Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

PTPRM (protein tyrosine phosphatase receptor type M)

Identity

Alias (NCBI)PTPRL1
R-PTP-MU
RPTPM
RPTPU
hR-PTPu
HGNC (Hugo) PTPRM
HGNC Alias symbRPTPU
hR-PTPu
HGNC Previous namePTPRL1
LocusID (NCBI) 5797
Atlas_Id 41934
Location 18p11.23  [Link to chromosome band 18p11]
Location_base_pair Starts at 7567316 and ends at 8406861 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ANKRD12 (18p11.22) / PTPRM (18p11.23)GABRE (Xq28) / PTPRM (18p11.23)GIMAP1 (7q36.1) / PTPRM (18p11.23)
LDOC1L (22q13.31) / PTPRM (18p11.23)PHACTR3 (20q13.32) / PTPRM (18p11.23)PTPRM (18p11.23) / KCTD1 (18q11.2)
PTPRM (18p11.23) / KIAA1468 (18q21.33)PTPRM (18p11.23) / PSG3 (19q13.2)PTPRM (18p11.23) / PTPRM (18p11.23)
PTPRM (18p11.23) / TET3 (2p13.1)ANKRD12 18p11.22 / PTPRM 18p11.23PTPRM 18p11.23 / KCTD1 18q11.2
PTPRM 18p11.23 / KIAA1468 18q21.33

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  del(18)(p11)


External links

 

Nomenclature
HGNC (Hugo)PTPRM   9675
Cards
Entrez_Gene (NCBI)PTPRM    protein tyrosine phosphatase receptor type M
AliasesPTPRL1; R-PTP-MU; RPTPM; RPTPU; 
hR-PTPu
GeneCards (Weizmann)PTPRM
Ensembl hg19 (Hinxton)ENSG00000173482 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000173482 [Gene_View]  ENSG00000173482 [Sequence]  chr18:7567316-8406861 [Contig_View]  PTPRM [Vega]
ICGC DataPortalENSG00000173482
TCGA cBioPortalPTPRM
AceView (NCBI)PTPRM
Genatlas (Paris)PTPRM
SOURCE (Princeton)PTPRM
Genetics Home Reference (NIH)PTPRM
Genomic and cartography
GoldenPath hg38 (UCSC)PTPRM  -     chr18:7567316-8406861 +  18p11.23   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PTPRM  -     18p11.23   [Description]    (hg19-Feb_2009)
GoldenPathPTPRM - 18p11.23 [CytoView hg19]  PTPRM - 18p11.23 [CytoView hg38]
ImmunoBaseENSG00000173482
Genome Data Viewer NCBIPTPRM [Mapview hg19]  
OMIM176888   
Gene and transcription
Genbank (Entrez)AA281524 AK294492 AK303652 BC040543 BC151842
RefSeq transcript (Entrez)NM_001105244 NM_001378142 NM_001378143 NM_001378144 NM_001378145 NM_001378146 NM_001378147 NM_002845
Consensus coding sequences : CCDS (NCBI)PTPRM
Gene ExpressionPTPRM [ NCBI-GEO ]   PTPRM [ EBI - ARRAY_EXPRESS ]   PTPRM [ SEEK ]   PTPRM [ MEM ]
Gene Expression Viewer (FireBrowse)PTPRM [ Firebrowse - Broad ]
GenevisibleExpression of PTPRM in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5797
GTEX Portal (Tissue expression)PTPRM
Human Protein AtlasENSG00000173482-PTPRM [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP28827   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP28827  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP28827
Catalytic activity : Enzyme3.1.3.48 [ Enzyme-Expasy ]   3.1.3.483.1.3.48 [ IntEnz-EBI ]   3.1.3.48 [ BRENDA ]   3.1.3.48 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusP28827
Domaine pattern : Prosite (Expaxy)FN3 (PS50853)    IG_LIKE (PS50835)    MAM_1 (PS00740)    MAM_2 (PS50060)    TYR_PHOSPHATASE_1 (PS00383)    TYR_PHOSPHATASE_2 (PS50056)    TYR_PHOSPHATASE_PTP (PS50055)   
Domains : Interpro (EBI)ConA-like_dom_sf    FN3_dom    FN3_sf    Ig-like_dom    Ig-like_dom_sf    Ig-like_fold    Ig_sub    Immunoglobulin    MAM_dom    Prot-tyrosine_phosphatase-like    PTPase_domain    PTPRJ_TM    Tyr_Pase_AS    Tyr_Pase_cat    TYR_PHOSPHATASE_dom   
Domain families : Pfam (Sanger)fn3 (PF00041)    ig (PF00047)    MAM (PF00629)    PTP_tm (PF18861)    Y_phosphatase (PF00102)   
Domain families : Pfam (NCBI)pfam00041    pfam00047    pfam00629    pfam18861    pfam00102   
Domain families : Smart (EMBL)FN3 (SM00060)  IG (SM00409)  MAM (SM00137)  PTPc (SM00194)  PTPc_motif (SM00404)  
Conserved Domain (NCBI)PTPRM
PDB (RSDB)1RPM    2C9A    2V5Y   
PDB Europe1RPM    2C9A    2V5Y   
PDB (PDBSum)1RPM    2C9A    2V5Y   
PDB (IMB)1RPM    2C9A    2V5Y   
Structural Biology KnowledgeBase1RPM    2C9A    2V5Y   
SCOP (Structural Classification of Proteins)1RPM    2C9A    2V5Y   
CATH (Classification of proteins structures)1RPM    2C9A    2V5Y   
SuperfamilyP28827
AlphaFold pdb e-kbP28827   
Human Protein Atlas [tissue]ENSG00000173482-PTPRM [tissue]
HPRD01479
Protein Interaction databases
DIP (DOE-UCLA)P28827
IntAct (EBI)P28827
BioGRIDPTPRM
STRING (EMBL)PTPRM
ZODIACPTPRM
Ontologies - Pathways
QuickGOP28827
Ontology : AmiGOnegative regulation of endothelial cell proliferation  protein tyrosine phosphatase activity  protein tyrosine phosphatase activity  transmembrane receptor protein tyrosine phosphatase activity  protein binding  cytoplasm  plasma membrane  integral component of plasma membrane  cell-cell junction  adherens junction  protein dephosphorylation  protein dephosphorylation  homophilic cell adhesion via plasma membrane adhesion molecules  signal transduction  negative regulation of endothelial cell migration  retina layer formation  negative regulation of angiogenesis  lamellipodium  neuron projection development  neuron projection development  retinal ganglion cell axon guidance  peptidyl-tyrosine dephosphorylation  response to drug  identical protein binding  cadherin binding  perinuclear region of cytoplasm  
Ontology : EGO-EBInegative regulation of endothelial cell proliferation  protein tyrosine phosphatase activity  protein tyrosine phosphatase activity  transmembrane receptor protein tyrosine phosphatase activity  protein binding  cytoplasm  plasma membrane  integral component of plasma membrane  cell-cell junction  adherens junction  protein dephosphorylation  protein dephosphorylation  homophilic cell adhesion via plasma membrane adhesion molecules  signal transduction  negative regulation of endothelial cell migration  retina layer formation  negative regulation of angiogenesis  lamellipodium  neuron projection development  neuron projection development  retinal ganglion cell axon guidance  peptidyl-tyrosine dephosphorylation  response to drug  identical protein binding  cadherin binding  perinuclear region of cytoplasm  
Pathways : KEGGCell adhesion molecules (CAMs)    Adherens junction   
NDEx NetworkPTPRM
Atlas of Cancer Signalling NetworkPTPRM
Wikipedia pathwaysPTPRM
Orthology - Evolution
OrthoDB5797
GeneTree (enSembl)ENSG00000173482
Phylogenetic Trees/Animal Genes : TreeFamPTPRM
Homologs : HomoloGenePTPRM
Homology/Alignments : Family Browser (UCSC)PTPRM
Gene fusions - Rearrangements
Fusion : MitelmanANKRD12/PTPRM [18p11.22/18p11.23]  
Fusion : MitelmanPHACTR3/PTPRM [20q13.32/18p11.23]  
Fusion : MitelmanPTPRM/KCTD1 [18p11.23/18q11.2]  
Fusion : MitelmanPTPRM/KIAA1468 [18p11.23/18q21.33]  
Fusion : QuiverPTPRM
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPTPRM [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PTPRM
dbVarPTPRM
ClinVarPTPRM
MonarchPTPRM
1000_GenomesPTPRM 
Exome Variant ServerPTPRM
GNOMAD BrowserENSG00000173482
Varsome BrowserPTPRM
ACMGPTPRM variants
VarityP28827
Genomic Variants (DGV)PTPRM [DGVbeta]
DECIPHERPTPRM [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPTPRM 
Mutations
ICGC Data PortalPTPRM 
TCGA Data PortalPTPRM 
Broad Tumor PortalPTPRM
OASIS PortalPTPRM [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPTPRM  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPTPRM
Mutations and Diseases : HGMDPTPRM
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaPTPRM
DgiDB (Drug Gene Interaction Database)PTPRM
DoCM (Curated mutations)PTPRM
CIViC (Clinical Interpretations of Variants in Cancer)PTPRM
Cancer3DPTPRM
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM176888   
Orphanet
DisGeNETPTPRM
MedgenPTPRM
Genetic Testing Registry PTPRM
NextProtP28827 [Medical]
GENETestsPTPRM
Target ValidationPTPRM
Huge Navigator PTPRM [HugePedia]
ClinGenPTPRM
Clinical trials, drugs, therapy
MyCancerGenomePTPRM
Protein Interactions : CTDPTPRM
Pharm GKB GenePA34020
PharosP28827
Clinical trialPTPRM
Miscellaneous
canSAR (ICR)PTPRM
HarmonizomePTPRM
DataMed IndexPTPRM
Probes
Litterature
PubMed59 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXPTPRM
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 4 15:27:32 CEST 2021

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.