PTGFR (prostaglandin F receptor)

2007-02-01  

Identity

HGNC
LOCATION
1p31.1
LOCUSID
ALIAS
FP

Other Information

Locus ID:

NCBI: 5737
MIM: 600563
HGNC: 9600
Ensembl: ENSG00000122420

Variants:

dbSNP: 5737
ClinVar: 5737
TCGA: ENSG00000122420
COSMIC: PTGFR

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000122420ENST00000370756P43088
ENSG00000122420ENST00000370757P43088
ENSG00000122420ENST00000370758P43088
ENSG00000122420ENST00000497923F2Z2Z6

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50

Pathways

PathwaySourceExternal ID
Calcium signaling pathwayKEGGko04020
Neuroactive ligand-receptor interactionKEGGko04080
Calcium signaling pathwayKEGGhsa04020
Neuroactive ligand-receptor interactionKEGGhsa04080
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Eicosanoid ligand-binding receptorsREACTOMER-HSA-391903
Prostanoid ligand receptorsREACTOMER-HSA-391908
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (q) signalling eventsREACTOMER-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907
Phospholipase D signaling pathwayKEGGko04072
Phospholipase D signaling pathwayKEGGhsa04072

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA164774763latanoprostChemicalClinicalAnnotationassociatedPD17467803, 25339146, 27336732
PA444282Glaucoma, Open-AngleDiseaseClinicalAnnotationassociatedPD17467803, 25339146, 27336732

References

Pubmed IDYearTitleCitations
92358891997Failure of parturition in mice lacking the prostaglandin F receptor.116
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
221829352013Genome-wide association study meta-analysis of European and Asian-ancestry samples identifies three novel loci associated with bipolar disorder.67
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
147648252004Expression, localization, and signaling of prostaglandin F2 alpha receptor in human endometrial adenocarcinoma: regulation of proliferation by activation of the epidermal growth factor receptor and mitogen-activated protein kinase signaling pathways.32
188187482008Preterm birth in Caucasians is associated with coagulation and inflammation pathway gene variants.31
195275142009Racial disparity in pathophysiologic pathways of preterm birth based on genetic variants.31
185874492008Identification and pharmacological characterization of the prostaglandin FP receptor and FP receptor variant complexes.29
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27
190193352009Spontaneous preterm birth in African Americans is associated with infection and inflammatory response gene variants.26

Citation

Dessen P

PTGFR (prostaglandin F receptor)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43835/ptgfr