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PTP4A1 (protein tyrosine phosphatase 4A1)

Identity

Alias (NCBI)HH72
PRL-1
PRL1
PTP(CAAX1)
PTPCAAX1
HGNC (Hugo) PTP4A1
HGNC Alias symbPTPCAAX1
PRL-1
PRL1
HGNC Alias namephosphatase of regenerating liver 1
HGNC Previous nameprotein tyrosine phosphatase type IVA, member 1
LocusID (NCBI) 7803
Atlas_Id 41906
Location 6q12  [Link to chromosome band 6q12]
Location_base_pair Starts at 63572012 and ends at 63583588 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ATAD5 (17q11.2) / PTP4A1 (6q12)PTP4A1 (6q12) / EYS (6q12)PTP4A1 (6q12) / PTP4A1 (6q12)
ATAD5 17q11.2 / PTP4A1 6q12PTP4A1 6q12 / EYS 6q12

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)PTP4A1   9634
Cards
Entrez_Gene (NCBI)PTP4A1    protein tyrosine phosphatase 4A1
AliasesHH72; PRL-1; PRL1; PTP(CAAX1); 
PTPCAAX1
GeneCards (Weizmann)PTP4A1
Ensembl hg19 (Hinxton)ENSG00000112245 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000112245 [Gene_View]  ENSG00000112245 [Sequence]  chr6:63572012-63583588 [Contig_View]  PTP4A1 [Vega]
ICGC DataPortalENSG00000112245
TCGA cBioPortalPTP4A1
AceView (NCBI)PTP4A1
Genatlas (Paris)PTP4A1
SOURCE (Princeton)PTP4A1
Genetics Home Reference (NIH)PTP4A1
Genomic and cartography
GoldenPath hg38 (UCSC)PTP4A1  -     chr6:63572012-63583588 +  6q12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PTP4A1  -     6q12   [Description]    (hg19-Feb_2009)
GoldenPathPTP4A1 - 6q12 [CytoView hg19]  PTP4A1 - 6q12 [CytoView hg38]
ImmunoBaseENSG00000112245
Genome Data Viewer NCBIPTP4A1 [Mapview hg19]  
OMIM601585   
Gene and transcription
Genbank (Entrez)AB451314 AB451444 AJ420505 AK312526 AW136267
RefSeq transcript (Entrez)NM_001385254 NM_001385255 NM_001385256 NM_001385257 NM_001385258 NM_001385259 NM_001385260 NM_001385262 NM_001385263 NM_001385265 NM_001385266 NM_001385267 NM_001385268 NM_003463
Consensus coding sequences : CCDS (NCBI)PTP4A1
Gene ExpressionPTP4A1 [ NCBI-GEO ]   PTP4A1 [ EBI - ARRAY_EXPRESS ]   PTP4A1 [ SEEK ]   PTP4A1 [ MEM ]
Gene Expression Viewer (FireBrowse)PTP4A1 [ Firebrowse - Broad ]
GenevisibleExpression of PTP4A1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7803
GTEX Portal (Tissue expression)PTP4A1
Human Protein AtlasENSG00000112245-PTP4A1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ93096   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ93096  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ93096
Catalytic activity : Enzyme3.1.3.48 [ Enzyme-Expasy ]   3.1.3.483.1.3.48 [ IntEnz-EBI ]   3.1.3.48 [ BRENDA ]   3.1.3.48 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ93096
Domaine pattern : Prosite (Expaxy)TYR_PHOSPHATASE_2 (PS50056)    TYR_PHOSPHATASE_DUAL (PS50054)   
Domains : Interpro (EBI)Dual-sp_phosphatase_cat-dom    Prot-tyrosine_phosphatase-like    Tyr_Pase_cat    TYR_PHOSPHATASE_dom   
Domain families : Pfam (Sanger)DSPc (PF00782)   
Domain families : Pfam (NCBI)pfam00782   
Domain families : Smart (EMBL)PTPc_motif (SM00404)  
Conserved Domain (NCBI)PTP4A1
PDB (RSDB)1RXD    1XM2    5BX1   
PDB Europe1RXD    1XM2    5BX1   
PDB (PDBSum)1RXD    1XM2    5BX1   
PDB (IMB)1RXD    1XM2    5BX1   
Structural Biology KnowledgeBase1RXD    1XM2    5BX1   
SCOP (Structural Classification of Proteins)1RXD    1XM2    5BX1   
CATH (Classification of proteins structures)1RXD    1XM2    5BX1   
SuperfamilyQ93096
AlphaFold pdb e-kbQ93096   
Human Protein Atlas [tissue]ENSG00000112245-PTP4A1 [tissue]
HPRD03349
Protein Interaction databases
DIP (DOE-UCLA)Q93096
IntAct (EBI)Q93096
BioGRIDPTP4A1
STRING (EMBL)PTP4A1
ZODIACPTP4A1
Ontologies - Pathways
QuickGOQ93096
Ontology : AmiGOprotein tyrosine phosphatase activity  protein tyrosine phosphatase activity  protein binding  nucleus  cytoplasm  cytoplasm  early endosome  endoplasmic reticulum  spindle  cell cycle  multicellular organism development  cytoplasmic side of plasma membrane  positive regulation of cell migration  peptidyl-tyrosine dephosphorylation  
Ontology : EGO-EBIprotein tyrosine phosphatase activity  protein tyrosine phosphatase activity  protein binding  nucleus  cytoplasm  cytoplasm  early endosome  endoplasmic reticulum  spindle  cell cycle  multicellular organism development  cytoplasmic side of plasma membrane  positive regulation of cell migration  peptidyl-tyrosine dephosphorylation  
NDEx NetworkPTP4A1
Atlas of Cancer Signalling NetworkPTP4A1
Wikipedia pathwaysPTP4A1
Orthology - Evolution
OrthoDB7803
GeneTree (enSembl)ENSG00000112245
Phylogenetic Trees/Animal Genes : TreeFamPTP4A1
Homologs : HomoloGenePTP4A1
Homology/Alignments : Family Browser (UCSC)PTP4A1
Gene fusions - Rearrangements
Fusion : MitelmanATAD5/PTP4A1 [17q11.2/6q12]  
Fusion : QuiverPTP4A1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPTP4A1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PTP4A1
dbVarPTP4A1
ClinVarPTP4A1
MonarchPTP4A1
1000_GenomesPTP4A1 
Exome Variant ServerPTP4A1
GNOMAD BrowserENSG00000112245
Varsome BrowserPTP4A1
ACMGPTP4A1 variants
VarityQ93096
Genomic Variants (DGV)PTP4A1 [DGVbeta]
DECIPHERPTP4A1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPTP4A1 
Mutations
ICGC Data PortalPTP4A1 
TCGA Data PortalPTP4A1 
Broad Tumor PortalPTP4A1
OASIS PortalPTP4A1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPTP4A1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPTP4A1
Mutations and Diseases : HGMDPTP4A1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaPTP4A1
DgiDB (Drug Gene Interaction Database)PTP4A1
DoCM (Curated mutations)PTP4A1
CIViC (Clinical Interpretations of Variants in Cancer)PTP4A1
Cancer3DPTP4A1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601585   
Orphanet
DisGeNETPTP4A1
MedgenPTP4A1
Genetic Testing Registry PTP4A1
NextProtQ93096 [Medical]
GENETestsPTP4A1
Target ValidationPTP4A1
Huge Navigator PTP4A1 [HugePedia]
ClinGenPTP4A1
Clinical trials, drugs, therapy
MyCancerGenomePTP4A1
Protein Interactions : CTDPTP4A1
Pharm GKB GenePA33977
PharosQ93096
Clinical trialPTP4A1
Miscellaneous
canSAR (ICR)PTP4A1
HarmonizomePTP4A1
DataMed IndexPTP4A1
Probes
Litterature
PubMed73 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXPTP4A1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:27:28 CEST 2021

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