POLR1B (RNA polymerase I subunit B)

2003-12-01 Affiliation

Identity

HGNC

POLR1B

LOCATION

2q14.1

LOCUSID

84172

ALIAS

A135,RPA135,RPA2,Rpo1-2,TCS4

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 84172
MIM: 602000
HGNC: 20454
Ensembl: ENSG00000125630

Variants:

dbSNP: 84172
ClinVar: 84172
TCGA: ENSG00000125630
COSMIC: POLR1B

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000125630	ENST00000263331	Q9H9Y6
ENSG00000125630	ENST00000333990	F8WAK7
ENSG00000125630	ENST00000409894	Q9H9Y6
ENSG00000125630	ENST00000417433	Q9H9Y6
ENSG00000125630	ENST00000424062	F8WBB9
ENSG00000125630	ENST00000430293	F8WDS4
ENSG00000125630	ENST00000430769	C9JJG2
ENSG00000125630	ENST00000438748	C9JS83
ENSG00000125630	ENST00000448770	F8WCS3
ENSG00000125630	ENST00000458012	H7C0D9
ENSG00000125630	ENST00000537335	Q9H9Y6
ENSG00000125630	ENST00000541869	Q9H9Y6

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Purine metabolism	KEGG	ko00230
Pyrimidine metabolism	KEGG	ko00240
RNA polymerase	KEGG	ko03020
Purine metabolism	KEGG	hsa00230
Pyrimidine metabolism	KEGG	hsa00240
RNA polymerase	KEGG	hsa03020
Metabolic pathways	KEGG	hsa01100
RNA polymerase I, eukaryotes	KEGG	hsa_M00182
RNA polymerase I, eukaryotes	KEGG	M00182
Gene Expression	REACTOME	R-HSA-74160
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription	REACTOME	R-HSA-504046
RNA Polymerase I Transcription	REACTOME	R-HSA-73864
RNA Polymerase I Promoter Clearance	REACTOME	R-HSA-73854
RNA Polymerase I Transcription Initiation	REACTOME	R-HSA-73762
RNA Polymerase I Promoter Escape	REACTOME	R-HSA-73772
RNA Polymerase I Chain Elongation	REACTOME	R-HSA-73777
RNA Polymerase I Transcription Termination	REACTOME	R-HSA-73863
Epigenetic regulation of gene expression	REACTOME	R-HSA-212165
Negative epigenetic regulation of rRNA expression	REACTOME	R-HSA-5250941
NoRC negatively regulates rRNA expression	REACTOME	R-HSA-427413
Positive epigenetic regulation of rRNA expression	REACTOME	R-HSA-5250913
B-WICH complex positively regulates rRNA expression	REACTOME	R-HSA-5250924

References

Pubmed ID	Year	Title	Citations
17499043	2007	Mammalian Maf1 is a negative regulator of transcription by all three nuclear RNA polymerases.	64
16055704	2005	PTEN represses RNA Polymerase I transcription by disrupting the SL1 complex.	45
16880508	2006	Casein kinase 2 associates with initiation-competent RNA polymerase I and has multiple roles in ribosomal DNA transcription.	19
18194663	2008	Efficient protein expression from the endogenous RNA polymerase I promoter using a human ribosomal DNA targeting vector.	0

Citation

Dessen P

POLR1B (RNA polymerase I subunit B)

Atlas Genet Cytogenet Oncol Haematol. 2003-12-01

Online version: http://atlasgeneticsoncology.org/gene/41780/polr1b