Atlas of Genetics and Cytogenetics in Oncology and Haematology

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PRSS3 (serine protease 3)

Identity

Alias_namesPRSS4
protease, serine, 4 (trypsin 4, brain)
protease, serine, 3 (mesotrypsin)
Alias_symbol (synonym)TRY3
TRY4
Other aliasMTG
T9
HGNC (Hugo) PRSS3
LocusID (NCBI) 5646
Atlas_Id 45981
Location 9p13.3  [Link to chromosome band 9p13]
Location_base_pair Starts at 33750466 and ends at 33799231 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
RNF19A (8q22.2) / PRSS3 (9p13.3)UBE2R2 (9p13.3) / PRSS3 (9p13.3)ZCCHC7 (9p13.2) / PRSS3 (9p13.3)
RNF19A 8q22.2 / PRSS3 9p13.3UBE2R2 9p13.3 / PRSS3 9p13.3ZCCHC7 9p13.2 / PRSS3 9p13.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 3 ]
  t(8;9)(q22;p13) RNF19A/PRSS3
t(9;9)(p13;p13) UBE2R2/PRSS3
t(9;9)(p13;p13) ZCCHC7/PRSS3

External links

Nomenclature
HGNC (Hugo)PRSS3   9486
Cards
Entrez_Gene (NCBI)PRSS3  5646  serine protease 3
AliasesMTG; PRSS4; T9; TRY3; 
TRY4
GeneCards (Weizmann)PRSS3
Ensembl hg19 (Hinxton)ENSG00000010438 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000010438 [Gene_View]  chr9:33750466-33799231 [Contig_View]  PRSS3 [Vega]
ICGC DataPortalENSG00000010438
TCGA cBioPortalPRSS3
AceView (NCBI)PRSS3
Genatlas (Paris)PRSS3
WikiGenes5646
SOURCE (Princeton)PRSS3
Genetics Home Reference (NIH)PRSS3
Genomic and cartography
GoldenPath hg38 (UCSC)PRSS3  -     chr9:33750466-33799231 +  9p13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PRSS3  -     9p13.3   [Description]    (hg19-Feb_2009)
EnsemblPRSS3 - 9p13.3 [CytoView hg19]  PRSS3 - 9p13.3 [CytoView hg38]
Mapping of homologs : NCBIPRSS3 [Mapview hg19]  PRSS3 [Mapview hg38]
OMIM613578   
Gene and transcription
Genbank (Entrez)AB298285 AB298286 AY052783 BC030238 BC069476
RefSeq transcript (Entrez)NM_001197097 NM_001197098 NM_002771 NM_007343
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PRSS3
Cluster EST : UnigeneHs.654513 [ NCBI ]
CGAP (NCI)Hs.654513
Alternative Splicing GalleryENSG00000010438
Gene ExpressionPRSS3 [ NCBI-GEO ]   PRSS3 [ EBI - ARRAY_EXPRESS ]   PRSS3 [ SEEK ]   PRSS3 [ MEM ]
Gene Expression Viewer (FireBrowse)PRSS3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5646
GTEX Portal (Tissue expression)PRSS3
Human Protein AtlasENSG00000010438-PRSS3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP35030   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP35030  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP35030
Splice isoforms : SwissVarP35030
Catalytic activity : Enzyme3.4.21.4 [ Enzyme-Expasy ]   3.4.21.43.4.21.4 [ IntEnz-EBI ]   3.4.21.4 [ BRENDA ]   3.4.21.4 [ KEGG ]   
PhosPhoSitePlusP35030
Domaine pattern : Prosite (Expaxy)TRYPSIN_DOM (PS50240)    TRYPSIN_HIS (PS00134)   
Domains : Interpro (EBI)Peptidase_S1_PA    Peptidase_S1A    Trypsin_dom    TRYPSIN_HIS   
Domain families : Pfam (Sanger)Trypsin (PF00089)   
Domain families : Pfam (NCBI)pfam00089   
Domain families : Smart (EMBL)Tryp_SPc (SM00020)  
Conserved Domain (NCBI)PRSS3
DMDM Disease mutations5646
Blocks (Seattle)PRSS3
PDB (SRS)1H4W    2R9P    3L33    3L3T    3P92    3P95    4DG4    4U30    4U32    5C67   
PDB (PDBSum)1H4W    2R9P    3L33    3L3T    3P92    3P95    4DG4    4U30    4U32    5C67   
PDB (IMB)1H4W    2R9P    3L33    3L3T    3P92    3P95    4DG4    4U30    4U32    5C67   
PDB (RSDB)1H4W    2R9P    3L33    3L3T    3P92    3P95    4DG4    4U30    4U32    5C67   
Structural Biology KnowledgeBase1H4W    2R9P    3L33    3L3T    3P92    3P95    4DG4    4U30    4U32    5C67   
SCOP (Structural Classification of Proteins)1H4W    2R9P    3L33    3L3T    3P92    3P95    4DG4    4U30    4U32    5C67   
CATH (Classification of proteins structures)1H4W    2R9P    3L33    3L3T    3P92    3P95    4DG4    4U30    4U32    5C67   
SuperfamilyP35030
Human Protein Atlas [tissue]ENSG00000010438-PRSS3 [tissue]
Peptide AtlasP35030
HPRD06685
IPIIPI00015614   IPI00220839   IPI00843764   IPI00011695   IPI00976080   IPI00984586   
Protein Interaction databases
DIP (DOE-UCLA)P35030
IntAct (EBI)P35030
FunCoupENSG00000010438
BioGRIDPRSS3
STRING (EMBL)PRSS3
ZODIACPRSS3
Ontologies - Pathways
QuickGOP35030
Ontology : AmiGOserine-type endopeptidase activity  calcium ion binding  protein binding  extracellular region  extracellular space  proteolysis  proteolysis  digestion  serine-type peptidase activity  cobalamin metabolic process  antimicrobial humoral response  zymogen activation  neutrophil degranulation  endothelial cell migration  extracellular exosome  tertiary granule lumen  
Ontology : EGO-EBIserine-type endopeptidase activity  calcium ion binding  protein binding  extracellular region  extracellular space  proteolysis  proteolysis  digestion  serine-type peptidase activity  cobalamin metabolic process  antimicrobial humoral response  zymogen activation  neutrophil degranulation  endothelial cell migration  extracellular exosome  tertiary granule lumen  
NDEx NetworkPRSS3
Atlas of Cancer Signalling NetworkPRSS3
Wikipedia pathwaysPRSS3
Orthology - Evolution
OrthoDB5646
GeneTree (enSembl)ENSG00000010438
Phylogenetic Trees/Animal Genes : TreeFamPRSS3
HOVERGENP35030
HOGENOMP35030
Homologs : HomoloGenePRSS3
Homology/Alignments : Family Browser (UCSC)PRSS3
Gene fusions - Rearrangements
Fusion : MitelmanRNF19A/PRSS3 [8q22.2/9p13.3]  [t(8;9)(q22;p13)]  
Fusion : MitelmanUBE2R2/PRSS3 [9p13.3/9p13.3]  [t(9;9)(p13;p13)]  
Fusion : MitelmanZCCHC7/PRSS3 [9p13.2/9p13.3]  [t(9;9)(p13;p13)]  
Fusion: TCGA_MDACCRNF19A 8q22.2 PRSS3 9p13.3 LUSC
Fusion: TCGA_MDACCUBE2R2 9p13.3 PRSS3 9p13.3 LUSC
Fusion: TCGA_MDACCZCCHC7 9p13.2 PRSS3 9p13.3 OV
Fusion PortalRNF19A 8q22.2 PRSS3 9p13.3 LUSC
Fusion PortalUBE2R2 9p13.3 PRSS3 9p13.3 LUSC
Fusion PortalZCCHC7 9p13.2 PRSS3 9p13.3 OV
Fusion : QuiverPRSS3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPRSS3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PRSS3
dbVarPRSS3
ClinVarPRSS3
1000_GenomesPRSS3 
Exome Variant ServerPRSS3
ExAC (Exome Aggregation Consortium)ENSG00000010438
GNOMAD BrowserENSG00000010438
Genetic variants : HAPMAP5646
Genomic Variants (DGV)PRSS3 [DGVbeta]
DECIPHERPRSS3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPRSS3 
Mutations
ICGC Data PortalPRSS3 
TCGA Data PortalPRSS3 
Broad Tumor PortalPRSS3
OASIS PortalPRSS3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPRSS3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPRSS3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PRSS3
DgiDB (Drug Gene Interaction Database)PRSS3
DoCM (Curated mutations)PRSS3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PRSS3 (select a term)
intoGenPRSS3
Cancer3DPRSS3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM613578   
Orphanet
DisGeNETPRSS3
MedgenPRSS3
Genetic Testing Registry PRSS3
NextProtP35030 [Medical]
TSGene5646
GENETestsPRSS3
Target ValidationPRSS3
Huge Navigator PRSS3 [HugePedia]
snp3D : Map Gene to Disease5646
BioCentury BCIQPRSS3
ClinGenPRSS3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5646
Chemical/Pharm GKB GenePA33838
Clinical trialPRSS3
Miscellaneous
canSAR (ICR)PRSS3 (select the gene name)
Probes
Litterature
PubMed46 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePRSS3
EVEXPRSS3
GoPubMedPRSS3
iHOPPRSS3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Feb 28 13:32:44 CET 2018
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