| Nomenclature |
|---|
| HGNC (Hugo) | PPARA 9232 |
| Cards |
|---|
| Entrez_Gene (NCBI) | PPARA 5465 peroxisome proliferator activated receptor alpha |
| Aliases | NR1C1; PPAR; PPARalpha; hPPAR |
| GeneCards (Weizmann) | PPARA |
| Ensembl hg19 (Hinxton) | ENSG00000186951 [Gene_View] |
| Ensembl hg38 (Hinxton) | ENSG00000186951 [Gene_View] ENSG00000186951 [Sequence] chr22:46150596-46243756 [Contig_View] PPARA [Vega] |
| ICGC DataPortal | ENSG00000186951 |
| TCGA cBioPortal | PPARA |
| AceView (NCBI) | PPARA |
| Genatlas (Paris) | PPARA |
| WikiGenes | 5465 |
| SOURCE (Princeton) | PPARA |
| Genetics Home Reference (NIH) | PPARA |
| Genomic and cartography |
|---|
| GoldenPath hg38 (UCSC) | PPARA - chr22:46150596-46243756 + 22q13.31 [Description] (hg38-Dec_2013) |
| GoldenPath hg19 (UCSC) | PPARA - 22q13.31 [Description] (hg19-Feb_2009) |
| Ensembl | PPARA - 22q13.31 [CytoView hg19] PPARA - 22q13.31 [CytoView hg38] |
| Mapping of homologs : NCBI | PPARA [Mapview hg19] PPARA [Mapview hg38] |
| OMIM | 170998 |
| Gene and transcription |
|---|
| Genbank (Entrez) | AB073605 AB307690 AF018254 AF086231 AF270490 |
| RefSeq transcript (Entrez) | NM_001001928 NM_001001929 NM_001001930 NM_005036 NM_032644 |
| RefSeq genomic (Entrez) | |
| Consensus coding sequences : CCDS (NCBI) | PPARA |
| Cluster EST : Unigene | Hs.710044 [ NCBI ] |
| CGAP (NCI) | Hs.710044 |
| Alternative Splicing Gallery | ENSG00000186951 |
| Gene Expression | PPARA [ NCBI-GEO ] PPARA [ EBI - ARRAY_EXPRESS ]
PPARA [ SEEK ] PPARA [ MEM ] |
| Gene Expression Viewer (FireBrowse) | PPARA [ Firebrowse - Broad ] |
| SOURCE (Princeton) | Expression in : [Datasets] [Normal Tissue Atlas] [carcinoma Classsification] [NCI60] |
| Genevestigator | Expression in : [tissues] [cell-lines] [cancer] [perturbations] |
| BioGPS (Tissue expression) | 5465 |
| GTEX Portal (Tissue expression) | PPARA |
| Human Protein Atlas | ENSG00000186951-PPARA [pathology] [cell] [tissue] |
| Protein : pattern, domain, 3D structure |
|---|
| UniProt/SwissProt | Q07869 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction] |
| NextProt | Q07869 [Sequence] [Exons] [Medical] [Publications] |
| With graphics : InterPro | Q07869 |
| Splice isoforms : SwissVar | Q07869 |
| PhosPhoSitePlus | Q07869 |
| Domaine pattern : Prosite (Expaxy) | NUCLEAR_REC_DBD_1 (PS00031) NUCLEAR_REC_DBD_2 (PS51030) |
| Domains : Interpro (EBI) | 1Cnucl_rcpt 1Cnucl_rcpt_A Nucl_hrmn_rcpt_lig-bd Nuclear_hrmn_rcpt Znf_hrmn_rcpt Znf_NHR/GATA |
| Domain families : Pfam (Sanger) | Hormone_recep (PF00104) zf-C4 (PF00105) |
| Domain families : Pfam (NCBI) | pfam00104 pfam00105 |
| Domain families : Smart (EMBL) | HOLI (SM00430) ZnF_C4 (SM00399) |
| Conserved Domain (NCBI) | PPARA |
| DMDM Disease mutations | 5465 |
| Blocks (Seattle) | PPARA |
| PDB (SRS) | 1I7G 1K7L 1KKQ 2NPA 2P54 2REW 2ZNN 3ET1 3FEI 3G8I 3KDT 3KDU 3SP6 3VI8 4BCR 4CI4 5AZT 5HYK |
| PDB (PDBSum) | 1I7G 1K7L 1KKQ 2NPA 2P54 2REW 2ZNN 3ET1 3FEI 3G8I 3KDT 3KDU 3SP6 3VI8 4BCR 4CI4 5AZT 5HYK |
| PDB (IMB) | 1I7G 1K7L 1KKQ 2NPA 2P54 2REW 2ZNN 3ET1 3FEI 3G8I 3KDT 3KDU 3SP6 3VI8 4BCR 4CI4 5AZT 5HYK |
| PDB (RSDB) | 1I7G 1K7L 1KKQ 2NPA 2P54 2REW 2ZNN 3ET1 3FEI 3G8I 3KDT 3KDU 3SP6 3VI8 4BCR 4CI4 5AZT 5HYK |
| Structural Biology KnowledgeBase | 1I7G 1K7L 1KKQ 2NPA 2P54 2REW 2ZNN 3ET1 3FEI 3G8I 3KDT 3KDU 3SP6 3VI8 4BCR 4CI4 5AZT 5HYK |
| SCOP (Structural Classification of Proteins) | 1I7G 1K7L 1KKQ 2NPA 2P54 2REW 2ZNN 3ET1 3FEI 3G8I 3KDT 3KDU 3SP6 3VI8 4BCR 4CI4 5AZT 5HYK |
| CATH (Classification of proteins structures) | 1I7G 1K7L 1KKQ 2NPA 2P54 2REW 2ZNN 3ET1 3FEI 3G8I 3KDT 3KDU 3SP6 3VI8 4BCR 4CI4 5AZT 5HYK |
| Superfamily | Q07869 |
| Human Protein Atlas [tissue] | ENSG00000186951-PPARA [tissue] |
| Peptide Atlas | Q07869 |
| HPRD | 01369 |
| IPI | IPI00020097 IPI00896375 IPI01012608 IPI00815903 IPI00878492 |
| Protein Interaction databases |
|---|
| DIP (DOE-UCLA) | Q07869 |
| IntAct (EBI) | Q07869 |
| FunCoup | ENSG00000186951 |
| BioGRID | PPARA |
| STRING (EMBL) | PPARA |
| ZODIAC | PPARA |
| Ontologies - Pathways |
|---|
| QuickGO | Q07869 |
| Ontology : AmiGO | negative regulation of transcription by RNA polymerase II RNA polymerase II proximal promoter sequence-specific DNA binding transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding RNA polymerase II repressing transcription factor binding transcriptional activator activity, RNA polymerase II transcription factor binding transcription coactivator binding response to hypoxia DNA binding DNA binding transcription factor activity DNA binding transcription factor activity steroid hormone receptor activity nuclear receptor activity protein binding nucleus nucleus nucleoplasm nucleoplasm transcription initiation from RNA polymerase II promoter lipid metabolic process fatty acid metabolic process heart development transcription factor binding drug binding zinc ion binding lipid binding epidermis development negative regulation of macrophage derived foam cell differentiation negative regulation of macrophage derived foam cell differentiation negative regulation of receptor biosynthetic process negative regulation of cholesterol storage negative regulation of sequestering of triglyceride fatty acid transport regulation of lipid metabolic process phosphatase binding protein domain specific binding intracellular receptor signaling pathway ubiquitin conjugating enzyme binding positive regulation of fatty acid beta-oxidation negative regulation of protein binding negative regulation of appetite protein complex binding response to insulin circadian regulation of gene expression behavioral response to nicotine wound healing lipoprotein metabolic process regulation of circadian rhythm steroid hormone mediated signaling pathway sequence-specific DNA binding positive regulation of gluconeogenesis negative regulation of blood pressure negative regulation of glycolytic process positive regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II positive regulation of fatty acid oxidation negative regulation of inflammatory response NFAT protein binding enamel mineralization regulation of glycolytic process by positive regulation of transcription from RNA polymerase II promoter regulation of cellular ketone metabolic process by positive regulation of transcription from RNA polymerase II promoter regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter MDM2/MDM4 family protein binding negative regulation of neuron death negative regulation of pri-miRNA transcription by RNA polymerase II negative regulation of leukocyte cell-cell adhesion negative regulation of transcription regulatory region DNA binding |
| Ontology : EGO-EBI | negative regulation of transcription by RNA polymerase II RNA polymerase II proximal promoter sequence-specific DNA binding transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding RNA polymerase II repressing transcription factor binding transcriptional activator activity, RNA polymerase II transcription factor binding transcription coactivator binding response to hypoxia DNA binding DNA binding transcription factor activity DNA binding transcription factor activity steroid hormone receptor activity nuclear receptor activity protein binding nucleus nucleus nucleoplasm nucleoplasm transcription initiation from RNA polymerase II promoter lipid metabolic process fatty acid metabolic process heart development transcription factor binding drug binding zinc ion binding lipid binding epidermis development negative regulation of macrophage derived foam cell differentiation negative regulation of macrophage derived foam cell differentiation negative regulation of receptor biosynthetic process negative regulation of cholesterol storage negative regulation of sequestering of triglyceride fatty acid transport regulation of lipid metabolic process phosphatase binding protein domain specific binding intracellular receptor signaling pathway ubiquitin conjugating enzyme binding positive regulation of fatty acid beta-oxidation negative regulation of protein binding negative regulation of appetite protein complex binding response to insulin circadian regulation of gene expression behavioral response to nicotine wound healing lipoprotein metabolic process regulation of circadian rhythm steroid hormone mediated signaling pathway sequence-specific DNA binding positive regulation of gluconeogenesis negative regulation of blood pressure negative regulation of glycolytic process positive regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II positive regulation of fatty acid oxidation negative regulation of inflammatory response NFAT protein binding enamel mineralization regulation of glycolytic process by positive regulation of transcription from RNA polymerase II promoter regulation of cellular ketone metabolic process by positive regulation of transcription from RNA polymerase II promoter regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter MDM2/MDM4 family protein binding negative regulation of neuron death negative regulation of pri-miRNA transcription by RNA polymerase II negative regulation of leukocyte cell-cell adhesion negative regulation of transcription regulatory region DNA binding |
| Pathways : BIOCARTA | Regulation of PGC-1a [Genes] Mechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha) [Genes] ¿-arrestins in GPCR Desensitization [Genes] Toll-Like Receptor Pathway [Genes] Basic mechanism of action of PPARa, PPARb(d) and PPARg and effects on gene expression [Genes] Nuclear Receptors in Lipid Metabolism and Toxicity [Genes] |
| Pathways : KEGG | Adipocytokine signaling pathway PPAR signaling pathway |
| NDEx Network | PPARA |
| Atlas of Cancer Signalling Network | PPARA |
| Wikipedia pathways | PPARA |
| Orthology - Evolution |
|---|
| OrthoDB | 5465 |
| GeneTree (enSembl) | ENSG00000186951 |
| Phylogenetic Trees/Animal Genes : TreeFam | PPARA |
| HOVERGEN | Q07869 |
| HOGENOM | Q07869 |
| Homologs : HomoloGene | PPARA |
| Homology/Alignments : Family Browser (UCSC) | PPARA |
| Gene fusions - Rearrangements |
|---|
| Fusion : Quiver | PPARA |
| Polymorphisms : SNP and Copy number variants |
|---|
| NCBI Variation Viewer | PPARA [hg38] |
| dbSNP Single Nucleotide Polymorphism (NCBI) | PPARA |
| dbVar | PPARA |
| ClinVar | PPARA |
| 1000_Genomes | PPARA |
| Exome Variant Server | PPARA |
| ExAC (Exome Aggregation Consortium) | ENSG00000186951 |
| GNOMAD Browser | ENSG00000186951 |
| Genetic variants : HAPMAP | 5465 |
| Genomic Variants (DGV) | PPARA [DGVbeta] |
| DECIPHER | PPARA [patients] [syndromes] [variants] [genes] |
| CONAN: Copy Number Analysis | PPARA |
| Mutations |
|---|
| ICGC Data Portal | PPARA |
| TCGA Data Portal | PPARA |
| Broad Tumor Portal | PPARA |
| OASIS Portal | PPARA [ Somatic mutations - Copy number] |
| Somatic Mutations in Cancer : COSMIC | PPARA [overview] [genome browser] [tissue] [distribution] |
| Mutations and Diseases : HGMD | PPARA |
| LOVD (Leiden Open Variation Database) | Whole genome datasets |
| LOVD (Leiden Open Variation Database) | LOVD 3.0 shared installation |
| BioMuta | search PPARA |
| DgiDB (Drug Gene Interaction Database) | PPARA |
| DoCM (Curated mutations) | PPARA (select the gene name) |
| CIViC (Clinical Interpretations of Variants in Cancer) | PPARA (select a term) |
| intoGen | PPARA |
| Cancer3D | PPARA(select the gene name) |
| Impact of mutations | [PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser] |
| Diseases |
|---|
| OMIM | 170998 |
| Orphanet | |
| DisGeNET | PPARA |
| Medgen | PPARA |
| Genetic Testing Registry | PPARA
|
| NextProt | Q07869 [Medical] |
| TSGene | 5465 |
| GENETests | PPARA |
| Target Validation | PPARA |
| Huge Navigator |
PPARA [HugePedia] |
| snp3D : Map Gene to Disease | 5465 |
| BioCentury BCIQ | PPARA |
| ClinGen | PPARA |
| Clinical trials, drugs, therapy |
|---|
| Chemical/Protein Interactions : CTD | 5465 |
| Chemical/Pharm GKB Gene | PA280 |
| Clinical trial | PPARA |
| Miscellaneous |
|---|
| canSAR (ICR) | PPARA (select the gene name) |
| Probes |
|---|
| Litterature |
|---|
| PubMed | 499 Pubmed reference(s) in Entrez |
| GeneRIFs | Gene References Into Functions (Entrez) |
| CoreMine | PPARA |
| EVEX | PPARA |
| GoPubMed | PPARA |
| iHOP | PPARA |
