PTGIR (prostaglandin I2 receptor)

2008-03-01  

Identity

HGNC
PTGIR
LOCATION
19q13.32
LOCUSID
5739
ALIAS
IP,PRIPR

Other Information

Locus ID:

NCBI: 5739
MIM: 600022
HGNC: 9602
Ensembl: ENSG00000160013

Variants:

dbSNP: 5739
ClinVar: 5739
TCGA: ENSG00000160013
COSMIC: PTGIR

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000160013ENST00000291294P43119
ENSG00000160013ENST00000594275M0QXV5
ENSG00000160013ENST00000596260A0A0B4J2A7
ENSG00000160013ENST00000597185M0QZI2
ENSG00000160013ENST00000598865M0QZW0

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Neuroactive ligand-receptor interactionKEGGhsa04080
Vascular smooth muscle contractionKEGGhsa04270
Vascular smooth muscle contractionKEGGko04270
Platelet activationKEGGhsa04611
HemostasisREACTOMER-HSA-109582
Platelet homeostasisREACTOMER-HSA-418346
Prostacyclin signalling through prostacyclin receptorREACTOMER-HSA-392851
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Eicosanoid ligand-binding receptorsREACTOMER-HSA-391903
Prostanoid ligand receptorsREACTOMER-HSA-391908
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (s) signalling eventsREACTOMER-HSA-418555

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA175GNASGenePathwayassociated20938371
PA443450AsthmaDiseaseClinicalAnnotationassociatedPD17496729
PA448497aspirinChemicalClinicalAnnotationassociatedPD17496729

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
183235282008Acceleration of cardiovascular disease by a dysfunctional prostacyclin receptor mutation: potential implications for cyclooxygenase-2 inhibition.42
154718682004Dimerization of the human receptors for prostacyclin and thromboxane facilitates thromboxane receptor-mediated cAMP generation.37
163998672006The prostacyclin receptor induces human vascular smooth muscle cell differentiation via the protein kinase A pathway.28
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27
221599952012Prostacyclin receptor-mediated ATP release from erythrocytes requires the voltage-dependent anion channel.24
174967292007Association between polymorphisms in prostanoid receptor genes and aspirin-intolerant asthma.21
190587892009A common variant in DRD3 receptor is associated with autism spectrum disorder.19
180050482008Prostanoid receptors in anagen human hair follicles.18
118542992002Impaired receptor binding and activation associated with a human prostacyclin receptor polymorphism.15

Citation

Dessen P

PTGIR (prostaglandin I2 receptor)

Atlas Genet Cytogenet Oncol Haematol. 2008-03-01

Online version: http://atlasgeneticsoncology.org/gene/50074/ptgir