PTPN18 (protein tyrosine phosphatase non-receptor type 18)

2003-06-01  

Identity

HGNC
LOCATION
2q21.1
LOCUSID
ALIAS
BDP1,PTP-HSCF
FUSION GENES

Other Information

Locus ID:

NCBI: 26469
MIM: 606587
HGNC: 9649
Ensembl: ENSG00000072135

Variants:

dbSNP: 26469
ClinVar: 26469
TCGA: ENSG00000072135
COSMIC: PTPN18

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000072135ENST00000175756Q99952
ENSG00000072135ENST00000347849Q99952
ENSG00000072135ENST00000409022E7EMB8
ENSG00000072135ENST00000428843F8WBM9

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by ERBB2REACTOMER-HSA-1227986
Downregulation of ERBB2 signalingREACTOMER-HSA-8863795

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
250810582014The catalytic region and PEST domain of PTPN18 distinctly regulate the HER2 phosphorylation and ubiquitination barcodes.27
146606512004Negative regulation of HER2 signaling by the PEST-type protein-tyrosine phosphatase BDP1.15
297424972018Prognostic Value of Phosphotyrosine Phosphatases in Hepatocellular Carcinoma.3
163037402005A bioinformatics analysis of protein tyrosine phosphatases in humans.2

Citation

Dessen P

PTPN18 (protein tyrosine phosphatase non-receptor type 18)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/41914/ptpn18