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POLR1B (RNA polymerase I subunit B)

Identity

Alias (NCBI)A135
RPA135
RPA2
Rpo1-2
TCS4
HGNC (Hugo) POLR1B
HGNC Alias symbRpo1-2
FLJ21921
FLJ10816
RPA2
RPA135
HGNC Previous namepolymerase (RNA) I polypeptide B, 128kDa
LocusID (NCBI) 84172
Atlas_Id 41780
Location 2q14.1  [Link to chromosome band 2q14]
Location_base_pair Starts at 112542465 and ends at 112579818 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
SLC20A1 (2q13) / POLR1B (2q13)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)POLR1B   20454
Cards
Entrez_Gene (NCBI)POLR1B    RNA polymerase I subunit B
AliasesA135; RPA135; RPA2; Rpo1-2; 
TCS4
GeneCards (Weizmann)POLR1B
Ensembl hg19 (Hinxton)ENSG00000125630 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000125630 [Gene_View]  ENSG00000125630 [Sequence]  chr2:112542465-112579818 [Contig_View]  POLR1B [Vega]
ICGC DataPortalENSG00000125630
TCGA cBioPortalPOLR1B
AceView (NCBI)POLR1B
Genatlas (Paris)POLR1B
SOURCE (Princeton)POLR1B
Genetics Home Reference (NIH)POLR1B
Genomic and cartography
GoldenPath hg38 (UCSC)POLR1B  -     chr2:112542465-112579818 +  2q14.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)POLR1B  -     2q14.1   [Description]    (hg19-Feb_2009)
GoldenPathPOLR1B - 2q14.1 [CytoView hg19]  POLR1B - 2q14.1 [CytoView hg38]
ImmunoBaseENSG00000125630
Genome Data Viewer NCBIPOLR1B [Mapview hg19]  
OMIM602000   618939   
Gene and transcription
Genbank (Entrez)AA484631 AK001678 AK022533 AK022890 AK025574
RefSeq transcript (Entrez)NM_001137604 NM_001282772 NM_001282774 NM_001282776 NM_001282777 NM_001282779 NM_001371969 NM_001371970 NM_001371971 NM_019014
Consensus coding sequences : CCDS (NCBI)POLR1B
Gene ExpressionPOLR1B [ NCBI-GEO ]   POLR1B [ EBI - ARRAY_EXPRESS ]   POLR1B [ SEEK ]   POLR1B [ MEM ]
Gene Expression Viewer (FireBrowse)POLR1B [ Firebrowse - Broad ]
GenevisibleExpression of POLR1B in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)84172
GTEX Portal (Tissue expression)POLR1B
Human Protein AtlasENSG00000125630-POLR1B [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9H9Y6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9H9Y6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9H9Y6
Catalytic activity : Enzyme2.7.7.6 [ Enzyme-Expasy ]   2.7.7.62.7.7.6 [ IntEnz-EBI ]   2.7.7.6 [ BRENDA ]   2.7.7.6 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ9H9Y6
Domaine pattern : Prosite (Expaxy)RNA_POL_BETA (PS01166)   
Domains : Interpro (EBI)DNA-dir_RNA_pol_su2    DNA-dir_RNAP_su2_dom    DNA-dir_RNAP_su2_hyb_sf    RNA_pol_bsu_CS    RNA_pol_bsu_protrusion    RNA_pol_Rpb2_2    RNA_pol_Rpb2_2_sf    RNA_pol_Rpb2_3    RNA_pol_Rpb2_7    RNA_pol_RPB2_OB-fold    Rpa2_dom_4   
Domain families : Pfam (Sanger)RNA_pol_Rpa2_4 (PF06883)    RNA_pol_Rpb2_1 (PF04563)    RNA_pol_Rpb2_2 (PF04561)    RNA_pol_Rpb2_3 (PF04565)    RNA_pol_Rpb2_6 (PF00562)    RNA_pol_Rpb2_7 (PF04560)   
Domain families : Pfam (NCBI)pfam06883    pfam04563    pfam04561    pfam04565    pfam00562    pfam04560   
Conserved Domain (NCBI)POLR1B
SuperfamilyQ9H9Y6
AlphaFold pdb e-kbQ9H9Y6   
Human Protein Atlas [tissue]ENSG00000125630-POLR1B [tissue]
HPRD06852
Protein Interaction databases
DIP (DOE-UCLA)Q9H9Y6
IntAct (EBI)Q9H9Y6
BioGRIDPOLR1B
STRING (EMBL)POLR1B
ZODIACPOLR1B
Ontologies - Pathways
QuickGOQ9H9Y6
Ontology : AmiGODNA binding  DNA-directed 5'-3' RNA polymerase activity  protein binding  nucleoplasm  chromosome  nucleolus  RNA polymerase I complex  cytosol  transcription initiation from RNA polymerase I promoter  termination of RNA polymerase I transcription  embryo implantation  rRNA transcription  neural crest formation  nucleologenesis  ribonucleoside binding  positive regulation of gene expression, epigenetic  metal ion binding  
Ontology : EGO-EBIDNA binding  DNA-directed 5'-3' RNA polymerase activity  protein binding  nucleoplasm  chromosome  nucleolus  RNA polymerase I complex  cytosol  transcription initiation from RNA polymerase I promoter  termination of RNA polymerase I transcription  embryo implantation  rRNA transcription  neural crest formation  nucleologenesis  ribonucleoside binding  positive regulation of gene expression, epigenetic  metal ion binding  
Pathways : BIOCARTATumor Suppressor Arf Inhibits Ribosomal Biogenesis [Genes]   
Pathways : KEGGPurine metabolism    Pyrimidine metabolism    RNA polymerase   
NDEx NetworkPOLR1B
Atlas of Cancer Signalling NetworkPOLR1B
Wikipedia pathwaysPOLR1B
Orthology - Evolution
OrthoDB84172
GeneTree (enSembl)ENSG00000125630
Phylogenetic Trees/Animal Genes : TreeFamPOLR1B
Homologs : HomoloGenePOLR1B
Homology/Alignments : Family Browser (UCSC)POLR1B
Gene fusions - Rearrangements
Fusion : QuiverPOLR1B
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPOLR1B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)POLR1B
dbVarPOLR1B
ClinVarPOLR1B
MonarchPOLR1B
1000_GenomesPOLR1B 
Exome Variant ServerPOLR1B
GNOMAD BrowserENSG00000125630
Varsome BrowserPOLR1B
ACMGPOLR1B variants
VarityQ9H9Y6
Genomic Variants (DGV)POLR1B [DGVbeta]
DECIPHERPOLR1B [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPOLR1B 
Mutations
ICGC Data PortalPOLR1B 
TCGA Data PortalPOLR1B 
Broad Tumor PortalPOLR1B
OASIS PortalPOLR1B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPOLR1B  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPOLR1B
Mutations and Diseases : HGMDPOLR1B
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaPOLR1B
DgiDB (Drug Gene Interaction Database)POLR1B
DoCM (Curated mutations)POLR1B
CIViC (Clinical Interpretations of Variants in Cancer)POLR1B
Cancer3DPOLR1B
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602000    618939   
Orphanet
DisGeNETPOLR1B
MedgenPOLR1B
Genetic Testing Registry POLR1B
NextProtQ9H9Y6 [Medical]
GENETestsPOLR1B
Target ValidationPOLR1B
Huge Navigator POLR1B [HugePedia]
ClinGenPOLR1B
Clinical trials, drugs, therapy
MyCancerGenomePOLR1B
Protein Interactions : CTDPOLR1B
Pharm GKB GenePA130601182
PharosQ9H9Y6
Clinical trialPOLR1B
Miscellaneous
canSAR (ICR)POLR1B
HarmonizomePOLR1B
DataMed IndexPOLR1B
Probes
Litterature
PubMed61 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXPOLR1B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Mon Oct 4 15:26:04 CEST 2021

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