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PTPRZ1 (protein tyrosine phosphatase, receptor type Z1)

Identity

Alias_namesPTPZ
PTPRZ
protein tyrosine phosphatase
Alias_symbol (synonym)PTP18
RPTPB
phosphacan
Other aliasHPTPZ
HPTPzeta
PTP-ZETA
R-PTP-zeta-2
RPTPbeta
HGNC (Hugo) PTPRZ1
LocusID (NCBI) 5803
Atlas_Id 41941
Location 7q31.32  [Link to chromosome band 7q31]
Location_base_pair Starts at 121873105 and ends at 122062036 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
PTPRZ1 (7q31.32) / FYN (6q21)PTPRZ1 (7q31.32) / HMCN1 (1q25.3)PTPRZ1 (7q31.32) / MET (7q31.2)
PTPRZ1 (7q31.32) / PIN1 (19p13.2)PTPRZ1 (7q31.32) / PTPRZ1 (7q31.32)PTPRZ1 (7q31.32) / SND1 (7q32.1)
PTPRZ1 (7q31.32) / TSPAN33 (7q32.1)ZNF708 (19p12) / PTPRZ1 (7q31.32)PTPRZ1 7q31.32 / FYN 6q21
PTPRZ1 7q31.32 / TSPAN33 7q32.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PTPRZ1   9685
Cards
Entrez_Gene (NCBI)PTPRZ1  5803  protein tyrosine phosphatase, receptor type Z1
AliasesHPTPZ; HPTPzeta; PTP-ZETA; PTP18; 
PTPRZ; PTPZ; R-PTP-zeta-2; RPTPB; RPTPbeta; phosphacan
GeneCards (Weizmann)PTPRZ1
Ensembl hg19 (Hinxton)ENSG00000106278 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000106278 [Gene_View]  chr7:121873105-122062036 [Contig_View]  PTPRZ1 [Vega]
ICGC DataPortalENSG00000106278
TCGA cBioPortalPTPRZ1
AceView (NCBI)PTPRZ1
Genatlas (Paris)PTPRZ1
WikiGenes5803
SOURCE (Princeton)PTPRZ1
Genetics Home Reference (NIH)PTPRZ1
Genomic and cartography
GoldenPath hg38 (UCSC)PTPRZ1  -     chr7:121873105-122062036 +  7q31.32   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PTPRZ1  -     7q31.32   [Description]    (hg19-Feb_2009)
EnsemblPTPRZ1 - 7q31.32 [CytoView hg19]  PTPRZ1 - 7q31.32 [CytoView hg38]
Mapping of homologs : NCBIPTPRZ1 [Mapview hg19]  PTPRZ1 [Mapview hg38]
OMIM176891   600263   
Gene and transcription
Genbank (Entrez)AK294062 BC131736 BC172407 CX868991 CX872418
RefSeq transcript (Entrez)NM_001206838 NM_001206839 NM_002851
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PTPRZ1
Cluster EST : UnigeneHs.489824 [ NCBI ]
CGAP (NCI)Hs.489824
Alternative Splicing GalleryENSG00000106278
Gene ExpressionPTPRZ1 [ NCBI-GEO ]   PTPRZ1 [ EBI - ARRAY_EXPRESS ]   PTPRZ1 [ SEEK ]   PTPRZ1 [ MEM ]
Gene Expression Viewer (FireBrowse)PTPRZ1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5803
GTEX Portal (Tissue expression)PTPRZ1
Protein : pattern, domain, 3D structure
UniProt/SwissProtP23471   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP23471  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP23471
Splice isoforms : SwissVarP23471
PhosPhoSitePlusP23471
Domaine pattern : Prosite (Expaxy)ALPHA_CA_2 (PS51144)    FN3 (PS50853)    TYR_PHOSPHATASE_1 (PS00383)    TYR_PHOSPHATASE_2 (PS50056)    TYR_PHOSPHATASE_PTP (PS50055)   
Domains : Interpro (EBI)Carbonic_anhydrase_a    FN3_dom    Ig-like_fold    Prot-tyrosine_phosphatase-like    PTPase_domain    Tyr_Pase_AS    Tyr_Pase_cat    TYR_PHOSPHATASE_dom   
Domain families : Pfam (Sanger)Carb_anhydrase (PF00194)    fn3 (PF00041)    Y_phosphatase (PF00102)   
Domain families : Pfam (NCBI)pfam00194    pfam00041    pfam00102   
Domain families : Smart (EMBL)Carb_anhydrase (SM01057)  FN3 (SM00060)  PTPc (SM00194)  PTPc_motif (SM00404)  
Conserved Domain (NCBI)PTPRZ1
DMDM Disease mutations5803
Blocks (Seattle)PTPRZ1
PDB (SRS)3JXF    3S97    5AWX   
PDB (PDBSum)3JXF    3S97    5AWX   
PDB (IMB)3JXF    3S97    5AWX   
PDB (RSDB)3JXF    3S97    5AWX   
Structural Biology KnowledgeBase3JXF    3S97    5AWX   
SCOP (Structural Classification of Proteins)3JXF    3S97    5AWX   
CATH (Classification of proteins structures)3JXF    3S97    5AWX   
SuperfamilyP23471
Human Protein AtlasENSG00000106278
Peptide AtlasP23471
HPRD01481
IPIIPI00748312   IPI00871792   IPI01011977   
Protein Interaction databases
DIP (DOE-UCLA)P23471
IntAct (EBI)P23471
FunCoupENSG00000106278
BioGRIDPTPRZ1
STRING (EMBL)PTPRZ1
ZODIACPTPRZ1
Ontologies - Pathways
QuickGOP23471
Ontology : AmiGOhematopoietic progenitor cell differentiation  protein tyrosine phosphatase activity  transmembrane receptor protein tyrosine phosphatase activity  protein binding  proteinaceous extracellular matrix  integral component of plasma membrane  protein dephosphorylation  axonogenesis  central nervous system development  learning or memory  intrinsic component of plasma membrane  peptidyl-tyrosine dephosphorylation  oligodendrocyte differentiation  regulation of oligodendrocyte progenitor proliferation  perineuronal net  
Ontology : EGO-EBIhematopoietic progenitor cell differentiation  protein tyrosine phosphatase activity  transmembrane receptor protein tyrosine phosphatase activity  protein binding  proteinaceous extracellular matrix  integral component of plasma membrane  protein dephosphorylation  axonogenesis  central nervous system development  learning or memory  intrinsic component of plasma membrane  peptidyl-tyrosine dephosphorylation  oligodendrocyte differentiation  regulation of oligodendrocyte progenitor proliferation  perineuronal net  
Pathways : KEGGEpithelial cell signaling in Helicobacter pylori infection   
NDEx NetworkPTPRZ1
Atlas of Cancer Signalling NetworkPTPRZ1
Wikipedia pathwaysPTPRZ1
Orthology - Evolution
OrthoDB5803
GeneTree (enSembl)ENSG00000106278
Phylogenetic Trees/Animal Genes : TreeFamPTPRZ1
HOVERGENP23471
HOGENOMP23471
Homologs : HomoloGenePTPRZ1
Homology/Alignments : Family Browser (UCSC)PTPRZ1
Gene fusions - Rearrangements
Fusion : MitelmanPTPRZ1/FYN [7q31.32/6q21]  
Fusion : MitelmanPTPRZ1/TSPAN33 [7q31.32/7q32.1]  [t(7;7)(q31;q32)]  
Fusion: TCGAPTPRZ1 7q31.32 FYN 6q21 LGG
Fusion: TCGAPTPRZ1 7q31.32 TSPAN33 7q32.1 HNSC
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPTPRZ1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PTPRZ1
dbVarPTPRZ1
ClinVarPTPRZ1
1000_GenomesPTPRZ1 
Exome Variant ServerPTPRZ1
ExAC (Exome Aggregation Consortium)PTPRZ1 (select the gene name)
Genetic variants : HAPMAP5803
Genomic Variants (DGV)PTPRZ1 [DGVbeta]
DECIPHERPTPRZ1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPTPRZ1 
Mutations
ICGC Data PortalPTPRZ1 
TCGA Data PortalPTPRZ1 
Broad Tumor PortalPTPRZ1
OASIS PortalPTPRZ1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPTPRZ1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPTPRZ1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PTPRZ1
DgiDB (Drug Gene Interaction Database)PTPRZ1
DoCM (Curated mutations)PTPRZ1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PTPRZ1 (select a term)
intoGenPTPRZ1
Cancer3DPTPRZ1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM176891    600263   
Orphanet
MedgenPTPRZ1
Genetic Testing Registry PTPRZ1
NextProtP23471 [Medical]
TSGene5803
GENETestsPTPRZ1
Target ValidationPTPRZ1
Huge Navigator PTPRZ1 [HugePedia]
snp3D : Map Gene to Disease5803
BioCentury BCIQPTPRZ1
ClinGenPTPRZ1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5803
Chemical/Pharm GKB GenePA34029
Clinical trialPTPRZ1
Miscellaneous
canSAR (ICR)PTPRZ1 (select the gene name)
Probes
Litterature
PubMed72 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePTPRZ1
EVEXPTPRZ1
GoPubMedPTPRZ1
iHOPPTPRZ1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:27:18 CEST 2017

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