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PRKAA2 (protein kinase AMP-activated catalytic subunit alpha 2)

Identity

Alias_namesPRKAA
protein kinase
Alias_symbol (synonym)AMPK
AMPKa2
Other aliasAMPK2
HGNC (Hugo) PRKAA2
LocusID (NCBI) 5563
Atlas_Id 41845
Location 1p32.2  [Link to chromosome band 1p32]
Location_base_pair Starts at 56645317 and ends at 56715335 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
BCAS3 (17q23.2) / PRKAA2 (1p32.2)PRKAA2 (1p32.2) / PRKAA2 (1p32.2)BCAS3 17q23.2 / PRKAA2 1p32.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PRKAA2   9377
Cards
Entrez_Gene (NCBI)PRKAA2  5563  protein kinase AMP-activated catalytic subunit alpha 2
AliasesAMPK; AMPK2; AMPKa2; PRKAA
GeneCards (Weizmann)PRKAA2
Ensembl hg19 (Hinxton)ENSG00000162409 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000162409 [Gene_View]  chr1:56645317-56715335 [Contig_View]  PRKAA2 [Vega]
ICGC DataPortalENSG00000162409
TCGA cBioPortalPRKAA2
AceView (NCBI)PRKAA2
Genatlas (Paris)PRKAA2
WikiGenes5563
SOURCE (Princeton)PRKAA2
Genetics Home Reference (NIH)PRKAA2
Genomic and cartography
GoldenPath hg38 (UCSC)PRKAA2  -     chr1:56645317-56715335 +  1p32.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PRKAA2  -     1p32.2   [Description]    (hg19-Feb_2009)
EnsemblPRKAA2 - 1p32.2 [CytoView hg19]  PRKAA2 - 1p32.2 [CytoView hg38]
Mapping of homologs : NCBIPRKAA2 [Mapview hg19]  PRKAA2 [Mapview hg38]
OMIM600497   
Gene and transcription
Genbank (Entrez)AI732856 AK314011 AL596521 AL710110 BC043195
RefSeq transcript (Entrez)NM_006252
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PRKAA2
Cluster EST : UnigeneHs.437039 [ NCBI ]
CGAP (NCI)Hs.437039
Alternative Splicing GalleryENSG00000162409
Gene ExpressionPRKAA2 [ NCBI-GEO ]   PRKAA2 [ EBI - ARRAY_EXPRESS ]   PRKAA2 [ SEEK ]   PRKAA2 [ MEM ]
Gene Expression Viewer (FireBrowse)PRKAA2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5563
GTEX Portal (Tissue expression)PRKAA2
Protein : pattern, domain, 3D structure
UniProt/SwissProtP54646   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP54646  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP54646
Splice isoforms : SwissVarP54646
PhosPhoSitePlusP54646
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)AMPK_C    KA1/Ssp2_C    Kinase-like_dom    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)AdenylateSensor (PF16579)    Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam16579    pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)PRKAA2
DMDM Disease mutations5563
Blocks (Seattle)PRKAA2
PDB (SRS)2H6D    2LTU    2YZA    3AQV    4CFE    4CFF    4ZHX    5EZV   
PDB (PDBSum)2H6D    2LTU    2YZA    3AQV    4CFE    4CFF    4ZHX    5EZV   
PDB (IMB)2H6D    2LTU    2YZA    3AQV    4CFE    4CFF    4ZHX    5EZV   
PDB (RSDB)2H6D    2LTU    2YZA    3AQV    4CFE    4CFF    4ZHX    5EZV   
Structural Biology KnowledgeBase2H6D    2LTU    2YZA    3AQV    4CFE    4CFF    4ZHX    5EZV   
SCOP (Structural Classification of Proteins)2H6D    2LTU    2YZA    3AQV    4CFE    4CFF    4ZHX    5EZV   
CATH (Classification of proteins structures)2H6D    2LTU    2YZA    3AQV    4CFE    4CFF    4ZHX    5EZV   
SuperfamilyP54646
Human Protein AtlasENSG00000162409
Peptide AtlasP54646
HPRD02735
IPIIPI00307755   
Protein Interaction databases
DIP (DOE-UCLA)P54646
IntAct (EBI)P54646
FunCoupENSG00000162409
BioGRIDPRKAA2
STRING (EMBL)PRKAA2
ZODIACPRKAA2
Ontologies - Pathways
QuickGOP54646
Ontology : AmiGOchromatin binding  protein kinase activity  protein serine/threonine kinase activity  AMP-activated protein kinase activity  protein serine/threonine/tyrosine kinase activity  protein binding  ATP binding  nucleus  nucleoplasm  cytoplasm  Golgi apparatus  cytosol  transcription, DNA-templated  regulation of transcription, DNA-templated  protein phosphorylation  fatty acid biosynthetic process  cholesterol biosynthetic process  carnitine shuttle  response to stress  cell cycle arrest  signal transduction  lipid biosynthetic process  positive regulation of autophagy  response to muscle activity  Wnt signaling pathway  macroautophagy  positive regulation of macroautophagy  regulation of macroautophagy  nuclear speck  nucleotide-activated protein kinase complex  cellular response to nutrient levels  negative regulation of TOR signaling  negative regulation of TOR signaling  histone serine kinase activity  histone serine kinase activity  histone-serine phosphorylation  intracellular signal transduction  cellular response to drug  cellular response to glucose starvation  cellular response to glucose starvation  regulation of fatty acid biosynthetic process  glucose homeostasis  regulation of circadian rhythm  negative regulation of apoptotic process  positive regulation of glycolytic process  metal ion binding  [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity  rhythmic process  [acetyl-CoA carboxylase] kinase activity  fatty acid homeostasis  cellular response to prostaglandin E stimulus  regulation of signal transduction by p53 class mediator  regulation of energy homeostasis  
Ontology : EGO-EBIchromatin binding  protein kinase activity  protein serine/threonine kinase activity  AMP-activated protein kinase activity  protein serine/threonine/tyrosine kinase activity  protein binding  ATP binding  nucleus  nucleoplasm  cytoplasm  Golgi apparatus  cytosol  transcription, DNA-templated  regulation of transcription, DNA-templated  protein phosphorylation  fatty acid biosynthetic process  cholesterol biosynthetic process  carnitine shuttle  response to stress  cell cycle arrest  signal transduction  lipid biosynthetic process  positive regulation of autophagy  response to muscle activity  Wnt signaling pathway  macroautophagy  positive regulation of macroautophagy  regulation of macroautophagy  nuclear speck  nucleotide-activated protein kinase complex  cellular response to nutrient levels  negative regulation of TOR signaling  negative regulation of TOR signaling  histone serine kinase activity  histone serine kinase activity  histone-serine phosphorylation  intracellular signal transduction  cellular response to drug  cellular response to glucose starvation  cellular response to glucose starvation  regulation of fatty acid biosynthetic process  glucose homeostasis  regulation of circadian rhythm  negative regulation of apoptotic process  positive regulation of glycolytic process  metal ion binding  [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity  rhythmic process  [acetyl-CoA carboxylase] kinase activity  fatty acid homeostasis  cellular response to prostaglandin E stimulus  regulation of signal transduction by p53 class mediator  regulation of energy homeostasis  
Pathways : BIOCARTAChREBP regulation by carbohydrates and cAMP [Genes]    Reversal of Insulin Resistance by Leptin [Genes]   
Pathways : KEGG   
NDEx NetworkPRKAA2
Atlas of Cancer Signalling NetworkPRKAA2
Wikipedia pathwaysPRKAA2
Orthology - Evolution
OrthoDB5563
GeneTree (enSembl)ENSG00000162409
Phylogenetic Trees/Animal Genes : TreeFamPRKAA2
HOVERGENP54646
HOGENOMP54646
Homologs : HomoloGenePRKAA2
Homology/Alignments : Family Browser (UCSC)PRKAA2
Gene fusions - Rearrangements
Fusion : MitelmanBCAS3/PRKAA2 [17q23.2/1p32.2]  [t(1;17)(p32;q23)]  
Fusion: TCGABCAS3 17q23.2 PRKAA2 1p32.2 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPRKAA2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PRKAA2
dbVarPRKAA2
ClinVarPRKAA2
1000_GenomesPRKAA2 
Exome Variant ServerPRKAA2
ExAC (Exome Aggregation Consortium)PRKAA2 (select the gene name)
Genetic variants : HAPMAP5563
Genomic Variants (DGV)PRKAA2 [DGVbeta]
DECIPHERPRKAA2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPRKAA2 
Mutations
ICGC Data PortalPRKAA2 
TCGA Data PortalPRKAA2 
Broad Tumor PortalPRKAA2
OASIS PortalPRKAA2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPRKAA2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPRKAA2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PRKAA2
DgiDB (Drug Gene Interaction Database)PRKAA2
DoCM (Curated mutations)PRKAA2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PRKAA2 (select a term)
intoGenPRKAA2
Cancer3DPRKAA2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600497   
Orphanet
MedgenPRKAA2
Genetic Testing Registry PRKAA2
NextProtP54646 [Medical]
TSGene5563
GENETestsPRKAA2
Huge Navigator PRKAA2 [HugePedia]
snp3D : Map Gene to Disease5563
BioCentury BCIQPRKAA2
ClinGenPRKAA2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5563
Chemical/Pharm GKB GenePA33745
Clinical trialPRKAA2
Miscellaneous
canSAR (ICR)PRKAA2 (select the gene name)
Probes
Litterature
PubMed152 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePRKAA2
EVEXPRKAA2
GoPubMedPRKAA2
iHOPPRKAA2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 12:32:46 CEST 2017

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