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PPP6C (protein phosphatase 6 catalytic subunit)

Identity

Alias_namesprotein phosphatase 6
Alias_symbol (synonym)PP6
HGNC (Hugo) PPP6C
LocusID (NCBI) 5537
Atlas_Id 41826
Location 9q33.3  [Link to chromosome band 9q33]
Location_base_pair Starts at 127908852 and ends at 127952218 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
LEMD3 (12q14.3) / PPP6C (9q33.3)PPP6C (9q33.3) / C11orf84 (11q13.1)PPP6C (9q33.3) / PPM1E (17q22)
PPP6C (9q33.3) / SUFU (10q24.32)SCAI (9q33.3) / PPP6C (9q33.3)PPP6C 9q33.3 / C11orf84 11q13.1
SCAI 9q33.3 / PPP6C 9q33.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PPP6C   9323
Cards
Entrez_Gene (NCBI)PPP6C  5537  protein phosphatase 6 catalytic subunit
AliasesPP6; PP6C
GeneCards (Weizmann)PPP6C
Ensembl hg19 (Hinxton)ENSG00000119414 [Gene_View]  chr9:127908852-127952218 [Contig_View]  PPP6C [Vega]
Ensembl hg38 (Hinxton)ENSG00000119414 [Gene_View]  chr9:127908852-127952218 [Contig_View]  PPP6C [Vega]
ICGC DataPortalENSG00000119414
TCGA cBioPortalPPP6C
AceView (NCBI)PPP6C
Genatlas (Paris)PPP6C
WikiGenes5537
SOURCE (Princeton)PPP6C
Genetics Home Reference (NIH)PPP6C
Genomic and cartography
GoldenPath hg19 (UCSC)PPP6C  -     chr9:127908852-127952218 -  9q33.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PPP6C  -     9q33.3   [Description]    (hg38-Dec_2013)
EnsemblPPP6C - 9q33.3 [CytoView hg19]  PPP6C - 9q33.3 [CytoView hg38]
Mapping of homologs : NCBIPPP6C [Mapview hg19]  PPP6C [Mapview hg38]
OMIM612725   
Gene and transcription
Genbank (Entrez)AA251321 AF035158 AK295190 AK295752 AK299087
RefSeq transcript (Entrez)NM_001123355 NM_001123369 NM_002721
RefSeq genomic (Entrez)NC_000009 NC_018920 NT_008470 NW_004929366
Consensus coding sequences : CCDS (NCBI)PPP6C
Cluster EST : UnigeneHs.744091 [ NCBI ]
CGAP (NCI)Hs.744091
Alternative Splicing GalleryENSG00000119414
Gene ExpressionPPP6C [ NCBI-GEO ]   PPP6C [ EBI - ARRAY_EXPRESS ]   PPP6C [ SEEK ]   PPP6C [ MEM ]
Gene Expression Viewer (FireBrowse)PPP6C [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5537
GTEX Portal (Tissue expression)PPP6C
Protein : pattern, domain, 3D structure
UniProt/SwissProtO00743   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO00743  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO00743
Splice isoforms : SwissVarO00743
Catalytic activity : Enzyme3.1.3.16 [ Enzyme-Expasy ]   3.1.3.163.1.3.16 [ IntEnz-EBI ]   3.1.3.16 [ BRENDA ]   3.1.3.16 [ KEGG ]   
PhosPhoSitePlusO00743
Domaine pattern : Prosite (Expaxy)SER_THR_PHOSPHATASE (PS00125)   
Domains : Interpro (EBI)Calcineurin-like_PHP_apaH    Metallo-depent_PP-like    Ser/Thr-sp_prot-phosphatase   
Domain families : Pfam (Sanger)Metallophos (PF00149)   
Domain families : Pfam (NCBI)pfam00149   
Domain families : Smart (EMBL)PP2Ac (SM00156)  
Conserved Domain (NCBI)PPP6C
DMDM Disease mutations5537
Blocks (Seattle)PPP6C
SuperfamilyO00743
Human Protein AtlasENSG00000119414
Peptide AtlasO00743
HPRD02141
IPIIPI00012970   IPI00890827   IPI00890743   IPI01012187   IPI00514237   
Protein Interaction databases
DIP (DOE-UCLA)O00743
IntAct (EBI)O00743
FunCoupENSG00000119414
BioGRIDPPP6C
STRING (EMBL)PPP6C
ZODIACPPP6C
Ontologies - Pathways
QuickGOO00743
Ontology : AmiGOG1/S transition of mitotic cell cycle  Golgi membrane  protein serine/threonine phosphatase activity  protein serine/threonine phosphatase activity  protein binding  cytosol  cytosol  protein dephosphorylation  metal ion binding  COPII vesicle coating  
Ontology : EGO-EBIG1/S transition of mitotic cell cycle  Golgi membrane  protein serine/threonine phosphatase activity  protein serine/threonine phosphatase activity  protein binding  cytosol  cytosol  protein dephosphorylation  metal ion binding  COPII vesicle coating  
NDEx NetworkPPP6C
Atlas of Cancer Signalling NetworkPPP6C
Wikipedia pathwaysPPP6C
Orthology - Evolution
OrthoDB5537
GeneTree (enSembl)ENSG00000119414
Phylogenetic Trees/Animal Genes : TreeFamPPP6C
HOVERGENO00743
HOGENOMO00743
Homologs : HomoloGenePPP6C
Homology/Alignments : Family Browser (UCSC)PPP6C
Gene fusions - Rearrangements
Fusion : MitelmanPPP6C/C11orf84 [9q33.3/11q13.1]  
Fusion : MitelmanSCAI/PPP6C [9q33.3/9q33.3]  [t(9;9)(q33;q33)]  
Fusion: TCGAPPP6C 9q33.3 C11orf84 11q13.1 GBM
Fusion: TCGASCAI 9q33.3 PPP6C 9q33.3 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPPP6C [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PPP6C
dbVarPPP6C
ClinVarPPP6C
1000_GenomesPPP6C 
Exome Variant ServerPPP6C
ExAC (Exome Aggregation Consortium)PPP6C (select the gene name)
Genetic variants : HAPMAP5537
Genomic Variants (DGV)PPP6C [DGVbeta]
DECIPHER (Syndromes)9:127908852-127952218  ENSG00000119414
CONAN: Copy Number AnalysisPPP6C 
Mutations
ICGC Data PortalPPP6C 
TCGA Data PortalPPP6C 
Broad Tumor PortalPPP6C
OASIS PortalPPP6C [ Somatic mutations - Copy number]
Cancer Gene: CensusPPP6C 
Somatic Mutations in Cancer : COSMICPPP6C  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPPP6C
intOGen PortalPPP6C
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PPP6C
DgiDB (Drug Gene Interaction Database)PPP6C
DoCM (Curated mutations)PPP6C (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PPP6C (select a term)
intoGenPPP6C
Cancer3DPPP6C(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM612725   
Orphanet
MedgenPPP6C
Genetic Testing Registry PPP6C
NextProtO00743 [Medical]
TSGene5537
GENETestsPPP6C
Huge Navigator PPP6C [HugePedia]
snp3D : Map Gene to Disease5537
BioCentury BCIQPPP6C
ClinGenPPP6C
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5537
Chemical/Pharm GKB GenePA33687
Clinical trialPPP6C
Miscellaneous
canSAR (ICR)PPP6C (select the gene name)
Probes
Litterature
PubMed57 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePPP6C
EVEXPPP6C
GoPubMedPPP6C
iHOPPPP6C
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Nov 18 19:48:21 CET 2016

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