Atlas of Genetics and Cytogenetics in Oncology and Haematology


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PTPRC (protein tyrosine phosphatase, receptor type C)

Identity

Alias_namesCD45
Alias_symbol (synonym)LCA
T200
GP180
Other aliasB220
CD45R
L-CA
LY5
HGNC (Hugo) PTPRC
LocusID (NCBI) 5788
Atlas_Id 41925
Location 1q31.3  [Link to chromosome band 1q31]
Location_base_pair Starts at 198638968 and ends at 198757476 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CCDC80 (3q13.2) / PTPRC (1q31.3)PTPRC (1q31.3) / NIPBL (5p13.2)PTPRC (1q31.3) / PRAM1 (19p13.2)
PTPRC (1q31.3) / PTPRC (1q31.3)TCF7L2 (10q25.2) / PTPRC (1q31.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PTPRC   9666
LRG (Locus Reference Genomic)LRG_95
Cards
Entrez_Gene (NCBI)PTPRC  5788  protein tyrosine phosphatase, receptor type C
AliasesB220; CD45; CD45R; GP180; 
L-CA; LCA; LY5; T200
GeneCards (Weizmann)PTPRC
Ensembl hg19 (Hinxton)ENSG00000081237 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000081237 [Gene_View]  ENSG00000081237 [Sequence]  chr1:198638968-198757476 [Contig_View]  PTPRC [Vega]
ICGC DataPortalENSG00000081237
TCGA cBioPortalPTPRC
AceView (NCBI)PTPRC
Genatlas (Paris)PTPRC
WikiGenes5788
SOURCE (Princeton)PTPRC
Genetics Home Reference (NIH)PTPRC
Genomic and cartography
GoldenPath hg38 (UCSC)PTPRC  -     chr1:198638968-198757476 +  1q31.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PTPRC  -     1q31.3   [Description]    (hg19-Feb_2009)
EnsemblPTPRC - 1q31.3 [CytoView hg19]  PTPRC - 1q31.3 [CytoView hg38]
Mapping of homologs : NCBIPTPRC [Mapview hg19]  PTPRC [Mapview hg38]
OMIM151460   608971   609532   
Gene and transcription
Genbank (Entrez)AA403163 AA904360 AK130573 AK292131 AK299986
RefSeq transcript (Entrez)NM_001267798 NM_002838 NM_080921 NM_080922
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PTPRC
Cluster EST : UnigeneHs.654514 [ NCBI ]
CGAP (NCI)Hs.654514
Alternative Splicing GalleryENSG00000081237
Gene ExpressionPTPRC [ NCBI-GEO ]   PTPRC [ EBI - ARRAY_EXPRESS ]   PTPRC [ SEEK ]   PTPRC [ MEM ]
Gene Expression Viewer (FireBrowse)PTPRC [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5788
GTEX Portal (Tissue expression)PTPRC
Human Protein AtlasENSG00000081237-PTPRC [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP08575   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP08575  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP08575
Splice isoforms : SwissVarP08575
Catalytic activity : Enzyme3.1.3.48 [ Enzyme-Expasy ]   3.1.3.483.1.3.48 [ IntEnz-EBI ]   3.1.3.48 [ BRENDA ]   3.1.3.48 [ KEGG ]   
PhosPhoSitePlusP08575
Domaine pattern : Prosite (Expaxy)FN3 (PS50853)    TYR_PHOSPHATASE_1 (PS00383)    TYR_PHOSPHATASE_2 (PS50056)    TYR_PHOSPHATASE_PTP (PS50055)   
Domains : Interpro (EBI)FN3_dom    FN3_sf    Ig-like_fold    Prot-tyrosine_phosphatase-like    PTP_recept_N    PTPase_domain    Ptprc    Tyr_Pase_AS    Tyr_Pase_cat    TYR_PHOSPHATASE_dom   
Domain families : Pfam (Sanger)CD45 (PF12567)    fn3 (PF00041)    PTP_N (PF12453)    Y_phosphatase (PF00102)   
Domain families : Pfam (NCBI)pfam12567    pfam00041    pfam12453    pfam00102   
Domain families : Smart (EMBL)FN3 (SM00060)  PTPc (SM00194)  PTPc_motif (SM00404)  
Conserved Domain (NCBI)PTPRC
DMDM Disease mutations5788
Blocks (Seattle)PTPRC
PDB (RSDB)1YGR    1YGU    5FMV    5FN6    5FN7   
PDB Europe1YGR    1YGU    5FMV    5FN6    5FN7   
PDB (PDBSum)1YGR    1YGU    5FMV    5FN6    5FN7   
PDB (IMB)1YGR    1YGU    5FMV    5FN6    5FN7   
Structural Biology KnowledgeBase1YGR    1YGU    5FMV    5FN6    5FN7   
SCOP (Structural Classification of Proteins)1YGR    1YGU    5FMV    5FN6    5FN7   
CATH (Classification of proteins structures)1YGR    1YGU    5FMV    5FN6    5FN7   
SuperfamilyP08575
Human Protein Atlas [tissue]ENSG00000081237-PTPRC [tissue]
Peptide AtlasP08575
HPRD01050
IPIIPI00844079   IPI00306325   IPI00155168   IPI00645319   IPI00974246   IPI01010697   IPI01009652   IPI00375125   IPI00974481   IPI00646701   IPI00979661   
Protein Interaction databases
DIP (DOE-UCLA)P08575
IntAct (EBI)P08575
FunCoupENSG00000081237
BioGRIDPTPRC
STRING (EMBL)PTPRC
ZODIACPTPRC
Ontologies - Pathways
QuickGOP08575
Ontology : AmiGOactivation of MAPK activity  natural killer cell differentiation  negative regulation of T cell mediated cytotoxicity  positive regulation of T cell mediated cytotoxicity  negative regulation of cytokine-mediated signaling pathway  hematopoietic progenitor cell differentiation  immunoglobulin biosynthetic process  positive regulation of humoral immune response mediated by circulating immunoglobulin  protein tyrosine phosphatase activity  protein tyrosine phosphatase activity  protein tyrosine phosphatase activity  transmembrane receptor protein tyrosine phosphatase activity  signaling receptor binding  protein binding  plasma membrane  plasma membrane  integral component of plasma membrane  focal adhesion  negative regulation of protein kinase activity  negative regulation of protein kinase activity  protein dephosphorylation  negative regulation of cell adhesion involved in substrate-bound cell migration  leukocyte cell-cell adhesion  cell surface receptor signaling pathway  heparin binding  external side of plasma membrane  cytoplasmic side of plasma membrane  cell surface  response to gamma radiation  regulation of gene expression  membrane  integral component of membrane  dephosphorylation  protein kinase binding  B cell differentiation  T cell differentiation  ankyrin binding  spectrin binding  secretory granule membrane  positive regulation of B cell proliferation  cellular response to extracellular stimulus  negative regulation of protein autophosphorylation  bleb  regulation of interleukin-8 production  positive regulation of tumor necrosis factor production  heterotypic cell-cell adhesion  peptidyl-tyrosine dephosphorylation  calcium-mediated signaling using intracellular calcium source  T cell proliferation  B cell proliferation  positive regulation of T cell proliferation  T cell activation  protein homodimerization activity  neutrophil degranulation  heparan sulfate proteoglycan binding  positive regulation of MAPK cascade  cell cycle phase transition  plasma membrane raft distribution  positive thymic T cell selection  negative thymic T cell selection  negative regulation of interleukin-2 biosynthetic process  positive regulation of interleukin-2 biosynthetic process  membrane raft  regulation of B cell differentiation  positive regulation of gamma-delta T cell differentiation  positive regulation of protein kinase activity  regulation of JAK-STAT cascade  positive regulation of alpha-beta T cell proliferation  positive regulation of isotype switching to IgG isotypes  bone marrow development  stem cell development  positive regulation of peptidyl-tyrosine phosphorylation  regulation of phagocytosis  T cell receptor signaling pathway  T cell receptor signaling pathway  B cell receptor signaling pathway  regulation of B cell receptor signaling pathway  positive regulation of antigen receptor-mediated signaling pathway  release of sequestered calcium ion into cytosol  defense response to virus  regulation of cell cycle  regulation of protein tyrosine kinase activity  negative regulation of protein tyrosine kinase activity  extracellular exosome  negative regulation of ERK1 and ERK2 cascade  positive regulation of ERK1 and ERK2 cascade  membrane microdomain  positive regulation of protein tyrosine phosphatase activity  negative regulation of microglial cell activation  DN2 thymocyte differentiation  positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis  positive regulation of hematopoietic stem cell migration  positive regulation of stem cell proliferation  positive regulation of extrinsic apoptotic signaling pathway  
Ontology : EGO-EBIactivation of MAPK activity  natural killer cell differentiation  negative regulation of T cell mediated cytotoxicity  positive regulation of T cell mediated cytotoxicity  negative regulation of cytokine-mediated signaling pathway  hematopoietic progenitor cell differentiation  immunoglobulin biosynthetic process  positive regulation of humoral immune response mediated by circulating immunoglobulin  protein tyrosine phosphatase activity  protein tyrosine phosphatase activity  protein tyrosine phosphatase activity  transmembrane receptor protein tyrosine phosphatase activity  signaling receptor binding  protein binding  plasma membrane  plasma membrane  integral component of plasma membrane  focal adhesion  negative regulation of protein kinase activity  negative regulation of protein kinase activity  protein dephosphorylation  negative regulation of cell adhesion involved in substrate-bound cell migration  leukocyte cell-cell adhesion  cell surface receptor signaling pathway  heparin binding  external side of plasma membrane  cytoplasmic side of plasma membrane  cell surface  response to gamma radiation  regulation of gene expression  membrane  integral component of membrane  dephosphorylation  protein kinase binding  B cell differentiation  T cell differentiation  ankyrin binding  spectrin binding  secretory granule membrane  positive regulation of B cell proliferation  cellular response to extracellular stimulus  negative regulation of protein autophosphorylation  bleb  regulation of interleukin-8 production  positive regulation of tumor necrosis factor production  heterotypic cell-cell adhesion  peptidyl-tyrosine dephosphorylation  calcium-mediated signaling using intracellular calcium source  T cell proliferation  B cell proliferation  positive regulation of T cell proliferation  T cell activation  protein homodimerization activity  neutrophil degranulation  heparan sulfate proteoglycan binding  positive regulation of MAPK cascade  cell cycle phase transition  plasma membrane raft distribution  positive thymic T cell selection  negative thymic T cell selection  negative regulation of interleukin-2 biosynthetic process  positive regulation of interleukin-2 biosynthetic process  membrane raft  regulation of B cell differentiation  positive regulation of gamma-delta T cell differentiation  positive regulation of protein kinase activity  regulation of JAK-STAT cascade  positive regulation of alpha-beta T cell proliferation  positive regulation of isotype switching to IgG isotypes  bone marrow development  stem cell development  positive regulation of peptidyl-tyrosine phosphorylation  regulation of phagocytosis  T cell receptor signaling pathway  T cell receptor signaling pathway  B cell receptor signaling pathway  regulation of B cell receptor signaling pathway  positive regulation of antigen receptor-mediated signaling pathway  release of sequestered calcium ion into cytosol  defense response to virus  regulation of cell cycle  regulation of protein tyrosine kinase activity  negative regulation of protein tyrosine kinase activity  extracellular exosome  negative regulation of ERK1 and ERK2 cascade  positive regulation of ERK1 and ERK2 cascade  membrane microdomain  positive regulation of protein tyrosine phosphatase activity  negative regulation of microglial cell activation  DN2 thymocyte differentiation  positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis  positive regulation of hematopoietic stem cell migration  positive regulation of stem cell proliferation  positive regulation of extrinsic apoptotic signaling pathway  
Pathways : KEGGCell adhesion molecules (CAMs)    T cell receptor signaling pathway    Fc gamma R-mediated phagocytosis    Primary immunodeficiency   
NDEx NetworkPTPRC
Atlas of Cancer Signalling NetworkPTPRC
Wikipedia pathwaysPTPRC
Orthology - Evolution
OrthoDB5788
GeneTree (enSembl)ENSG00000081237
Phylogenetic Trees/Animal Genes : TreeFamPTPRC
HOGENOMP08575
Homologs : HomoloGenePTPRC
Homology/Alignments : Family Browser (UCSC)PTPRC
Gene fusions - Rearrangements
Fusion : QuiverPTPRC
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPTPRC [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PTPRC
dbVarPTPRC
ClinVarPTPRC
1000_GenomesPTPRC 
Exome Variant ServerPTPRC
ExAC (Exome Aggregation Consortium)ENSG00000081237
GNOMAD BrowserENSG00000081237
Varsome BrowserPTPRC
Genetic variants : HAPMAP5788
Genomic Variants (DGV)PTPRC [DGVbeta]
DECIPHERPTPRC [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPTPRC 
Mutations
ICGC Data PortalPTPRC 
TCGA Data PortalPTPRC 
Broad Tumor PortalPTPRC
OASIS PortalPTPRC [ Somatic mutations - Copy number]
Cancer Gene: CensusPTPRC 
Somatic Mutations in Cancer : COSMICPTPRC  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPTPRC
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)**PUBLIC** CCHMC Molecular Genetics Laboratory Mutation Database
BioMutasearch PTPRC
DgiDB (Drug Gene Interaction Database)PTPRC
DoCM (Curated mutations)PTPRC (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PTPRC (select a term)
intoGenPTPRC
Cancer3DPTPRC(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM151460    608971    609532   
Orphanet17830   
DisGeNETPTPRC
MedgenPTPRC
Genetic Testing Registry PTPRC
NextProtP08575 [Medical]
TSGene5788
GENETestsPTPRC
Target ValidationPTPRC
Huge Navigator PTPRC [HugePedia]
snp3D : Map Gene to Disease5788
BioCentury BCIQPTPRC
ClinGenPTPRC
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5788
Chemical/Pharm GKB GenePA34011
Clinical trialPTPRC
Miscellaneous
canSAR (ICR)PTPRC (select the gene name)
DataMed IndexPTPRC
Probes
Litterature
PubMed292 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePTPRC
EVEXPTPRC
GoPubMedPTPRC
iHOPPTPRC
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Jan 17 18:33:34 CET 2019

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