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PTP4A1 (protein tyrosine phosphatase type IVA, member 1)

Identity

Alias_symbol (synonym)PTPCAAX1
PRL-1
Other aliasHH72
PRL1
PTP(CAAX1)
HGNC (Hugo) PTP4A1
LocusID (NCBI) 7803
Atlas_Id 41906
Location 6q12  [Link to chromosome band 6q12]
Location_base_pair Starts at 63572012 and ends at 63583588 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ATAD5 (17q11.2) / PTP4A1 (6q12)PTP4A1 (6q12) / EYS (6q12)PTP4A1 (6q12) / PTP4A1 (6q12)
ATAD5 17q11.2 / PTP4A1 6q12PTP4A1 6q12 / EYS 6q12

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(6;17)(q12;q11) ATAD5/PTP4A1


External links

Nomenclature
HGNC (Hugo)PTP4A1   9634
Cards
Entrez_Gene (NCBI)PTP4A1  7803  protein tyrosine phosphatase type IVA, member 1
AliasesHH72; PRL-1; PRL1; PTP(CAAX1); 
PTPCAAX1
GeneCards (Weizmann)PTP4A1
Ensembl hg19 (Hinxton)ENSG00000112245 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000112245 [Gene_View]  ENSG00000112245 [Sequence]  chr6:63572012-63583588 [Contig_View]  PTP4A1 [Vega]
ICGC DataPortalENSG00000112245
TCGA cBioPortalPTP4A1
AceView (NCBI)PTP4A1
Genatlas (Paris)PTP4A1
WikiGenes7803
SOURCE (Princeton)PTP4A1
Genetics Home Reference (NIH)PTP4A1
Genomic and cartography
GoldenPath hg38 (UCSC)PTP4A1  -     chr6:63572012-63583588 +  6q12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PTP4A1  -     6q12   [Description]    (hg19-Feb_2009)
EnsemblPTP4A1 - 6q12 [CytoView hg19]  PTP4A1 - 6q12 [CytoView hg38]
Mapping of homologs : NCBIPTP4A1 [Mapview hg19]  PTP4A1 [Mapview hg38]
OMIM601585   
Gene and transcription
Genbank (Entrez)AB451314 AB451444 AJ420505 AK312526 AW136267
RefSeq transcript (Entrez)NM_003463
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PTP4A1
Cluster EST : UnigeneHs.706850 [ NCBI ]
CGAP (NCI)Hs.706850
Alternative Splicing GalleryENSG00000112245
Gene ExpressionPTP4A1 [ NCBI-GEO ]   PTP4A1 [ EBI - ARRAY_EXPRESS ]   PTP4A1 [ SEEK ]   PTP4A1 [ MEM ]
Gene Expression Viewer (FireBrowse)PTP4A1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7803
GTEX Portal (Tissue expression)PTP4A1
Human Protein AtlasENSG00000112245-PTP4A1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ93096   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ93096  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ93096
Splice isoforms : SwissVarQ93096
Catalytic activity : Enzyme3.1.3.48 [ Enzyme-Expasy ]   3.1.3.483.1.3.48 [ IntEnz-EBI ]   3.1.3.48 [ BRENDA ]   3.1.3.48 [ KEGG ]   
PhosPhoSitePlusQ93096
Domaine pattern : Prosite (Expaxy)TYR_PHOSPHATASE_2 (PS50056)   
Domains : Interpro (EBI)Dual-sp_phosphatase_cat-dom    Prot-tyrosine_phosphatase-like    Tyr_Pase_cat    TYR_PHOSPHATASE_dom   
Domain families : Pfam (Sanger)DSPc (PF00782)   
Domain families : Pfam (NCBI)pfam00782   
Domain families : Smart (EMBL)PTPc_motif (SM00404)  
Conserved Domain (NCBI)PTP4A1
DMDM Disease mutations7803
Blocks (Seattle)PTP4A1
PDB (SRS)1RXD    1XM2    5BX1   
PDB (PDBSum)1RXD    1XM2    5BX1   
PDB (IMB)1RXD    1XM2    5BX1   
PDB (RSDB)1RXD    1XM2    5BX1   
Structural Biology KnowledgeBase1RXD    1XM2    5BX1   
SCOP (Structural Classification of Proteins)1RXD    1XM2    5BX1   
CATH (Classification of proteins structures)1RXD    1XM2    5BX1   
SuperfamilyQ93096
Human Protein Atlas [tissue]ENSG00000112245-PTP4A1 [tissue]
Peptide AtlasQ93096
HPRD03349
IPIIPI00020164   IPI00513693   
Protein Interaction databases
DIP (DOE-UCLA)Q93096
IntAct (EBI)Q93096
FunCoupENSG00000112245
BioGRIDPTP4A1
STRING (EMBL)PTP4A1
ZODIACPTP4A1
Ontologies - Pathways
QuickGOQ93096
Ontology : AmiGOprotein tyrosine phosphatase activity  protein tyrosine phosphatase activity  protein binding  nucleus  cytoplasm  cytoplasm  early endosome  endoplasmic reticulum  spindle  cell cycle  multicellular organism development  protein tyrosine/serine/threonine phosphatase activity  cytoplasmic side of plasma membrane  positive regulation of cell migration  peptidyl-tyrosine dephosphorylation  
Ontology : EGO-EBIprotein tyrosine phosphatase activity  protein tyrosine phosphatase activity  protein binding  nucleus  cytoplasm  cytoplasm  early endosome  endoplasmic reticulum  spindle  cell cycle  multicellular organism development  protein tyrosine/serine/threonine phosphatase activity  cytoplasmic side of plasma membrane  positive regulation of cell migration  peptidyl-tyrosine dephosphorylation  
NDEx NetworkPTP4A1
Atlas of Cancer Signalling NetworkPTP4A1
Wikipedia pathwaysPTP4A1
Orthology - Evolution
OrthoDB7803
GeneTree (enSembl)ENSG00000112245
Phylogenetic Trees/Animal Genes : TreeFamPTP4A1
HOVERGENQ93096
HOGENOMQ93096
Homologs : HomoloGenePTP4A1
Homology/Alignments : Family Browser (UCSC)PTP4A1
Gene fusions - Rearrangements
Fusion : MitelmanATAD5/PTP4A1 [17q11.2/6q12]  [t(6;17)(q12;q11)]  
Fusion PortalATAD5 17q11.2 PTP4A1 6q12 BLCA
Fusion PortalPTP4A1 6q12 EYS 6q12 BRCA
Fusion : QuiverPTP4A1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPTP4A1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PTP4A1
dbVarPTP4A1
ClinVarPTP4A1
1000_GenomesPTP4A1 
Exome Variant ServerPTP4A1
ExAC (Exome Aggregation Consortium)ENSG00000112245
GNOMAD BrowserENSG00000112245
Varsome BrowserPTP4A1
Genetic variants : HAPMAP7803
Genomic Variants (DGV)PTP4A1 [DGVbeta]
DECIPHERPTP4A1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPTP4A1 
Mutations
ICGC Data PortalPTP4A1 
TCGA Data PortalPTP4A1 
Broad Tumor PortalPTP4A1
OASIS PortalPTP4A1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPTP4A1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPTP4A1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PTP4A1
DgiDB (Drug Gene Interaction Database)PTP4A1
DoCM (Curated mutations)PTP4A1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PTP4A1 (select a term)
intoGenPTP4A1
Cancer3DPTP4A1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601585   
Orphanet
DisGeNETPTP4A1
MedgenPTP4A1
Genetic Testing Registry PTP4A1
NextProtQ93096 [Medical]
TSGene7803
GENETestsPTP4A1
Target ValidationPTP4A1
Huge Navigator PTP4A1 [HugePedia]
snp3D : Map Gene to Disease7803
BioCentury BCIQPTP4A1
ClinGenPTP4A1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7803
Chemical/Pharm GKB GenePA33977
Clinical trialPTP4A1
Miscellaneous
canSAR (ICR)PTP4A1 (select the gene name)
Probes
Litterature
PubMed63 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePTP4A1
EVEXPTP4A1
GoPubMedPTP4A1
iHOPPTP4A1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 6 11:33:16 CET 2018

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