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PTPN18 (protein tyrosine phosphatase, non-receptor type 18)

Identity

Alias_namesprotein tyrosine phosphatase
Alias_symbol (synonym)BDP1
Other aliasPTP-HSCF
HGNC (Hugo) PTPN18
LocusID (NCBI) 26469
Atlas_Id 41914
Location 2q21.1  [Link to chromosome band 2q21]
Location_base_pair Starts at 130356007 and ends at 130375409 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
PTPN18 (2q21.1) / MIEF1 (22q13.1)PTPN18 (2q21.1) / TUBA1B (12q13.12)PTPN18 (2q21.1) / WIPI1 (17q24.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PTPN18   9649
Cards
Entrez_Gene (NCBI)PTPN18  26469  protein tyrosine phosphatase, non-receptor type 18
AliasesBDP1; PTP-HSCF
GeneCards (Weizmann)PTPN18
Ensembl hg19 (Hinxton)ENSG00000072135 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000072135 [Gene_View]  chr2:130356007-130375409 [Contig_View]  PTPN18 [Vega]
ICGC DataPortalENSG00000072135
TCGA cBioPortalPTPN18
AceView (NCBI)PTPN18
Genatlas (Paris)PTPN18
WikiGenes26469
SOURCE (Princeton)PTPN18
Genetics Home Reference (NIH)PTPN18
Genomic and cartography
GoldenPath hg38 (UCSC)PTPN18  -     chr2:130356007-130375409 +  2q21.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PTPN18  -     2q21.1   [Description]    (hg19-Feb_2009)
EnsemblPTPN18 - 2q21.1 [CytoView hg19]  PTPN18 - 2q21.1 [CytoView hg38]
Mapping of homologs : NCBIPTPN18 [Mapview hg19]  PTPN18 [Mapview hg38]
OMIM606587   
Gene and transcription
Genbank (Entrez)AK297884 AK303804 AK311140 BC024280 BC031076
RefSeq transcript (Entrez)NM_001142370 NM_014369
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PTPN18
Cluster EST : UnigeneHs.744861 [ NCBI ]
CGAP (NCI)Hs.744861
Alternative Splicing GalleryENSG00000072135
Gene ExpressionPTPN18 [ NCBI-GEO ]   PTPN18 [ EBI - ARRAY_EXPRESS ]   PTPN18 [ SEEK ]   PTPN18 [ MEM ]
Gene Expression Viewer (FireBrowse)PTPN18 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)26469
GTEX Portal (Tissue expression)PTPN18
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ99952   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ99952  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ99952
Splice isoforms : SwissVarQ99952
Catalytic activity : Enzyme3.1.3.48 [ Enzyme-Expasy ]   3.1.3.483.1.3.48 [ IntEnz-EBI ]   3.1.3.48 [ BRENDA ]   3.1.3.48 [ KEGG ]   
PhosPhoSitePlusQ99952
Domaine pattern : Prosite (Expaxy)TYR_PHOSPHATASE_1 (PS00383)    TYR_PHOSPHATASE_2 (PS50056)    TYR_PHOSPHATASE_PTP (PS50055)   
Domains : Interpro (EBI)Prot-tyrosine_phosphatase-like    PTPase_domain    Tyr_Pase_AS    Tyr_Pase_cat    TYR_PHOSPHATASE_dom   
Domain families : Pfam (Sanger)Y_phosphatase (PF00102)   
Domain families : Pfam (NCBI)pfam00102   
Domain families : Smart (EMBL)PTPc (SM00194)  PTPc_motif (SM00404)  
Conserved Domain (NCBI)PTPN18
DMDM Disease mutations26469
Blocks (Seattle)PTPN18
PDB (SRS)2OC3    4GFU    4GFV    4NND   
PDB (PDBSum)2OC3    4GFU    4GFV    4NND   
PDB (IMB)2OC3    4GFU    4GFV    4NND   
PDB (RSDB)2OC3    4GFU    4GFV    4NND   
Structural Biology KnowledgeBase2OC3    4GFU    4GFV    4NND   
SCOP (Structural Classification of Proteins)2OC3    4GFU    4GFV    4NND   
CATH (Classification of proteins structures)2OC3    4GFU    4GFV    4NND   
SuperfamilyQ99952
Human Protein AtlasENSG00000072135
Peptide AtlasQ99952
HPRD05961
IPIIPI00219132   IPI00152019   IPI00917824   IPI00917953   IPI00915878   
Protein Interaction databases
DIP (DOE-UCLA)Q99952
IntAct (EBI)Q99952
FunCoupENSG00000072135
BioGRIDPTPN18
STRING (EMBL)PTPN18
ZODIACPTPN18
Ontologies - Pathways
QuickGOQ99952
Ontology : AmiGOprotein tyrosine phosphatase activity  non-membrane spanning protein tyrosine phosphatase activity  protein binding  nucleus  cytosol  protein dephosphorylation  peptidyl-tyrosine dephosphorylation  ERBB2 signaling pathway  negative regulation of ERBB signaling pathway  
Ontology : EGO-EBIprotein tyrosine phosphatase activity  non-membrane spanning protein tyrosine phosphatase activity  protein binding  nucleus  cytosol  protein dephosphorylation  peptidyl-tyrosine dephosphorylation  ERBB2 signaling pathway  negative regulation of ERBB signaling pathway  
NDEx NetworkPTPN18
Atlas of Cancer Signalling NetworkPTPN18
Wikipedia pathwaysPTPN18
Orthology - Evolution
OrthoDB26469
GeneTree (enSembl)ENSG00000072135
Phylogenetic Trees/Animal Genes : TreeFamPTPN18
HOVERGENQ99952
HOGENOMQ99952
Homologs : HomoloGenePTPN18
Homology/Alignments : Family Browser (UCSC)PTPN18
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPTPN18 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PTPN18
dbVarPTPN18
ClinVarPTPN18
1000_GenomesPTPN18 
Exome Variant ServerPTPN18
ExAC (Exome Aggregation Consortium)PTPN18 (select the gene name)
Genetic variants : HAPMAP26469
Genomic Variants (DGV)PTPN18 [DGVbeta]
DECIPHERPTPN18 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPTPN18 
Mutations
ICGC Data PortalPTPN18 
TCGA Data PortalPTPN18 
Broad Tumor PortalPTPN18
OASIS PortalPTPN18 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPTPN18  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPTPN18
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PTPN18
DgiDB (Drug Gene Interaction Database)PTPN18
DoCM (Curated mutations)PTPN18 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PTPN18 (select a term)
intoGenPTPN18
Cancer3DPTPN18(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606587   
Orphanet
MedgenPTPN18
Genetic Testing Registry PTPN18
NextProtQ99952 [Medical]
TSGene26469
GENETestsPTPN18
Target ValidationPTPN18
Huge Navigator PTPN18 [HugePedia]
snp3D : Map Gene to Disease26469
BioCentury BCIQPTPN18
ClinGenPTPN18
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD26469
Chemical/Pharm GKB GenePA33991
Clinical trialPTPN18
Miscellaneous
canSAR (ICR)PTPN18 (select the gene name)
Probes
Litterature
PubMed20 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePTPN18
EVEXPTPN18
GoPubMedPTPN18
iHOPPTPN18
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Aug 1 17:12:05 CEST 2017

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