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Taking over the Atlas
Dear Colleagues,
The Atlas, once more, is in great danger, and I will have to proceed to a collective economic lay-off of all the team involved in the Atlas before the begining of April 2015 (a foundation having suddenly withdrawn its commitment to support the Atlas). I ask you herein if any Scientific Society (a Society of Cytogenetics, of Clinical Genetics, of Hematology, or a Cancer Society, or any other...), any University and/or Hospital, any Charity, or any database would be interested in taking over the Atlas, in whole or in part. If taking charge of the whole lot is too big, a consortium of various actors could be the solution (I am myself trying to find partners). Could you please spread the information, contact the relevant authorities, and find partners.
Survival of the Atlas will be critically dependant upon your ability to find solutions (and urgently!).
Kind regards.
Jean-Loup Huret jlhuret@AtlasGeneticsOncology.org
Donations are also welcome
If each casual visitor gives 3 Euros or Dollars, the Atlas is saved in a week !
If each professional gives 100 Euros or Dollars once a year (now), the Atlas is saved in 2 weeks !
Don't let the Atlas imminent demise
Note: we send fiscal receipts for donations equal or above 50 Euros or Dollars

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PPP1CB (protein phosphatase 1, catalytic subunit, beta isozyme)

Identity

Other namesHEL-S-80p
PP-1B
PP1B
PP1beta
PPP1CD
HGNC (Hugo) PPP1CB
LocusID (NCBI) 5500
Location 2p23.2
Location_base_pair Starts at 28974626 and ends at 29025806 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas)

Solid Tumors AmeloblastomID5945

External links

Nomenclature
HGNC (Hugo)PPP1CB   9282
Cards
Entrez_Gene (NCBI)PPP1CB  5500  protein phosphatase 1, catalytic subunit, beta isozyme
GeneCards (Weizmann)PPP1CB
Ensembl hg19 (Hinxton)ENSG00000213639 [Gene_View]  chr2:28974626-29025806 [Contig_View]  PPP1CB [Vega]
Ensembl hg38 (Hinxton)ENSG00000213639 [Gene_View]  chr2:28974626-29025806 [Contig_View]  PPP1CB [Vega]
ICGC DataPortalENSG00000213639
cBioPortalPPP1CB
AceView (NCBI)PPP1CB
Genatlas (Paris)PPP1CB
WikiGenes5500
SOURCE (Princeton)PPP1CB
Genomic and cartography
GoldenPath hg19 (UCSC)PPP1CB  -     chr2:28974626-29025806 +  2p23.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PPP1CB  -     2p23.2   [Description]    (hg38-Dec_2013)
EnsemblPPP1CB - 2p23.2 [CytoView hg19]  PPP1CB - 2p23.2 [CytoView hg38]
Mapping of homologs : NCBIPPP1CB [Mapview hg19]  PPP1CB [Mapview hg38]
OMIM600590   
Gene and transcription
Genbank (Entrez)AF092905 AI147919 AK295957 AK303682 AK312329
RefSeq transcript (Entrez)NM_002709 NM_206876 NM_206877
RefSeq genomic (Entrez)NC_000002 NC_018913 NT_022184 NW_004929300
Consensus coding sequences : CCDS (NCBI)PPP1CB
Cluster EST : UnigeneHs.702907 [ NCBI ]
CGAP (NCI)Hs.702907
Alternative Splicing : Fast-db (Paris)GSHG0016348
Alternative Splicing GalleryENSG00000213639
Gene ExpressionPPP1CB [ NCBI-GEO ]     PPP1CB [ SEEK ]   PPP1CB [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP62140 (Uniprot)
NextProtP62140  [Medical]
With graphics : InterProP62140
Splice isoforms : SwissVarP62140 (Swissvar)
Catalytic activity : Enzyme3.1.3.16 [ Enzyme-Expasy ]   3.1.3.163.1.3.16 [ IntEnz-EBI ]   3.1.3.16 [ BRENDA ]   3.1.3.16 [ KEGG ]   
Domaine pattern : Prosite (Expaxy)SER_THR_PHOSPHATASE (PS00125)   
Domains : Interpro (EBI)Calcineurin-like_PHP_apaH    Metallo-depent_PP-like    Ser/Thr-sp_prot-phosphatase   
Related proteins : CluSTrP62140
Domain families : Pfam (Sanger)Metallophos (PF00149)   
Domain families : Pfam (NCBI)pfam00149   
Domain families : Smart (EMBL)PP2Ac (SM00156)  
DMDM Disease mutations5500
Blocks (Seattle)P62140
Human Protein AtlasENSG00000213639
Peptide AtlasP62140
HPRD11792
IPIIPI00218236   IPI00894274   IPI00930380   IPI00892668   IPI00894333   IPI00894160   
Protein Interaction databases
DIP (DOE-UCLA)P62140
IntAct (EBI)P62140
FunCoupENSG00000213639
BioGRIDPPP1CB
IntegromeDBPPP1CB
STRING (EMBL)PPP1CB
Ontologies - Pathways
QuickGOP62140
Ontology : AmiGOG2/M transition of mitotic cell cycle  protein phosphatase type 1 complex  mitotic cell cycle  protein binding  nucleus  nucleoplasm  nucleolus  focal adhesion  glycogen metabolic process  regulation of glycogen biosynthetic process  regulation of glycogen catabolic process  protein dephosphorylation  transforming growth factor beta receptor signaling pathway  phosphatase activity  myosin phosphatase activity  triglyceride catabolic process  protein kinase binding  regulation of cell adhesion  negative regulation of transforming growth factor beta receptor signaling pathway  circadian regulation of gene expression  glycogen granule  regulation of circadian rhythm  entrainment of circadian clock by photoperiod  small molecule metabolic process  metal ion binding  myosin-light-chain-phosphatase activity  cell division  extracellular exosome  MLL5-L complex  PTW/PP1 phosphatase complex  
Ontology : EGO-EBIG2/M transition of mitotic cell cycle  protein phosphatase type 1 complex  mitotic cell cycle  protein binding  nucleus  nucleoplasm  nucleolus  focal adhesion  glycogen metabolic process  regulation of glycogen biosynthetic process  regulation of glycogen catabolic process  protein dephosphorylation  transforming growth factor beta receptor signaling pathway  phosphatase activity  myosin phosphatase activity  triglyceride catabolic process  protein kinase binding  regulation of cell adhesion  negative regulation of transforming growth factor beta receptor signaling pathway  circadian regulation of gene expression  glycogen granule  regulation of circadian rhythm  entrainment of circadian clock by photoperiod  small molecule metabolic process  metal ion binding  myosin-light-chain-phosphatase activity  cell division  extracellular exosome  MLL5-L complex  PTW/PP1 phosphatase complex  
Pathways : KEGGmRNA surveillance pathway    Oocyte meiosis    Adrenergic signaling in cardiomyocytes    Vascular smooth muscle contraction    Hippo signaling pathway    Focal adhesion    Long-term potentiation    Dopaminergic synapse    Regulation of actin cytoskeleton    Insulin signaling pathway    Amphetamine addiction    Alcoholism    Herpes simplex infection    Proteoglycans in cancer   
Protein Interaction DatabasePPP1CB
DoCM (Curated mutations)PPP1CB
Wikipedia pathwaysPPP1CB
Gene fusion - rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerPPP1CB [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PPP1CB
dbVarPPP1CB
ClinVarPPP1CB
1000_GenomesPPP1CB 
Exome Variant ServerPPP1CB
SNP (GeneSNP Utah)PPP1CB
SNP : HGBasePPP1CB
Genetic variants : HAPMAPPPP1CB
Genomic Variants (DGV)PPP1CB [DGVbeta]
Mutations
ICGC Data PortalENSG00000213639 
Somatic Mutations in Cancer : COSMICPPP1CB 
CONAN: Copy Number AnalysisPPP1CB 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)2:28974626-29025806
Mutations and Diseases : HGMDPPP1CB
OMIM600590   
MedgenPPP1CB
NextProtP62140 [Medical]
GENETestsPPP1CB
Disease Genetic AssociationPPP1CB
Huge Navigator PPP1CB [HugePedia]  PPP1CB [HugeCancerGEM]
snp3D : Map Gene to Disease5500
DGIdb (Drug Gene Interaction db)PPP1CB
General knowledge
Homologs : HomoloGenePPP1CB
Homology/Alignments : Family Browser (UCSC)PPP1CB
Phylogenetic Trees/Animal Genes : TreeFamPPP1CB
Chemical/Protein Interactions : CTD5500
Chemical/Pharm GKB GenePA33610
Clinical trialPPP1CB
Cancer Resource (Charite)ENSG00000213639
Other databases
Probes
Litterature
PubMed99 Pubmed reference(s) in Entrez
CoreMinePPP1CB
GoPubMedPPP1CB
iHOPPPP1CB
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated02-2015Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Mar 28 16:59:20 CET 2015

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For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.