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POLN (DNA polymerase nu)

Identity

Alias_namespolymerase (DNA directed) nu
polymerase (DNA) nu
Other aliasPOL4P
HGNC (Hugo) POLN
LocusID (NCBI) 353497
Atlas_Id 43422
Location 4p16.3  [Link to chromosome band 4p16]
Location_base_pair Starts at 2071958 and ends at 2242164 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
PLEKHM1P1 (17q24.1) / POLN (4p16.3)PML (15q24.1) / POLN (4p16.3)POLN (4p16.3) / ADD1 (4p16.3)
POLN (4p16.3) / C1orf159 (1p36.33)POLN (4p16.3) / PITPNC1 (17q24.2)POLN (4p16.3) / POLN (4p16.3)
PML 15q24.1 / POLN 4p16.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)POLN   18870
Cards
Entrez_Gene (NCBI)POLN  353497  DNA polymerase nu
AliasesPOL4P
GeneCards (Weizmann)POLN
Ensembl hg19 (Hinxton)ENSG00000130997 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000130997 [Gene_View]  chr4:2071958-2242164 [Contig_View]  POLN [Vega]
ICGC DataPortalENSG00000130997
TCGA cBioPortalPOLN
AceView (NCBI)POLN
Genatlas (Paris)POLN
WikiGenes353497
SOURCE (Princeton)POLN
Genetics Home Reference (NIH)POLN
Genomic and cartography
GoldenPath hg38 (UCSC)POLN  -     chr4:2071958-2242164 -  4p16.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)POLN  -     4p16.3   [Description]    (hg19-Feb_2009)
EnsemblPOLN - 4p16.3 [CytoView hg19]  POLN - 4p16.3 [CytoView hg38]
Mapping of homologs : NCBIPOLN [Mapview hg19]  POLN [Mapview hg38]
OMIM610887   
Gene and transcription
Genbank (Entrez)AF044578 AK131239 AK303673 AL122048 AY136549
RefSeq transcript (Entrez)NM_181808
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)POLN
Cluster EST : UnigeneHs.368454 [ NCBI ]
CGAP (NCI)Hs.368454
Alternative Splicing GalleryENSG00000130997
Gene ExpressionPOLN [ NCBI-GEO ]   POLN [ EBI - ARRAY_EXPRESS ]   POLN [ SEEK ]   POLN [ MEM ]
Gene Expression Viewer (FireBrowse)POLN [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)353497
GTEX Portal (Tissue expression)POLN
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ7Z5Q5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ7Z5Q5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ7Z5Q5
Splice isoforms : SwissVarQ7Z5Q5
PhosPhoSitePlusQ7Z5Q5
Domains : Interpro (EBI)DNA-dir_DNA_pol_A_palm_dom    DNA_polymerase_A    RNaseH-like_dom   
Domain families : Pfam (Sanger)DNA_pol_A (PF00476)   
Domain families : Pfam (NCBI)pfam00476   
Domain families : Smart (EMBL)POLAc (SM00482)  
Conserved Domain (NCBI)POLN
DMDM Disease mutations353497
Blocks (Seattle)POLN
PDB (SRS)4XVI    4XVK    4XVL    4XVM   
PDB (PDBSum)4XVI    4XVK    4XVL    4XVM   
PDB (IMB)4XVI    4XVK    4XVL    4XVM   
PDB (RSDB)4XVI    4XVK    4XVL    4XVM   
Structural Biology KnowledgeBase4XVI    4XVK    4XVL    4XVM   
SCOP (Structural Classification of Proteins)4XVI    4XVK    4XVL    4XVM   
CATH (Classification of proteins structures)4XVI    4XVK    4XVL    4XVM   
SuperfamilyQ7Z5Q5
Human Protein AtlasENSG00000130997
Peptide AtlasQ7Z5Q5
HPRD17876
IPIIPI00385298   IPI00909016   IPI00969018   IPI00028880   
Protein Interaction databases
DIP (DOE-UCLA)Q7Z5Q5
IntAct (EBI)Q7Z5Q5
FunCoupENSG00000130997
BioGRIDPOLN
STRING (EMBL)POLN
ZODIACPOLN
Ontologies - Pathways
QuickGOQ7Z5Q5
Ontology : AmiGOdouble-strand break repair via homologous recombination  DNA binding  DNA-directed DNA polymerase activity  DNA-directed DNA polymerase activity  protein binding  nucleus  nucleoplasm  nucleoplasm  nucleolus  cytoplasm  DNA-dependent DNA replication  5'-3' exonuclease activity  translesion synthesis  translesion synthesis  cyclin binding  interstrand cross-link repair  interstrand cross-link repair  
Ontology : EGO-EBIdouble-strand break repair via homologous recombination  DNA binding  DNA-directed DNA polymerase activity  DNA-directed DNA polymerase activity  protein binding  nucleus  nucleoplasm  nucleoplasm  nucleolus  cytoplasm  DNA-dependent DNA replication  5'-3' exonuclease activity  translesion synthesis  translesion synthesis  cyclin binding  interstrand cross-link repair  interstrand cross-link repair  
Pathways : KEGGFanconi anemia pathway   
NDEx NetworkPOLN
Atlas of Cancer Signalling NetworkPOLN
Wikipedia pathwaysPOLN
Orthology - Evolution
OrthoDB353497
GeneTree (enSembl)ENSG00000130997
Phylogenetic Trees/Animal Genes : TreeFamPOLN
HOVERGENQ7Z5Q5
HOGENOMQ7Z5Q5
Homologs : HomoloGenePOLN
Homology/Alignments : Family Browser (UCSC)POLN
Gene fusions - Rearrangements
Fusion : MitelmanPML/POLN [15q24.1/4p16.3]  [t(4;15)(p16;q22)]  
Fusion: TCGAPML 15q24.1 POLN 4p16.3 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPOLN [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)POLN
dbVarPOLN
ClinVarPOLN
1000_GenomesPOLN 
Exome Variant ServerPOLN
ExAC (Exome Aggregation Consortium)POLN (select the gene name)
Genetic variants : HAPMAP353497
Genomic Variants (DGV)POLN [DGVbeta]
DECIPHERPOLN [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPOLN 
Mutations
ICGC Data PortalPOLN 
TCGA Data PortalPOLN 
Broad Tumor PortalPOLN
OASIS PortalPOLN [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPOLN  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPOLN
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch POLN
DgiDB (Drug Gene Interaction Database)POLN
DoCM (Curated mutations)POLN (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)POLN (select a term)
intoGenPOLN
Cancer3DPOLN(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610887   
Orphanet
MedgenPOLN
Genetic Testing Registry POLN
NextProtQ7Z5Q5 [Medical]
TSGene353497
GENETestsPOLN
Huge Navigator POLN [HugePedia]
snp3D : Map Gene to Disease353497
BioCentury BCIQPOLN
ClinGenPOLN
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD353497
Chemical/Pharm GKB GenePA134979866
Clinical trialPOLN
Miscellaneous
canSAR (ICR)POLN (select the gene name)
Probes
Litterature
PubMed23 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePOLN
EVEXPOLN
GoPubMedPOLN
iHOPPOLN
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri May 19 12:31:59 CEST 2017

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