Atlas of Genetics and Cytogenetics in Oncology and Haematology

Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   
X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

PPARA (peroxisome proliferator-activated receptor alpha)

Identity

Other namesNR1C1
PPAR
PPARalpha
hPPAR
HGNC (Hugo) PPARA
LocusID (NCBI) 5465
Location 22q13.31
Location_base_pair Starts at 46546499 and ends at 46639653 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)PPARA   9232
Cards
Entrez_Gene (NCBI)PPARA  5465  peroxisome proliferator-activated receptor alpha
GeneCards (Weizmann)PPARA
Ensembl hg19 (Hinxton)ENSG00000186951 [Gene_View]  chr22:46546499-46639653 [Contig_View]  PPARA [Vega]
Ensembl hg38 (Hinxton)ENSG00000186951 [Gene_View]  chr22:46546499-46639653 [Contig_View]  PPARA [Vega]
ICGC DataPortalENSG00000186951
cBioPortalPPARA
AceView (NCBI)PPARA
Genatlas (Paris)PPARA
WikiGenes5465
SOURCE (Princeton)PPARA
Genomic and cartography
GoldenPath hg19 (UCSC)PPARA  -     chr22:46546499-46639653 +  22q13.31   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PPARA  -     22q13.31   [Description]    (hg38-Dec_2013)
EnsemblPPARA - 22q13.31 [CytoView hg19]  PPARA - 22q13.31 [CytoView hg38]
Mapping of homologs : NCBIPPARA [Mapview hg19]  PPARA [Mapview hg38]
OMIM170998   
Gene and transcription
Genbank (Entrez)AB073605 AB307690 AF018254 AF086231 AF270490
RefSeq transcript (Entrez)NM_001001928 NM_001001929 NM_001001930 NM_005036 NM_032644
RefSeq genomic (Entrez)AC_000154 NC_000022 NC_018933 NG_012204 NT_011520 NW_001838753 NW_004929430
Consensus coding sequences : CCDS (NCBI)PPARA
Cluster EST : UnigeneHs.710044 [ NCBI ]
CGAP (NCI)Hs.710044
Alternative Splicing : Fast-db (Paris)GSHG0020104
Alternative Splicing GalleryENSG00000186951
Gene ExpressionPPARA [ NCBI-GEO ]     PPARA [ SEEK ]   PPARA [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ07869 (Uniprot)
NextProtQ07869  [Medical]
With graphics : InterProQ07869
Splice isoforms : SwissVarQ07869 (Swissvar)
Domaine pattern : Prosite (Expaxy)NUCLEAR_REC_DBD_1 (PS00031)    NUCLEAR_REC_DBD_2 (PS51030)   
Domains : Interpro (EBI)1Cnucl_rcpt    1Cnucl_rcpt_A    Nucl_hormone_rcpt_ligand-bd    Nucl_hrmn_rcpt_lig-bd_core    Str_hrmn_rcpt    Znf_hrmn_rcpt    Znf_NHR/GATA   
Related proteins : CluSTrQ07869
Domain families : Pfam (Sanger)Hormone_recep (PF00104)    zf-C4 (PF00105)   
Domain families : Pfam (NCBI)pfam00104    pfam00105   
Domain families : Smart (EMBL)HOLI (SM00430)  ZnF_C4 (SM00399)  
DMDM Disease mutations5465
Blocks (Seattle)Q07869
PDB (SRS)1I7G    1K7L    1KKQ    2NPA    2P54    2REW    2ZNN    3ET1    3FEI    3G8I    3KDT    3KDU    3SP6    3VI8    4BCR   
PDB (PDBSum)1I7G    1K7L    1KKQ    2NPA    2P54    2REW    2ZNN    3ET1    3FEI    3G8I    3KDT    3KDU    3SP6    3VI8    4BCR   
PDB (IMB)1I7G    1K7L    1KKQ    2NPA    2P54    2REW    2ZNN    3ET1    3FEI    3G8I    3KDT    3KDU    3SP6    3VI8    4BCR   
PDB (RSDB)1I7G    1K7L    1KKQ    2NPA    2P54    2REW    2ZNN    3ET1    3FEI    3G8I    3KDT    3KDU    3SP6    3VI8    4BCR   
Human Protein AtlasENSG00000186951
Peptide AtlasQ07869
HPRD01369
IPIIPI00020097   IPI00896375   IPI01012608   IPI00815903   IPI00878492   
Protein Interaction databases
DIP (DOE-UCLA)Q07869
IntAct (EBI)Q07869
FunCoupENSG00000186951
BioGRIDPPARA
IntegromeDBPPARA
STRING (EMBL)PPARA
Ontologies - Pathways
QuickGOQ07869
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  RNA polymerase II core promoter proximal region sequence-specific DNA binding  RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription  RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription  RNA polymerase II repressing transcription factor binding  response to hypoxia  DNA binding  sequence-specific DNA binding transcription factor activity  sequence-specific DNA binding transcription factor activity  steroid hormone receptor activity  ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity  protein binding  nucleus  nucleoplasm  transcription initiation from RNA polymerase II promoter  lipid metabolic process  fatty acid metabolic process  heart development  drug binding  zinc ion binding  lipid binding  epidermis development  gene expression  negative regulation of macrophage derived foam cell differentiation  negative regulation of macrophage derived foam cell differentiation  negative regulation of receptor biosynthetic process  negative regulation of cholesterol storage  negative regulation of sequestering of triglyceride  fatty acid transport  phosphatase binding  protein domain specific binding  intracellular receptor signaling pathway  intracellular receptor signaling pathway  ubiquitin conjugating enzyme binding  positive regulation of fatty acid beta-oxidation  negative regulation of protein binding  negative regulation of appetite  protein complex binding  response to insulin  circadian regulation of gene expression  behavioral response to nicotine  wound healing  lipoprotein metabolic process  regulation of circadian rhythm  steroid hormone mediated signaling pathway  sequence-specific DNA binding  cellular lipid metabolic process  small molecule metabolic process  negative regulation of blood pressure  negative regulation of glycolytic process  positive regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  positive regulation of fatty acid oxidation  NFAT protein binding  enamel mineralization  regulation of glycolytic by positive regulation of transcription from RNA polymerase II promoter  regulation of cellular ketone metabolic process by positive regulation of transcription from RNA polymerase II promoter  regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter  MDM2/MDM4 family protein binding  negative regulation of neuron death  negative regulation of transcription regulatory region DNA binding  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  RNA polymerase II core promoter proximal region sequence-specific DNA binding  RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription  RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription  RNA polymerase II repressing transcription factor binding  response to hypoxia  DNA binding  sequence-specific DNA binding transcription factor activity  sequence-specific DNA binding transcription factor activity  steroid hormone receptor activity  ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity  protein binding  nucleus  nucleoplasm  transcription initiation from RNA polymerase II promoter  lipid metabolic process  fatty acid metabolic process  heart development  drug binding  zinc ion binding  lipid binding  epidermis development  gene expression  negative regulation of macrophage derived foam cell differentiation  negative regulation of macrophage derived foam cell differentiation  negative regulation of receptor biosynthetic process  negative regulation of cholesterol storage  negative regulation of sequestering of triglyceride  fatty acid transport  phosphatase binding  protein domain specific binding  intracellular receptor signaling pathway  intracellular receptor signaling pathway  ubiquitin conjugating enzyme binding  positive regulation of fatty acid beta-oxidation  negative regulation of protein binding  negative regulation of appetite  protein complex binding  response to insulin  circadian regulation of gene expression  behavioral response to nicotine  wound healing  lipoprotein metabolic process  regulation of circadian rhythm  steroid hormone mediated signaling pathway  sequence-specific DNA binding  cellular lipid metabolic process  small molecule metabolic process  negative regulation of blood pressure  negative regulation of glycolytic process  positive regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  positive regulation of fatty acid oxidation  NFAT protein binding  enamel mineralization  regulation of glycolytic by positive regulation of transcription from RNA polymerase II promoter  regulation of cellular ketone metabolic process by positive regulation of transcription from RNA polymerase II promoter  regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter  MDM2/MDM4 family protein binding  negative regulation of neuron death  negative regulation of transcription regulatory region DNA binding  
Pathways : BIOCARTARegulation of PGC-1a [Genes]    Mechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha) [Genes]    _-arrestins in GPCR Desensitization [Genes]    Toll-Like Receptor Pathway [Genes]    Basic mechanism of action of PPARa, PPARb(d) and PPARg and effects on gene expression [Genes]    Nuclear Receptors in Lipid Metabolism and Toxicity [Genes]   
Pathways : KEGGPPAR signaling pathway    Adipocytokine signaling pathway    Non-alcoholic fatty liver disease (NAFLD)    Hepatitis C   
Protein Interaction DatabasePPARA
DoCM (Curated mutations)PPARA
Wikipedia pathwaysPPARA
Gene fusion - rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerPPARA [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PPARA
dbVarPPARA
ClinVarPPARA
1000_GenomesPPARA 
Exome Variant ServerPPARA
SNP (GeneSNP Utah)PPARA
SNP : HGBasePPARA
Genetic variants : HAPMAPPPARA
Genomic VariantsPPARA  PPARA [DGVbeta]
Mutations
ICGC Data PortalENSG00000186951 
Somatic Mutations in Cancer : COSMICPPARA 
CONAN: Copy Number AnalysisPPARA 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)22:46546499-46639653
Mutations and Diseases : HGMDPPARA
OMIM170998   
MedgenPPARA
NextProtQ07869 [Medical]
GENETestsPPARA
Disease Genetic AssociationPPARA
Huge Navigator PPARA [HugePedia]  PPARA [HugeCancerGEM]
snp3D : Map Gene to Disease5465
DGIdb (Drug Gene Interaction db)PPARA
General knowledge
Homologs : HomoloGenePPARA
Homology/Alignments : Family Browser (UCSC)PPARA
Phylogenetic Trees/Animal Genes : TreeFamPPARA
Chemical/Protein Interactions : CTD5465
Chemical/Pharm GKB GenePA280
Clinical trialPPARA
Cancer Resource (Charite)ENSG00000186951
Other databases
Probes
Litterature
PubMed419 Pubmed reference(s) in Entrez
CoreMinePPARA
GoPubMedPPARA
iHOPPPARA
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2014Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sun Dec 21 00:55:17 CET 2014
Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.