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PRPF18 (pre-mRNA processing factor 18)

Identity

Alias_namesPRP18 pre-mRNA processing factor 18 homolog (yeast)
PRP18 pre-mRNA processing factor 18 homolog (S. cerevisiae)
Alias_symbol (synonym)hPrp18
Other aliasPRP18
HGNC (Hugo) PRPF18
LocusID (NCBI) 8559
Atlas_Id 72250
Location 10p13  [Link to chromosome band 10p13]
Location_base_pair Starts at 13586939 and ends at 13630868 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
PRPF18 (10p13) / CACNA1B (9q34.3)PRPF18 (10p13) / CACNB2 (10p12.33)PRPF18 (10p13) / CDC123 (10p13)
PRPF18 (10p13) / FDFT1 (8p23.1)PRPF18 (10p13) / MCM10 (10p13)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PRPF18   17351
Cards
Entrez_Gene (NCBI)PRPF18  8559  pre-mRNA processing factor 18
AliasesPRP18; hPrp18
GeneCards (Weizmann)PRPF18
Ensembl hg19 (Hinxton)ENSG00000165630 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000165630 [Gene_View]  chr10:13586939-13630868 [Contig_View]  PRPF18 [Vega]
ICGC DataPortalENSG00000165630
TCGA cBioPortalPRPF18
AceView (NCBI)PRPF18
Genatlas (Paris)PRPF18
WikiGenes8559
SOURCE (Princeton)PRPF18
Genetics Home Reference (NIH)PRPF18
Genomic and cartography
GoldenPath hg38 (UCSC)PRPF18  -     chr10:13586939-13630868 +  10p13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PRPF18  -     10p13   [Description]    (hg19-Feb_2009)
EnsemblPRPF18 - 10p13 [CytoView hg19]  PRPF18 - 10p13 [CytoView hg38]
Mapping of homologs : NCBIPRPF18 [Mapview hg19]  PRPF18 [Mapview hg38]
OMIM604993   
Gene and transcription
Genbank (Entrez)AF087997 AI580379 AK056870 AK314814 AU142253
RefSeq transcript (Entrez)NM_003675
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PRPF18
Cluster EST : UnigeneHs.729158 [ NCBI ]
CGAP (NCI)Hs.729158
Alternative Splicing GalleryENSG00000165630
Gene ExpressionPRPF18 [ NCBI-GEO ]   PRPF18 [ EBI - ARRAY_EXPRESS ]   PRPF18 [ SEEK ]   PRPF18 [ MEM ]
Gene Expression Viewer (FireBrowse)PRPF18 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8559
GTEX Portal (Tissue expression)PRPF18
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ99633   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ99633  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ99633
Splice isoforms : SwissVarQ99633
PhosPhoSitePlusQ99633
Domains : Interpro (EBI)Prp18    PRP4-like   
Domain families : Pfam (Sanger)Prp18 (PF02840)    PRP4 (PF08799)   
Domain families : Pfam (NCBI)pfam02840    pfam08799   
Domain families : Smart (EMBL)SFM (SM00500)  
Conserved Domain (NCBI)PRPF18
DMDM Disease mutations8559
Blocks (Seattle)PRPF18
PDB (SRS)2DK4   
PDB (PDBSum)2DK4   
PDB (IMB)2DK4   
PDB (RSDB)2DK4   
Structural Biology KnowledgeBase2DK4   
SCOP (Structural Classification of Proteins)2DK4   
CATH (Classification of proteins structures)2DK4   
SuperfamilyQ99633
Human Protein AtlasENSG00000165630
Peptide AtlasQ99633
HPRD05407
IPIIPI00021146   IPI00024021   IPI00105539   IPI00647857   IPI00644341   
Protein Interaction databases
DIP (DOE-UCLA)Q99633
IntAct (EBI)Q99633
FunCoupENSG00000165630
BioGRIDPRPF18
STRING (EMBL)PRPF18
ZODIACPRPF18
Ontologies - Pathways
QuickGOQ99633
Ontology : AmiGOgeneration of catalytic spliceosome for second transesterification step  second spliceosomal transesterification activity  nucleus  spliceosomal complex  U5 snRNP  mRNA processing  RNA splicing  nuclear speck  U4/U6 x U5 tri-snRNP complex  U2-type post-spliceosomal complex  nuclear retention of unspliced pre-mRNA at the site of transcription  
Ontology : EGO-EBIgeneration of catalytic spliceosome for second transesterification step  second spliceosomal transesterification activity  nucleus  spliceosomal complex  U5 snRNP  mRNA processing  RNA splicing  nuclear speck  U4/U6 x U5 tri-snRNP complex  U2-type post-spliceosomal complex  nuclear retention of unspliced pre-mRNA at the site of transcription  
Pathways : KEGGSpliceosome   
NDEx NetworkPRPF18
Atlas of Cancer Signalling NetworkPRPF18
Wikipedia pathwaysPRPF18
Orthology - Evolution
OrthoDB8559
GeneTree (enSembl)ENSG00000165630
Phylogenetic Trees/Animal Genes : TreeFamPRPF18
HOVERGENQ99633
HOGENOMQ99633
Homologs : HomoloGenePRPF18
Homology/Alignments : Family Browser (UCSC)PRPF18
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPRPF18 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PRPF18
dbVarPRPF18
ClinVarPRPF18
1000_GenomesPRPF18 
Exome Variant ServerPRPF18
ExAC (Exome Aggregation Consortium)PRPF18 (select the gene name)
Genetic variants : HAPMAP8559
Genomic Variants (DGV)PRPF18 [DGVbeta]
DECIPHERPRPF18 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPRPF18 
Mutations
ICGC Data PortalPRPF18 
TCGA Data PortalPRPF18 
Broad Tumor PortalPRPF18
OASIS PortalPRPF18 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPRPF18  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPRPF18
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PRPF18
DgiDB (Drug Gene Interaction Database)PRPF18
DoCM (Curated mutations)PRPF18 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PRPF18 (select a term)
intoGenPRPF18
Cancer3DPRPF18(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604993   
Orphanet
MedgenPRPF18
Genetic Testing Registry PRPF18
NextProtQ99633 [Medical]
TSGene8559
GENETestsPRPF18
Target ValidationPRPF18
Huge Navigator PRPF18 [HugePedia]
snp3D : Map Gene to Disease8559
BioCentury BCIQPRPF18
ClinGenPRPF18
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8559
Chemical/Pharm GKB GenePA38449
Clinical trialPRPF18
Miscellaneous
canSAR (ICR)PRPF18 (select the gene name)
Probes
Litterature
PubMed16 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePRPF18
EVEXPRPF18
GoPubMedPRPF18
iHOPPRPF18
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 13:35:21 CEST 2017

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