RAD18 (RAD18 E3 ubiquitin protein ligase)

2003-02-01  

Identity

HGNC
LOCATION
3p25.3
LOCUSID
ALIAS
RNF73
FUSION GENES

Other Information

Locus ID:

NCBI: 56852
MIM: 605256
HGNC: 18278
Ensembl: ENSG00000070950

Variants:

dbSNP: 56852
ClinVar: 56852
TCGA: ENSG00000070950
COSMIC: RAD18

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000070950ENST00000264926Q9NS91
ENSG00000070950ENST00000413832C9J0Q4
ENSG00000070950ENST00000415439F8WE49
ENSG00000070950ENST00000418463F8WAZ7
ENSG00000070950ENST00000421052F8WFA6
ENSG00000070950ENST00000427329H7C3I2
ENSG00000070950ENST00000429790H7C0A5

Expression (GTEx)

0
5
10
15
20

Pathways

PathwaySourceExternal ID
DNA RepairREACTOMER-HSA-73894
DNA Damage BypassREACTOMER-HSA-73893
Recognition of DNA damage by PCNA-containing replication complexREACTOMER-HSA-110314

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
193961642009RAD18 transmits DNA damage signalling to elicit homologous recombination repair.120
166119942006Rad18 regulates DNA polymerase kappa and is required for recovery from S-phase checkpoint-mediated arrest.72
227428332012Tandem protein interaction modules organize the ubiquitin-dependent response to DNA double-strand breaks.70
209376992010RAD18-mediated ubiquitination of PCNA activates the Fanconi anemia DNA repair network.53
214222912011E3 ligase Rad18 promotes monoubiquitination rather than ubiquitin chain formation by E2 enzyme Rad6.50
213550962011The E3 ubiquitin ligase RAD18 regulates ubiquitylation and chromatin loading of FANCD2 and FANCI.43
172422002007RAD18 and poly(ADP-ribose) polymerase independently suppress the access of nonhomologous end joining to double-strand breaks and facilitate homologous recombination-mediated repair.39
206756552010Rad18-mediated translesion synthesis of bulky DNA adducts is coupled to activation of the Fanconi anemia DNA repair pathway.38
171581482007Human RAD18 is involved in S phase-specific single-strand break repair without PCNA monoubiquitination.36
214786702011Rad18 E3 ubiquitin ligase activity mediates Fanconi anemia pathway activation and cell survival following DNA Topoisomerase 1 inhibition.34

Citation

Dessen P

RAD18 (RAD18 E3 ubiquitin protein ligase)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42025/rad18