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PTPRC (protein tyrosine phosphatase, receptor type, C)

Identity

Other namesB220
CD45
CD45R
GP180
L-CA
LCA
LY5
T200
HGNC (Hugo) PTPRC
LocusID (NCBI) 5788
Location 1q31.3
Location_base_pair Starts at 198608098 and ends at 198664300 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)PTPRC   9666
Cards
Entrez_Gene (NCBI)PTPRC  5788  protein tyrosine phosphatase, receptor type, C
GeneCards (Weizmann)PTPRC
Ensembl (Hinxton)ENSG00000081237 [Gene_View]  chr1:198608098-198664300 [Contig_View]  PTPRC [Vega]
ICGC DataPortalENSG00000081237
cBioPortalPTPRC
AceView (NCBI)PTPRC
Genatlas (Paris)PTPRC
WikiGenes5788
SOURCE (Princeton)NM_001267798 NM_002838 NM_080921 NM_080922
Genomic and cartography
GoldenPath (UCSC)PTPRC  -  1q31.3   chr1:198608098-198664300 +  1q31.3   [Description]    (hg19-Feb_2009)
EnsemblPTPRC - 1q31.3 [CytoView]
Mapping of homologs : NCBIPTPRC [Mapview]
OMIM151460   608971   609532   
Gene and transcription
Genbank (Entrez)AA403163 AA904360 AK130573 AK292131 AK299986
RefSeq transcript (Entrez)NM_001267798 NM_002838 NM_080921 NM_080922
RefSeq genomic (Entrez)AC_000133 NC_000001 NC_018912 NG_007730 NT_004487 NW_001838533 NW_003315907 NW_004929293
Consensus coding sequences : CCDS (NCBI)PTPRC
Cluster EST : UnigeneHs.654514 [ NCBI ]
CGAP (NCI)Hs.654514
Alternative Splicing : Fast-db (Paris)GSHG0001309
Alternative Splicing GalleryENSG00000081237
Gene ExpressionPTPRC [ NCBI-GEO ]     PTPRC [ SEEK ]   PTPRC [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP08575 (Uniprot)
NextProtP08575  [Medical]
With graphics : InterProP08575
Splice isoforms : SwissVarP08575 (Swissvar)
Catalytic activity : Enzyme3.1.3.48 [ Enzyme-Expasy ]   3.1.3.483.1.3.48 [ IntEnz-EBI ]   3.1.3.48 [ BRENDA ]   3.1.3.48 [ KEGG ]   
Domaine pattern : Prosite (Expaxy)FN3 (PS50853)    TYR_PHOSPHATASE_1 (PS00383)    TYR_PHOSPHATASE_2 (PS50056)    TYR_PHOSPHATASE_PTP (PS50055)   
Domains : Interpro (EBI)Fibronectin_type3 [organisation]   Ig-like_fold [organisation]   Leukocyte_common_ag [organisation]   Prot-tyrosine_phosphatase-like [organisation]   PTP_recept_N [organisation]   Tyr/Dual-sp_Pase [organisation]   Tyr_Pase_AS [organisation]   Tyr_Pase_rcpt/non-rcpt [organisation]  
Related proteins : CluSTrP08575
Domain families : Pfam (Sanger)CD45 (PF12567)    fn3 (PF00041)    PTP_N (PF12453)    Y_phosphatase (PF00102)   
Domain families : Pfam (NCBI)pfam12567    pfam00041    pfam12453    pfam00102   
Domain families : Smart (EMBL)FN3 (SM00060)  PTPc (SM00194)  
DMDM Disease mutations5788
Blocks (Seattle)P08575
PDB (SRS)1YGR    1YGU   
PDB (PDBSum)1YGR    1YGU   
PDB (IMB)1YGR    1YGU   
PDB (RSDB)1YGR    1YGU   
Human Protein AtlasENSG00000081237 [gene] [tissue] [antibody] [cell] [cancer]
Peptide AtlasP08575
HPRD01050
IPIIPI00844079   IPI00306325   IPI00155168   IPI00645319   IPI00974246   IPI01010697   IPI01009652   IPI00375125   IPI00974481   IPI00646701   IPI00979661   
Protein Interaction databases
DIP (DOE-UCLA)P08575
IntAct (EBI)P08575
FunCoupENSG00000081237
BioGRIDPTPRC
InParanoidP08575
Interologous Interaction database P08575
IntegromeDBPTPRC
STRING (EMBL)PTPRC
Ontologies - Pathways
Ontology : AmiGOnegative regulation of T cell mediated cytotoxicity  negative regulation of cytokine-mediated signaling pathway  hematopoietic progenitor cell differentiation  immunoglobulin biosynthetic process  protein tyrosine phosphatase activity  transmembrane receptor protein tyrosine phosphatase activity  protein binding  plasma membrane  integral component of plasma membrane  focal adhesion  negative regulation of protein kinase activity  negative regulation of protein kinase activity  protein dephosphorylation  negative regulation of cell adhesion involved in substrate-bound cell migration  cell surface receptor signaling pathway  axon guidance  external side of plasma membrane  membrane  dephosphorylation  protein kinase binding  T cell differentiation  positive regulation of B cell proliferation  peptidyl-tyrosine dephosphorylation  peptidyl-tyrosine dephosphorylation  peptidyl-tyrosine dephosphorylation  B cell proliferation  positive regulation of T cell proliferation  cell cycle phase transition  membrane raft  positive regulation of protein kinase activity  bone marrow development  stem cell development  T cell receptor signaling pathway  T cell receptor signaling pathway  B cell receptor signaling pathway  positive regulation of antigen receptor-mediated signaling pathway  release of sequestered calcium ion into cytosol  defense response to virus  regulation of cell cycle  extracellular vesicular exosome  positive regulation of hematopoietic stem cell migration  positive regulation of stem cell proliferation  
Ontology : EGO-EBInegative regulation of T cell mediated cytotoxicity  negative regulation of cytokine-mediated signaling pathway  hematopoietic progenitor cell differentiation  immunoglobulin biosynthetic process  protein tyrosine phosphatase activity  transmembrane receptor protein tyrosine phosphatase activity  protein binding  plasma membrane  integral component of plasma membrane  focal adhesion  negative regulation of protein kinase activity  negative regulation of protein kinase activity  protein dephosphorylation  negative regulation of cell adhesion involved in substrate-bound cell migration  cell surface receptor signaling pathway  axon guidance  external side of plasma membrane  membrane  dephosphorylation  protein kinase binding  T cell differentiation  positive regulation of B cell proliferation  peptidyl-tyrosine dephosphorylation  peptidyl-tyrosine dephosphorylation  peptidyl-tyrosine dephosphorylation  B cell proliferation  positive regulation of T cell proliferation  cell cycle phase transition  membrane raft  positive regulation of protein kinase activity  bone marrow development  stem cell development  T cell receptor signaling pathway  T cell receptor signaling pathway  B cell receptor signaling pathway  positive regulation of antigen receptor-mediated signaling pathway  release of sequestered calcium ion into cytosol  defense response to virus  regulation of cell cycle  extracellular vesicular exosome  positive regulation of hematopoietic stem cell migration  positive regulation of stem cell proliferation  
Pathways : BIOCARTALck and Fyn tyrosine kinases in initiation of TCR Activation [Genes]    T Helper Cell Surface Molecules [Genes]    Activation of Csk by cAMP-dependent Protein Kinase Inhibits Signaling through the T Cell Receptor [Genes]    B Lymphocyte Cell Surface Molecules [Genes]    T Cytotoxic Cell Surface Molecules [Genes]   
Pathways : KEGGCell adhesion molecules (CAMs)    T cell receptor signaling pathway    Fc gamma R-mediated phagocytosis    Primary immunodeficiency   
Protein Interaction DatabasePTPRC
Wikipedia pathwaysPTPRC
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)PTPRC
snp3D : Map Gene to Disease5788
SNP (GeneSNP Utah)PTPRC
SNP : HGBasePTPRC
Genetic variants : HAPMAPPTPRC
Exome VariantPTPRC
1000_GenomesPTPRC 
ICGC programENSG00000081237 
Cancer Gene: CensusPTPRC 
Somatic Mutations in Cancer : COSMICPTPRC 
CONAN: Copy Number AnalysisPTPRC 
Mutations and Diseases : HGMDPTPRC
Mutations and Diseases : intOGenPTPRC
Genomic VariantsPTPRC  PTPRC [DGVbeta]
dbVarPTPRC
ClinVarPTPRC
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM151460    608971    609532   
MedgenPTPRC
GENETestsPTPRC
Disease Genetic AssociationPTPRC
Huge Navigator PTPRC [HugePedia]  PTPRC [HugeCancerGEM]
General knowledge
Homologs : HomoloGenePTPRC
Homology/Alignments : Family Browser (UCSC)PTPRC
Phylogenetic Trees/Animal Genes : TreeFamPTPRC
Chemical/Protein Interactions : CTD5788
Chemical/Pharm GKB GenePA34011
Clinical trialPTPRC
Cancer Resource (Charite)ENSG00000081237
Other databases
Probes
Litterature
PubMed239 Pubmed reference(s) in Entrez
CoreMinePTPRC
iHOPPTPRC
OncoSearchPTPRC
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Sep 22 19:13:26 CEST 2014

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