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PPP6C (protein phosphatase 6 catalytic subunit)

Identity

Alias (NCBI)PP6
PP6C
HGNC (Hugo) PPP6C
HGNC Alias symbPP6
HGNC Previous nameprotein phosphatase 6, catalytic subunit
LocusID (NCBI) 5537
Atlas_Id 41826
Location 9q33.3  [Link to chromosome band 9q33]
Location_base_pair Starts at 125146573 and ends at 125189803 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
LEMD3 (12q14.3) / PPP6C (9q33.3)PPP6C (9q33.3) / C11orf84 (11q13.1)PPP6C (9q33.3) / PPM1E (17q22)
PPP6C (9q33.3) / SUFU (10q24.32)SCAI (9q33.3) / PPP6C (9q33.3)PPP6C 9q33.3 / C11orf84 11q13.1
SCAI 9q33.3 / PPP6C 9q33.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)PPP6C   9323
Cards
Entrez_Gene (NCBI)PPP6C    protein phosphatase 6 catalytic subunit
AliasesPP6; PP6C
GeneCards (Weizmann)PPP6C
Ensembl hg19 (Hinxton)ENSG00000119414 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000119414 [Gene_View]  ENSG00000119414 [Sequence]  chr9:125146573-125189803 [Contig_View]  PPP6C [Vega]
ICGC DataPortalENSG00000119414
TCGA cBioPortalPPP6C
AceView (NCBI)PPP6C
Genatlas (Paris)PPP6C
SOURCE (Princeton)PPP6C
Genetics Home Reference (NIH)PPP6C
Genomic and cartography
GoldenPath hg38 (UCSC)PPP6C  -     chr9:125146573-125189803 -  9q33.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PPP6C  -     9q33.3   [Description]    (hg19-Feb_2009)
GoldenPathPPP6C - 9q33.3 [CytoView hg19]  PPP6C - 9q33.3 [CytoView hg38]
ImmunoBaseENSG00000119414
Genome Data Viewer NCBIPPP6C [Mapview hg19]  
OMIM612725   
Gene and transcription
Genbank (Entrez)AA251321 AF035158 AK295190 AK295752 AK299087
RefSeq transcript (Entrez)NM_001123355 NM_001123369 NM_002721
Consensus coding sequences : CCDS (NCBI)PPP6C
Gene ExpressionPPP6C [ NCBI-GEO ]   PPP6C [ EBI - ARRAY_EXPRESS ]   PPP6C [ SEEK ]   PPP6C [ MEM ]
Gene Expression Viewer (FireBrowse)PPP6C [ Firebrowse - Broad ]
GenevisibleExpression of PPP6C in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5537
GTEX Portal (Tissue expression)PPP6C
Human Protein AtlasENSG00000119414-PPP6C [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO00743   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO00743  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO00743
PhosPhoSitePlusO00743
Domaine pattern : Prosite (Expaxy)SER_THR_PHOSPHATASE (PS00125)   
Domains : Interpro (EBI)Calcineurin-like_PHP_ApaH    Metallo-depent_PP-like    Ser/Thr-sp_prot-phosphatase   
Domain families : Pfam (Sanger)Metallophos (PF00149)   
Domain families : Pfam (NCBI)pfam00149   
Domain families : Smart (EMBL)PP2Ac (SM00156)  
Conserved Domain (NCBI)PPP6C
SuperfamilyO00743
AlphaFold pdb e-kbO00743   
Human Protein Atlas [tissue]ENSG00000119414-PPP6C [tissue]
HPRD02141
Protein Interaction databases
DIP (DOE-UCLA)O00743
IntAct (EBI)O00743
BioGRIDPPP6C
STRING (EMBL)PPP6C
ZODIACPPP6C
Ontologies - Pathways
QuickGOO00743
Ontology : AmiGOG1/S transition of mitotic cell cycle  protein serine/threonine phosphatase activity  protein binding  nucleoplasm  mitochondrion  cytosol  cytosol  protein dephosphorylation  telomere maintenance via telomerase  innate immune response  metal ion binding  COPII vesicle coating  protein serine phosphatase activity  protein threonine phosphatase activity  
Ontology : EGO-EBIG1/S transition of mitotic cell cycle  protein serine/threonine phosphatase activity  protein binding  nucleoplasm  mitochondrion  cytosol  cytosol  protein dephosphorylation  telomere maintenance via telomerase  innate immune response  metal ion binding  COPII vesicle coating  protein serine phosphatase activity  protein threonine phosphatase activity  
NDEx NetworkPPP6C
Atlas of Cancer Signalling NetworkPPP6C
Wikipedia pathwaysPPP6C
Orthology - Evolution
OrthoDB5537
GeneTree (enSembl)ENSG00000119414
Phylogenetic Trees/Animal Genes : TreeFamPPP6C
Homologs : HomoloGenePPP6C
Homology/Alignments : Family Browser (UCSC)PPP6C
Gene fusions - Rearrangements
Fusion : MitelmanPPP6C/C11orf84 [9q33.3/11q13.1]  
Fusion : MitelmanSCAI/PPP6C [9q33.3/9q33.3]  
Fusion : QuiverPPP6C
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPPP6C [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PPP6C
dbVarPPP6C
ClinVarPPP6C
MonarchPPP6C
1000_GenomesPPP6C 
Exome Variant ServerPPP6C
GNOMAD BrowserENSG00000119414
Varsome BrowserPPP6C
ACMGPPP6C variants
VarityO00743
Genomic Variants (DGV)PPP6C [DGVbeta]
DECIPHERPPP6C [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPPP6C 
Mutations
ICGC Data PortalPPP6C 
TCGA Data PortalPPP6C 
Broad Tumor PortalPPP6C
OASIS PortalPPP6C [ Somatic mutations - Copy number]
Cancer Gene: CensusPPP6C 
Somatic Mutations in Cancer : COSMICPPP6C  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPPP6C
Mutations and Diseases : HGMDPPP6C
intOGen PortalPPP6C
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaPPP6C
DgiDB (Drug Gene Interaction Database)PPP6C
DoCM (Curated mutations)PPP6C
CIViC (Clinical Interpretations of Variants in Cancer)PPP6C
Cancer3DPPP6C
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM612725   
Orphanet
DisGeNETPPP6C
MedgenPPP6C
Genetic Testing Registry PPP6C
NextProtO00743 [Medical]
GENETestsPPP6C
Target ValidationPPP6C
Huge Navigator PPP6C [HugePedia]
ClinGenPPP6C
Clinical trials, drugs, therapy
MyCancerGenomePPP6C
Protein Interactions : CTDPPP6C
Pharm GKB GenePA33687
PharosO00743
Clinical trialPPP6C
Miscellaneous
canSAR (ICR)PPP6C
HarmonizomePPP6C
DataMed IndexPPP6C
Probes
Litterature
PubMed98 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXPPP6C
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:26:35 CEST 2021

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