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RAB27B (RAB27B, member RAS oncogene family)

Identity

Other aliasC25KG
HGNC (Hugo) RAB27B
LocusID (NCBI) 5874
Atlas_Id 41973
Location 18q21.2  [Link to chromosome band 18q21]
Location_base_pair Starts at 54828477 and ends at 54895516 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
RAB27B (18q21.2) / PXDC1 (6p25.2)RAB27B 18q21.2 C6orf145

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)RAB27B   9767
Cards
Entrez_Gene (NCBI)RAB27B  5874  RAB27B, member RAS oncogene family
AliasesC25KG
GeneCards (Weizmann)RAB27B
Ensembl hg19 (Hinxton)ENSG00000041353 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000041353 [Gene_View]  chr18:54828477-54895516 [Contig_View]  RAB27B [Vega]
ICGC DataPortalENSG00000041353
TCGA cBioPortalRAB27B
AceView (NCBI)RAB27B
Genatlas (Paris)RAB27B
WikiGenes5874
SOURCE (Princeton)RAB27B
Genetics Home Reference (NIH)RAB27B
Genomic and cartography
GoldenPath hg38 (UCSC)RAB27B  -     chr18:54828477-54895516 +  18q21.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RAB27B  -     18q21.2   [Description]    (hg19-Feb_2009)
EnsemblRAB27B - 18q21.2 [CytoView hg19]  RAB27B - 18q21.2 [CytoView hg38]
Mapping of homologs : NCBIRAB27B [Mapview hg19]  RAB27B [Mapview hg38]
OMIM603869   
Gene and transcription
Genbank (Entrez)AF131784 AF329499 AF498954 AK314115 BC027474
RefSeq transcript (Entrez)NM_004163
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)RAB27B
Cluster EST : UnigeneHs.25318 [ NCBI ]
CGAP (NCI)Hs.25318
Alternative Splicing GalleryENSG00000041353
Gene ExpressionRAB27B [ NCBI-GEO ]   RAB27B [ EBI - ARRAY_EXPRESS ]   RAB27B [ SEEK ]   RAB27B [ MEM ]
Gene Expression Viewer (FireBrowse)RAB27B [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5874
GTEX Portal (Tissue expression)RAB27B
Protein : pattern, domain, 3D structure
UniProt/SwissProtO00194   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO00194  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO00194
Splice isoforms : SwissVarO00194
PhosPhoSitePlusO00194
Domaine pattern : Prosite (Expaxy)RAB (PS51419)   
Domains : Interpro (EBI)P-loop_NTPase    Small_GTP-bd_dom    Small_GTPase   
Domain families : Pfam (Sanger)Ras (PF00071)   
Domain families : Pfam (NCBI)pfam00071   
Conserved Domain (NCBI)RAB27B
DMDM Disease mutations5874
Blocks (Seattle)RAB27B
PDB (SRS)2F7S   
PDB (PDBSum)2F7S   
PDB (IMB)2F7S   
PDB (RSDB)2F7S   
Structural Biology KnowledgeBase2F7S   
SCOP (Structural Classification of Proteins)2F7S   
CATH (Classification of proteins structures)2F7S   
SuperfamilyO00194
Human Protein AtlasENSG00000041353
Peptide AtlasO00194
HPRD04846
IPIIPI00010491   
Protein Interaction databases
DIP (DOE-UCLA)O00194
IntAct (EBI)O00194
FunCoupENSG00000041353
BioGRIDRAB27B
STRING (EMBL)RAB27B
ZODIACRAB27B
Ontologies - Pathways
QuickGOO00194
Ontology : AmiGOplatelet degranulation  GTPase activity  protein binding  GTP binding  GTP binding  Golgi stack  plasma membrane  apical plasma membrane  GDP binding  protein domain specific binding  trans-Golgi network transport vesicle  secretory granule  platelet dense granule membrane  myosin V binding  melanosome transport  multivesicular body membrane  melanosome  zymogen granule membrane  positive regulation of exocytosis  extracellular exosome  multivesicular body sorting pathway  
Ontology : EGO-EBIplatelet degranulation  GTPase activity  protein binding  GTP binding  GTP binding  Golgi stack  plasma membrane  apical plasma membrane  GDP binding  protein domain specific binding  trans-Golgi network transport vesicle  secretory granule  platelet dense granule membrane  myosin V binding  melanosome transport  multivesicular body membrane  melanosome  zymogen granule membrane  positive regulation of exocytosis  extracellular exosome  multivesicular body sorting pathway  
Pathways : KEGGPancreatic secretion   
NDEx NetworkRAB27B
Atlas of Cancer Signalling NetworkRAB27B
Wikipedia pathwaysRAB27B
Orthology - Evolution
OrthoDB5874
GeneTree (enSembl)ENSG00000041353
Phylogenetic Trees/Animal Genes : TreeFamRAB27B
HOVERGENO00194
HOGENOMO00194
Homologs : HomoloGeneRAB27B
Homology/Alignments : Family Browser (UCSC)RAB27B
Gene fusions - Rearrangements
Fusion : MitelmanRAB27B/PXDC1 [18q21.2/6p25.2]  
Fusion: TCGARAB27B 18q21.2 C6orf145 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRAB27B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RAB27B
dbVarRAB27B
ClinVarRAB27B
1000_GenomesRAB27B 
Exome Variant ServerRAB27B
ExAC (Exome Aggregation Consortium)RAB27B (select the gene name)
Genetic variants : HAPMAP5874
Genomic Variants (DGV)RAB27B [DGVbeta]
DECIPHERRAB27B [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRAB27B 
Mutations
ICGC Data PortalRAB27B 
TCGA Data PortalRAB27B 
Broad Tumor PortalRAB27B
OASIS PortalRAB27B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRAB27B  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDRAB27B
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RAB27B
DgiDB (Drug Gene Interaction Database)RAB27B
DoCM (Curated mutations)RAB27B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RAB27B (select a term)
intoGenRAB27B
Cancer3DRAB27B(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603869   
Orphanet
MedgenRAB27B
Genetic Testing Registry RAB27B
NextProtO00194 [Medical]
TSGene5874
GENETestsRAB27B
Target ValidationRAB27B
Huge Navigator RAB27B [HugePedia]
snp3D : Map Gene to Disease5874
BioCentury BCIQRAB27B
ClinGenRAB27B
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5874
Chemical/Pharm GKB GenePA34118
Clinical trialRAB27B
Miscellaneous
canSAR (ICR)RAB27B (select the gene name)
Probes
Litterature
PubMed43 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRAB27B
EVEXRAB27B
GoPubMedRAB27B
iHOPRAB27B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:52:05 CEST 2017

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