Atlas of Genetics and Cytogenetics in Oncology and Haematology


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PPARA (peroxisome proliferator activated receptor alpha)

Identity

Alias_namesPPAR
peroxisome proliferative activated receptor, alpha
peroxisome proliferator-activated receptor alpha
Alias_symbol (synonym)hPPAR
NR1C1
HGNC (Hugo) PPARA
LocusID (NCBI) 5465
Atlas_Id 41792
Location 22q13.31  [Link to chromosome band 22q13]
Location_base_pair Starts at 46546499 and ends at 46639653 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
PPARA (22q13.31) / AP2M1 (3q27.1)PPARA (22q13.31) / PPARA (22q13.31)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Soft tissue tumors: an overview


External links

Nomenclature
HGNC (Hugo)PPARA   9232
Cards
Entrez_Gene (NCBI)PPARA  5465  peroxisome proliferator activated receptor alpha
AliasesNR1C1; PPAR; PPARalpha; hPPAR
GeneCards (Weizmann)PPARA
Ensembl hg19 (Hinxton)ENSG00000186951 [Gene_View]  chr22:46546499-46639653 [Contig_View]  PPARA [Vega]
Ensembl hg38 (Hinxton)ENSG00000186951 [Gene_View]  chr22:46546499-46639653 [Contig_View]  PPARA [Vega]
ICGC DataPortalENSG00000186951
TCGA cBioPortalPPARA
AceView (NCBI)PPARA
Genatlas (Paris)PPARA
WikiGenes5465
SOURCE (Princeton)PPARA
Genetics Home Reference (NIH)PPARA
Genomic and cartography
GoldenPath hg19 (UCSC)PPARA  -     chr22:46546499-46639653 +  22q13.31   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PPARA  -     22q13.31   [Description]    (hg38-Dec_2013)
EnsemblPPARA - 22q13.31 [CytoView hg19]  PPARA - 22q13.31 [CytoView hg38]
Mapping of homologs : NCBIPPARA [Mapview hg19]  PPARA [Mapview hg38]
OMIM170998   
Gene and transcription
Genbank (Entrez)AB073605 AB307690 AF018254 AF086231 AF270490
RefSeq transcript (Entrez)NM_001001928 NM_001001929 NM_001001930 NM_005036 NM_032644
RefSeq genomic (Entrez)NC_000022 NC_018933 NG_012204 NT_011520 NW_004929430
Consensus coding sequences : CCDS (NCBI)PPARA
Cluster EST : UnigeneHs.710044 [ NCBI ]
CGAP (NCI)Hs.710044
Alternative Splicing GalleryENSG00000186951
Gene ExpressionPPARA [ NCBI-GEO ]   PPARA [ EBI - ARRAY_EXPRESS ]   PPARA [ SEEK ]   PPARA [ MEM ]
Gene Expression Viewer (FireBrowse)PPARA [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5465
GTEX Portal (Tissue expression)PPARA
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ07869   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ07869  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ07869
Splice isoforms : SwissVarQ07869
PhosPhoSitePlusQ07869
Domaine pattern : Prosite (Expaxy)NUCLEAR_REC_DBD_1 (PS00031)    NUCLEAR_REC_DBD_2 (PS51030)   
Domains : Interpro (EBI)1Cnucl_rcpt    1Cnucl_rcpt_A    Nucl_hrmn_rcpt_lig-bd    Nuclear_hrmn_rcpt    Znf_hrmn_rcpt    Znf_NHR/GATA   
Domain families : Pfam (Sanger)Hormone_recep (PF00104)    zf-C4 (PF00105)   
Domain families : Pfam (NCBI)pfam00104    pfam00105   
Domain families : Smart (EMBL)HOLI (SM00430)  ZnF_C4 (SM00399)  
Conserved Domain (NCBI)PPARA
DMDM Disease mutations5465
Blocks (Seattle)PPARA
PDB (SRS)1I7G    1K7L    1KKQ    2NPA    2P54    2REW    2ZNN    3ET1    3FEI    3G8I    3KDT    3KDU    3SP6    3VI8    4BCR    4CI4   
PDB (PDBSum)1I7G    1K7L    1KKQ    2NPA    2P54    2REW    2ZNN    3ET1    3FEI    3G8I    3KDT    3KDU    3SP6    3VI8    4BCR    4CI4   
PDB (IMB)1I7G    1K7L    1KKQ    2NPA    2P54    2REW    2ZNN    3ET1    3FEI    3G8I    3KDT    3KDU    3SP6    3VI8    4BCR    4CI4   
PDB (RSDB)1I7G    1K7L    1KKQ    2NPA    2P54    2REW    2ZNN    3ET1    3FEI    3G8I    3KDT    3KDU    3SP6    3VI8    4BCR    4CI4   
Structural Biology KnowledgeBase1I7G    1K7L    1KKQ    2NPA    2P54    2REW    2ZNN    3ET1    3FEI    3G8I    3KDT    3KDU    3SP6    3VI8    4BCR    4CI4   
SCOP (Structural Classification of Proteins)1I7G    1K7L    1KKQ    2NPA    2P54    2REW    2ZNN    3ET1    3FEI    3G8I    3KDT    3KDU    3SP6    3VI8    4BCR    4CI4   
CATH (Classification of proteins structures)1I7G    1K7L    1KKQ    2NPA    2P54    2REW    2ZNN    3ET1    3FEI    3G8I    3KDT    3KDU    3SP6    3VI8    4BCR    4CI4   
SuperfamilyQ07869
Human Protein AtlasENSG00000186951
Peptide AtlasQ07869
HPRD01369
IPIIPI00020097   IPI00896375   IPI01012608   IPI00815903   IPI00878492   
Protein Interaction databases
DIP (DOE-UCLA)Q07869
IntAct (EBI)Q07869
FunCoupENSG00000186951
BioGRIDPPARA
STRING (EMBL)PPARA
ZODIACPPARA
Ontologies - Pathways
QuickGOQ07869
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  RNA polymerase II core promoter proximal region sequence-specific DNA binding  transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding  transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding  RNA polymerase II repressing transcription factor binding  transcriptional activator activity, RNA polymerase II transcription factor binding  transcription coactivator binding  response to hypoxia  DNA binding  transcription factor activity, sequence-specific DNA binding  transcription factor activity, sequence-specific DNA binding  steroid hormone receptor activity  RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding  protein binding  nucleus  nucleoplasm  transcription initiation from RNA polymerase II promoter  lipid metabolic process  fatty acid metabolic process  heart development  drug binding  zinc ion binding  lipid binding  epidermis development  negative regulation of macrophage derived foam cell differentiation  negative regulation of macrophage derived foam cell differentiation  negative regulation of receptor biosynthetic process  negative regulation of cholesterol storage  negative regulation of sequestering of triglyceride  fatty acid transport  phosphatase binding  protein domain specific binding  intracellular receptor signaling pathway  ubiquitin conjugating enzyme binding  positive regulation of fatty acid beta-oxidation  negative regulation of protein binding  negative regulation of appetite  protein complex binding  response to insulin  circadian regulation of gene expression  behavioral response to nicotine  wound healing  lipoprotein metabolic process  regulation of circadian rhythm  steroid hormone mediated signaling pathway  sequence-specific DNA binding  cellular lipid metabolic process  positive regulation of gluconeogenesis  negative regulation of blood pressure  negative regulation of glycolytic process  positive regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  positive regulation of fatty acid oxidation  negative regulation of inflammatory response  NFAT protein binding  enamel mineralization  regulation of glycolytic process by positive regulation of transcription from RNA polymerase II promoter  regulation of cellular ketone metabolic process by positive regulation of transcription from RNA polymerase II promoter  regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter  MDM2/MDM4 family protein binding  negative regulation of neuron death  negative regulation of pri-miRNA transcription from RNA polymerase II promoter  negative regulation of leukocyte cell-cell adhesion  negative regulation of transcription regulatory region DNA binding  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  RNA polymerase II core promoter proximal region sequence-specific DNA binding  transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding  transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding  RNA polymerase II repressing transcription factor binding  transcriptional activator activity, RNA polymerase II transcription factor binding  transcription coactivator binding  response to hypoxia  DNA binding  transcription factor activity, sequence-specific DNA binding  transcription factor activity, sequence-specific DNA binding  steroid hormone receptor activity  RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding  protein binding  nucleus  nucleoplasm  transcription initiation from RNA polymerase II promoter  lipid metabolic process  fatty acid metabolic process  heart development  drug binding  zinc ion binding  lipid binding  epidermis development  negative regulation of macrophage derived foam cell differentiation  negative regulation of macrophage derived foam cell differentiation  negative regulation of receptor biosynthetic process  negative regulation of cholesterol storage  negative regulation of sequestering of triglyceride  fatty acid transport  phosphatase binding  protein domain specific binding  intracellular receptor signaling pathway  ubiquitin conjugating enzyme binding  positive regulation of fatty acid beta-oxidation  negative regulation of protein binding  negative regulation of appetite  protein complex binding  response to insulin  circadian regulation of gene expression  behavioral response to nicotine  wound healing  lipoprotein metabolic process  regulation of circadian rhythm  steroid hormone mediated signaling pathway  sequence-specific DNA binding  cellular lipid metabolic process  positive regulation of gluconeogenesis  negative regulation of blood pressure  negative regulation of glycolytic process  positive regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  positive regulation of fatty acid oxidation  negative regulation of inflammatory response  NFAT protein binding  enamel mineralization  regulation of glycolytic process by positive regulation of transcription from RNA polymerase II promoter  regulation of cellular ketone metabolic process by positive regulation of transcription from RNA polymerase II promoter  regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter  MDM2/MDM4 family protein binding  negative regulation of neuron death  negative regulation of pri-miRNA transcription from RNA polymerase II promoter  negative regulation of leukocyte cell-cell adhesion  negative regulation of transcription regulatory region DNA binding  
Pathways : BIOCARTARegulation of PGC-1a [Genes]    Mechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha) [Genes]    -arrestins in GPCR Desensitization [Genes]    Toll-Like Receptor Pathway [Genes]    Basic mechanism of action of PPARa, PPARb(d) and PPARg and effects on gene expression [Genes]    Nuclear Receptors in Lipid Metabolism and Toxicity [Genes]   
Pathways : KEGGPPAR signaling pathway    Adipocytokine signaling pathway    Non-alcoholic fatty liver disease (NAFLD)    Hepatitis C   
NDEx NetworkPPARA
Atlas of Cancer Signalling NetworkPPARA
Wikipedia pathwaysPPARA
Orthology - Evolution
OrthoDB5465
GeneTree (enSembl)ENSG00000186951
Phylogenetic Trees/Animal Genes : TreeFamPPARA
HOVERGENQ07869
HOGENOMQ07869
Homologs : HomoloGenePPARA
Homology/Alignments : Family Browser (UCSC)PPARA
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPPARA [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PPARA
dbVarPPARA
ClinVarPPARA
1000_GenomesPPARA 
Exome Variant ServerPPARA
ExAC (Exome Aggregation Consortium)PPARA (select the gene name)
Genetic variants : HAPMAP5465
Genomic Variants (DGV)PPARA [DGVbeta]
DECIPHER (Syndromes)22:46546499-46639653  ENSG00000186951
CONAN: Copy Number AnalysisPPARA 
Mutations
ICGC Data PortalPPARA 
TCGA Data PortalPPARA 
Broad Tumor PortalPPARA
OASIS PortalPPARA [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPPARA  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPPARA
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PPARA
DgiDB (Drug Gene Interaction Database)PPARA
DoCM (Curated mutations)PPARA (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PPARA (select a term)
intoGenPPARA
Cancer3DPPARA(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM170998   
Orphanet
MedgenPPARA
Genetic Testing Registry PPARA
NextProtQ07869 [Medical]
TSGene5465
GENETestsPPARA
Huge Navigator PPARA [HugePedia]
snp3D : Map Gene to Disease5465
BioCentury BCIQPPARA
ClinGenPPARA
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5465
Chemical/Pharm GKB GenePA280
Clinical trialPPARA
Miscellaneous
canSAR (ICR)PPARA (select the gene name)
Probes
Litterature
PubMed480 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePPARA
EVEXPPARA
GoPubMedPPARA
iHOPPPARA
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri Nov 18 19:48:08 CET 2016

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