PTPRZ1 (protein tyrosine phosphatase receptor type Z1)

2003-11-01  

Identity

HGNC
LOCATION
7q31.32
LOCUSID
ALIAS
HPTPZ,HPTPzeta,PTP-ZETA,PTP18,PTPRZ,PTPZ,R-PTP-zeta-2,RPTPB,RPTPbeta,phosphacan
FUSION GENES

Other Information

Locus ID:

NCBI: 5803
MIM: 176891
HGNC: 9685
Ensembl: ENSG00000106278

Variants:

dbSNP: 5803
ClinVar: 5803
TCGA: ENSG00000106278
COSMIC: PTPRZ1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000106278ENST00000393386P23471
ENSG00000106278ENST00000449182P23471
ENSG00000106278ENST00000650681A0A494C0U4
ENSG00000106278ENST00000650728A0A494C1R4
ENSG00000106278ENST00000650826A0A494C036
ENSG00000106278ENST00000651065A0A494C1H9
ENSG00000106278ENST00000651320A0A494C055
ENSG00000106278ENST00000651390A0A494C1B4
ENSG00000106278ENST00000651841A0A494C1J5
ENSG00000106278ENST00000651842A0A494C1B4
ENSG00000106278ENST00000651863A0A494C087
ENSG00000106278ENST00000652054A0A494C0V2
ENSG00000106278ENST00000652298P23471
ENSG00000106278ENST00000652708A0A494C1F0

Expression (GTEx)

0
10
20
30
40
50
60
70
80

Pathways

PathwaySourceExternal ID
Epithelial cell signaling in Helicobacter pylori infectionKEGGko05120
Epithelial cell signaling in Helicobacter pylori infectionKEGGhsa05120

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
251359582014RNA-seq of 272 gliomas revealed a novel, recurrent PTPRZ1-MET fusion transcript in secondary glioblastomas.97
176819472007Anaplastic lymphoma kinase is activated through the pleiotrophin/receptor protein-tyrosine phosphatase beta/zeta signaling pathway: an alternative mechanism of receptor tyrosine kinase activation.46
201337742010The protein tyrosine phosphatases PTPRZ and PTPRG bind to distinct members of the contactin family of neural recognition molecules.46
123550662002A critical role for the protein tyrosine phosphatase receptor type Z in functional recovery from demyelinating lesions.45
202019262010Human variation in alcohol response is influenced by variation in neuronal signaling genes.45
237440802013Receptor-type protein-tyrosine phosphatase ζ is a functional receptor for interleukin-34.44
145559792003A role for receptor tyrosine phosphatase zeta in glioma cell migration.36
188383832008Receptor tyrosine phosphatase beta (RPTPbeta) activity and signaling are attenuated by glycosylation and subsequent cell surface galectin-1 binding.34
219695502011A complex between contactin-1 and the protein tyrosine phosphatase PTPRZ controls the development of oligodendrocyte precursor cells.34
285697472017Tumour-associated macrophages secrete pleiotrophin to promote PTPRZ1 signalling in glioblastoma stem cells for tumour growth.34

Citation

Dessen P

PTPRZ1 (protein tyrosine phosphatase receptor type Z1)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/41941/ptprz1