Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

PRKAA2 (protein kinase AMP-activated catalytic subunit alpha 2)

Identity

Alias (NCBI)AMPK
AMPK2
AMPKa2
PRKAA
HGNC (Hugo) PRKAA2
HGNC Alias symbAMPK
AMPKa2
HGNC Previous namePRKAA
HGNC Previous nameprotein kinase, AMP-activated, alpha 2 catalytic subunit
LocusID (NCBI) 5563
Atlas_Id 41845
Location 1p32.2  [Link to chromosome band 1p32]
Location_base_pair Starts at 56645314 and ends at 56715335 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
BCAS3 (17q23.2) / PRKAA2 (1p32.2)PRKAA2 (1p32.2) / PRKAA2 (1p32.2)BCAS3 17q23.2 / PRKAA2 1p32.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)PRKAA2   9377
Cards
Entrez_Gene (NCBI)PRKAA2    protein kinase AMP-activated catalytic subunit alpha 2
AliasesAMPK; AMPK2; AMPKa2; PRKAA
GeneCards (Weizmann)PRKAA2
Ensembl hg19 (Hinxton)ENSG00000162409 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000162409 [Gene_View]  ENSG00000162409 [Sequence]  chr1:56645314-56715335 [Contig_View]  PRKAA2 [Vega]
ICGC DataPortalENSG00000162409
TCGA cBioPortalPRKAA2
AceView (NCBI)PRKAA2
Genatlas (Paris)PRKAA2
SOURCE (Princeton)PRKAA2
Genetics Home Reference (NIH)PRKAA2
Genomic and cartography
GoldenPath hg38 (UCSC)PRKAA2  -     chr1:56645314-56715335 +  1p32.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PRKAA2  -     1p32.2   [Description]    (hg19-Feb_2009)
GoldenPathPRKAA2 - 1p32.2 [CytoView hg19]  PRKAA2 - 1p32.2 [CytoView hg38]
ImmunoBaseENSG00000162409
Genome Data Viewer NCBIPRKAA2 [Mapview hg19]  
OMIM600497   
Gene and transcription
Genbank (Entrez)AI732856 AK314011 AL596521 AL710110 BC043195
RefSeq transcript (Entrez)NM_006252
Consensus coding sequences : CCDS (NCBI)PRKAA2
Gene ExpressionPRKAA2 [ NCBI-GEO ]   PRKAA2 [ EBI - ARRAY_EXPRESS ]   PRKAA2 [ SEEK ]   PRKAA2 [ MEM ]
Gene Expression Viewer (FireBrowse)PRKAA2 [ Firebrowse - Broad ]
GenevisibleExpression of PRKAA2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5563
GTEX Portal (Tissue expression)PRKAA2
Human Protein AtlasENSG00000162409-PRKAA2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP54646   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP54646  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP54646
PhosPhoSitePlusP54646
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)AMPK_C    AMPKA2_C    KA1/Ssp2_C    Kinase-like_dom_sf    PRKAA2    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)AdenylateSensor (PF16579)    Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam16579    pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)PRKAA2
PDB (RSDB)2H6D    2LTU    2YZA    3AQV    4CFE    4CFF    4ZHX    5EZV    5ISO    6B1U    6B2E    6BX6   
PDB Europe2H6D    2LTU    2YZA    3AQV    4CFE    4CFF    4ZHX    5EZV    5ISO    6B1U    6B2E    6BX6   
PDB (PDBSum)2H6D    2LTU    2YZA    3AQV    4CFE    4CFF    4ZHX    5EZV    5ISO    6B1U    6B2E    6BX6   
PDB (IMB)2H6D    2LTU    2YZA    3AQV    4CFE    4CFF    4ZHX    5EZV    5ISO    6B1U    6B2E    6BX6   
Structural Biology KnowledgeBase2H6D    2LTU    2YZA    3AQV    4CFE    4CFF    4ZHX    5EZV    5ISO    6B1U    6B2E    6BX6   
SCOP (Structural Classification of Proteins)2H6D    2LTU    2YZA    3AQV    4CFE    4CFF    4ZHX    5EZV    5ISO    6B1U    6B2E    6BX6   
CATH (Classification of proteins structures)2H6D    2LTU    2YZA    3AQV    4CFE    4CFF    4ZHX    5EZV    5ISO    6B1U    6B2E    6BX6   
SuperfamilyP54646
AlphaFold pdb e-kbP54646   
Human Protein Atlas [tissue]ENSG00000162409-PRKAA2 [tissue]
HPRD02735
Protein Interaction databases
DIP (DOE-UCLA)P54646
IntAct (EBI)P54646
BioGRIDPRKAA2
STRING (EMBL)PRKAA2
ZODIACPRKAA2
Ontologies - Pathways
QuickGOP54646
Ontology : AmiGOchromatin binding  protein kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  AMP-activated protein kinase activity  AMP-activated protein kinase activity  protein serine/threonine/tyrosine kinase activity  protein binding  ATP binding  nucleus  nucleus  nucleoplasm  cytoplasm  Golgi apparatus  cytosol  protein phosphorylation  fatty acid biosynthetic process  cholesterol biosynthetic process  carnitine shuttle  signal transduction  lipid biosynthetic process  cytoplasmic stress granule  positive regulation of autophagy  negative regulation of gene expression  response to muscle activity  Wnt signaling pathway  macroautophagy  positive regulation of macroautophagy  regulation of macroautophagy  regulation of macroautophagy  nuclear speck  axon  dendrite  cellular response to nutrient levels  negative regulation of TOR signaling  cellular response to oxidative stress  histone serine kinase activity  histone-serine phosphorylation  intracellular signal transduction  cellular response to drug  cellular response to glucose starvation  regulation of fatty acid biosynthetic process  glucose homeostasis  regulation of circadian rhythm  neuronal cell body  negative regulation of apoptotic process  positive regulation of glycolytic process  metal ion binding  [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity  rhythmic process  [acetyl-CoA carboxylase] kinase activity  fatty acid homeostasis  regulation of stress granule assembly  regulation of microtubule cytoskeleton organization  cellular response to calcium ion  cellular response to glucose stimulus  cellular response to prostaglandin E stimulus  energy homeostasis  protein serine kinase activity  protein threonine kinase activity  regulation of signal transduction by p53 class mediator  positive regulation of cellular protein localization  negative regulation of tubulin deacetylation  positive regulation of peptidyl-lysine acetylation  
Ontology : EGO-EBIchromatin binding  protein kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  AMP-activated protein kinase activity  AMP-activated protein kinase activity  protein serine/threonine/tyrosine kinase activity  protein binding  ATP binding  nucleus  nucleus  nucleoplasm  cytoplasm  Golgi apparatus  cytosol  protein phosphorylation  fatty acid biosynthetic process  cholesterol biosynthetic process  carnitine shuttle  signal transduction  lipid biosynthetic process  cytoplasmic stress granule  positive regulation of autophagy  negative regulation of gene expression  response to muscle activity  Wnt signaling pathway  macroautophagy  positive regulation of macroautophagy  regulation of macroautophagy  regulation of macroautophagy  nuclear speck  axon  dendrite  cellular response to nutrient levels  negative regulation of TOR signaling  cellular response to oxidative stress  histone serine kinase activity  histone-serine phosphorylation  intracellular signal transduction  cellular response to drug  cellular response to glucose starvation  regulation of fatty acid biosynthetic process  glucose homeostasis  regulation of circadian rhythm  neuronal cell body  negative regulation of apoptotic process  positive regulation of glycolytic process  metal ion binding  [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity  rhythmic process  [acetyl-CoA carboxylase] kinase activity  fatty acid homeostasis  regulation of stress granule assembly  regulation of microtubule cytoskeleton organization  cellular response to calcium ion  cellular response to glucose stimulus  cellular response to prostaglandin E stimulus  energy homeostasis  protein serine kinase activity  protein threonine kinase activity  regulation of signal transduction by p53 class mediator  positive regulation of cellular protein localization  negative regulation of tubulin deacetylation  positive regulation of peptidyl-lysine acetylation  
Pathways : BIOCARTAChREBP regulation by carbohydrates and cAMP [Genes]    Reversal of Insulin Resistance by Leptin [Genes]   
Pathways : KEGGFoxO signaling pathway    Regulation of autophagy    mTOR signaling pathway    PI3K-Akt signaling pathway    Circadian rhythm    Insulin signaling pathway    Adipocytokine signaling pathway    Non-alcoholic fatty liver disease (NAFLD)    Hypertrophic cardiomyopathy (HCM)   
NDEx NetworkPRKAA2
Atlas of Cancer Signalling NetworkPRKAA2
Wikipedia pathwaysPRKAA2
Orthology - Evolution
OrthoDB5563
GeneTree (enSembl)ENSG00000162409
Phylogenetic Trees/Animal Genes : TreeFamPRKAA2
Homologs : HomoloGenePRKAA2
Homology/Alignments : Family Browser (UCSC)PRKAA2
Gene fusions - Rearrangements
Fusion : MitelmanBCAS3/PRKAA2 [17q23.2/1p32.2]  
Fusion : QuiverPRKAA2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPRKAA2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PRKAA2
dbVarPRKAA2
ClinVarPRKAA2
MonarchPRKAA2
1000_GenomesPRKAA2 
Exome Variant ServerPRKAA2
GNOMAD BrowserENSG00000162409
Varsome BrowserPRKAA2
ACMGPRKAA2 variants
VarityP54646
Genomic Variants (DGV)PRKAA2 [DGVbeta]
DECIPHERPRKAA2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPRKAA2 
Mutations
ICGC Data PortalPRKAA2 
TCGA Data PortalPRKAA2 
Broad Tumor PortalPRKAA2
OASIS PortalPRKAA2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPRKAA2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPRKAA2
Mutations and Diseases : HGMDPRKAA2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaPRKAA2
DgiDB (Drug Gene Interaction Database)PRKAA2
DoCM (Curated mutations)PRKAA2
CIViC (Clinical Interpretations of Variants in Cancer)PRKAA2
Cancer3DPRKAA2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600497   
Orphanet
DisGeNETPRKAA2
MedgenPRKAA2
Genetic Testing Registry PRKAA2
NextProtP54646 [Medical]
GENETestsPRKAA2
Target ValidationPRKAA2
Huge Navigator PRKAA2 [HugePedia]
ClinGenPRKAA2
Clinical trials, drugs, therapy
MyCancerGenomePRKAA2
Protein Interactions : CTDPRKAA2
Pharm GKB GenePA33745
Pharm GKB PathwaysPA165948566   PA165984799   
PharosP54646
Clinical trialPRKAA2
Miscellaneous
canSAR (ICR)PRKAA2
HarmonizomePRKAA2
DataMed IndexPRKAA2
Probes
Litterature
PubMed188 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXPRKAA2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 4 15:26:48 CEST 2021

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.