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PRKRA (protein activator of interferon induced protein kinase EIF2AK2)

Identity

Alias_namesprotein kinase
Alias_symbol (synonym)PACT
RAX
HSD14
DYT16
Other alias
HGNC (Hugo) PRKRA
LocusID (NCBI) 8575
Atlas_Id 53143
Location 2q31.2  [Link to chromosome band 2q31]
Location_base_pair Starts at 178431414 and ends at 178450757 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
PRKRA (2q31.2) / AGPS (2q31.2)PRKRA 2q31.2 / AGPS 2q31.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PRKRA   9438
Cards
Entrez_Gene (NCBI)PRKRA  8575  protein activator of interferon induced protein kinase EIF2AK2
AliasesDYT16; HSD14; PACT; RAX
GeneCards (Weizmann)PRKRA
Ensembl hg19 (Hinxton)ENSG00000180228 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000180228 [Gene_View]  chr2:178431414-178450757 [Contig_View]  PRKRA [Vega]
ICGC DataPortalENSG00000180228
TCGA cBioPortalPRKRA
AceView (NCBI)PRKRA
Genatlas (Paris)PRKRA
WikiGenes8575
SOURCE (Princeton)PRKRA
Genetics Home Reference (NIH)PRKRA
Genomic and cartography
GoldenPath hg38 (UCSC)PRKRA  -     chr2:178431414-178450757 -  2q31.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PRKRA  -     2q31.2   [Description]    (hg19-Feb_2009)
EnsemblPRKRA - 2q31.2 [CytoView hg19]  PRKRA - 2q31.2 [CytoView hg38]
Mapping of homologs : NCBIPRKRA [Mapview hg19]  PRKRA [Mapview hg38]
OMIM603424   612067   
Gene and transcription
Genbank (Entrez)AA084317 AF072860 AF083033 AK092918 AK093360
RefSeq transcript (Entrez)NM_001139517 NM_001139518 NM_001316362 NM_003690
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PRKRA
Cluster EST : UnigeneHs.570274 [ NCBI ]
CGAP (NCI)Hs.570274
Alternative Splicing GalleryENSG00000180228
Gene ExpressionPRKRA [ NCBI-GEO ]   PRKRA [ EBI - ARRAY_EXPRESS ]   PRKRA [ SEEK ]   PRKRA [ MEM ]
Gene Expression Viewer (FireBrowse)PRKRA [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8575
GTEX Portal (Tissue expression)PRKRA
Protein : pattern, domain, 3D structure
UniProt/SwissProtO75569   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO75569  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO75569
Splice isoforms : SwissVarO75569
PhosPhoSitePlusO75569
Domaine pattern : Prosite (Expaxy)DS_RBD (PS50137)   
Domains : Interpro (EBI)dsRBD_dom    PRKRA    Staufen_C   
Domain families : Pfam (Sanger)dsrm (PF00035)    Staufen_C (PF16482)   
Domain families : Pfam (NCBI)pfam00035    pfam16482   
Domain families : Smart (EMBL)DSRM (SM00358)  
Conserved Domain (NCBI)PRKRA
DMDM Disease mutations8575
Blocks (Seattle)PRKRA
PDB (SRS)2DIX   
PDB (PDBSum)2DIX   
PDB (IMB)2DIX   
PDB (RSDB)2DIX   
Structural Biology KnowledgeBase2DIX   
SCOP (Structural Classification of Proteins)2DIX   
CATH (Classification of proteins structures)2DIX   
SuperfamilyO75569
Human Protein AtlasENSG00000180228
Peptide AtlasO75569
HPRD04573
IPIIPI00021167   IPI00718940   IPI00719567   IPI01009958   IPI00916597   IPI00915919   IPI00917410   
Protein Interaction databases
DIP (DOE-UCLA)O75569
IntAct (EBI)O75569
FunCoupENSG00000180228
BioGRIDPRKRA
STRING (EMBL)PRKRA
ZODIACPRKRA
Ontologies - Pathways
QuickGOO75569
Ontology : AmiGORNA binding  double-stranded RNA binding  protein binding  nucleoplasm  cytoplasm  cytosol  cytosol  protein phosphorylation  immune response  enzyme activator activity  negative regulation of cell proliferation  response to virus  membrane  enzyme binding  production of siRNA involved in RNA interference  gene silencing by RNA  pre-miRNA processing  cellular response to oxidative stress  production of miRNAs involved in gene silencing by miRNA  outer ear morphogenesis  middle ear morphogenesis  identical protein binding  protein homodimerization activity  positive regulation of catalytic activity  perinuclear region of cytoplasm  skeletal system morphogenesis  protein stabilization  RISC-loading complex  positive regulation of intrinsic apoptotic signaling pathway  
Ontology : EGO-EBIRNA binding  double-stranded RNA binding  protein binding  nucleoplasm  cytoplasm  cytosol  cytosol  protein phosphorylation  immune response  enzyme activator activity  negative regulation of cell proliferation  response to virus  membrane  enzyme binding  production of siRNA involved in RNA interference  gene silencing by RNA  pre-miRNA processing  cellular response to oxidative stress  production of miRNAs involved in gene silencing by miRNA  outer ear morphogenesis  middle ear morphogenesis  identical protein binding  protein homodimerization activity  positive regulation of catalytic activity  perinuclear region of cytoplasm  skeletal system morphogenesis  protein stabilization  RISC-loading complex  positive regulation of intrinsic apoptotic signaling pathway  
NDEx NetworkPRKRA
Atlas of Cancer Signalling NetworkPRKRA
Wikipedia pathwaysPRKRA
Orthology - Evolution
OrthoDB8575
GeneTree (enSembl)ENSG00000180228
Phylogenetic Trees/Animal Genes : TreeFamPRKRA
HOVERGENO75569
HOGENOMO75569
Homologs : HomoloGenePRKRA
Homology/Alignments : Family Browser (UCSC)PRKRA
Gene fusions - Rearrangements
Fusion : MitelmanPRKRA/AGPS [2q31.2/2q31.2]  
Fusion: TCGAPRKRA 2q31.2 AGPS 2q31.2 LUAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPRKRA [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PRKRA
dbVarPRKRA
ClinVarPRKRA
1000_GenomesPRKRA 
Exome Variant ServerPRKRA
ExAC (Exome Aggregation Consortium)PRKRA (select the gene name)
Genetic variants : HAPMAP8575
Genomic Variants (DGV)PRKRA [DGVbeta]
DECIPHERPRKRA [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPRKRA 
Mutations
ICGC Data PortalPRKRA 
TCGA Data PortalPRKRA 
Broad Tumor PortalPRKRA
OASIS PortalPRKRA [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPRKRA  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPRKRA
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PRKRA
DgiDB (Drug Gene Interaction Database)PRKRA
DoCM (Curated mutations)PRKRA (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PRKRA (select a term)
intoGenPRKRA
Cancer3DPRKRA(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603424    612067   
Orphanet18695   
MedgenPRKRA
Genetic Testing Registry PRKRA
NextProtO75569 [Medical]
TSGene8575
GENETestsPRKRA
Target ValidationPRKRA
Huge Navigator PRKRA [HugePedia]
snp3D : Map Gene to Disease8575
BioCentury BCIQPRKRA
ClinGenPRKRA
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8575
Chemical/Pharm GKB GenePA33780
Clinical trialPRKRA
Miscellaneous
canSAR (ICR)PRKRA (select the gene name)
Probes
Litterature
PubMed92 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePRKRA
EVEXPRKRA
GoPubMedPRKRA
iHOPPRKRA
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Aug 1 17:11:41 CEST 2017

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