| Nomenclature |
|---|
| HGNC (Hugo) | PPARA 9232 |
| Cards |
|---|
| Entrez_Gene (NCBI) | PPARA 5465 peroxisome proliferator activated receptor alpha |
| Aliases | NR1C1; PPAR; PPARalpha; hPPAR |
| GeneCards (Weizmann) | PPARA |
| Ensembl hg19 (Hinxton) | ENSG00000186951 [Gene_View] |
| Ensembl hg38 (Hinxton) | ENSG00000186951 [Gene_View] ENSG00000186951 [Sequence] chr22:46150596-46243756 [Contig_View] PPARA [Vega] |
| ICGC DataPortal | ENSG00000186951 |
| TCGA cBioPortal | PPARA |
| AceView (NCBI) | PPARA |
| Genatlas (Paris) | PPARA |
| WikiGenes | 5465 |
| SOURCE (Princeton) | PPARA |
| Genetics Home Reference (NIH) | PPARA |
| Genomic and cartography |
|---|
| GoldenPath hg38 (UCSC) | PPARA - chr22:46150596-46243756 + 22q13.31 [Description] (hg38-Dec_2013) |
| GoldenPath hg19 (UCSC) | PPARA - 22q13.31 [Description] (hg19-Feb_2009) |
| GoldenPath | PPARA - 22q13.31 [CytoView hg19] PPARA - 22q13.31 [CytoView hg38] |
| ImmunoBase | ENSG00000186951 |
| Mapping of homologs : NCBI | PPARA [Mapview hg19] PPARA [Mapview hg38] |
| OMIM | 170998 |
| Gene and transcription |
|---|
| Genbank (Entrez) | AB073605 AB307690 AF018254 AF086231 AF270490 |
| RefSeq transcript (Entrez) | NM_001001928 NM_001001929 NM_001001930 NM_001362872 NM_001362873 NM_005036 NM_032644 |
| RefSeq genomic (Entrez) | |
| Consensus coding sequences : CCDS (NCBI) | PPARA |
| Cluster EST : Unigene | Hs.710044 [ NCBI ] |
| CGAP (NCI) | Hs.710044 |
| Alternative Splicing Gallery | ENSG00000186951 |
| Gene Expression | PPARA [ NCBI-GEO ] PPARA [ EBI - ARRAY_EXPRESS ]
PPARA [ SEEK ] PPARA [ MEM ] |
| Gene Expression Viewer (FireBrowse) | PPARA [ Firebrowse - Broad ] |
| SOURCE (Princeton) | Expression in : [Datasets] [Normal Tissue Atlas] [carcinoma Classsification] [NCI60] |
| Genevestigator | Expression in : [tissues] [cell-lines] [cancer] [perturbations] |
| BioGPS (Tissue expression) | 5465 |
| GTEX Portal (Tissue expression) | PPARA |
| Human Protein Atlas | ENSG00000186951-PPARA [pathology] [cell] [tissue] |
| Protein : pattern, domain, 3D structure |
|---|
| UniProt/SwissProt | Q07869 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction] |
| NextProt | Q07869 [Sequence] [Exons] [Medical] [Publications] |
| With graphics : InterPro | Q07869 |
| Splice isoforms : SwissVar | Q07869 |
| PhosPhoSitePlus | Q07869 |
| Domaine pattern : Prosite (Expaxy) | NR_LBD (PS51843) NUCLEAR_REC_DBD_1 (PS00031) NUCLEAR_REC_DBD_2 (PS51030) |
| Domains : Interpro (EBI) | 1Cnucl_rcpt NHR_like_dom_sf Nucl_hrmn_rcpt_lig-bd Nuclear_hrmn_rcpt PPAR-alpha Znf_hrmn_rcpt Znf_NHR/GATA |
| Domain families : Pfam (Sanger) | Hormone_recep (PF00104) zf-C4 (PF00105) |
| Domain families : Pfam (NCBI) | pfam00104 pfam00105 |
| Domain families : Smart (EMBL) | HOLI (SM00430) ZnF_C4 (SM00399) |
| Conserved Domain (NCBI) | PPARA |
| DMDM Disease mutations | 5465 |
| Blocks (Seattle) | PPARA |
| PDB (RSDB) | 1I7G 1K7L 1KKQ 2NPA 2P54 2REW 2ZNN 3ET1 3FEI 3G8I 3KDT 3KDU 3SP6 3VI8 4BCR 4CI4 5AZT 5HYK |
| PDB Europe | 1I7G 1K7L 1KKQ 2NPA 2P54 2REW 2ZNN 3ET1 3FEI 3G8I 3KDT 3KDU 3SP6 3VI8 4BCR 4CI4 5AZT 5HYK |
| PDB (PDBSum) | 1I7G 1K7L 1KKQ 2NPA 2P54 2REW 2ZNN 3ET1 3FEI 3G8I 3KDT 3KDU 3SP6 3VI8 4BCR 4CI4 5AZT 5HYK |
| PDB (IMB) | 1I7G 1K7L 1KKQ 2NPA 2P54 2REW 2ZNN 3ET1 3FEI 3G8I 3KDT 3KDU 3SP6 3VI8 4BCR 4CI4 5AZT 5HYK |
| Structural Biology KnowledgeBase | 1I7G 1K7L 1KKQ 2NPA 2P54 2REW 2ZNN 3ET1 3FEI 3G8I 3KDT 3KDU 3SP6 3VI8 4BCR 4CI4 5AZT 5HYK |
| SCOP (Structural Classification of Proteins) | 1I7G 1K7L 1KKQ 2NPA 2P54 2REW 2ZNN 3ET1 3FEI 3G8I 3KDT 3KDU 3SP6 3VI8 4BCR 4CI4 5AZT 5HYK |
| CATH (Classification of proteins structures) | 1I7G 1K7L 1KKQ 2NPA 2P54 2REW 2ZNN 3ET1 3FEI 3G8I 3KDT 3KDU 3SP6 3VI8 4BCR 4CI4 5AZT 5HYK |
| Superfamily | Q07869 |
| Human Protein Atlas [tissue] | ENSG00000186951-PPARA [tissue] |
| Peptide Atlas | Q07869 |
| HPRD | 01369 |
| IPI | IPI00020097 IPI00896375 IPI01012608 IPI00815903 IPI00878492 |
| Protein Interaction databases |
|---|
| DIP (DOE-UCLA) | Q07869 |
| IntAct (EBI) | Q07869 |
| FunCoup | ENSG00000186951 |
| BioGRID | PPARA |
| STRING (EMBL) | PPARA |
| ZODIAC | PPARA |
| Ontologies - Pathways |
|---|
| QuickGO | Q07869 |
| Ontology : AmiGO | negative regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II transcription regulatory region sequence-specific DNA binding RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II proximal promoter sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II repressing transcription factor binding RNA polymerase II repressing transcription factor binding transcription coactivator binding DNA-binding transcription repressor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific response to hypoxia DNA binding DNA-binding transcription factor activity DNA-binding transcription factor activity steroid hormone receptor activity nuclear receptor activity fatty acid binding protein binding nucleus nucleus nucleus nucleoplasm nucleoplasm transcription initiation from RNA polymerase II promoter lipid metabolic process fatty acid metabolic process multicellular organism development heart development transcription factor binding transcription factor binding drug binding drug binding zinc ion binding lipid binding lipid binding epidermis development hormone-mediated signaling pathway negative regulation of macrophage derived foam cell differentiation negative regulation of macrophage derived foam cell differentiation negative regulation of receptor biosynthetic process negative regulation of cholesterol storage negative regulation of cholesterol storage negative regulation of sequestering of triglyceride fatty acid transport regulation of lipid metabolic process regulation of lipid metabolic process phosphatase binding protein domain specific binding cell differentiation nuclear receptor transcription coactivator activity intracellular receptor signaling pathway ubiquitin conjugating enzyme binding positive regulation of fatty acid beta-oxidation negative regulation of protein binding negative regulation of appetite response to insulin circadian regulation of gene expression response to lipid behavioral response to nicotine signaling receptor activity wound healing lipoprotein metabolic process regulation of circadian rhythm steroid hormone mediated signaling pathway sequence-specific DNA binding protein-containing complex binding positive regulation of gluconeogenesis negative regulation of blood pressure negative regulation of glycolytic process negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II positive regulation of fatty acid oxidation negative regulation of inflammatory response negative regulation of inflammatory response NFAT protein binding negative regulation of cell growth involved in cardiac muscle cell development enamel mineralization regulation of glycolytic process by positive regulation of transcription from RNA polymerase II promoter regulation of cellular ketone metabolic process by positive regulation of transcription from RNA polymerase II promoter regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter RNA polymerase II transcription factor complex MDM2/MDM4 family protein binding negative regulation of neuron death negative regulation of pri-miRNA transcription by RNA polymerase II negative regulation of leukocyte cell-cell adhesion |
| Ontology : EGO-EBI | negative regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II transcription regulatory region sequence-specific DNA binding RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II proximal promoter sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II repressing transcription factor binding RNA polymerase II repressing transcription factor binding transcription coactivator binding DNA-binding transcription repressor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific response to hypoxia DNA binding DNA-binding transcription factor activity DNA-binding transcription factor activity steroid hormone receptor activity nuclear receptor activity fatty acid binding protein binding nucleus nucleus nucleus nucleoplasm nucleoplasm transcription initiation from RNA polymerase II promoter lipid metabolic process fatty acid metabolic process multicellular organism development heart development transcription factor binding transcription factor binding drug binding drug binding zinc ion binding lipid binding lipid binding epidermis development hormone-mediated signaling pathway negative regulation of macrophage derived foam cell differentiation negative regulation of macrophage derived foam cell differentiation negative regulation of receptor biosynthetic process negative regulation of cholesterol storage negative regulation of cholesterol storage negative regulation of sequestering of triglyceride fatty acid transport regulation of lipid metabolic process regulation of lipid metabolic process phosphatase binding protein domain specific binding cell differentiation nuclear receptor transcription coactivator activity intracellular receptor signaling pathway ubiquitin conjugating enzyme binding positive regulation of fatty acid beta-oxidation negative regulation of protein binding negative regulation of appetite response to insulin circadian regulation of gene expression response to lipid behavioral response to nicotine signaling receptor activity wound healing lipoprotein metabolic process regulation of circadian rhythm steroid hormone mediated signaling pathway sequence-specific DNA binding protein-containing complex binding positive regulation of gluconeogenesis negative regulation of blood pressure negative regulation of glycolytic process negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II positive regulation of fatty acid oxidation negative regulation of inflammatory response negative regulation of inflammatory response NFAT protein binding negative regulation of cell growth involved in cardiac muscle cell development enamel mineralization regulation of glycolytic process by positive regulation of transcription from RNA polymerase II promoter regulation of cellular ketone metabolic process by positive regulation of transcription from RNA polymerase II promoter regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter RNA polymerase II transcription factor complex MDM2/MDM4 family protein binding negative regulation of neuron death negative regulation of pri-miRNA transcription by RNA polymerase II negative regulation of leukocyte cell-cell adhesion |
| Pathways : KEGG | PPAR signaling pathway Adipocytokine signaling pathway Non-alcoholic fatty liver disease (NAFLD) Hepatitis C |
| NDEx Network | PPARA |
| Atlas of Cancer Signalling Network | PPARA |
| Wikipedia pathways | PPARA |
| Orthology - Evolution |
|---|
| OrthoDB | 5465 |
| GeneTree (enSembl) | ENSG00000186951 |
| Phylogenetic Trees/Animal Genes : TreeFam | PPARA |
| HOGENOM | Q07869 |
| Homologs : HomoloGene | PPARA |
| Homology/Alignments : Family Browser (UCSC) | PPARA |
| Gene fusions - Rearrangements |
|---|
| Fusion : Quiver | PPARA |
| Polymorphisms : SNP and Copy number variants |
|---|
| NCBI Variation Viewer | PPARA [hg38] |
| dbSNP Single Nucleotide Polymorphism (NCBI) | PPARA |
| dbVar | PPARA |
| ClinVar | PPARA |
| 1000_Genomes | PPARA |
| Exome Variant Server | PPARA |
| ExAC (Exome Aggregation Consortium) | ENSG00000186951 |
| GNOMAD Browser | ENSG00000186951 |
| Varsome Browser | PPARA |
| Genetic variants : HAPMAP | 5465 |
| Genomic Variants (DGV) | PPARA [DGVbeta] |
| DECIPHER | PPARA [patients] [syndromes] [variants] [genes] |
| CONAN: Copy Number Analysis | PPARA |
| Mutations |
|---|
| ICGC Data Portal | PPARA |
| TCGA Data Portal | PPARA |
| Broad Tumor Portal | PPARA |
| OASIS Portal | PPARA [ Somatic mutations - Copy number] |
| Somatic Mutations in Cancer : COSMIC | PPARA [overview] [genome browser] [tissue] [distribution] |
| Somatic Mutations in Cancer : COSMIC3D | PPARA |
| Mutations and Diseases : HGMD | PPARA |
| LOVD (Leiden Open Variation Database) | Whole genome datasets |
| LOVD (Leiden Open Variation Database) | LOVD 3.0 shared installation |
| BioMuta | search PPARA |
| DgiDB (Drug Gene Interaction Database) | PPARA |
| DoCM (Curated mutations) | PPARA (select the gene name) |
| CIViC (Clinical Interpretations of Variants in Cancer) | PPARA (select a term) |
| intoGen | PPARA |
| Cancer3D | PPARA(select the gene name) |
| Impact of mutations | [PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser] |
| Diseases |
|---|
| OMIM | 170998 |
| Orphanet | |
| DisGeNET | PPARA |
| Medgen | PPARA |
| Genetic Testing Registry | PPARA
|
| NextProt | Q07869 [Medical] |
| TSGene | 5465 |
| GENETests | PPARA |
| Target Validation | PPARA |
| Huge Navigator |
PPARA [HugePedia] |
| snp3D : Map Gene to Disease | 5465 |
| BioCentury BCIQ | PPARA |
| ClinGen | PPARA |
| Clinical trials, drugs, therapy |
|---|
| Chemical/Protein Interactions : CTD | 5465 |
| Chemical/Pharm GKB Gene | PA280 |
| Clinical trial | PPARA |
| Miscellaneous |
|---|
| canSAR (ICR) | PPARA (select the gene name) |
| DataMed Index | PPARA |
| Probes |
|---|
| Litterature |
|---|
| PubMed | 499 Pubmed reference(s) in Entrez |
| GeneRIFs | Gene References Into Functions (Entrez) |
| CoreMine | PPARA |
| EVEX | PPARA |
| GoPubMed | PPARA |
| iHOP | PPARA |
