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PRSS1 (protease, serine, 1 (trypsin 1))

Identity

Other namesTRP1
TRY1
TRY4
TRYP1
HGNC (Hugo) PRSS1
LocusID (NCBI) 5644
Location 7q34
Location_base_pair Starts at 142457319 and ends at 142460927 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)PRSS1   9475
Cards
Entrez_Gene (NCBI)PRSS1  5644  protease, serine, 1 (trypsin 1)
GeneCards (Weizmann)PRSS1
Ensembl hg19 (Hinxton)ENSG00000204983 [Gene_View]  chr7:142457319-142460927 [Contig_View]  PRSS1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000204983 [Gene_View]  chr7:142457319-142460927 [Contig_View]  PRSS1 [Vega]
ICGC DataPortalENSG00000204983
cBioPortalPRSS1
AceView (NCBI)PRSS1
Genatlas (Paris)PRSS1
WikiGenes5644
SOURCE (Princeton)PRSS1
Genomic and cartography
GoldenPath hg19 (UCSC)PRSS1  -     chr7:142457319-142460927 +  7q34   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PRSS1  -     7q34   [Description]    (hg38-Dec_2013)
EnsemblPRSS1 - 7q34 [CytoView hg19]  PRSS1 - 7q34 [CytoView hg38]
Mapping of homologs : NCBIPRSS1 [Mapview hg19]  PRSS1 [Mapview hg38]
OMIM167800   276000   614044   
Gene and transcription
Genbank (Entrez)AA835201 AK293375 AK312199 BC035777 BC128226
RefSeq transcript (Entrez)NM_002769
RefSeq genomic (Entrez)AC_000139 NC_000007 NC_018918 NG_001333 NG_008307 NT_007933 NT_187562 NW_001839073 NW_004929333
Consensus coding sequences : CCDS (NCBI)PRSS1
Cluster EST : UnigeneHs.449281 [ NCBI ]
CGAP (NCI)Hs.449281
Alternative Splicing : Fast-db (Paris)GSHG0027805
Alternative Splicing GalleryENSG00000204983
Gene ExpressionPRSS1 [ NCBI-GEO ]     PRSS1 [ SEEK ]   PRSS1 [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP07477 (Uniprot)
NextProtP07477  [Medical]
With graphics : InterProP07477
Splice isoforms : SwissVarP07477 (Swissvar)
Catalytic activity : Enzyme3.4.21.4 [ Enzyme-Expasy ]   3.4.21.43.4.21.4 [ IntEnz-EBI ]   3.4.21.4 [ BRENDA ]   3.4.21.4 [ KEGG ]   
Domaine pattern : Prosite (Expaxy)TRYPSIN_DOM (PS50240)    TRYPSIN_HIS (PS00134)    TRYPSIN_SER (PS00135)   
Domains : Interpro (EBI)Peptidase_S1    Peptidase_S1_AS    Peptidase_S1A    Trypsin-like_Pept_dom   
Related proteins : CluSTrP07477
Domain families : Pfam (Sanger)Trypsin (PF00089)   
Domain families : Pfam (NCBI)pfam00089   
Domain families : Smart (EMBL)Tryp_SPc (SM00020)  
DMDM Disease mutations5644
Blocks (Seattle)P07477
PDB (SRS)1FXY    1TRN    2RA3   
PDB (PDBSum)1FXY    1TRN    2RA3   
PDB (IMB)1FXY    1TRN    2RA3   
PDB (RSDB)1FXY    1TRN    2RA3   
Human Protein AtlasENSG00000204983
Peptide AtlasP07477
HPRD02039
IPIIPI00815665   
Protein Interaction databases
DIP (DOE-UCLA)P07477
IntAct (EBI)P07477
FunCoupENSG00000204983
BioGRIDPRSS1
IntegromeDBPRSS1
STRING (EMBL)PRSS1
Ontologies - Pathways
QuickGOP07477
Ontology : AmiGOserine-type endopeptidase activity  extracellular region  extracellular region  proteolysis  vitamin metabolic process  water-soluble vitamin metabolic process  digestion  cobalamin metabolic process  extracellular matrix disassembly  extracellular matrix organization  small molecule metabolic process  metal ion binding  extracellular vesicular exosome  blood microparticle  
Ontology : EGO-EBIserine-type endopeptidase activity  extracellular region  extracellular region  proteolysis  vitamin metabolic process  water-soluble vitamin metabolic process  digestion  cobalamin metabolic process  extracellular matrix disassembly  extracellular matrix organization  small molecule metabolic process  metal ion binding  extracellular vesicular exosome  blood microparticle  
Pathways : KEGGNeuroactive ligand-receptor interaction    Pancreatic secretion    Protein digestion and absorption    Influenza A   
Protein Interaction DatabasePRSS1
DoCM (Curated mutations)PRSS1
Wikipedia pathwaysPRSS1
Gene fusion - rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerPRSS1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PRSS1
dbVarPRSS1
ClinVarPRSS1
1000_GenomesPRSS1 
Exome Variant ServerPRSS1
SNP (GeneSNP Utah)PRSS1
SNP : HGBasePRSS1
Genetic variants : HAPMAPPRSS1
Genomic VariantsPRSS1  PRSS1 [DGVbeta]
Mutations
ICGC Data PortalENSG00000204983 
Somatic Mutations in Cancer : COSMICPRSS1 
CONAN: Copy Number AnalysisPRSS1 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)7:142457319-142460927
Mutations and Diseases : HGMDPRSS1
OMIM167800    276000    614044   
MedgenPRSS1
NextProtP07477 [Medical]
GENETestsPRSS1
Disease Genetic AssociationPRSS1
Huge Navigator PRSS1 [HugePedia]  PRSS1 [HugeCancerGEM]
snp3D : Map Gene to Disease5644
DGIdb (Drug Gene Interaction db)PRSS1
General knowledge
Homologs : HomoloGenePRSS1
Homology/Alignments : Family Browser (UCSC)PRSS1
Phylogenetic Trees/Animal Genes : TreeFamPRSS1
Chemical/Protein Interactions : CTD5644
Chemical/Pharm GKB GenePA33828
Clinical trialPRSS1
Cancer Resource (Charite)ENSG00000204983
Other databases
Probes
Litterature
PubMed145 Pubmed reference(s) in Entrez
CoreMinePRSS1
GoPubMedPRSS1
iHOPPRSS1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2014Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sun Dec 21 01:00:25 CET 2014

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