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POLR1B (RNA polymerase I subunit B)

Identity

Alias_namespolymerase (RNA) I polypeptide B
Alias_symbol (synonym)Rpo1-2
FLJ21921
FLJ10816
RPA2
Other aliasRPA135
HGNC (Hugo) POLR1B
LocusID (NCBI) 84172
Atlas_Id 41780
Location 2q14.1  [Link to chromosome band 2q14]
Location_base_pair Starts at 112541915 and ends at 112577152 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
SLC20A1 (2q13) / POLR1B (2q13)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)POLR1B   20454
Cards
Entrez_Gene (NCBI)POLR1B  84172  RNA polymerase I subunit B
AliasesRPA135; RPA2; Rpo1-2
GeneCards (Weizmann)POLR1B
Ensembl hg19 (Hinxton)ENSG00000125630 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000125630 [Gene_View]  chr2:112541915-112577152 [Contig_View]  POLR1B [Vega]
ICGC DataPortalENSG00000125630
TCGA cBioPortalPOLR1B
AceView (NCBI)POLR1B
Genatlas (Paris)POLR1B
WikiGenes84172
SOURCE (Princeton)POLR1B
Genetics Home Reference (NIH)POLR1B
Genomic and cartography
GoldenPath hg38 (UCSC)POLR1B  -     chr2:112541915-112577152 +  2q14.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)POLR1B  -     2q14.1   [Description]    (hg19-Feb_2009)
EnsemblPOLR1B - 2q14.1 [CytoView hg19]  POLR1B - 2q14.1 [CytoView hg38]
Mapping of homologs : NCBIPOLR1B [Mapview hg19]  POLR1B [Mapview hg38]
OMIM602000   
Gene and transcription
Genbank (Entrez)AA484631 AK001678 AK022533 AK022890 AK025574
RefSeq transcript (Entrez)NM_001137604 NM_001282772 NM_001282774 NM_001282776 NM_001282777 NM_001282779 NM_019014
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)POLR1B
Cluster EST : UnigeneHs.745127 [ NCBI ]
CGAP (NCI)Hs.745127
Alternative Splicing GalleryENSG00000125630
Gene ExpressionPOLR1B [ NCBI-GEO ]   POLR1B [ EBI - ARRAY_EXPRESS ]   POLR1B [ SEEK ]   POLR1B [ MEM ]
Gene Expression Viewer (FireBrowse)POLR1B [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)84172
GTEX Portal (Tissue expression)POLR1B
Human Protein AtlasENSG00000125630-POLR1B [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9H9Y6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9H9Y6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9H9Y6
Splice isoforms : SwissVarQ9H9Y6
Catalytic activity : Enzyme2.7.7.6 [ Enzyme-Expasy ]   2.7.7.62.7.7.6 [ IntEnz-EBI ]   2.7.7.6 [ BRENDA ]   2.7.7.6 [ KEGG ]   
PhosPhoSitePlusQ9H9Y6
Domaine pattern : Prosite (Expaxy)RNA_POL_BETA (PS01166)   
Domains : Interpro (EBI)DNA-dir_RNA_pol_su2    DNA-dir_RNA_pol_su2_6    RNA_pol_bsu_CS    RNA_pol_bsu_protrusion    RNA_pol_Rpb2_2    RNA_pol_Rpb2_3    RNA_pol_Rpb2_7    RNA_pol_RPB2_OB-fold    Rpa2_dom_4   
Domain families : Pfam (Sanger)RNA_pol_Rpa2_4 (PF06883)    RNA_pol_Rpb2_1 (PF04563)    RNA_pol_Rpb2_2 (PF04561)    RNA_pol_Rpb2_3 (PF04565)    RNA_pol_Rpb2_6 (PF00562)    RNA_pol_Rpb2_7 (PF04560)   
Domain families : Pfam (NCBI)pfam06883    pfam04563    pfam04561    pfam04565    pfam00562    pfam04560   
Conserved Domain (NCBI)POLR1B
DMDM Disease mutations84172
Blocks (Seattle)POLR1B
SuperfamilyQ9H9Y6
Human Protein Atlas [tissue]ENSG00000125630-POLR1B [tissue]
Peptide AtlasQ9H9Y6
HPRD06852
IPIIPI01010348   IPI00026445   IPI00418797   IPI00184886   IPI01013053   IPI00916595   IPI00916790   IPI00915797   IPI00917238   IPI00917431   IPI00916381   IPI00916605   IPI00917845   
Protein Interaction databases
DIP (DOE-UCLA)Q9H9Y6
IntAct (EBI)Q9H9Y6
FunCoupENSG00000125630
BioGRIDPOLR1B
STRING (EMBL)POLR1B
ZODIACPOLR1B
Ontologies - Pathways
QuickGOQ9H9Y6
Ontology : AmiGORNA polymerase I activity  DNA binding  protein binding  nucleoplasm  nucleolus  DNA-directed RNA polymerase I complex  cytosol  transcription initiation from RNA polymerase I promoter  transcription elongation from RNA polymerase I promoter  termination of RNA polymerase I transcription  embryo implantation  rRNA transcription  nucleologenesis  ribonucleoside binding  positive regulation of gene expression, epigenetic  metal ion binding  
Ontology : EGO-EBIRNA polymerase I activity  DNA binding  protein binding  nucleoplasm  nucleolus  DNA-directed RNA polymerase I complex  cytosol  transcription initiation from RNA polymerase I promoter  transcription elongation from RNA polymerase I promoter  termination of RNA polymerase I transcription  embryo implantation  rRNA transcription  nucleologenesis  ribonucleoside binding  positive regulation of gene expression, epigenetic  metal ion binding  
Pathways : BIOCARTATumor Suppressor Arf Inhibits Ribosomal Biogenesis [Genes]   
Pathways : KEGGPurine metabolism    Pyrimidine metabolism    RNA polymerase   
NDEx NetworkPOLR1B
Atlas of Cancer Signalling NetworkPOLR1B
Wikipedia pathwaysPOLR1B
Orthology - Evolution
OrthoDB84172
GeneTree (enSembl)ENSG00000125630
Phylogenetic Trees/Animal Genes : TreeFamPOLR1B
HOVERGENQ9H9Y6
HOGENOMQ9H9Y6
Homologs : HomoloGenePOLR1B
Homology/Alignments : Family Browser (UCSC)POLR1B
Gene fusions - Rearrangements
Tumor Fusion PortalPOLR1B
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPOLR1B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)POLR1B
dbVarPOLR1B
ClinVarPOLR1B
1000_GenomesPOLR1B 
Exome Variant ServerPOLR1B
ExAC (Exome Aggregation Consortium)ENSG00000125630
GNOMAD BrowserENSG00000125630
Genetic variants : HAPMAP84172
Genomic Variants (DGV)POLR1B [DGVbeta]
DECIPHERPOLR1B [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPOLR1B 
Mutations
ICGC Data PortalPOLR1B 
TCGA Data PortalPOLR1B 
Broad Tumor PortalPOLR1B
OASIS PortalPOLR1B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPOLR1B  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPOLR1B
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch POLR1B
DgiDB (Drug Gene Interaction Database)POLR1B
DoCM (Curated mutations)POLR1B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)POLR1B (select a term)
intoGenPOLR1B
Cancer3DPOLR1B(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602000   
Orphanet
DisGeNETPOLR1B
MedgenPOLR1B
Genetic Testing Registry POLR1B
NextProtQ9H9Y6 [Medical]
TSGene84172
GENETestsPOLR1B
Target ValidationPOLR1B
Huge Navigator POLR1B [HugePedia]
snp3D : Map Gene to Disease84172
BioCentury BCIQPOLR1B
ClinGenPOLR1B
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD84172
Chemical/Pharm GKB GenePA130601182
Clinical trialPOLR1B
Miscellaneous
canSAR (ICR)POLR1B (select the gene name)
Probes
Litterature
PubMed38 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePOLR1B
EVEXPOLR1B
GoPubMedPOLR1B
iHOPPOLR1B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 21 14:29:32 CET 2017

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