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PTPRZ1 (protein tyrosine phosphatase receptor type Z1)

Identity

Alias_namesPTPZ
PTPRZ
protein tyrosine phosphatase, receptor-type, Z polypeptide 1
Alias_symbol (synonym)PTP18
RPTPB
phosphacan
Other aliasHPTPZ
HPTPzeta
PTP-ZETA
R-PTP-zeta-2
RPTPbeta
HGNC (Hugo) PTPRZ1
LocusID (NCBI) 5803
Atlas_Id 41941
Location 7q31.32  [Link to chromosome band 7q31]
Location_base_pair Starts at 121873161 and ends at 122062036 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
PTPRZ1 (7q31.32) / FYN (6q21)PTPRZ1 (7q31.32) / HMCN1 (1q25.3)PTPRZ1 (7q31.32) / MET (7q31.2)
PTPRZ1 (7q31.32) / PIN1 (19p13.2)PTPRZ1 (7q31.32) / PTPRZ1 (7q31.32)PTPRZ1 (7q31.32) / SND1 (7q32.1)
PTPRZ1 (7q31.32) / TSPAN33 (7q32.1)ZNF708 (19p12) / PTPRZ1 (7q31.32)PTPRZ1 7q31.32 / FYN 6q21
PTPRZ1 7q31.32 / TSPAN33 7q32.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 4 ]
  t(6;7)(q21;q31) PTPRZ1/FYN
PTPRZ1/MET (7q31)
t(7;7)(q31;q32) PTPRZ1/TSPAN33
t(7;22)(q31;q13) PTPRZ1/NFAM1


External links

Nomenclature
HGNC (Hugo)PTPRZ1   9685
Cards
Entrez_Gene (NCBI)PTPRZ1  5803  protein tyrosine phosphatase receptor type Z1
AliasesHPTPZ; HPTPzeta; PTP-ZETA; PTP18; 
PTPRZ; PTPZ; R-PTP-zeta-2; RPTPB; RPTPbeta; phosphacan
GeneCards (Weizmann)PTPRZ1
Ensembl hg19 (Hinxton)ENSG00000106278 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000106278 [Gene_View]  ENSG00000106278 [Sequence]  chr7:121873161-122062036 [Contig_View]  PTPRZ1 [Vega]
ICGC DataPortalENSG00000106278
TCGA cBioPortalPTPRZ1
AceView (NCBI)PTPRZ1
Genatlas (Paris)PTPRZ1
WikiGenes5803
SOURCE (Princeton)PTPRZ1
Genetics Home Reference (NIH)PTPRZ1
Genomic and cartography
GoldenPath hg38 (UCSC)PTPRZ1  -     chr7:121873161-122062036 +  7q31.32   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PTPRZ1  -     7q31.32   [Description]    (hg19-Feb_2009)
GoldenPathPTPRZ1 - 7q31.32 [CytoView hg19]  PTPRZ1 - 7q31.32 [CytoView hg38]
Genome Data Viewer NCBIPTPRZ1 [Mapview hg19]  
OMIM176891   
Gene and transcription
Genbank (Entrez)AK294062 BC131736 CX868991 CX872418 DA101746
RefSeq transcript (Entrez)NM_001206838 NM_001206839 NM_001369395 NM_001369396 NM_002851
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PTPRZ1
Alternative Splicing GalleryENSG00000106278
Gene ExpressionPTPRZ1 [ NCBI-GEO ]   PTPRZ1 [ EBI - ARRAY_EXPRESS ]   PTPRZ1 [ SEEK ]   PTPRZ1 [ MEM ]
Gene Expression Viewer (FireBrowse)PTPRZ1 [ Firebrowse - Broad ]
GenevisibleExpression of PTPRZ1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5803
GTEX Portal (Tissue expression)PTPRZ1
Human Protein AtlasENSG00000106278-PTPRZ1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP23471   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP23471  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP23471
Splice isoforms : SwissVarP23471
PhosPhoSitePlusP23471
Domaine pattern : Prosite (Expaxy)ALPHA_CA_2 (PS51144)    FN3 (PS50853)    TYR_PHOSPHATASE_1 (PS00383)    TYR_PHOSPHATASE_2 (PS50056)    TYR_PHOSPHATASE_PTP (PS50055)   
Domains : Interpro (EBI)Alpha_CARP_receptor-type    CA_dom    CA_dom_sf    FN3_dom    FN3_sf    Ig-like_fold    Prot-tyrosine_phosphatase-like    PTPase_domain    Tyr_Pase_AS    Tyr_Pase_cat    TYR_PHOSPHATASE_dom   
Domain families : Pfam (Sanger)Carb_anhydrase (PF00194)    fn3 (PF00041)    Y_phosphatase (PF00102)   
Domain families : Pfam (NCBI)pfam00194    pfam00041    pfam00102   
Domain families : Smart (EMBL)Carb_anhydrase (SM01057)  FN3 (SM00060)  PTPc (SM00194)  PTPc_motif (SM00404)  
Conserved Domain (NCBI)PTPRZ1
DMDM Disease mutations5803
PDB (RSDB)3JXF    3S97    5AWX    5H08   
PDB Europe3JXF    3S97    5AWX    5H08   
PDB (PDBSum)3JXF    3S97    5AWX    5H08   
PDB (IMB)3JXF    3S97    5AWX    5H08   
Structural Biology KnowledgeBase3JXF    3S97    5AWX    5H08   
SCOP (Structural Classification of Proteins)3JXF    3S97    5AWX    5H08   
CATH (Classification of proteins structures)3JXF    3S97    5AWX    5H08   
SuperfamilyP23471
Human Protein Atlas [tissue]ENSG00000106278-PTPRZ1 [tissue]
Peptide AtlasP23471
HPRD01481
IPIIPI00748312   IPI00871792   IPI01011977   
Protein Interaction databases
DIP (DOE-UCLA)P23471
IntAct (EBI)P23471
FunCoupENSG00000106278
BioGRIDPTPRZ1
STRING (EMBL)PTPRZ1
ZODIACPTPRZ1
Ontologies - Pathways
QuickGOP23471
Ontology : AmiGOhematopoietic progenitor cell differentiation  protein tyrosine phosphatase activity  protein tyrosine phosphatase activity  protein tyrosine phosphatase activity  transmembrane receptor protein tyrosine phosphatase activity  integrin binding  protein binding  plasma membrane  plasma membrane  integral component of plasma membrane  protein dephosphorylation  axonogenesis  central nervous system development  learning or memory  cytokine-mediated signaling pathway  intrinsic component of plasma membrane  regulation of myelination  peptidyl-tyrosine dephosphorylation  peptidyl-tyrosine dephosphorylation  negative regulation of neuron apoptotic process  synapse  oligodendrocyte differentiation  positive regulation of oligodendrocyte differentiation  regulation of oligodendrocyte progenitor proliferation  perineuronal net  
Ontology : EGO-EBIhematopoietic progenitor cell differentiation  protein tyrosine phosphatase activity  protein tyrosine phosphatase activity  protein tyrosine phosphatase activity  transmembrane receptor protein tyrosine phosphatase activity  integrin binding  protein binding  plasma membrane  plasma membrane  integral component of plasma membrane  protein dephosphorylation  axonogenesis  central nervous system development  learning or memory  cytokine-mediated signaling pathway  intrinsic component of plasma membrane  regulation of myelination  peptidyl-tyrosine dephosphorylation  peptidyl-tyrosine dephosphorylation  negative regulation of neuron apoptotic process  synapse  oligodendrocyte differentiation  positive regulation of oligodendrocyte differentiation  regulation of oligodendrocyte progenitor proliferation  perineuronal net  
Pathways : KEGGEpithelial cell signaling in Helicobacter pylori infection   
NDEx NetworkPTPRZ1
Atlas of Cancer Signalling NetworkPTPRZ1
Wikipedia pathwaysPTPRZ1
Orthology - Evolution
OrthoDB5803
GeneTree (enSembl)ENSG00000106278
Phylogenetic Trees/Animal Genes : TreeFamPTPRZ1
HOGENOMP23471
Homologs : HomoloGenePTPRZ1
Homology/Alignments : Family Browser (UCSC)PTPRZ1
Gene fusions - Rearrangements
Fusion : MitelmanPTPRZ1/FYN [7q31.32/6q21]  
Fusion : MitelmanPTPRZ1/TSPAN33 [7q31.32/7q32.1]  
Fusion PortalPTPRZ1 7q31.32 FYN 6q21 LGG
Fusion PortalPTPRZ1 7q31.32 TSPAN33 7q32.1 HNSC
Fusion : QuiverPTPRZ1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPTPRZ1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PTPRZ1
dbVarPTPRZ1
ClinVarPTPRZ1
1000_GenomesPTPRZ1 
Exome Variant ServerPTPRZ1
GNOMAD BrowserENSG00000106278
Varsome BrowserPTPRZ1
Genetic variants : HAPMAP5803
Genomic Variants (DGV)PTPRZ1 [DGVbeta]
DECIPHERPTPRZ1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPTPRZ1 
Mutations
ICGC Data PortalPTPRZ1 
TCGA Data PortalPTPRZ1 
Broad Tumor PortalPTPRZ1
OASIS PortalPTPRZ1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPTPRZ1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPTPRZ1
Mutations and Diseases : HGMDPTPRZ1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutaselect PTPRZ1
DgiDB (Drug Gene Interaction Database)PTPRZ1
DoCM (Curated mutations)PTPRZ1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PTPRZ1 (select a term)
intoGenPTPRZ1
Cancer3DPTPRZ1 (select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM176891   
Orphanet
DisGeNETPTPRZ1
MedgenPTPRZ1
Genetic Testing Registry PTPRZ1
NextProtP23471 [Medical]
TSGene5803
GENETestsPTPRZ1
Open Targets GeneticsENSG00000106278  [validation]
snp3D : Map Gene to Disease5803
BioCentury BCIQPTPRZ1
ClinGenPTPRZ1
Clinical trials, drugs, therapy
Protein Interactions : CTD5803
Pharm GKB GenePA34029
Clinical trialPTPRZ1
Miscellaneous
canSAR (ICR)PTPRZ1 (select the gene name)
HarmonizomePTPRZ1
DataMed IndexPTPRZ1
Probes
Litterature
PubMed85 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePTPRZ1
EVEXPTPRZ1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Sat Jul 11 20:07:30 CEST 2020

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