Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

PPP1CB (protein phosphatase 1 catalytic subunit beta)

Identity

Other namesHEL-S-80p
PP-1B
PP1B
PP1beta
PPP1CD
HGNC (Hugo) PPP1CB
LocusID (NCBI) 5500
Atlas_Id 41805
Location 2p23.2  [Link to chromosome band 2p23]
Location_base_pair Starts at 28974626 and ends at 29025806 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
C1orf174 (1p36.32) / PPP1CB (2p23.2)FOXP1 (3p13) / PPP1CB (2p23.2)PDLIM1 (10q23.33) / PPP1CB (2p23.2)
PPP1CB (2p23.2) / BRE (2p23.2)PPP1CB (2p23.2) / MIR548N (2q31.2)PPP1CB (2p23.2) / PLB1 (2p23.2)
PPP1CB (2p23.2) / PPP1CB (2p23.2)PPP1CB (2p23.2) / YPEL5 (2p23.1)PSME4 (2p16.2) / PPP1CB (2p23.2)
RAPGEF1 (9q34.13) / PPP1CB (2p23.2)YPEL5 (2p23.1) / PPP1CB (2p23.2)PPP1CB 2p23.2 / BRE 2p23.2
PPP1CB 2p23.2 / PLB1 2p23.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 0 ]
  Lung: Translocations in Squamous Cell Carcinoma

External links

Nomenclature
HGNC (Hugo)PPP1CB   9282
Cards
Entrez_Gene (NCBI)PPP1CB  5500  protein phosphatase 1 catalytic subunit beta
AliasesHEL-S-80p; PP-1B; PP1B; PP1beta; 
PPP1CD
GeneCards (Weizmann)PPP1CB
Ensembl hg19 (Hinxton)ENSG00000213639 [Gene_View]  chr2:28974626-29025806 [Contig_View]  PPP1CB [Vega]
Ensembl hg38 (Hinxton)ENSG00000213639 [Gene_View]  chr2:28974626-29025806 [Contig_View]  PPP1CB [Vega]
ICGC DataPortalENSG00000213639
TCGA cBioPortalPPP1CB
AceView (NCBI)PPP1CB
Genatlas (Paris)PPP1CB
WikiGenes5500
SOURCE (Princeton)PPP1CB
Genomic and cartography
GoldenPath hg19 (UCSC)PPP1CB  -     chr2:28974626-29025806 +  2p23.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PPP1CB  -     2p23.2   [Description]    (hg38-Dec_2013)
EnsemblPPP1CB - 2p23.2 [CytoView hg19]  PPP1CB - 2p23.2 [CytoView hg38]
Mapping of homologs : NCBIPPP1CB [Mapview hg19]  PPP1CB [Mapview hg38]
OMIM600590   
Gene and transcription
Genbank (Entrez)AF092905 AI147919 AK295957 AK303682 AK312329
RefSeq transcript (Entrez)NM_002709 NM_206876 NM_206877
RefSeq genomic (Entrez)NC_000002 NC_018913 NT_022184 NW_004929300
Consensus coding sequences : CCDS (NCBI)PPP1CB
Cluster EST : UnigeneHs.702907 [ NCBI ]
CGAP (NCI)Hs.702907
Alternative Splicing GalleryENSG00000213639
Gene ExpressionPPP1CB [ NCBI-GEO ]   PPP1CB [ EBI - ARRAY_EXPRESS ]   PPP1CB [ SEEK ]   PPP1CB [ MEM ]
Gene Expression Viewer (FireBrowse)PPP1CB [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5500
GTEX Portal (Tissue expression)PPP1CB
Protein : pattern, domain, 3D structure
UniProt/SwissProtP62140 (Uniprot)
NextProtP62140  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP62140
Splice isoforms : SwissVarP62140 (Swissvar)
Catalytic activity : Enzyme3.1.3.16 [ Enzyme-Expasy ]   3.1.3.163.1.3.16 [ IntEnz-EBI ]   3.1.3.16 [ BRENDA ]   3.1.3.16 [ KEGG ]   
PhosPhoSitePlusP62140
Domaine pattern : Prosite (Expaxy)SER_THR_PHOSPHATASE (PS00125)   
Domains : Interpro (EBI)Calcineurin-like_PHP_apaH    Metallo-depent_PP-like    Ser/Thr-sp_prot-phosphatase    STPPase_N   
Domain families : Pfam (Sanger)Metallophos (PF00149)    STPPase_N (PF16891)   
Domain families : Pfam (NCBI)pfam00149    pfam16891   
Domain families : Smart (EMBL)PP2Ac (SM00156)  
DMDM Disease mutations5500
Blocks (Seattle)PPP1CB
SuperfamilyP62140
Human Protein AtlasENSG00000213639
Peptide AtlasP62140
HPRD11792
IPIIPI00218236   IPI00894274   IPI00930380   IPI00892668   IPI00894333   IPI00894160   
Protein Interaction databases
DIP (DOE-UCLA)P62140
IntAct (EBI)P62140
FunCoupENSG00000213639
BioGRIDPPP1CB
STRING (EMBL)PPP1CB
ZODIACPPP1CB
Ontologies - Pathways
QuickGOP62140
Ontology : AmiGOG2/M transition of mitotic cell cycle  protein phosphatase type 1 complex  nuclear chromosome, telomeric region  protein binding  nucleus  nucleoplasm  nucleolus  cytosol  focal adhesion  glycogen metabolic process  regulation of glycogen biosynthetic process  regulation of glycogen catabolic process  protein dephosphorylation  phosphatase activity  myosin phosphatase activity  protein kinase binding  regulation of cell adhesion  circadian regulation of gene expression  glycogen granule  regulation of circadian rhythm  entrainment of circadian clock by photoperiod  metal ion binding  myosin-light-chain-phosphatase activity  cell division  extracellular exosome  MLL5-L complex  PTW/PP1 phosphatase complex  
Ontology : EGO-EBIG2/M transition of mitotic cell cycle  protein phosphatase type 1 complex  nuclear chromosome, telomeric region  protein binding  nucleus  nucleoplasm  nucleolus  cytosol  focal adhesion  glycogen metabolic process  regulation of glycogen biosynthetic process  regulation of glycogen catabolic process  protein dephosphorylation  phosphatase activity  myosin phosphatase activity  protein kinase binding  regulation of cell adhesion  circadian regulation of gene expression  glycogen granule  regulation of circadian rhythm  entrainment of circadian clock by photoperiod  metal ion binding  myosin-light-chain-phosphatase activity  cell division  extracellular exosome  MLL5-L complex  PTW/PP1 phosphatase complex  
Pathways : KEGGmRNA surveillance pathway    Oocyte meiosis    Adrenergic signaling in cardiomyocytes    Vascular smooth muscle contraction    Hippo signaling pathway    Focal adhesion    Long-term potentiation    Dopaminergic synapse    Regulation of actin cytoskeleton    Insulin signaling pathway    Amphetamine addiction    Alcoholism    Herpes simplex infection    Proteoglycans in cancer   
NDEx NetworkPPP1CB
Atlas of Cancer Signalling NetworkPPP1CB
Wikipedia pathwaysPPP1CB
Orthology - Evolution
OrthoDB5500
GeneTree (enSembl)ENSG00000213639
Phylogenetic Trees/Animal Genes : TreeFamPPP1CB
Homologs : HomoloGenePPP1CB
Homology/Alignments : Family Browser (UCSC)PPP1CB
Gene fusions - Rearrangements
Fusion: TCGAPPP1CB 2p23.2 BRE 2p23.2 BRCA
Fusion: TCGAPPP1CB 2p23.2 PLB1 2p23.2 BRCA OV
Polymorphisms : SNP, variants
NCBI Variation ViewerPPP1CB [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PPP1CB
dbVarPPP1CB
ClinVarPPP1CB
1000_GenomesPPP1CB 
Exome Variant ServerPPP1CB
ExAC (Exome Aggregation Consortium)PPP1CB (select the gene name)
Genetic variants : HAPMAP5500
Genomic Variants (DGV)PPP1CB [DGVbeta]
Mutations
ICGC Data PortalPPP1CB 
TCGA Data PortalPPP1CB 
Broad Tumor PortalPPP1CB
OASIS PortalPPP1CB [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPPP1CB 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PPP1CB
DgiDB (Drug Gene Interaction Database)PPP1CB
DoCM (Curated mutations)PPP1CB (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PPP1CB (select a term)
intoGenPPP1CB
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)2:28974626-29025806  ENSG00000213639
CONAN: Copy Number AnalysisPPP1CB 
Mutations and Diseases : HGMDPPP1CB
OMIM600590   
MedgenPPP1CB
Genetic Testing Registry PPP1CB
NextProtP62140 [Medical]
TSGene5500
GENETestsPPP1CB
Huge Navigator PPP1CB [HugePedia]
snp3D : Map Gene to Disease5500
BioCentury BCIQPPP1CB
ClinGenPPP1CB
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5500
Chemical/Pharm GKB GenePA33610
Clinical trialPPP1CB
Miscellaneous
canSAR (ICR)PPP1CB (select the gene name)
Probes
Litterature
PubMed117 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePPP1CB
EVEXPPP1CB
GoPubMedPPP1CB
iHOPPPP1CB
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Sep 19 19:08:09 CEST 2016

Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.