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PTPRZ1 (protein tyrosine phosphatase receptor type Z1)

Identity

Alias (NCBI)HPTPZ
HPTPzeta
PTP-ZETA
PTP18
PTPRZ
PTPZ
R-PTP-zeta-2
RPTPB
RPTPbeta
phosphacan
HGNC (Hugo) PTPRZ1
HGNC Alias symbPTP18
RPTPB
phosphacan
HGNC Previous namePTPZ
 PTPRZ
HGNC Previous nameprotein tyrosine phosphatase, receptor-type, Z polypeptide 1
LocusID (NCBI) 5803
Atlas_Id 41941
Location 7q31.32  [Link to chromosome band 7q31]
Location_base_pair Starts at 121873161 and ends at 122062036 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
PTPRZ1 (7q31.32)::FYN (6q21)PTPRZ1 (7q31.32)::HMCN1 (1q25.3)PTPRZ1 (7q31.32)::MET (7q31.2)
PTPRZ1 (7q31.32)::PIN1 (19p13.2)PTPRZ1 (7q31.32)::PTPRZ1 (7q31.32)PTPRZ1 (7q31.32)::SND1 (7q32.1)
PTPRZ1 (7q31.32)::TSPAN33 (7q32.1)ZNF708 (19p12)::PTPRZ1 (7q31.32)PTPRZ1 7q31.32::FYN 6q21
PTPRZ1 7q31.32::TSPAN33 7q32.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)PTPRZ1   9685
LRG (Locus Reference Genomic)LRG_1387
Cards
Entrez_Gene (NCBI)PTPRZ1    protein tyrosine phosphatase receptor type Z1
AliasesHPTPZ; HPTPzeta; PTP-ZETA; PTP18; 
PTPRZ; PTPZ; R-PTP-zeta-2; RPTPB; RPTPbeta; phosphacan
GeneCards (Weizmann)PTPRZ1
Ensembl hg19 (Hinxton)ENSG00000106278 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000106278 [Gene_View]  ENSG00000106278 [Sequence]  chr7:121873161-122062036 [Contig_View]  PTPRZ1 [Vega]
ICGC DataPortalENSG00000106278
TCGA cBioPortalPTPRZ1
AceView (NCBI)PTPRZ1
Genatlas (Paris)PTPRZ1
SOURCE (Princeton)PTPRZ1
Genetics Home Reference (NIH)PTPRZ1
Genomic and cartography
GoldenPath hg38 (UCSC)PTPRZ1  -     chr7:121873161-122062036 +  7q31.32   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PTPRZ1  -     7q31.32   [Description]    (hg19-Feb_2009)
GoldenPathPTPRZ1 - 7q31.32 [CytoView hg19]  PTPRZ1 - 7q31.32 [CytoView hg38]
ImmunoBaseENSG00000106278
Genome Data Viewer NCBIPTPRZ1 [Mapview hg19]  
OMIM176891   
Gene and transcription
Genbank (Entrez)AK294062 BC131736 CX868991 CX872418 DA101746
RefSeq transcript (Entrez)NM_001206838 NM_001206839 NM_001369395 NM_001369396 NM_002851
Consensus coding sequences : CCDS (NCBI)PTPRZ1
Gene ExpressionPTPRZ1 [ NCBI-GEO ]   PTPRZ1 [ EBI - ARRAY_EXPRESS ]   PTPRZ1 [ SEEK ]   PTPRZ1 [ MEM ]
Gene Expression Viewer (FireBrowse)PTPRZ1 [ Firebrowse - Broad ]
GenevisibleExpression of PTPRZ1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5803
GTEX Portal (Tissue expression)PTPRZ1
Human Protein AtlasENSG00000106278-PTPRZ1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP23471   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP23471  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP23471
PhosPhoSitePlusP23471
Domaine pattern : Prosite (Expaxy)ALPHA_CA_2 (PS51144)    FN3 (PS50853)    TYR_PHOSPHATASE_1 (PS00383)    TYR_PHOSPHATASE_2 (PS50056)    TYR_PHOSPHATASE_PTP (PS50055)   
Domains : Interpro (EBI)Alpha_CARP_receptor-type    CA_dom    CA_dom_sf    FN3_dom    FN3_sf    Ig-like_fold    Prot-tyrosine_phosphatase-like    PTPase_domain    Tyr_Pase_AS    Tyr_Pase_cat    TYR_PHOSPHATASE_dom   
Domain families : Pfam (Sanger)Carb_anhydrase (PF00194)    fn3 (PF00041)    Y_phosphatase (PF00102)   
Domain families : Pfam (NCBI)pfam00194    pfam00041    pfam00102   
Domain families : Smart (EMBL)Carb_anhydrase (SM01057)  FN3 (SM00060)  PTPc (SM00194)  PTPc_motif (SM00404)  
Conserved Domain (NCBI)PTPRZ1
PDB (RSDB)3JXF    3S97    5AWX    5H08   
PDB Europe3JXF    3S97    5AWX    5H08   
PDB (PDBSum)3JXF    3S97    5AWX    5H08   
PDB (IMB)3JXF    3S97    5AWX    5H08   
Structural Biology KnowledgeBase3JXF    3S97    5AWX    5H08   
SCOP (Structural Classification of Proteins)3JXF    3S97    5AWX    5H08   
CATH (Classification of proteins structures)3JXF    3S97    5AWX    5H08   
SuperfamilyP23471
AlphaFold pdb e-kbP23471   
Human Protein Atlas [tissue]ENSG00000106278-PTPRZ1 [tissue]
HPRD01481
Protein Interaction databases
DIP (DOE-UCLA)P23471
IntAct (EBI)P23471
BioGRIDPTPRZ1
STRING (EMBL)PTPRZ1
ZODIACPTPRZ1
Ontologies - Pathways
QuickGOP23471
Ontology : AmiGOhematopoietic progenitor cell differentiation  protein tyrosine phosphatase activity  protein tyrosine phosphatase activity  protein tyrosine phosphatase activity  protein tyrosine phosphatase activity  transmembrane receptor protein tyrosine phosphatase activity  integrin binding  protein binding  extracellular region  plasma membrane  plasma membrane  integral component of plasma membrane  protein dephosphorylation  axonogenesis  central nervous system development  learning or memory  intrinsic component of plasma membrane  regulation of myelination  peptidyl-tyrosine dephosphorylation  peptidyl-tyrosine dephosphorylation  negative regulation of neuron apoptotic process  synapse  oligodendrocyte differentiation  positive regulation of oligodendrocyte differentiation  regulation of oligodendrocyte progenitor proliferation  perineuronal net  
Ontology : EGO-EBIhematopoietic progenitor cell differentiation  protein tyrosine phosphatase activity  protein tyrosine phosphatase activity  protein tyrosine phosphatase activity  protein tyrosine phosphatase activity  transmembrane receptor protein tyrosine phosphatase activity  integrin binding  protein binding  extracellular region  plasma membrane  plasma membrane  integral component of plasma membrane  protein dephosphorylation  axonogenesis  central nervous system development  learning or memory  intrinsic component of plasma membrane  regulation of myelination  peptidyl-tyrosine dephosphorylation  peptidyl-tyrosine dephosphorylation  negative regulation of neuron apoptotic process  synapse  oligodendrocyte differentiation  positive regulation of oligodendrocyte differentiation  regulation of oligodendrocyte progenitor proliferation  perineuronal net  
Pathways : KEGGKEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION   
NDEx NetworkPTPRZ1
Atlas of Cancer Signalling NetworkPTPRZ1
Wikipedia pathwaysPTPRZ1
Orthology - Evolution
OrthoDB5803
GeneTree (enSembl)ENSG00000106278
Phylogenetic Trees/Animal Genes : TreeFamPTPRZ1
Homologs : HomoloGenePTPRZ1
Homology/Alignments : Family Browser (UCSC)PTPRZ1
Gene fusions - Rearrangements
Fusion : MitelmanPTPRZ1::FYN [7q31.32/6q21]  
Fusion : MitelmanPTPRZ1::TSPAN33 [7q31.32/7q32.1]  
Fusion : QuiverPTPRZ1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPTPRZ1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PTPRZ1
dbVarPTPRZ1
ClinVarPTPRZ1
MonarchPTPRZ1
1000_GenomesPTPRZ1 
Exome Variant ServerPTPRZ1
GNOMAD BrowserENSG00000106278
Varsome BrowserPTPRZ1
ACMGPTPRZ1 variants
VarityP23471
Genomic Variants (DGV)PTPRZ1 [DGVbeta]
DECIPHERPTPRZ1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPTPRZ1 
Mutations
ICGC Data PortalPTPRZ1 
TCGA Data PortalPTPRZ1 
Broad Tumor PortalPTPRZ1
OASIS PortalPTPRZ1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPTPRZ1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPTPRZ1
Mutations and Diseases : HGMDPTPRZ1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaPTPRZ1
DgiDB (Drug Gene Interaction Database)PTPRZ1
DoCM (Curated mutations)PTPRZ1
CIViC (Clinical Interpretations of Variants in Cancer)PTPRZ1
Cancer3DPTPRZ1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM176891   
Orphanet
DisGeNETPTPRZ1
MedgenPTPRZ1
Genetic Testing Registry PTPRZ1
NextProtP23471 [Medical]
GENETestsPTPRZ1
Target ValidationPTPRZ1
Huge Navigator PTPRZ1 [HugePedia]
ClinGenPTPRZ1
Clinical trials, drugs, therapy
MyCancerGenomePTPRZ1
Protein Interactions : CTDPTPRZ1
Pharm GKB GenePA34029
PharosP23471
Clinical trialPTPRZ1
Miscellaneous
canSAR (ICR)PTPRZ1
HarmonizomePTPRZ1
ARCHS4PTPRZ1
DataMed IndexPTPRZ1
Probes
Litterature
PubMed89 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXPTPRZ1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Thu Jan 20 12:54:38 CET 2022

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