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PTCRA (pre T cell antigen receptor alpha)

Identity

Alias_symbol (synonym)PTA
PT-ALPHA
Other alias
HGNC (Hugo) PTCRA
LocusID (NCBI) 171558
Atlas_Id 43929
Location 6p21.1  [Link to chromosome band 6p21]
Location_base_pair Starts at 42915989 and ends at 42925837 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
FAM168A (11q13.4) / PTCRA (6p21.1)PTK7 (6p21.1) / PTCRA (6p21.1)FAM168A 11q13.4 / PTCRA 6p21.1
PTK7 6p21.1 / PTCRA 6p21.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  PTK7/PTCRA (6p21)
t(6;11)(p21;q13) FAM168A/PTCRA


External links

Nomenclature
HGNC (Hugo)PTCRA   21290
Cards
Entrez_Gene (NCBI)PTCRA  171558  pre T cell antigen receptor alpha
AliasesPT-ALPHA; PTA
GeneCards (Weizmann)PTCRA
Ensembl hg19 (Hinxton)ENSG00000171611 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000171611 [Gene_View]  ENSG00000171611 [Sequence]  chr6:42915989-42925837 [Contig_View]  PTCRA [Vega]
ICGC DataPortalENSG00000171611
TCGA cBioPortalPTCRA
AceView (NCBI)PTCRA
Genatlas (Paris)PTCRA
WikiGenes171558
SOURCE (Princeton)PTCRA
Genetics Home Reference (NIH)PTCRA
Genomic and cartography
GoldenPath hg38 (UCSC)PTCRA  -     chr6:42915989-42925837 +  6p21.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PTCRA  -     6p21.1   [Description]    (hg19-Feb_2009)
EnsemblPTCRA - 6p21.1 [CytoView hg19]  PTCRA - 6p21.1 [CytoView hg38]
Mapping of homologs : NCBIPTCRA [Mapview hg19]  PTCRA [Mapview hg38]
OMIM606817   
Gene and transcription
Genbank (Entrez)AF101436 AF165312 AK130819 AK303523 AK310559
RefSeq transcript (Entrez)NM_001243168 NM_001243169 NM_001243170 NM_138296
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PTCRA
Cluster EST : UnigeneHs.169002 [ NCBI ]
CGAP (NCI)Hs.169002
Alternative Splicing GalleryENSG00000171611
Gene ExpressionPTCRA [ NCBI-GEO ]   PTCRA [ EBI - ARRAY_EXPRESS ]   PTCRA [ SEEK ]   PTCRA [ MEM ]
Gene Expression Viewer (FireBrowse)PTCRA [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)171558
GTEX Portal (Tissue expression)PTCRA
Human Protein AtlasENSG00000171611-PTCRA [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ6ISU1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ6ISU1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ6ISU1
Splice isoforms : SwissVarQ6ISU1
PhosPhoSitePlusQ6ISU1
Domains : Interpro (EBI)Ig-like_dom_sf    Ig-like_fold    PTCRA   
Domain families : Pfam (Sanger)PTCRA (PF15028)   
Domain families : Pfam (NCBI)pfam15028   
Conserved Domain (NCBI)PTCRA
DMDM Disease mutations171558
Blocks (Seattle)PTCRA
PDB (SRS)3OF6   
PDB (PDBSum)3OF6   
PDB (IMB)3OF6   
PDB (RSDB)3OF6   
Structural Biology KnowledgeBase3OF6   
SCOP (Structural Classification of Proteins)3OF6   
CATH (Classification of proteins structures)3OF6   
SuperfamilyQ6ISU1
Human Protein Atlas [tissue]ENSG00000171611-PTCRA [tissue]
Peptide AtlasQ6ISU1
HPRD08435
IPIIPI00514715   IPI00885032   IPI00884912   IPI00419990   IPI00941945   
Protein Interaction databases
DIP (DOE-UCLA)Q6ISU1
IntAct (EBI)Q6ISU1
FunCoupENSG00000171611
BioGRIDPTCRA
STRING (EMBL)PTCRA
ZODIACPTCRA
Ontologies - Pathways
QuickGOQ6ISU1
Ontology : AmiGOprotein binding  integral component of membrane  negative regulation of thymocyte apoptotic process  
Ontology : EGO-EBIprotein binding  integral component of membrane  negative regulation of thymocyte apoptotic process  
Pathways : KEGGNotch signaling pathway    Transcriptional misregulation in cancer   
NDEx NetworkPTCRA
Atlas of Cancer Signalling NetworkPTCRA
Wikipedia pathwaysPTCRA
Orthology - Evolution
OrthoDB171558
GeneTree (enSembl)ENSG00000171611
Phylogenetic Trees/Animal Genes : TreeFamPTCRA
HOVERGENQ6ISU1
HOGENOMQ6ISU1
Homologs : HomoloGenePTCRA
Homology/Alignments : Family Browser (UCSC)PTCRA
Gene fusions - Rearrangements
Fusion : MitelmanFAM168A/PTCRA [11q13.4/6p21.1]  [t(6;11)(p21;q13)]  
Fusion : MitelmanPTK7/PTCRA [6p21.1/6p21.1]  [t(6;6)(p21;p21)]  
Fusion PortalFAM168A 11q13.4 PTCRA 6p21.1 BRCA
Fusion PortalPTK7 6p21.1 PTCRA 6p21.1 BRCA
Fusion : QuiverPTCRA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPTCRA [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PTCRA
dbVarPTCRA
ClinVarPTCRA
1000_GenomesPTCRA 
Exome Variant ServerPTCRA
ExAC (Exome Aggregation Consortium)ENSG00000171611
GNOMAD BrowserENSG00000171611
Varsome BrowserPTCRA
Genetic variants : HAPMAP171558
Genomic Variants (DGV)PTCRA [DGVbeta]
DECIPHERPTCRA [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPTCRA 
Mutations
ICGC Data PortalPTCRA 
TCGA Data PortalPTCRA 
Broad Tumor PortalPTCRA
OASIS PortalPTCRA [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPTCRA  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPTCRA
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PTCRA
DgiDB (Drug Gene Interaction Database)PTCRA
DoCM (Curated mutations)PTCRA (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PTCRA (select a term)
intoGenPTCRA
Cancer3DPTCRA(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606817   
Orphanet
DisGeNETPTCRA
MedgenPTCRA
Genetic Testing Registry PTCRA
NextProtQ6ISU1 [Medical]
TSGene171558
GENETestsPTCRA
Target ValidationPTCRA
Huge Navigator PTCRA [HugePedia]
snp3D : Map Gene to Disease171558
BioCentury BCIQPTCRA
ClinGenPTCRA
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD171558
Chemical/Pharm GKB GenePA134993184
Clinical trialPTCRA
Miscellaneous
canSAR (ICR)PTCRA (select the gene name)
Probes
Litterature
PubMed18 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePTCRA
EVEXPTCRA
GoPubMedPTCRA
iHOPPTCRA
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 6 11:33:07 CET 2018

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