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PTPRC (protein tyrosine phosphatase, receptor type C)

Identity

Alias_namesCD45
Alias_symbol (synonym)LCA
T200
GP180
HGNC (Hugo) PTPRC
LocusID (NCBI) 5788
Atlas_Id 41925
Location 1q31.3  [Link to chromosome band 1q31]
Location_base_pair Starts at 198608098 and ends at 198664300 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
CCDC80 (3q13.2) / PTPRC (1q31.3)PTPRC (1q31.3) / NIPBL (5p13.2)PTPRC (1q31.3) / PRAM1 (19p13.2)
PTPRC (1q31.3) / PTPRC (1q31.3)TCF7L2 (10q25.2) / PTPRC (1q31.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(1;9)(p34;q34) SFPQ/ABL1


External links

Nomenclature
HGNC (Hugo)PTPRC   9666
LRG (Locus Reference Genomic)LRG_95
Cards
Entrez_Gene (NCBI)PTPRC  5788  protein tyrosine phosphatase, receptor type C
AliasesB220; CD45; CD45R; GP180; 
L-CA; LCA; LY5; T200
GeneCards (Weizmann)PTPRC
Ensembl hg19 (Hinxton)ENSG00000081237 [Gene_View]  chr1:198608098-198664300 [Contig_View]  PTPRC [Vega]
Ensembl hg38 (Hinxton)ENSG00000081237 [Gene_View]  chr1:198608098-198664300 [Contig_View]  PTPRC [Vega]
ICGC DataPortalENSG00000081237
TCGA cBioPortalPTPRC
AceView (NCBI)PTPRC
Genatlas (Paris)PTPRC
WikiGenes5788
SOURCE (Princeton)PTPRC
Genetics Home Reference (NIH)PTPRC
Genomic and cartography
GoldenPath hg19 (UCSC)PTPRC  -     chr1:198608098-198664300 +  1q31.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PTPRC  -     1q31.3   [Description]    (hg38-Dec_2013)
EnsemblPTPRC - 1q31.3 [CytoView hg19]  PTPRC - 1q31.3 [CytoView hg38]
Mapping of homologs : NCBIPTPRC [Mapview hg19]  PTPRC [Mapview hg38]
OMIM151460   608971   609532   
Gene and transcription
Genbank (Entrez)AA403163 AA904360 AK130573 AK292131 AK299986
RefSeq transcript (Entrez)NM_001267798 NM_002838 NM_080921 NM_080922
RefSeq genomic (Entrez)NC_000001 NC_018912 NG_007730 NT_004487 NW_003315907 NW_004929293
Consensus coding sequences : CCDS (NCBI)PTPRC
Cluster EST : UnigeneHs.654514 [ NCBI ]
CGAP (NCI)Hs.654514
Alternative Splicing GalleryENSG00000081237
Gene ExpressionPTPRC [ NCBI-GEO ]   PTPRC [ EBI - ARRAY_EXPRESS ]   PTPRC [ SEEK ]   PTPRC [ MEM ]
Gene Expression Viewer (FireBrowse)PTPRC [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5788
GTEX Portal (Tissue expression)PTPRC
Protein : pattern, domain, 3D structure
UniProt/SwissProtP08575   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP08575  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP08575
Splice isoforms : SwissVarP08575
Catalytic activity : Enzyme3.1.3.48 [ Enzyme-Expasy ]   3.1.3.483.1.3.48 [ IntEnz-EBI ]   3.1.3.48 [ BRENDA ]   3.1.3.48 [ KEGG ]   
PhosPhoSitePlusP08575
Domaine pattern : Prosite (Expaxy)FN3 (PS50853)    TYR_PHOSPHATASE_1 (PS00383)    TYR_PHOSPHATASE_2 (PS50056)    TYR_PHOSPHATASE_PTP (PS50055)   
Domains : Interpro (EBI)FN3_dom    Ig-like_fold    Prot-tyrosine_phosphatase-like    PTP_recept_N    PTPase_domain    Ptprc    Tyr_Pase_AS    TYR_PHOSPHATASE_dom   
Domain families : Pfam (Sanger)CD45 (PF12567)    fn3 (PF00041)    PTP_N (PF12453)    Y_phosphatase (PF00102)   
Domain families : Pfam (NCBI)pfam12567    pfam00041    pfam12453    pfam00102   
Domain families : Smart (EMBL)FN3 (SM00060)  PTPc (SM00194)  
Conserved Domain (NCBI)PTPRC
DMDM Disease mutations5788
Blocks (Seattle)PTPRC
PDB (SRS)1YGR    1YGU   
PDB (PDBSum)1YGR    1YGU   
PDB (IMB)1YGR    1YGU   
PDB (RSDB)1YGR    1YGU   
Structural Biology KnowledgeBase1YGR    1YGU   
SCOP (Structural Classification of Proteins)1YGR    1YGU   
CATH (Classification of proteins structures)1YGR    1YGU   
SuperfamilyP08575
Human Protein AtlasENSG00000081237
Peptide AtlasP08575
HPRD01050
IPIIPI00844079   IPI00306325   IPI00155168   IPI00645319   IPI00974246   IPI01010697   IPI01009652   IPI00375125   IPI00974481   IPI00646701   IPI00979661   
Protein Interaction databases
DIP (DOE-UCLA)P08575
IntAct (EBI)P08575
FunCoupENSG00000081237
BioGRIDPTPRC
STRING (EMBL)PTPRC
ZODIACPTPRC
Ontologies - Pathways
QuickGOP08575
Ontology : AmiGOnegative regulation of T cell mediated cytotoxicity  negative regulation of cytokine-mediated signaling pathway  hematopoietic progenitor cell differentiation  immunoglobulin biosynthetic process  protein tyrosine phosphatase activity  protein tyrosine phosphatase activity  transmembrane receptor protein tyrosine phosphatase activity  protein binding  intracellular  plasma membrane  integral component of plasma membrane  focal adhesion  negative regulation of protein kinase activity  negative regulation of protein kinase activity  protein dephosphorylation  negative regulation of cell adhesion involved in substrate-bound cell migration  cell surface receptor signaling pathway  external side of plasma membrane  cell surface  membrane  dephosphorylation  protein kinase binding  T cell differentiation  positive regulation of B cell proliferation  peptidyl-tyrosine dephosphorylation  peptidyl-tyrosine dephosphorylation  peptidyl-tyrosine dephosphorylation  B cell proliferation  positive regulation of T cell proliferation  cell cycle phase transition  membrane raft  positive regulation of protein kinase activity  bone marrow development  stem cell development  T cell receptor signaling pathway  T cell receptor signaling pathway  B cell receptor signaling pathway  positive regulation of antigen receptor-mediated signaling pathway  release of sequestered calcium ion into cytosol  defense response to virus  regulation of cell cycle  extracellular exosome  positive regulation of hematopoietic stem cell migration  positive regulation of stem cell proliferation  
Ontology : EGO-EBInegative regulation of T cell mediated cytotoxicity  negative regulation of cytokine-mediated signaling pathway  hematopoietic progenitor cell differentiation  immunoglobulin biosynthetic process  protein tyrosine phosphatase activity  protein tyrosine phosphatase activity  transmembrane receptor protein tyrosine phosphatase activity  protein binding  intracellular  plasma membrane  integral component of plasma membrane  focal adhesion  negative regulation of protein kinase activity  negative regulation of protein kinase activity  protein dephosphorylation  negative regulation of cell adhesion involved in substrate-bound cell migration  cell surface receptor signaling pathway  external side of plasma membrane  cell surface  membrane  dephosphorylation  protein kinase binding  T cell differentiation  positive regulation of B cell proliferation  peptidyl-tyrosine dephosphorylation  peptidyl-tyrosine dephosphorylation  peptidyl-tyrosine dephosphorylation  B cell proliferation  positive regulation of T cell proliferation  cell cycle phase transition  membrane raft  positive regulation of protein kinase activity  bone marrow development  stem cell development  T cell receptor signaling pathway  T cell receptor signaling pathway  B cell receptor signaling pathway  positive regulation of antigen receptor-mediated signaling pathway  release of sequestered calcium ion into cytosol  defense response to virus  regulation of cell cycle  extracellular exosome  positive regulation of hematopoietic stem cell migration  positive regulation of stem cell proliferation  
Pathways : BIOCARTALck and Fyn tyrosine kinases in initiation of TCR Activation [Genes]    T Helper Cell Surface Molecules [Genes]    Activation of Csk by cAMP-dependent Protein Kinase Inhibits Signaling through the T Cell Receptor [Genes]    B Lymphocyte Cell Surface Molecules [Genes]    T Cytotoxic Cell Surface Molecules [Genes]   
Pathways : KEGGCell adhesion molecules (CAMs)    T cell receptor signaling pathway    Fc gamma R-mediated phagocytosis    Primary immunodeficiency   
NDEx NetworkPTPRC
Atlas of Cancer Signalling NetworkPTPRC
Wikipedia pathwaysPTPRC
Orthology - Evolution
OrthoDB5788
GeneTree (enSembl)ENSG00000081237
Phylogenetic Trees/Animal Genes : TreeFamPTPRC
HOVERGENP08575
HOGENOMP08575
Homologs : HomoloGenePTPRC
Homology/Alignments : Family Browser (UCSC)PTPRC
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPTPRC [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PTPRC
dbVarPTPRC
ClinVarPTPRC
1000_GenomesPTPRC 
Exome Variant ServerPTPRC
ExAC (Exome Aggregation Consortium)PTPRC (select the gene name)
Genetic variants : HAPMAP5788
Genomic Variants (DGV)PTPRC [DGVbeta]
DECIPHER (Syndromes)1:198608098-198664300  ENSG00000081237
CONAN: Copy Number AnalysisPTPRC 
Mutations
ICGC Data PortalPTPRC 
TCGA Data PortalPTPRC 
Broad Tumor PortalPTPRC
OASIS PortalPTPRC [ Somatic mutations - Copy number]
Cancer Gene: CensusPTPRC 
Somatic Mutations in Cancer : COSMICPTPRC  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPTPRC
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)**PUBLIC** CCHMC Molecular Genetics Laboratory Mutation Database
BioMutasearch PTPRC
DgiDB (Drug Gene Interaction Database)PTPRC
DoCM (Curated mutations)PTPRC (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PTPRC (select a term)
intoGenPTPRC
Cancer3DPTPRC(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM151460    608971    609532   
Orphanet17830   
MedgenPTPRC
Genetic Testing Registry PTPRC
NextProtP08575 [Medical]
TSGene5788
GENETestsPTPRC
Huge Navigator PTPRC [HugePedia]
snp3D : Map Gene to Disease5788
BioCentury BCIQPTPRC
ClinGenPTPRC
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5788
Chemical/Pharm GKB GenePA34011
Clinical trialPTPRC
Miscellaneous
canSAR (ICR)PTPRC (select the gene name)
Probes
Litterature
PubMed258 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePTPRC
EVEXPTPRC
GoPubMedPTPRC
iHOPPTPRC
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Nov 18 19:48:59 CET 2016

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