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PPARA (peroxisome proliferator activated receptor alpha)

Identity

Alias (NCBI)NR1C1
PPAR
PPAR-alpha
PPARalpha
hPPAR
HGNC (Hugo) PPARA
HGNC Alias symbhPPAR
NR1C1
HGNC Previous namePPAR
HGNC Previous nameperoxisome proliferative activated receptor, alpha
 peroxisome proliferator-activated receptor alpha
LocusID (NCBI) 5465
Atlas_Id 41792
Location 22q13.31  [Link to chromosome band 22q13]
Location_base_pair Starts at 46150526 and ends at 46243755 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
PPARA (22q13.31) / AP2M1 (3q27.1)PPARA (22q13.31) / PPARA (22q13.31)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)PPARA   9232
Cards
Entrez_Gene (NCBI)PPARA    peroxisome proliferator activated receptor alpha
AliasesNR1C1; PPAR; PPAR-alpha; PPARalpha; 
hPPAR
GeneCards (Weizmann)PPARA
Ensembl hg19 (Hinxton)ENSG00000186951 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000186951 [Gene_View]  ENSG00000186951 [Sequence]  chr22:46150526-46243755 [Contig_View]  PPARA [Vega]
ICGC DataPortalENSG00000186951
TCGA cBioPortalPPARA
AceView (NCBI)PPARA
Genatlas (Paris)PPARA
SOURCE (Princeton)PPARA
Genetics Home Reference (NIH)PPARA
Genomic and cartography
GoldenPath hg38 (UCSC)PPARA  -     chr22:46150526-46243755 +  22q13.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PPARA  -     22q13.31   [Description]    (hg19-Feb_2009)
GoldenPathPPARA - 22q13.31 [CytoView hg19]  PPARA - 22q13.31 [CytoView hg38]
ImmunoBaseENSG00000186951
Genome Data Viewer NCBIPPARA [Mapview hg19]  
OMIM170998   
Gene and transcription
Genbank (Entrez)AB073605 AB307690 AF018254 AF086231 AF270490
RefSeq transcript (Entrez)NM_001001928 NM_001001929 NM_001001930 NM_001362872 NM_001362873 NM_001393941 NM_001393942 NM_001393943 NM_001393944 NM_001393945 NM_001393946 NM_001393947 NM_005036 NM_032644
Consensus coding sequences : CCDS (NCBI)PPARA
Gene ExpressionPPARA [ NCBI-GEO ]   PPARA [ EBI - ARRAY_EXPRESS ]   PPARA [ SEEK ]   PPARA [ MEM ]
Gene Expression Viewer (FireBrowse)PPARA [ Firebrowse - Broad ]
GenevisibleExpression of PPARA in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5465
GTEX Portal (Tissue expression)PPARA
Human Protein AtlasENSG00000186951-PPARA [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ07869   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ07869  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ07869
PhosPhoSitePlusQ07869
Domaine pattern : Prosite (Expaxy)NR_LBD (PS51843)    NUCLEAR_REC_DBD_1 (PS00031)    NUCLEAR_REC_DBD_2 (PS51030)   
Domains : Interpro (EBI)1Cnucl_rcpt    NHR-like_dom_sf    Nucl_hrmn_rcpt_lig-bd    Nuclear_hrmn_rcpt    PPAR-alpha    Znf_hrmn_rcpt    Znf_NHR/GATA   
Domain families : Pfam (Sanger)Hormone_recep (PF00104)    zf-C4 (PF00105)   
Domain families : Pfam (NCBI)pfam00104    pfam00105   
Domain families : Smart (EMBL)HOLI (SM00430)  ZnF_C4 (SM00399)  
Conserved Domain (NCBI)PPARA
PDB (RSDB)1I7G    1K7L    1KKQ    2NPA    2P54    2REW    2ZNN    3ET1    3FEI    3G8I    3KDT    3KDU    3SP6    3VI8    4BCR    4CI4    5AZT    5HYK    6KXX    6KXY    6L96   
PDB Europe1I7G    1K7L    1KKQ    2NPA    2P54    2REW    2ZNN    3ET1    3FEI    3G8I    3KDT    3KDU    3SP6    3VI8    4BCR    4CI4    5AZT    5HYK    6KXX    6KXY    6L96   
PDB (PDBSum)1I7G    1K7L    1KKQ    2NPA    2P54    2REW    2ZNN    3ET1    3FEI    3G8I    3KDT    3KDU    3SP6    3VI8    4BCR    4CI4    5AZT    5HYK    6KXX    6KXY    6L96   
PDB (IMB)1I7G    1K7L    1KKQ    2NPA    2P54    2REW    2ZNN    3ET1    3FEI    3G8I    3KDT    3KDU    3SP6    3VI8    4BCR    4CI4    5AZT    5HYK    6KXX    6KXY    6L96   
Structural Biology KnowledgeBase1I7G    1K7L    1KKQ    2NPA    2P54    2REW    2ZNN    3ET1    3FEI    3G8I    3KDT    3KDU    3SP6    3VI8    4BCR    4CI4    5AZT    5HYK    6KXX    6KXY    6L96   
SCOP (Structural Classification of Proteins)1I7G    1K7L    1KKQ    2NPA    2P54    2REW    2ZNN    3ET1    3FEI    3G8I    3KDT    3KDU    3SP6    3VI8    4BCR    4CI4    5AZT    5HYK    6KXX    6KXY    6L96   
CATH (Classification of proteins structures)1I7G    1K7L    1KKQ    2NPA    2P54    2REW    2ZNN    3ET1    3FEI    3G8I    3KDT    3KDU    3SP6    3VI8    4BCR    4CI4    5AZT    5HYK    6KXX    6KXY    6L96   
SuperfamilyQ07869
AlphaFold pdb e-kbQ07869   
Human Protein Atlas [tissue]ENSG00000186951-PPARA [tissue]
HPRD01369
Protein Interaction databases
DIP (DOE-UCLA)Q07869
IntAct (EBI)Q07869
BioGRIDPPARA
STRING (EMBL)PPARA
ZODIACPPARA
Ontologies - Pathways
QuickGOQ07869
Ontology : AmiGOnegative regulation of transcription by RNA polymerase II  negative regulation of transcription by RNA polymerase II  chromatin  RNA polymerase II cis-regulatory region sequence-specific DNA binding  RNA polymerase II cis-regulatory region sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  transcription coactivator binding  DNA-binding transcription repressor activity, RNA polymerase II-specific  DNA-binding transcription repressor activity, RNA polymerase II-specific  DNA-binding transcription activator activity, RNA polymerase II-specific  response to hypoxia  DNA binding  DNA-binding transcription factor activity  DNA-binding transcription factor activity  steroid hormone receptor activity  nuclear receptor activity  nuclear receptor activity  protein binding  nucleus  nucleus  nucleoplasm  nucleoplasm  transcription initiation from RNA polymerase II promoter  fatty acid metabolic process  heart development  transcription factor binding  drug binding  zinc ion binding  lipid binding  epidermis development  cellular response to starvation  hormone-mediated signaling pathway  regulation of cellular ketone metabolic process  negative regulation of macrophage derived foam cell differentiation  negative regulation of macrophage derived foam cell differentiation  lipid localization  negative regulation of cholesterol storage  negative regulation of cholesterol storage  negative regulation of sequestering of triglyceride  regulation of lipid metabolic process  regulation of lipid metabolic process  regulation of fatty acid metabolic process  phosphatase binding  protein domain specific binding  cell differentiation  negative regulation of transforming growth factor beta receptor signaling pathway  intracellular receptor signaling pathway  ubiquitin conjugating enzyme binding  positive regulation of fatty acid beta-oxidation  negative regulation of protein binding  negative regulation of appetite  response to insulin  circadian regulation of gene expression  response to lipid  behavioral response to nicotine  wound healing  lipoprotein metabolic process  regulation of circadian rhythm  steroid hormone mediated signaling pathway  sequence-specific DNA binding  protein-containing complex binding  positive regulation of viral genome replication  response to ethanol  positive regulation of gluconeogenesis  negative regulation of blood pressure  negative regulation of glycolytic process  positive regulation of transcription, DNA-templated  positive regulation of fatty acid metabolic process  positive regulation of transcription by RNA polymerase II  positive regulation of transcription by RNA polymerase II  positive regulation of transcription by RNA polymerase II  positive regulation of fatty acid oxidation  positive regulation of lipid biosynthetic process  negative regulation of inflammatory response  negative regulation of inflammatory response  NFAT protein binding  negative regulation of protein kinase B signaling  negative regulation of cell growth involved in cardiac muscle cell development  RNA polymerase II-specific DNA-binding transcription factor binding  RNA polymerase II-specific DNA-binding transcription factor binding  enamel mineralization  MDM2/MDM4 family protein binding  negative regulation of cytokine production involved in inflammatory response  negative regulation of neuron death  negative regulation of pri-miRNA transcription by RNA polymerase II  negative regulation of leukocyte cell-cell adhesion  negative regulation of reactive oxygen species biosynthetic process  negative regulation of hepatocyte apoptotic process  regulation of fatty acid transport  negative regulation of signaling receptor activity  positive regulation of ATP biosynthetic process  
Ontology : EGO-EBInegative regulation of transcription by RNA polymerase II  negative regulation of transcription by RNA polymerase II  chromatin  RNA polymerase II cis-regulatory region sequence-specific DNA binding  RNA polymerase II cis-regulatory region sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  transcription coactivator binding  DNA-binding transcription repressor activity, RNA polymerase II-specific  DNA-binding transcription repressor activity, RNA polymerase II-specific  DNA-binding transcription activator activity, RNA polymerase II-specific  response to hypoxia  DNA binding  DNA-binding transcription factor activity  DNA-binding transcription factor activity  steroid hormone receptor activity  nuclear receptor activity  nuclear receptor activity  protein binding  nucleus  nucleus  nucleoplasm  nucleoplasm  transcription initiation from RNA polymerase II promoter  fatty acid metabolic process  heart development  transcription factor binding  drug binding  zinc ion binding  lipid binding  epidermis development  cellular response to starvation  hormone-mediated signaling pathway  regulation of cellular ketone metabolic process  negative regulation of macrophage derived foam cell differentiation  negative regulation of macrophage derived foam cell differentiation  lipid localization  negative regulation of cholesterol storage  negative regulation of cholesterol storage  negative regulation of sequestering of triglyceride  regulation of lipid metabolic process  regulation of lipid metabolic process  regulation of fatty acid metabolic process  phosphatase binding  protein domain specific binding  cell differentiation  negative regulation of transforming growth factor beta receptor signaling pathway  intracellular receptor signaling pathway  ubiquitin conjugating enzyme binding  positive regulation of fatty acid beta-oxidation  negative regulation of protein binding  negative regulation of appetite  response to insulin  circadian regulation of gene expression  response to lipid  behavioral response to nicotine  wound healing  lipoprotein metabolic process  regulation of circadian rhythm  steroid hormone mediated signaling pathway  sequence-specific DNA binding  protein-containing complex binding  positive regulation of viral genome replication  response to ethanol  positive regulation of gluconeogenesis  negative regulation of blood pressure  negative regulation of glycolytic process  positive regulation of transcription, DNA-templated  positive regulation of fatty acid metabolic process  positive regulation of transcription by RNA polymerase II  positive regulation of transcription by RNA polymerase II  positive regulation of transcription by RNA polymerase II  positive regulation of fatty acid oxidation  positive regulation of lipid biosynthetic process  negative regulation of inflammatory response  negative regulation of inflammatory response  NFAT protein binding  negative regulation of protein kinase B signaling  negative regulation of cell growth involved in cardiac muscle cell development  RNA polymerase II-specific DNA-binding transcription factor binding  RNA polymerase II-specific DNA-binding transcription factor binding  enamel mineralization  MDM2/MDM4 family protein binding  negative regulation of cytokine production involved in inflammatory response  negative regulation of neuron death  negative regulation of pri-miRNA transcription by RNA polymerase II  negative regulation of leukocyte cell-cell adhesion  negative regulation of reactive oxygen species biosynthetic process  negative regulation of hepatocyte apoptotic process  regulation of fatty acid transport  negative regulation of signaling receptor activity  positive regulation of ATP biosynthetic process  
Pathways : BIOCARTARegulation of PGC-1a [Genes]    Mechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha) [Genes]    ?-arrestins in GPCR Desensitization [Genes]    Toll-Like Receptor Pathway [Genes]    Basic mechanism of action of PPARa, PPARb(d) and PPARg and effects on gene expression [Genes]    Nuclear Receptors in Lipid Metabolism and Toxicity [Genes]   
Pathways : KEGGPPAR signaling pathway    Adipocytokine signaling pathway    Non-alcoholic fatty liver disease (NAFLD)    Hepatitis C   
NDEx NetworkPPARA
Atlas of Cancer Signalling NetworkPPARA
Wikipedia pathwaysPPARA
Orthology - Evolution
OrthoDB5465
GeneTree (enSembl)ENSG00000186951
Phylogenetic Trees/Animal Genes : TreeFamPPARA
Homologs : HomoloGenePPARA
Homology/Alignments : Family Browser (UCSC)PPARA
Gene fusions - Rearrangements
Fusion : QuiverPPARA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPPARA [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PPARA
dbVarPPARA
ClinVarPPARA
MonarchPPARA
1000_GenomesPPARA 
Exome Variant ServerPPARA
GNOMAD BrowserENSG00000186951
Varsome BrowserPPARA
ACMGPPARA variants
VarityQ07869
Genomic Variants (DGV)PPARA [DGVbeta]
DECIPHERPPARA [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPPARA 
Mutations
ICGC Data PortalPPARA 
TCGA Data PortalPPARA 
Broad Tumor PortalPPARA
OASIS PortalPPARA [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPPARA  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPPARA
Mutations and Diseases : HGMDPPARA
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaPPARA
DgiDB (Drug Gene Interaction Database)PPARA
DoCM (Curated mutations)PPARA
CIViC (Clinical Interpretations of Variants in Cancer)PPARA
Cancer3DPPARA
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM170998   
Orphanet
DisGeNETPPARA
MedgenPPARA
Genetic Testing Registry PPARA
NextProtQ07869 [Medical]
GENETestsPPARA
Target ValidationPPARA
Huge Navigator PPARA [HugePedia]
ClinGenPPARA
Clinical trials, drugs, therapy
MyCancerGenomePPARA
Protein Interactions : CTDPPARA
Pharm GKB GenePA280
PharosQ07869
Clinical trialPPARA
Miscellaneous
canSAR (ICR)PPARA
HarmonizomePPARA
DataMed IndexPPARA
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXPPARA
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:26:16 CEST 2021

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