| Nomenclature |
|---|
| HGNC (Hugo) | PPARA 9232 |
| Cards |
|---|
| Entrez_Gene (NCBI) | PPARA peroxisome proliferator activated receptor alpha |
| Aliases | NR1C1; PPAR; PPAR-alpha; PPARalpha; |
| hPPAR |
| GeneCards (Weizmann) | PPARA |
| Ensembl hg19 (Hinxton) | ENSG00000186951 [Gene_View] |
| Ensembl hg38 (Hinxton) | ENSG00000186951 [Gene_View] ENSG00000186951 [Sequence] chr22:46150526-46243755 [Contig_View] PPARA [Vega] |
| ICGC DataPortal | ENSG00000186951 |
| TCGA cBioPortal | PPARA |
| AceView (NCBI) | PPARA |
| Genatlas (Paris) | PPARA |
| SOURCE (Princeton) | PPARA |
| Genetics Home Reference (NIH) | PPARA |
| Genomic and cartography |
|---|
| GoldenPath hg38 (UCSC) | PPARA - chr22:46150526-46243755 + 22q13.31 [Description] (hg38-Dec_2013) |
| GoldenPath hg19 (UCSC) | PPARA - 22q13.31 [Description] (hg19-Feb_2009) |
| GoldenPath | PPARA - 22q13.31 [CytoView hg19] PPARA - 22q13.31 [CytoView hg38] |
| ImmunoBase | ENSG00000186951 |
| Genome Data Viewer NCBI | PPARA [Mapview hg19] |
| OMIM | 170998 |
| Gene and transcription |
|---|
| Genbank (Entrez) | AB073605 AB307690 AF018254 AF086231 AF270490 |
| RefSeq transcript (Entrez) | NM_001001928 NM_001001929 NM_001001930 NM_001362872 NM_001362873 NM_001393941 NM_001393942 NM_001393943 NM_001393944 NM_001393945 NM_001393946 NM_001393947 NM_005036 NM_032644 |
| Consensus coding sequences : CCDS (NCBI) | PPARA |
| Gene Expression | PPARA [ NCBI-GEO ] PPARA [ EBI - ARRAY_EXPRESS ]
PPARA [ SEEK ] PPARA [ MEM ] |
| Gene Expression Viewer (FireBrowse) | PPARA [ Firebrowse - Broad ] |
| Genevisible | Expression of PPARA in : [tissues] [cell-lines] [cancer] [perturbations] |
| BioGPS (Tissue expression) | 5465 |
| GTEX Portal (Tissue expression) | PPARA |
| Human Protein Atlas | ENSG00000186951-PPARA [pathology] [cell] [tissue] |
| Protein : pattern, domain, 3D structure |
|---|
| UniProt/SwissProt | Q07869 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction] |
| NextProt | Q07869 [Sequence] [Exons] [Medical] [Publications] |
| With graphics : InterPro | Q07869 |
| PhosPhoSitePlus | Q07869 |
| Domaine pattern : Prosite (Expaxy) | NR_LBD (PS51843) NUCLEAR_REC_DBD_1 (PS00031) NUCLEAR_REC_DBD_2 (PS51030) |
| Domains : Interpro (EBI) | 1Cnucl_rcpt NHR-like_dom_sf Nucl_hrmn_rcpt_lig-bd Nuclear_hrmn_rcpt PPAR-alpha Znf_hrmn_rcpt Znf_NHR/GATA |
| Domain families : Pfam (Sanger) | Hormone_recep (PF00104) zf-C4 (PF00105) |
| Domain families : Pfam (NCBI) | pfam00104 pfam00105 |
| Domain families : Smart (EMBL) | HOLI (SM00430) ZnF_C4 (SM00399) |
| Conserved Domain (NCBI) | PPARA |
| PDB (RSDB) | 1I7G 1K7L 1KKQ 2NPA 2P54 2REW 2ZNN 3ET1 3FEI 3G8I 3KDT 3KDU 3SP6 3VI8 4BCR 4CI4 5AZT 5HYK 6KXX 6KXY 6L96 |
| PDB Europe | 1I7G 1K7L 1KKQ 2NPA 2P54 2REW 2ZNN 3ET1 3FEI 3G8I 3KDT 3KDU 3SP6 3VI8 4BCR 4CI4 5AZT 5HYK 6KXX 6KXY 6L96 |
| PDB (PDBSum) | 1I7G 1K7L 1KKQ 2NPA 2P54 2REW 2ZNN 3ET1 3FEI 3G8I 3KDT 3KDU 3SP6 3VI8 4BCR 4CI4 5AZT 5HYK 6KXX 6KXY 6L96 |
| PDB (IMB) | 1I7G 1K7L 1KKQ 2NPA 2P54 2REW 2ZNN 3ET1 3FEI 3G8I 3KDT 3KDU 3SP6 3VI8 4BCR 4CI4 5AZT 5HYK 6KXX 6KXY 6L96 |
| Structural Biology KnowledgeBase | 1I7G 1K7L 1KKQ 2NPA 2P54 2REW 2ZNN 3ET1 3FEI 3G8I 3KDT 3KDU 3SP6 3VI8 4BCR 4CI4 5AZT 5HYK 6KXX 6KXY 6L96 |
| SCOP (Structural Classification of Proteins) | 1I7G 1K7L 1KKQ 2NPA 2P54 2REW 2ZNN 3ET1 3FEI 3G8I 3KDT 3KDU 3SP6 3VI8 4BCR 4CI4 5AZT 5HYK 6KXX 6KXY 6L96 |
| CATH (Classification of proteins structures) | 1I7G 1K7L 1KKQ 2NPA 2P54 2REW 2ZNN 3ET1 3FEI 3G8I 3KDT 3KDU 3SP6 3VI8 4BCR 4CI4 5AZT 5HYK 6KXX 6KXY 6L96 |
| Superfamily | Q07869 |
| AlphaFold pdb e-kb | Q07869 |
| Human Protein Atlas [tissue] | ENSG00000186951-PPARA [tissue] |
| HPRD | 01369 |
| Protein Interaction databases |
|---|
| DIP (DOE-UCLA) | Q07869 |
| IntAct (EBI) | Q07869 |
| BioGRID | PPARA |
| STRING (EMBL) | PPARA |
| ZODIAC | PPARA |
| Ontologies - Pathways |
|---|
| QuickGO | Q07869 |
| Ontology : AmiGO | negative regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II chromatin RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription coactivator binding DNA-binding transcription repressor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific response to hypoxia DNA binding DNA-binding transcription factor activity DNA-binding transcription factor activity steroid hormone receptor activity nuclear receptor activity nuclear receptor activity protein binding nucleus nucleus nucleoplasm nucleoplasm transcription initiation from RNA polymerase II promoter fatty acid metabolic process heart development transcription factor binding drug binding zinc ion binding lipid binding epidermis development cellular response to starvation hormone-mediated signaling pathway regulation of cellular ketone metabolic process negative regulation of macrophage derived foam cell differentiation negative regulation of macrophage derived foam cell differentiation lipid localization negative regulation of cholesterol storage negative regulation of cholesterol storage negative regulation of sequestering of triglyceride regulation of lipid metabolic process regulation of lipid metabolic process regulation of fatty acid metabolic process phosphatase binding protein domain specific binding cell differentiation negative regulation of transforming growth factor beta receptor signaling pathway intracellular receptor signaling pathway ubiquitin conjugating enzyme binding positive regulation of fatty acid beta-oxidation negative regulation of protein binding negative regulation of appetite response to insulin circadian regulation of gene expression response to lipid behavioral response to nicotine wound healing lipoprotein metabolic process regulation of circadian rhythm steroid hormone mediated signaling pathway sequence-specific DNA binding protein-containing complex binding positive regulation of viral genome replication response to ethanol positive regulation of gluconeogenesis negative regulation of blood pressure negative regulation of glycolytic process positive regulation of transcription, DNA-templated positive regulation of fatty acid metabolic process positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II positive regulation of fatty acid oxidation positive regulation of lipid biosynthetic process negative regulation of inflammatory response negative regulation of inflammatory response NFAT protein binding negative regulation of protein kinase B signaling negative regulation of cell growth involved in cardiac muscle cell development RNA polymerase II-specific DNA-binding transcription factor binding RNA polymerase II-specific DNA-binding transcription factor binding enamel mineralization MDM2/MDM4 family protein binding negative regulation of cytokine production involved in inflammatory response negative regulation of neuron death negative regulation of pri-miRNA transcription by RNA polymerase II negative regulation of leukocyte cell-cell adhesion negative regulation of reactive oxygen species biosynthetic process negative regulation of hepatocyte apoptotic process regulation of fatty acid transport negative regulation of signaling receptor activity positive regulation of ATP biosynthetic process |
| Ontology : EGO-EBI | negative regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II chromatin RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription coactivator binding DNA-binding transcription repressor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific response to hypoxia DNA binding DNA-binding transcription factor activity DNA-binding transcription factor activity steroid hormone receptor activity nuclear receptor activity nuclear receptor activity protein binding nucleus nucleus nucleoplasm nucleoplasm transcription initiation from RNA polymerase II promoter fatty acid metabolic process heart development transcription factor binding drug binding zinc ion binding lipid binding epidermis development cellular response to starvation hormone-mediated signaling pathway regulation of cellular ketone metabolic process negative regulation of macrophage derived foam cell differentiation negative regulation of macrophage derived foam cell differentiation lipid localization negative regulation of cholesterol storage negative regulation of cholesterol storage negative regulation of sequestering of triglyceride regulation of lipid metabolic process regulation of lipid metabolic process regulation of fatty acid metabolic process phosphatase binding protein domain specific binding cell differentiation negative regulation of transforming growth factor beta receptor signaling pathway intracellular receptor signaling pathway ubiquitin conjugating enzyme binding positive regulation of fatty acid beta-oxidation negative regulation of protein binding negative regulation of appetite response to insulin circadian regulation of gene expression response to lipid behavioral response to nicotine wound healing lipoprotein metabolic process regulation of circadian rhythm steroid hormone mediated signaling pathway sequence-specific DNA binding protein-containing complex binding positive regulation of viral genome replication response to ethanol positive regulation of gluconeogenesis negative regulation of blood pressure negative regulation of glycolytic process positive regulation of transcription, DNA-templated positive regulation of fatty acid metabolic process positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II positive regulation of fatty acid oxidation positive regulation of lipid biosynthetic process negative regulation of inflammatory response negative regulation of inflammatory response NFAT protein binding negative regulation of protein kinase B signaling negative regulation of cell growth involved in cardiac muscle cell development RNA polymerase II-specific DNA-binding transcription factor binding RNA polymerase II-specific DNA-binding transcription factor binding enamel mineralization MDM2/MDM4 family protein binding negative regulation of cytokine production involved in inflammatory response negative regulation of neuron death negative regulation of pri-miRNA transcription by RNA polymerase II negative regulation of leukocyte cell-cell adhesion negative regulation of reactive oxygen species biosynthetic process negative regulation of hepatocyte apoptotic process regulation of fatty acid transport negative regulation of signaling receptor activity positive regulation of ATP biosynthetic process |
| Pathways : BIOCARTA | Regulation of PGC-1a [Genes] Mechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha) [Genes] ?-arrestins in GPCR Desensitization [Genes] Toll-Like Receptor Pathway [Genes] Basic mechanism of action of PPARa, PPARb(d) and PPARg and effects on gene expression [Genes] Nuclear Receptors in Lipid Metabolism and Toxicity [Genes] |
| Pathways : KEGG | PPAR signaling pathway Adipocytokine signaling pathway Non-alcoholic fatty liver disease (NAFLD) Hepatitis C |
| NDEx Network | PPARA |
| Atlas of Cancer Signalling Network | PPARA |
| Wikipedia pathways | PPARA |
| Orthology - Evolution |
|---|
| OrthoDB | 5465 |
| GeneTree (enSembl) | ENSG00000186951 |
| Phylogenetic Trees/Animal Genes : TreeFam | PPARA |
| Homologs : HomoloGene | PPARA |
| Homology/Alignments : Family Browser (UCSC) | PPARA |
| Gene fusions - Rearrangements |
|---|
| Fusion : Quiver | PPARA |
| Polymorphisms : SNP and Copy number variants |
|---|
| NCBI Variation Viewer | PPARA [hg38] |
| dbSNP Single Nucleotide Polymorphism (NCBI) | PPARA |
| dbVar | PPARA |
| ClinVar | PPARA |
| Monarch | PPARA |
| 1000_Genomes | PPARA |
| Exome Variant Server | PPARA |
| GNOMAD Browser | ENSG00000186951 |
| Varsome Browser | PPARA |
| ACMG | PPARA variants |
| Varity | Q07869 |
| Genomic Variants (DGV) | PPARA [DGVbeta] |
| DECIPHER | PPARA [patients] [syndromes] [variants] [genes] |
| CONAN: Copy Number Analysis | PPARA |
| Mutations |
|---|
| ICGC Data Portal | PPARA |
| TCGA Data Portal | PPARA |
| Broad Tumor Portal | PPARA |
| OASIS Portal | PPARA [ Somatic mutations - Copy number] |
| Somatic Mutations in Cancer : COSMIC | PPARA [overview] [genome browser] [tissue] [distribution] |
| Somatic Mutations in Cancer : COSMIC3D | PPARA |
| Mutations and Diseases : HGMD | PPARA |
| LOVD (Leiden Open Variation Database) | [gene] [transcripts] [variants] |
| BioMuta | PPARA |
| DgiDB (Drug Gene Interaction Database) | PPARA |
| DoCM (Curated mutations) | PPARA |
| CIViC (Clinical Interpretations of Variants in Cancer) | PPARA |
| Cancer3D | PPARA |
| Impact of mutations | [PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser] |
| Diseases |
|---|
| OMIM | 170998 |
| Orphanet | |
| DisGeNET | PPARA |
| Medgen | PPARA |
| Genetic Testing Registry | PPARA
|
| NextProt | Q07869 [Medical] |
| GENETests | PPARA |
| Target Validation | PPARA |
| Huge Navigator |
PPARA [HugePedia] |
| ClinGen | PPARA |
| Clinical trials, drugs, therapy |
|---|
| MyCancerGenome | PPARA |
| Protein Interactions : CTD | PPARA |
| Pharm GKB Gene | PA280 |
| Pharos | Q07869 |
| Clinical trial | PPARA |
| Miscellaneous |
|---|
| canSAR (ICR) | PPARA |
| Harmonizome | PPARA |
| DataMed Index | PPARA |
| Probes |
|---|
| Litterature |
|---|
| PubMed | 499 Pubmed reference(s) in Entrez |
| GeneRIFs | Gene References Into Functions (Entrez) |
| EVEX | PPARA |
