PPARA (peroxisome proliferator-activated receptor alpha)

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Taking over the Atlas
Dear Colleagues,
The Atlas, once more, is in great danger, and I will have to proceed to a collective economic lay-off of all the team involved in the Atlas before the begining of April 2015 (a foundation having suddenly withdrawn its commitment to support the Atlas). I ask you herein if any Scientific Society (a Society of Cytogenetics, of Clinical Genetics, of Hematology, or a Cancer Society, or any other...), any University and/or Hospital, any Charity, or any database would be interested in taking over the Atlas, in whole or in part. If taking charge of the whole lot is too big, a consortium of various actors could be the solution (I am myself trying to find partners). Could you please spread the information, contact the relevant authorities, and find partners.
Survival of the Atlas will be critically dependant upon your ability to find solutions (and urgently!).
Kind regards.
Jean-Loup Huret
Donations are also welcome

PPARA (peroxisome proliferator-activated receptor alpha)

Identity

Other names	NR1C1
	PPAR
	PPARalpha
	hPPAR
HGNC (Hugo)	PPARA
LocusID (NCBI)	5465
Location	22q13.31
Location_base_pair	Starts at 46546499 and ends at 46639653 bp from pter ( according to hg19-Feb_2009)
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to How to contribute

DNA/RNA

External links

	Nomenclature
HGNC (Hugo)	PPARA 9232
	Cards
Entrez_Gene (NCBI)	PPARA 5465 peroxisome proliferator-activated receptor alpha
GeneCards (Weizmann)	PPARA
Ensembl hg19 (Hinxton)	ENSG00000186951 [Gene_View] chr22:46546499-46639653 [Contig_View] PPARA [Vega]
Ensembl hg38 (Hinxton)	ENSG00000186951 [Gene_View] chr22:46546499-46639653 [Contig_View] PPARA [Vega]
ICGC DataPortal	ENSG00000186951
cBioPortal	PPARA
AceView (NCBI)	PPARA
Genatlas (Paris)	PPARA
WikiGenes	5465
SOURCE (Princeton)	PPARA
	Genomic and cartography
GoldenPath hg19 (UCSC)	PPARA - chr22:46546499-46639653 + 22q13.31 [Description] (hg19-Feb_2009)
GoldenPath hg38 (UCSC)	PPARA - 22q13.31 [Description] (hg38-Dec_2013)
Ensembl	PPARA - 22q13.31 [CytoView hg19] PPARA - 22q13.31 [CytoView hg38]
Mapping of homologs : NCBI	PPARA [Mapview hg19] PPARA [Mapview hg38]
OMIM	170998
	Gene and transcription
Genbank (Entrez)	AB073605 AB307690 AF018254 AF086231 AF270490
RefSeq transcript (Entrez)	NM_001001928 NM_001001929 NM_001001930 NM_005036 NM_032644
RefSeq genomic (Entrez)	AC_000154 NC_000022 NC_018933 NG_012204 NT_011520 NW_001838753 NW_004929430
Consensus coding sequences : CCDS (NCBI)	PPARA
Cluster EST : Unigene	Hs.710044 [ NCBI ]
CGAP (NCI)	Hs.710044
Alternative Splicing : Fast-db (Paris)	GSHG0020104
Alternative Splicing Gallery	ENSG00000186951
Gene Expression	PPARA [ NCBI-GEO ] PPARA [ SEEK ] PPARA [ MEM ]
SOURCE (Princeton)	Expression in : [Normal Tissue Atlas] [carcinoma Classsification] [NCI60]
	Protein : pattern, domain, 3D structure
UniProt/SwissProt	Q07869 (Uniprot)
NextProt	Q07869 [Medical]
With graphics : InterPro	Q07869
Splice isoforms : SwissVar	Q07869 (Swissvar)
Domaine pattern : Prosite (Expaxy)	NUCLEAR_REC_DBD_1 (PS00031) NUCLEAR_REC_DBD_2 (PS51030)
Domains : Interpro (EBI)	1Cnucl_rcpt 1Cnucl_rcpt_A Nucl_hormone_rcpt_ligand-bd Nucl_hrmn_rcpt_lig-bd_core Str_hrmn_rcpt Znf_hrmn_rcpt Znf_NHR/GATA
Related proteins : CluSTr	Q07869
Domain families : Pfam (Sanger)	Hormone_recep (PF00104) zf-C4 (PF00105)
Domain families : Pfam (NCBI)	pfam00104 pfam00105
Domain families : Smart (EMBL)	HOLI (SM00430) ZnF_C4 (SM00399)
DMDM Disease mutations	5465
Blocks (Seattle)	Q07869
PDB (SRS)	1I7G 1K7L 1KKQ 2NPA 2P54 2REW 2ZNN 3ET1 3FEI 3G8I 3KDT 3KDU 3SP6 3VI8 4BCR
PDB (PDBSum)	1I7G 1K7L 1KKQ 2NPA 2P54 2REW 2ZNN 3ET1 3FEI 3G8I 3KDT 3KDU 3SP6 3VI8 4BCR
PDB (IMB)	1I7G 1K7L 1KKQ 2NPA 2P54 2REW 2ZNN 3ET1 3FEI 3G8I 3KDT 3KDU 3SP6 3VI8 4BCR
PDB (RSDB)	1I7G 1K7L 1KKQ 2NPA 2P54 2REW 2ZNN 3ET1 3FEI 3G8I 3KDT 3KDU 3SP6 3VI8 4BCR
Human Protein Atlas	ENSG00000186951
Peptide Atlas	Q07869
HPRD	01369
IPI	IPI00020097 IPI00896375 IPI01012608 IPI00815903 IPI00878492
	Protein Interaction databases
DIP (DOE-UCLA)	Q07869
IntAct (EBI)	Q07869
FunCoup	ENSG00000186951
BioGRID	PPARA
IntegromeDB	PPARA
STRING (EMBL)	PPARA
	Ontologies - Pathways
QuickGO	Q07869
Ontology : AmiGO	negative regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription RNA polymerase II repressing transcription factor binding response to hypoxia DNA binding sequence-specific DNA binding transcription factor activity sequence-specific DNA binding transcription factor activity steroid hormone receptor activity ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity protein binding nucleus nucleoplasm transcription initiation from RNA polymerase II promoter lipid metabolic process fatty acid metabolic process heart development drug binding zinc ion binding lipid binding epidermis development gene expression negative regulation of macrophage derived foam cell differentiation negative regulation of macrophage derived foam cell differentiation negative regulation of receptor biosynthetic process negative regulation of cholesterol storage negative regulation of sequestering of triglyceride fatty acid transport phosphatase binding protein domain specific binding intracellular receptor signaling pathway intracellular receptor signaling pathway ubiquitin conjugating enzyme binding positive regulation of fatty acid beta-oxidation negative regulation of protein binding negative regulation of appetite protein complex binding response to insulin circadian regulation of gene expression behavioral response to nicotine wound healing lipoprotein metabolic process regulation of circadian rhythm steroid hormone mediated signaling pathway sequence-specific DNA binding cellular lipid metabolic process small molecule metabolic process negative regulation of blood pressure negative regulation of glycolytic process positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of fatty acid oxidation NFAT protein binding enamel mineralization regulation of glycolytic by positive regulation of transcription from RNA polymerase II promoter regulation of cellular ketone metabolic process by positive regulation of transcription from RNA polymerase II promoter regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter MDM2/MDM4 family protein binding negative regulation of neuron death negative regulation of transcription regulatory region DNA binding
Ontology : EGO-EBI	negative regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription RNA polymerase II repressing transcription factor binding response to hypoxia DNA binding sequence-specific DNA binding transcription factor activity sequence-specific DNA binding transcription factor activity steroid hormone receptor activity ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity protein binding nucleus nucleoplasm transcription initiation from RNA polymerase II promoter lipid metabolic process fatty acid metabolic process heart development drug binding zinc ion binding lipid binding epidermis development gene expression negative regulation of macrophage derived foam cell differentiation negative regulation of macrophage derived foam cell differentiation negative regulation of receptor biosynthetic process negative regulation of cholesterol storage negative regulation of sequestering of triglyceride fatty acid transport phosphatase binding protein domain specific binding intracellular receptor signaling pathway intracellular receptor signaling pathway ubiquitin conjugating enzyme binding positive regulation of fatty acid beta-oxidation negative regulation of protein binding negative regulation of appetite protein complex binding response to insulin circadian regulation of gene expression behavioral response to nicotine wound healing lipoprotein metabolic process regulation of circadian rhythm steroid hormone mediated signaling pathway sequence-specific DNA binding cellular lipid metabolic process small molecule metabolic process negative regulation of blood pressure negative regulation of glycolytic process positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of fatty acid oxidation NFAT protein binding enamel mineralization regulation of glycolytic by positive regulation of transcription from RNA polymerase II promoter regulation of cellular ketone metabolic process by positive regulation of transcription from RNA polymerase II promoter regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter MDM2/MDM4 family protein binding negative regulation of neuron death negative regulation of transcription regulatory region DNA binding
Pathways : BIOCARTA	Regulation of PGC-1a [Genes] Mechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha) [Genes] _-arrestins in GPCR Desensitization [Genes] Toll-Like Receptor Pathway [Genes] Basic mechanism of action of PPARa, PPARb(d) and PPARg and effects on gene expression [Genes] Nuclear Receptors in Lipid Metabolism and Toxicity [Genes]
Pathways : KEGG	PPAR signaling pathway Adipocytokine signaling pathway Non-alcoholic fatty liver disease (NAFLD) Hepatitis C
Protein Interaction Database	PPARA
DoCM (Curated mutations)	PPARA
Wikipedia pathways	PPARA
	Gene fusion - rearrangements
	Polymorphisms : SNP, variants
NCBI Variation Viewer	PPARA [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)	PPARA
dbVar	PPARA
ClinVar	PPARA
1000_Genomes	PPARA
Exome Variant Server	PPARA
SNP (GeneSNP Utah)	PPARA
SNP : HGBase	PPARA
Genetic variants : HAPMAP	PPARA
Genomic Variants (DGV)	PPARA [DGVbeta]
	Mutations
ICGC Data Portal	ENSG00000186951
Somatic Mutations in Cancer : COSMIC	PPARA
CONAN: Copy Number Analysis	PPARA
LOVD (Leiden Open Variation Database)	Whole genome datasets
LOVD (Leiden Open Variation Database)	LOVD 3.0 shared installation
Impact of mutations	[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor]
	Diseases
DECIPHER (Syndromes)	22:46546499-46639653
Mutations and Diseases : HGMD	PPARA
OMIM	170998
Medgen	PPARA
NextProt	Q07869 [Medical]
GENETests	PPARA
Disease Genetic Association	PPARA
Huge Navigator	PPARA [HugePedia] PPARA [HugeCancerGEM]
snp3D : Map Gene to Disease	5465
DGIdb (Drug Gene Interaction db)	PPARA
	General knowledge
Homologs : HomoloGene	PPARA
Homology/Alignments : Family Browser (UCSC)	PPARA
Phylogenetic Trees/Animal Genes : TreeFam	PPARA
Chemical/Protein Interactions : CTD	5465
Chemical/Pharm GKB Gene	PA280
Clinical trial	PPARA
Cancer Resource (Charite)	ENSG00000186951
	Other databases
	Probes
	Litterature
PubMed	419 Pubmed reference(s) in Entrez
CoreMine	PPARA
GoPubMed	PPARA
iHOP	PPARA

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI NCBI

Contributor(s)

Written	09-2002	Dessen P, Le Minor S

Updated	12-2014	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Sat Feb 14 18:04:48 CET 2015

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