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PPP1CA (protein phosphatase 1 catalytic subunit alpha)

Identity

Alias_namesPPP1A
protein phosphatase 1, catalytic subunit, alpha isoform
protein phosphatase 1, catalytic subunit, alpha isozyme
Alias_symbol (synonym)PP1A
PP-1A
PP1alpha
Other alias
HGNC (Hugo) PPP1CA
LocusID (NCBI) 5499
Atlas_Id 41804
Location 11q13.2  [Link to chromosome band 11q13]
Location_base_pair Starts at 67165652 and ends at 67169376 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
RAD9A (11q13.2) / PPP1CA (11q13.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PPP1CA   9281
Cards
Entrez_Gene (NCBI)PPP1CA  5499  protein phosphatase 1 catalytic subunit alpha
AliasesPP-1A; PP1A; PP1alpha; PPP1A
GeneCards (Weizmann)PPP1CA
Ensembl hg19 (Hinxton)ENSG00000172531 [Gene_View]  chr11:67165652-67169376 [Contig_View]  PPP1CA [Vega]
Ensembl hg38 (Hinxton)ENSG00000172531 [Gene_View]  chr11:67165652-67169376 [Contig_View]  PPP1CA [Vega]
ICGC DataPortalENSG00000172531
TCGA cBioPortalPPP1CA
AceView (NCBI)PPP1CA
Genatlas (Paris)PPP1CA
WikiGenes5499
SOURCE (Princeton)PPP1CA
Genetics Home Reference (NIH)PPP1CA
Genomic and cartography
GoldenPath hg19 (UCSC)PPP1CA  -     chr11:67165652-67169376 -  11q13.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PPP1CA  -     11q13.2   [Description]    (hg38-Dec_2013)
EnsemblPPP1CA - 11q13.2 [CytoView hg19]  PPP1CA - 11q13.2 [CytoView hg38]
Mapping of homologs : NCBIPPP1CA [Mapview hg19]  PPP1CA [Mapview hg38]
OMIM176875   
Gene and transcription
Genbank (Entrez)AK098311 AK127616 AK313586 AL557336 BC001888
RefSeq transcript (Entrez)NM_001008709 NM_002708 NM_206873
RefSeq genomic (Entrez)NC_000011 NC_018922 NT_167190 NW_004929380
Consensus coding sequences : CCDS (NCBI)PPP1CA
Cluster EST : UnigeneHs.183994 [ NCBI ]
CGAP (NCI)Hs.183994
Alternative Splicing GalleryENSG00000172531
Gene ExpressionPPP1CA [ NCBI-GEO ]   PPP1CA [ EBI - ARRAY_EXPRESS ]   PPP1CA [ SEEK ]   PPP1CA [ MEM ]
Gene Expression Viewer (FireBrowse)PPP1CA [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5499
GTEX Portal (Tissue expression)PPP1CA
Protein : pattern, domain, 3D structure
UniProt/SwissProtP62136   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP62136  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP62136
Splice isoforms : SwissVarP62136
PhosPhoSitePlusP62136
Domaine pattern : Prosite (Expaxy)SER_THR_PHOSPHATASE (PS00125)   
Domains : Interpro (EBI)Calcineurin-like_PHP_apaH    Metallo-depent_PP-like    Ser/Thr-sp_prot-phosphatase    STPPase_N   
Domain families : Pfam (Sanger)Metallophos (PF00149)    STPPase_N (PF16891)   
Domain families : Pfam (NCBI)pfam00149    pfam16891   
Domain families : Smart (EMBL)PP2Ac (SM00156)  
Conserved Domain (NCBI)PPP1CA
DMDM Disease mutations5499
Blocks (Seattle)PPP1CA
PDB (SRS)3E7A    3E7B    3EGG    3EGH    3HVQ    3N5U    3V4Y    4G9J    4MOV    4MOY    4MP0    4XPN   
PDB (PDBSum)3E7A    3E7B    3EGG    3EGH    3HVQ    3N5U    3V4Y    4G9J    4MOV    4MOY    4MP0    4XPN   
PDB (IMB)3E7A    3E7B    3EGG    3EGH    3HVQ    3N5U    3V4Y    4G9J    4MOV    4MOY    4MP0    4XPN   
PDB (RSDB)3E7A    3E7B    3EGG    3EGH    3HVQ    3N5U    3V4Y    4G9J    4MOV    4MOY    4MP0    4XPN   
Structural Biology KnowledgeBase3E7A    3E7B    3EGG    3EGH    3HVQ    3N5U    3V4Y    4G9J    4MOV    4MOY    4MP0    4XPN   
SCOP (Structural Classification of Proteins)3E7A    3E7B    3EGG    3EGH    3HVQ    3N5U    3V4Y    4G9J    4MOV    4MOY    4MP0    4XPN   
CATH (Classification of proteins structures)3E7A    3E7B    3EGG    3EGH    3HVQ    3N5U    3V4Y    4G9J    4MOV    4MOY    4MP0    4XPN   
SuperfamilyP62136
Human Protein AtlasENSG00000172531
Peptide AtlasP62136
HPRD15942
IPIIPI00550451   IPI00902512   IPI00027423   IPI00410128   IPI00980919   IPI01015316   
Protein Interaction databases
DIP (DOE-UCLA)P62136
IntAct (EBI)P62136
FunCoupENSG00000172531
BioGRIDPPP1CA
STRING (EMBL)PPP1CA
ZODIACPPP1CA
Ontologies - Pathways
QuickGOP62136
Ontology : AmiGOprotein phosphatase type 1 complex  nuclear chromosome, telomeric region  phosphoprotein phosphatase activity  protein serine/threonine phosphatase activity  protein binding  nucleus  nucleoplasm  nucleolus  cytoplasm  cytosol  plasma membrane  glycogen metabolic process  regulation of glycogen biosynthetic process  regulation of glycogen catabolic process  protein dephosphorylation  protein dephosphorylation  cell cycle  protein phosphatase 1 binding  dephosphorylation  phosphatase activity  lung development  negative regulation of protein binding  protein complex binding  circadian regulation of gene expression  regulation of translational initiation by eIF2 alpha dephosphorylation  glycogen granule  regulation of circadian rhythm  ribonucleoprotein complex binding  entrainment of circadian clock by photoperiod  dendritic spine  perikaryon  metal ion binding  branching morphogenesis of an epithelial tube  cell division  regulation of canonical Wnt signaling pathway  extracellular exosome  MLL5-L complex  PTW/PP1 phosphatase complex  beta-catenin destruction complex disassembly  positive regulation of extrinsic apoptotic signaling pathway in absence of ligand  
Ontology : EGO-EBIprotein phosphatase type 1 complex  nuclear chromosome, telomeric region  phosphoprotein phosphatase activity  protein serine/threonine phosphatase activity  protein binding  nucleus  nucleoplasm  nucleolus  cytoplasm  cytosol  plasma membrane  glycogen metabolic process  regulation of glycogen biosynthetic process  regulation of glycogen catabolic process  protein dephosphorylation  protein dephosphorylation  cell cycle  protein phosphatase 1 binding  dephosphorylation  phosphatase activity  lung development  negative regulation of protein binding  protein complex binding  circadian regulation of gene expression  regulation of translational initiation by eIF2 alpha dephosphorylation  glycogen granule  regulation of circadian rhythm  ribonucleoprotein complex binding  entrainment of circadian clock by photoperiod  dendritic spine  perikaryon  metal ion binding  branching morphogenesis of an epithelial tube  cell division  regulation of canonical Wnt signaling pathway  extracellular exosome  MLL5-L complex  PTW/PP1 phosphatase complex  beta-catenin destruction complex disassembly  positive regulation of extrinsic apoptotic signaling pathway in absence of ligand  
Pathways : KEGGmRNA surveillance pathway    Oocyte meiosis    Adrenergic signaling in cardiomyocytes    Vascular smooth muscle contraction    Hippo signaling pathway    Focal adhesion    Long-term potentiation    Dopaminergic synapse    Regulation of actin cytoskeleton    Insulin signaling pathway    Amphetamine addiction    Alcoholism    Herpes simplex infection    Proteoglycans in cancer   
NDEx NetworkPPP1CA
Atlas of Cancer Signalling NetworkPPP1CA
Wikipedia pathwaysPPP1CA
Orthology - Evolution
OrthoDB5499
GeneTree (enSembl)ENSG00000172531
Phylogenetic Trees/Animal Genes : TreeFamPPP1CA
HOVERGENP62136
HOGENOMP62136
Homologs : HomoloGenePPP1CA
Homology/Alignments : Family Browser (UCSC)PPP1CA
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPPP1CA [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PPP1CA
dbVarPPP1CA
ClinVarPPP1CA
1000_GenomesPPP1CA 
Exome Variant ServerPPP1CA
ExAC (Exome Aggregation Consortium)PPP1CA (select the gene name)
Genetic variants : HAPMAP5499
Genomic Variants (DGV)PPP1CA [DGVbeta]
DECIPHER (Syndromes)11:67165652-67169376  ENSG00000172531
CONAN: Copy Number AnalysisPPP1CA 
Mutations
ICGC Data PortalPPP1CA 
TCGA Data PortalPPP1CA 
Broad Tumor PortalPPP1CA
OASIS PortalPPP1CA [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPPP1CA  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPPP1CA
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PPP1CA
DgiDB (Drug Gene Interaction Database)PPP1CA
DoCM (Curated mutations)PPP1CA (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PPP1CA (select a term)
intoGenPPP1CA
Cancer3DPPP1CA(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM176875   
Orphanet
MedgenPPP1CA
Genetic Testing Registry PPP1CA
NextProtP62136 [Medical]
TSGene5499
GENETestsPPP1CA
Huge Navigator PPP1CA [HugePedia]
snp3D : Map Gene to Disease5499
BioCentury BCIQPPP1CA
ClinGenPPP1CA
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5499
Chemical/Pharm GKB GenePA33609
Clinical trialPPP1CA
Miscellaneous
canSAR (ICR)PPP1CA (select the gene name)
Probes
Litterature
PubMed200 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePPP1CA
EVEXPPP1CA
GoPubMedPPP1CA
iHOPPPP1CA
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 15:15:15 CEST 2017

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