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POLK (polymerase (DNA) kappa)

Identity

Alias_namesDINB1
polymerase (DNA directed) kappa
polymerase (DNA) kappa
Alias_symbol (synonym)POLQ
DINP
Other alias
HGNC (Hugo) POLK
LocusID (NCBI) 51426
Atlas_Id 41777
Location 5q13.3  [Link to chromosome band 5q13]
Location_base_pair Starts at 74807657 and ends at 74895646 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)POLK   9183
Cards
Entrez_Gene (NCBI)POLK  51426  polymerase (DNA) kappa
AliasesDINB1; DINP; POLQ
GeneCards (Weizmann)POLK
Ensembl hg19 (Hinxton)ENSG00000122008 [Gene_View]  chr5:74807657-74895646 [Contig_View]  POLK [Vega]
Ensembl hg38 (Hinxton)ENSG00000122008 [Gene_View]  chr5:74807657-74895646 [Contig_View]  POLK [Vega]
ICGC DataPortalENSG00000122008
TCGA cBioPortalPOLK
AceView (NCBI)POLK
Genatlas (Paris)POLK
WikiGenes51426
SOURCE (Princeton)POLK
Genetics Home Reference (NIH)POLK
Genomic and cartography
GoldenPath hg19 (UCSC)POLK  -     chr5:74807657-74895646 +  5q13.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)POLK  -     5q13.3   [Description]    (hg38-Dec_2013)
EnsemblPOLK - 5q13.3 [CytoView hg19]  POLK - 5q13.3 [CytoView hg38]
Mapping of homologs : NCBIPOLK [Mapview hg19]  POLK [Mapview hg38]
OMIM605650   
Gene and transcription
Genbank (Entrez)AB027564 AB209291 AF163570 AF194973 AF315601
RefSeq transcript (Entrez)NM_016218
RefSeq genomic (Entrez)NC_000005 NC_018916 NT_034772 NW_004929322
Consensus coding sequences : CCDS (NCBI)POLK
Cluster EST : UnigeneHs.135756 [ NCBI ]
CGAP (NCI)Hs.135756
Alternative Splicing GalleryENSG00000122008
Gene ExpressionPOLK [ NCBI-GEO ]   POLK [ EBI - ARRAY_EXPRESS ]   POLK [ SEEK ]   POLK [ MEM ]
Gene Expression Viewer (FireBrowse)POLK [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)51426
GTEX Portal (Tissue expression)POLK
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UBT6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UBT6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UBT6
Splice isoforms : SwissVarQ9UBT6
Catalytic activity : Enzyme2.7.7.7 [ Enzyme-Expasy ]   2.7.7.72.7.7.7 [ IntEnz-EBI ]   2.7.7.7 [ BRENDA ]   2.7.7.7 [ KEGG ]   
PhosPhoSitePlusQ9UBT6
Domaine pattern : Prosite (Expaxy)UMUC (PS50173)   
Domains : Interpro (EBI)DNA_pol_Y-fam_little_finger    DNApol_IV    PolY_HhH_motif    UmuC    Znf_Rad18_put   
Domain families : Pfam (Sanger)IMS (PF00817)    IMS_C (PF11799)    IMS_HHH (PF11798)   
Domain families : Pfam (NCBI)pfam00817    pfam11799    pfam11798   
Domain families : Smart (EMBL)ZnF_Rad18 (SM00734)  
Conserved Domain (NCBI)POLK
DMDM Disease mutations51426
Blocks (Seattle)POLK
PDB (SRS)1T94    2LSI    2OH2    2W7O    2W7P    3IN5    3PZP    4BA9    4GK5    4U6P    4U7C   
PDB (PDBSum)1T94    2LSI    2OH2    2W7O    2W7P    3IN5    3PZP    4BA9    4GK5    4U6P    4U7C   
PDB (IMB)1T94    2LSI    2OH2    2W7O    2W7P    3IN5    3PZP    4BA9    4GK5    4U6P    4U7C   
PDB (RSDB)1T94    2LSI    2OH2    2W7O    2W7P    3IN5    3PZP    4BA9    4GK5    4U6P    4U7C   
Structural Biology KnowledgeBase1T94    2LSI    2OH2    2W7O    2W7P    3IN5    3PZP    4BA9    4GK5    4U6P    4U7C   
SCOP (Structural Classification of Proteins)1T94    2LSI    2OH2    2W7O    2W7P    3IN5    3PZP    4BA9    4GK5    4U6P    4U7C   
CATH (Classification of proteins structures)1T94    2LSI    2OH2    2W7O    2W7P    3IN5    3PZP    4BA9    4GK5    4U6P    4U7C   
SuperfamilyQ9UBT6
Human Protein AtlasENSG00000122008
Peptide AtlasQ9UBT6
HPRD09291
IPIIPI00552440   IPI00033151   IPI00218100   IPI00552703   IPI01013677   IPI01018200   IPI00967979   IPI00967663   IPI00964555   IPI00965083   IPI00966124   
Protein Interaction databases
DIP (DOE-UCLA)Q9UBT6
IntAct (EBI)Q9UBT6
FunCoupENSG00000122008
BioGRIDPOLK
STRING (EMBL)POLK
ZODIACPOLK
Ontologies - Pathways
QuickGOQ9UBT6
Ontology : AmiGOdamaged DNA binding  DNA-directed DNA polymerase activity  nucleus  nucleoplasm  nucleoplasm  DNA replication  DNA repair  transcription-coupled nucleotide-excision repair  nucleotide-excision repair, DNA incision, 5'-to lesion  nucleotide-excision repair, DNA gap filling  nucleotide-excision repair, DNA gap filling  translesion synthesis  nucleotide-excision repair, DNA incision  error-prone translesion synthesis  intracellular membrane-bounded organelle  metal ion binding  
Ontology : EGO-EBIdamaged DNA binding  DNA-directed DNA polymerase activity  nucleus  nucleoplasm  nucleoplasm  DNA replication  DNA repair  transcription-coupled nucleotide-excision repair  nucleotide-excision repair, DNA incision, 5'-to lesion  nucleotide-excision repair, DNA gap filling  nucleotide-excision repair, DNA gap filling  translesion synthesis  nucleotide-excision repair, DNA incision  error-prone translesion synthesis  intracellular membrane-bounded organelle  metal ion binding  
Pathways : KEGGFanconi anemia pathway   
NDEx NetworkPOLK
Atlas of Cancer Signalling NetworkPOLK
Wikipedia pathwaysPOLK
Orthology - Evolution
OrthoDB51426
GeneTree (enSembl)ENSG00000122008
Phylogenetic Trees/Animal Genes : TreeFamPOLK
HOVERGENQ9UBT6
HOGENOMQ9UBT6
Homologs : HomoloGenePOLK
Homology/Alignments : Family Browser (UCSC)POLK
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPOLK [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)POLK
dbVarPOLK
ClinVarPOLK
1000_GenomesPOLK 
Exome Variant ServerPOLK
ExAC (Exome Aggregation Consortium)POLK (select the gene name)
Genetic variants : HAPMAP51426
Genomic Variants (DGV)POLK [DGVbeta]
DECIPHER (Syndromes)5:74807657-74895646  ENSG00000122008
CONAN: Copy Number AnalysisPOLK 
Mutations
ICGC Data PortalPOLK 
TCGA Data PortalPOLK 
Broad Tumor PortalPOLK
OASIS PortalPOLK [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPOLK  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPOLK
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch POLK
DgiDB (Drug Gene Interaction Database)POLK
DoCM (Curated mutations)POLK (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)POLK (select a term)
intoGenPOLK
Cancer3DPOLK(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605650   
Orphanet
MedgenPOLK
Genetic Testing Registry POLK
NextProtQ9UBT6 [Medical]
TSGene51426
GENETestsPOLK
Huge Navigator POLK [HugePedia]
snp3D : Map Gene to Disease51426
BioCentury BCIQPOLK
ClinGenPOLK
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD51426
Chemical/Pharm GKB GenePA33503
Clinical trialPOLK
Miscellaneous
canSAR (ICR)POLK (select the gene name)
Probes
Litterature
PubMed77 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePOLK
EVEXPOLK
GoPubMedPOLK
iHOPPOLK
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Mar 14 13:22:08 CET 2017

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