PTCRA (pre T cell antigen receptor alpha)

2007-02-01  

Identity

HGNC
LOCATION
6p21.1
LOCUSID
ALIAS
PT-ALPHA,PTA
FUSION GENES

Other Information

Locus ID:

NCBI: 171558
MIM: 606817
HGNC: 21290
Ensembl: ENSG00000171611

Variants:

dbSNP: 171558
ClinVar: 171558
TCGA: ENSG00000171611
COSMIC: PTCRA

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000171611ENST00000304672Q6ISU1
ENSG00000171611ENST00000441198Q6ISU1
ENSG00000171611ENST00000446507Q6ISU1
ENSG00000171611ENST00000616441A0A087WTE9

Expression (GTEx)

0
1
2
3
4
5
6

Pathways

PathwaySourceExternal ID
Notch signaling pathwayKEGGko04330
Notch signaling pathwayKEGGhsa04330
Transcriptional misregulation in cancerKEGGko05202
Transcriptional misregulation in cancerKEGGhsa05202

References

Pubmed IDYearTitleCitations
118913282002Combined expression of pTalpha and Notch3 in T cell leukemia identifies the requirement of preTCR for leukemogenesis.54
188187482008Preterm birth in Caucasians is associated with coagulation and inflammation pathway gene variants.31
195275142009Racial disparity in pathophysiologic pathways of preterm birth based on genetic variants.31
190193352009Spontaneous preterm birth in African Americans is associated with infection and inflammatory response gene variants.26
145006292003Extrathymic TCR gene rearrangement in human small intestine: identification of new splice forms of recombination activating gene-1 mRNA with selective tissue expression.8
178233092007Identification of CMS as a cytosolic adaptor of the human pTalpha chain involved in pre-TCR function.4

Citation

Dessen P

PTCRA (pre T cell antigen receptor alpha)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43929/ptcra