Atlas of Genetics and Cytogenetics in Oncology and Haematology


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PXK (PX domain containing serine/threonine kinase like)

Identity

Alias_namesPX domain containing serine/threonine kinase
Alias_symbol (synonym)FLJ20335
Other aliasMONaKA
HGNC (Hugo) PXK
LocusID (NCBI) 54899
Atlas_Id 43440
Location 3p14.3  [Link to chromosome band 3p14]
Location_base_pair Starts at 58318617 and ends at 58411854 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
DYNC1LI1 (3p22.3) / PXK (3p14.3)PXK (3p14.3) / PXK (3p14.3)PXK (3p14.3) / RPP14 (3p14.3)
TXNDC5 (6p24.3) / PXK (3p14.3)UHRF1BP1L (12q23.1) / PXK (3p14.3)PXK 3p14.3 / RPP14 3p14.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PXK   23326
Cards
Entrez_Gene (NCBI)PXK  54899  PX domain containing serine/threonine kinase like
AliasesMONaKA
GeneCards (Weizmann)PXK
Ensembl hg19 (Hinxton)ENSG00000168297 [Gene_View]  chr3:58318617-58411854 [Contig_View]  PXK [Vega]
Ensembl hg38 (Hinxton)ENSG00000168297 [Gene_View]  chr3:58318617-58411854 [Contig_View]  PXK [Vega]
ICGC DataPortalENSG00000168297
TCGA cBioPortalPXK
AceView (NCBI)PXK
Genatlas (Paris)PXK
WikiGenes54899
SOURCE (Princeton)PXK
Genetics Home Reference (NIH)PXK
Genomic and cartography
GoldenPath hg19 (UCSC)PXK  -     chr3:58318617-58411854 +  3p14.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PXK  -     3p14.3   [Description]    (hg38-Dec_2013)
EnsemblPXK - 3p14.3 [CytoView hg19]  PXK - 3p14.3 [CytoView hg38]
Mapping of homologs : NCBIPXK [Mapview hg19]  PXK [Mapview hg38]
OMIM611450   
Gene and transcription
Genbank (Entrez)AB209688 AF399753 AK000342 AK124775 AK131385
RefSeq transcript (Entrez)NM_001289095 NM_001289096 NM_001289098 NM_001289099 NM_001289100 NM_001289101 NM_017771
RefSeq genomic (Entrez)NC_000003 NC_018914 NT_022517 NW_004929309
Consensus coding sequences : CCDS (NCBI)PXK
Cluster EST : UnigeneHs.190544 [ NCBI ]
CGAP (NCI)Hs.190544
Alternative Splicing GalleryENSG00000168297
Gene ExpressionPXK [ NCBI-GEO ]   PXK [ EBI - ARRAY_EXPRESS ]   PXK [ SEEK ]   PXK [ MEM ]
Gene Expression Viewer (FireBrowse)PXK [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)54899
GTEX Portal (Tissue expression)PXK
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ7Z7A4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ7Z7A4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ7Z7A4
Splice isoforms : SwissVarQ7Z7A4
PhosPhoSitePlusQ7Z7A4
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_DOM (PS50011)    PX (PS50195)    WH2 (PS51082)   
Domains : Interpro (EBI)Kinase-like_dom    Phox    Prot_kinase_dom    WH2_dom   
Domain families : Pfam (Sanger)Pkinase (PF00069)    PX (PF00787)    WH2 (PF02205)   
Domain families : Pfam (NCBI)pfam00069    pfam00787    pfam02205   
Domain families : Smart (EMBL)PX (SM00312)  
Conserved Domain (NCBI)PXK
DMDM Disease mutations54899
Blocks (Seattle)PXK
SuperfamilyQ7Z7A4
Human Protein AtlasENSG00000168297
Peptide AtlasQ7Z7A4
HPRD17936
IPIIPI00479912   IPI00655607   IPI00656013   IPI00654715   IPI00655666   IPI00655529   IPI00556666   IPI00945014   IPI00946406   IPI00945334   IPI00946612   IPI00946053   IPI00947510   IPI00985173   IPI00945523   
Protein Interaction databases
DIP (DOE-UCLA)Q7Z7A4
IntAct (EBI)Q7Z7A4
FunCoupENSG00000168297
BioGRIDPXK
STRING (EMBL)PXK
ZODIACPXK
Ontologies - Pathways
QuickGOQ7Z7A4
Ontology : AmiGOnucleotide binding  actin binding  protein kinase activity  ATP binding  nucleus  cytoplasm  cytoplasm  microtubule organizing center  plasma membrane  plasma membrane  plasma membrane  protein phosphorylation  inflammatory response  protein C-terminus binding  protein C-terminus binding  negative regulation of ATPase activity  negative regulation of ATPase activity  phosphatidylinositol binding  phosphatidylinositol binding  regulation of membrane potential  protein complex  negative regulation of ion transport  negative regulation of ion transport  modulation of synaptic transmission  
Ontology : EGO-EBInucleotide binding  actin binding  protein kinase activity  ATP binding  nucleus  cytoplasm  cytoplasm  microtubule organizing center  plasma membrane  plasma membrane  plasma membrane  protein phosphorylation  inflammatory response  protein C-terminus binding  protein C-terminus binding  negative regulation of ATPase activity  negative regulation of ATPase activity  phosphatidylinositol binding  phosphatidylinositol binding  regulation of membrane potential  protein complex  negative regulation of ion transport  negative regulation of ion transport  modulation of synaptic transmission  
NDEx NetworkPXK
Atlas of Cancer Signalling NetworkPXK
Wikipedia pathwaysPXK
Orthology - Evolution
OrthoDB54899
GeneTree (enSembl)ENSG00000168297
Phylogenetic Trees/Animal Genes : TreeFamPXK
HOVERGENQ7Z7A4
HOGENOMQ7Z7A4
Homologs : HomoloGenePXK
Homology/Alignments : Family Browser (UCSC)PXK
Gene fusions - Rearrangements
Fusion : MitelmanPXK/RPP14 [3p14.3/3p14.3]  
Fusion: TCGAPXK 3p14.3 RPP14 3p14.3 OV
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPXK [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PXK
dbVarPXK
ClinVarPXK
1000_GenomesPXK 
Exome Variant ServerPXK
ExAC (Exome Aggregation Consortium)PXK (select the gene name)
Genetic variants : HAPMAP54899
Genomic Variants (DGV)PXK [DGVbeta]
DECIPHER (Syndromes)3:58318617-58411854  ENSG00000168297
CONAN: Copy Number AnalysisPXK 
Mutations
ICGC Data PortalPXK 
TCGA Data PortalPXK 
Broad Tumor PortalPXK
OASIS PortalPXK [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPXK  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPXK
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PXK
DgiDB (Drug Gene Interaction Database)PXK
DoCM (Curated mutations)PXK (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PXK (select a term)
intoGenPXK
Cancer3DPXK(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM611450   
Orphanet
MedgenPXK
Genetic Testing Registry PXK
NextProtQ7Z7A4 [Medical]
TSGene54899
GENETestsPXK
Huge Navigator PXK [HugePedia]
snp3D : Map Gene to Disease54899
BioCentury BCIQPXK
ClinGenPXK
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD54899
Chemical/Pharm GKB GenePA134899496
Clinical trialPXK
Miscellaneous
canSAR (ICR)PXK (select the gene name)
Probes
Litterature
PubMed24 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePXK
EVEXPXK
GoPubMedPXK
iHOPPXK
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Tue Mar 14 13:23:45 CET 2017

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