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PRPF18 (pre-mRNA processing factor 18)

Identity

Alias (NCBI)PRP18
hPrp18
HGNC (Hugo) PRPF18
HGNC Alias symbhPrp18
HGNC Previous namePRP18 pre-mRNA processing factor 18 homolog (yeast)
 PRP18 pre-mRNA processing factor 18 homolog (S. cerevisiae)
LocusID (NCBI) 8559
Atlas_Id 72250
Location 10p13  [Link to chromosome band 10p13]
Location_base_pair Starts at 13586965 and ends at 13630859 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
PRPF18 (10p13) / CACNA1B (9q34.3)PRPF18 (10p13) / CACNB2 (10p12.33)PRPF18 (10p13) / CDC123 (10p13)
PRPF18 (10p13) / FDFT1 (8p23.1)PRPF18 (10p13) / MCM10 (10p13)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)PRPF18   17351
Cards
Entrez_Gene (NCBI)PRPF18    pre-mRNA processing factor 18
AliasesPRP18; hPrp18
GeneCards (Weizmann)PRPF18
Ensembl hg19 (Hinxton)ENSG00000165630 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000165630 [Gene_View]  ENSG00000165630 [Sequence]  chr10:13586965-13630859 [Contig_View]  PRPF18 [Vega]
ICGC DataPortalENSG00000165630
TCGA cBioPortalPRPF18
AceView (NCBI)PRPF18
Genatlas (Paris)PRPF18
SOURCE (Princeton)PRPF18
Genetics Home Reference (NIH)PRPF18
Genomic and cartography
GoldenPath hg38 (UCSC)PRPF18  -     chr10:13586965-13630859 +  10p13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PRPF18  -     10p13   [Description]    (hg19-Feb_2009)
GoldenPathPRPF18 - 10p13 [CytoView hg19]  PRPF18 - 10p13 [CytoView hg38]
ImmunoBaseENSG00000165630
Genome Data Viewer NCBIPRPF18 [Mapview hg19]  
OMIM604993   
Gene and transcription
Genbank (Entrez)AF087997 AI580379 AK056870 AK314814 AU142253
RefSeq transcript (Entrez)NM_003675
Consensus coding sequences : CCDS (NCBI)PRPF18
Gene ExpressionPRPF18 [ NCBI-GEO ]   PRPF18 [ EBI - ARRAY_EXPRESS ]   PRPF18 [ SEEK ]   PRPF18 [ MEM ]
Gene Expression Viewer (FireBrowse)PRPF18 [ Firebrowse - Broad ]
GenevisibleExpression of PRPF18 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8559
GTEX Portal (Tissue expression)PRPF18
Human Protein AtlasENSG00000165630-PRPF18 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ99633   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ99633  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ99633
PhosPhoSitePlusQ99633
Domains : Interpro (EBI)Prp18    PRP4-like    PRP4-like_sf    PRPF18   
Domain families : Pfam (Sanger)Prp18 (PF02840)    PRP4 (PF08799)   
Domain families : Pfam (NCBI)pfam02840    pfam08799   
Domain families : Smart (EMBL)SFM (SM00500)  
Conserved Domain (NCBI)PRPF18
PDB (RSDB)2DK4   
PDB Europe2DK4   
PDB (PDBSum)2DK4   
PDB (IMB)2DK4   
Structural Biology KnowledgeBase2DK4   
SCOP (Structural Classification of Proteins)2DK4   
CATH (Classification of proteins structures)2DK4   
SuperfamilyQ99633
AlphaFold pdb e-kbQ99633   
Human Protein Atlas [tissue]ENSG00000165630-PRPF18 [tissue]
HPRD05407
Protein Interaction databases
DIP (DOE-UCLA)Q99633
IntAct (EBI)Q99633
BioGRIDPRPF18
STRING (EMBL)PRPF18
ZODIACPRPF18
Ontologies - Pathways
QuickGOQ99633
Ontology : AmiGOgeneration of catalytic spliceosome for second transesterification step  protein binding  nucleus  spliceosomal complex  U5 snRNP  mRNA processing  RNA splicing  nuclear speck  U4/U6 x U5 tri-snRNP complex  U2-type post-spliceosomal complex  nuclear retention of unspliced pre-mRNA at the site of transcription  
Ontology : EGO-EBIgeneration of catalytic spliceosome for second transesterification step  protein binding  nucleus  spliceosomal complex  U5 snRNP  mRNA processing  RNA splicing  nuclear speck  U4/U6 x U5 tri-snRNP complex  U2-type post-spliceosomal complex  nuclear retention of unspliced pre-mRNA at the site of transcription  
NDEx NetworkPRPF18
Atlas of Cancer Signalling NetworkPRPF18
Wikipedia pathwaysPRPF18
Orthology - Evolution
OrthoDB8559
GeneTree (enSembl)ENSG00000165630
Phylogenetic Trees/Animal Genes : TreeFamPRPF18
Homologs : HomoloGenePRPF18
Homology/Alignments : Family Browser (UCSC)PRPF18
Gene fusions - Rearrangements
Fusion : QuiverPRPF18
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPRPF18 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PRPF18
dbVarPRPF18
ClinVarPRPF18
MonarchPRPF18
1000_GenomesPRPF18 
Exome Variant ServerPRPF18
GNOMAD BrowserENSG00000165630
Varsome BrowserPRPF18
ACMGPRPF18 variants
VarityQ99633
Genomic Variants (DGV)PRPF18 [DGVbeta]
DECIPHERPRPF18 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPRPF18 
Mutations
ICGC Data PortalPRPF18 
TCGA Data PortalPRPF18 
Broad Tumor PortalPRPF18
OASIS PortalPRPF18 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPRPF18  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPRPF18
Mutations and Diseases : HGMDPRPF18
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaPRPF18
DgiDB (Drug Gene Interaction Database)PRPF18
DoCM (Curated mutations)PRPF18
CIViC (Clinical Interpretations of Variants in Cancer)PRPF18
Cancer3DPRPF18
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604993   
Orphanet
DisGeNETPRPF18
MedgenPRPF18
Genetic Testing Registry PRPF18
NextProtQ99633 [Medical]
GENETestsPRPF18
Target ValidationPRPF18
Huge Navigator PRPF18 [HugePedia]
ClinGenPRPF18
Clinical trials, drugs, therapy
MyCancerGenomePRPF18
Protein Interactions : CTDPRPF18
Pharm GKB GenePA38449
PharosQ99633
Clinical trialPRPF18
Miscellaneous
canSAR (ICR)PRPF18
HarmonizomePRPF18
DataMed IndexPRPF18
Probes
Litterature
PubMed21 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXPRPF18
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 16:17:14 CEST 2021

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