulation of angiogenesis  positive regulation of axonogenesis  dichotomous subdivision of terminal units involved in salivary gland branching  coronary vasculature development  semaphorin-plexin signaling pathway  
Ontology : EGO-EBIangiogenesis  branching involved in blood vessel morphogenesis  outflow tract morphogenesis  cardiac septum development  protein binding  plasma membrane  integral component of plasma membrane  negative regulation of cell adhesion  synapse assembly  regulation of cell shape  semaphorin receptor activity  protein domain specific binding  lamellipodium  regulation of cell migration  positive regulation of protein binding  aorta development  regulation of GTPase activity  endothelial cell migration  endothelial cell migration  regulation of angiogenesis  positive regulation of axonogenesis  dichotomous subdivision of terminal units involved in salivary gland branching  coronary vasculature development  semaphorin-plexin signaling pathway  
NDEx NetworkPLXND1
Atlas of Cancer Signalling NetworkPLXND1
Wikipedia pathwaysPLXND1
Orthology - Evolution
OrthoDB23129
GeneTree (enSembl)ENSG00000004399
Phylogenetic Trees/Animal Genes : TreeFamPLXND1
HOVERGENQ9Y4D7
HOGENOMQ9Y4D7
Homologs : HomoloGenePLXND1
Homology/Alignments : Family Browser (UCSC)PLXND1
Gene fusions - Rearrangements
Fusion : MitelmanPLXND1/TMCC1 [3q22.1/3q22.1]  
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPLXND1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PLXND1
dbVarPLXND1
ClinVarPLXND1
1000_GenomesPLXND1 
Exome Variant ServerPLXND1
ExAC (Exome Aggregation Consortium)PLXND1 (select the gene name)
Genetic variants : HAPMAP23129
Genomic Variants (DGV)PLXND1 [DGVbeta]
DECIPHERPLXND1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPLXND1 
Mutations
ICGC Data PortalPLXND1 
TCGA Data PortalPLXND1 
Broad Tumor PortalPLXND1
OASIS PortalPLXND1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPLXND1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPLXND1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PLXND1
DgiDB (Drug Gene Interaction Database)PLXND1
DoCM (Curated mutations)PLXND1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PLXND1 (select a term)
intoGenPLXND1
Cancer3DPLXND1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604282   
Orphanet542    2997   
MedgenPLXND1
Genetic Testing Registry PLXND1
NextProtQ9Y4D7 [Medical]
TSGene23129
GENETestsPLXND1
Huge Navigator PLXND1 [HugePedia]
snp3D : Map Gene to Disease23129
BioCentury BCIQPLXND1
ClinGenPLXND1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD23129
Chemical/Pharm GKB GenePA128394602
Clinical trialPLXND1
Miscellaneous
canSAR (ICR)PLXND1 (select the gene name)
Probes
Litterature
PubMed27 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePLXND1
EVEXPLXND1
GoPubMedPLXND1
iHOPPLXND1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 12:31:45 CEST 2017

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