Atlas of Genetics and Cytogenetics in Oncology and Haematology

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PRUNE2 (prune homolog 2 with BCH domain)

Identity

Alias_namesC9orf65
KIAA0367
chromosome 9 open reading frame 65
KIAA0367
prune homolog 2 (Drosophila)
prune homolog 2
Alias_symbol (synonym)BMCC1
BNIPXL
A214N16.3
bA214N16.3
Other alias
HGNC (Hugo) PRUNE2
LocusID (NCBI) 158471
Atlas_Id 43690
Location 9q21.2  [Link to chromosome band 9q21]
Location_base_pair Starts at 76611376 and ends at 76906114 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
PRUNE2 (9q21.2) / GNAQ (9q21.2)PRUNE2 (9q21.2) / TOR1AIP1 (1q25.2)PRUNE2 9q21.2 / GNAQ 9q21.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  PRUNE2/GNAQ (9q21)

External links

Nomenclature
HGNC (Hugo)PRUNE2   25209
Cards
Entrez_Gene (NCBI)PRUNE2  158471  prune homolog 2 with BCH domain
AliasesBMCC1; BNIPXL; C9orf65; KIAA0367
GeneCards (Weizmann)PRUNE2
Ensembl hg19 (Hinxton)ENSG00000106772 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000106772 [Gene_View]  ENSG00000106772 [Sequence]  chr9:76611376-76906114 [Contig_View]  PRUNE2 [Vega]
ICGC DataPortalENSG00000106772
TCGA cBioPortalPRUNE2
AceView (NCBI)PRUNE2
Genatlas (Paris)PRUNE2
WikiGenes158471
SOURCE (Princeton)PRUNE2
Genetics Home Reference (NIH)PRUNE2
Genomic and cartography
GoldenPath hg38 (UCSC)PRUNE2  -     chr9:76611376-76906114 -  9q21.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PRUNE2  -     9q21.2   [Description]    (hg19-Feb_2009)
GoldenPathPRUNE2 - 9q21.2 [CytoView hg19]  PRUNE2 - 9q21.2 [CytoView hg38]
Genome Data Viewer NCBIPRUNE2 [Mapview hg19]  
OMIM610691   
Gene and transcription
Genbank (Entrez)AB002365 AB050197 AB535152 AK296269 AK298805
RefSeq transcript (Entrez)NM_001308047 NM_001308048 NM_001308049 NM_001308050 NM_001308051 NM_001330680 NM_015225 NM_138818
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PRUNE2
Alternative Splicing GalleryENSG00000106772
Gene ExpressionPRUNE2 [ NCBI-GEO ]   PRUNE2 [ EBI - ARRAY_EXPRESS ]   PRUNE2 [ SEEK ]   PRUNE2 [ MEM ]
Gene Expression Viewer (FireBrowse)PRUNE2 [ Firebrowse - Broad ]
GenevisibleExpression of PRUNE2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)158471
GTEX Portal (Tissue expression)PRUNE2
Human Protein AtlasENSG00000106772-PRUNE2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8WUY3   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8WUY3  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8WUY3
Splice isoforms : SwissVarQ8WUY3
PhosPhoSitePlusQ8WUY3
Domaine pattern : Prosite (Expaxy)CRAL_TRIO (PS50191)   
Domains : Interpro (EBI)Bcl2-/adenovirus-E1B    CRAL-TRIO_dom    CRAL-TRIO_dom_sf    DHH_sf    DHHA2   
Domain families : Pfam (Sanger)BNIP2 (PF12496)    CRAL_TRIO_2 (PF13716)    DHHA2 (PF02833)   
Domain families : Pfam (NCBI)pfam12496    pfam13716    pfam02833   
Domain families : Smart (EMBL)DHHA2 (SM01131)  SEC14 (SM00516)  
Conserved Domain (NCBI)PRUNE2
DMDM Disease mutations158471
SuperfamilyQ8WUY3
Human Protein Atlas [tissue]ENSG00000106772-PRUNE2 [tissue]
Peptide AtlasQ8WUY3
HPRD12970
IPIIPI00853158   IPI00967031   IPI00966736   IPI00888914   IPI00941707   IPI00828096   IPI00939382   IPI01008814   IPI00641533   IPI00607780   
Protein Interaction databases
DIP (DOE-UCLA)Q8WUY3
IntAct (EBI)Q8WUY3
FunCoupENSG00000106772
BioGRIDPRUNE2
STRING (EMBL)PRUNE2
ZODIACPRUNE2
Ontologies - Pathways
QuickGOQ8WUY3
Ontology : AmiGOexopolyphosphatase activity  cytoplasm  polyphosphate catabolic process  apoptotic process  metal ion binding  
Ontology : EGO-EBIexopolyphosphatase activity  cytoplasm  polyphosphate catabolic process  apoptotic process  metal ion binding  
NDEx NetworkPRUNE2
Atlas of Cancer Signalling NetworkPRUNE2
Wikipedia pathwaysPRUNE2
Orthology - Evolution
OrthoDB158471
GeneTree (enSembl)ENSG00000106772
Phylogenetic Trees/Animal Genes : TreeFamPRUNE2
HOGENOMQ8WUY3
Homologs : HomoloGenePRUNE2
Homology/Alignments : Family Browser (UCSC)PRUNE2
Gene fusions - Rearrangements
Fusion : MitelmanPRUNE2/GNAQ [9q21.2/9q21.2]  
Fusion PortalPRUNE2 9q21.2 GNAQ 9q21.2 BRCA
Fusion : QuiverPRUNE2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPRUNE2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PRUNE2
dbVarPRUNE2
ClinVarPRUNE2
1000_GenomesPRUNE2 
Exome Variant ServerPRUNE2
GNOMAD BrowserENSG00000106772
Varsome BrowserPRUNE2
Genetic variants : HAPMAP158471
Genomic Variants (DGV)PRUNE2 [DGVbeta]
DECIPHERPRUNE2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPRUNE2 
Mutations
ICGC Data PortalPRUNE2 
TCGA Data PortalPRUNE2 
Broad Tumor PortalPRUNE2
OASIS PortalPRUNE2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPRUNE2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPRUNE2
Mutations and Diseases : HGMDPRUNE2
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
BioMutaselect PRUNE2
DgiDB (Drug Gene Interaction Database)PRUNE2
DoCM (Curated mutations)PRUNE2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PRUNE2 (select a term)
intoGenPRUNE2
Cancer3DPRUNE2 (select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610691   
Orphanet
DisGeNETPRUNE2
MedgenPRUNE2
Genetic Testing Registry PRUNE2
NextProtQ8WUY3 [Medical]
TSGene158471
GENETestsPRUNE2
Open Targets GeneticsENSG00000106772  [validation]
snp3D : Map Gene to Disease158471
BioCentury BCIQPRUNE2
ClinGenPRUNE2
Clinical trials, drugs, therapy
Protein Interactions : CTD158471
Pharm GKB GenePA162400198
Clinical trialPRUNE2
Miscellaneous
canSAR (ICR)PRUNE2 (select the gene name)
HarmonizomePRUNE2
DataMed IndexPRUNE2
Probes
Litterature
PubMed38 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePRUNE2
EVEXPRUNE2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sat Jul 11 20:07:02 CEST 2020
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