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RAD18 (RAD18, E3 ubiquitin protein ligase)

Identity

Alias_namesRAD18 homolog (S. cerevisiae)
Alias_symbol (synonym)RNF73
Other alias
HGNC (Hugo) RAD18
LocusID (NCBI) 56852
Atlas_Id 42025
Location 3p25.3  [Link to chromosome band 3p25]
Location_base_pair Starts at 8918880 and ends at 9005159 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
RAD18 (3p25.3) / CD86 (3q13.33)RAD18 (3p25.3) / FANCD2 (3p25.3)RAD18 3p25.3 / CD86 3q13.33

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)RAD18   18278
Cards
Entrez_Gene (NCBI)RAD18  56852  RAD18, E3 ubiquitin protein ligase
AliasesRNF73
GeneCards (Weizmann)RAD18
Ensembl hg19 (Hinxton)ENSG00000070950 [Gene_View]  chr3:8918880-9005159 [Contig_View]  RAD18 [Vega]
Ensembl hg38 (Hinxton)ENSG00000070950 [Gene_View]  chr3:8918880-9005159 [Contig_View]  RAD18 [Vega]
ICGC DataPortalENSG00000070950
TCGA cBioPortalRAD18
AceView (NCBI)RAD18
Genatlas (Paris)RAD18
WikiGenes56852
SOURCE (Princeton)RAD18
Genetics Home Reference (NIH)RAD18
Genomic and cartography
GoldenPath hg19 (UCSC)RAD18  -     chr3:8918880-9005159 -  3p25.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)RAD18  -     3p25.3   [Description]    (hg38-Dec_2013)
EnsemblRAD18 - 3p25.3 [CytoView hg19]  RAD18 - 3p25.3 [CytoView hg38]
Mapping of homologs : NCBIRAD18 [Mapview hg19]  RAD18 [Mapview hg38]
OMIM605256   
Gene and transcription
Genbank (Entrez)AB035274 AF169796 AK023075 AK123966 AK222771
RefSeq transcript (Entrez)NM_020165
RefSeq genomic (Entrez)NC_000003 NC_018914 NT_022517 NW_004929309
Consensus coding sequences : CCDS (NCBI)RAD18
Cluster EST : UnigeneHs.375684 [ NCBI ]
CGAP (NCI)Hs.375684
Alternative Splicing GalleryENSG00000070950
Gene ExpressionRAD18 [ NCBI-GEO ]   RAD18 [ EBI - ARRAY_EXPRESS ]   RAD18 [ SEEK ]   RAD18 [ MEM ]
Gene Expression Viewer (FireBrowse)RAD18 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)56852
GTEX Portal (Tissue expression)RAD18
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NS91   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NS91  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NS91
Splice isoforms : SwissVarQ9NS91
Catalytic activity : Enzyme6.3.2.- [ Enzyme-Expasy ]   6.3.2.-6.3.2.- [ IntEnz-EBI ]   6.3.2.- [ BRENDA ]   6.3.2.- [ KEGG ]   
PhosPhoSitePlusQ9NS91
Domaine pattern : Prosite (Expaxy)SAP (PS50800)    ZF_RING_1 (PS00518)    ZF_RING_2 (PS50089)   
Domains : Interpro (EBI)SAP_dom    Znf_C3HC4_RING-type    Znf_Rad18_put    Znf_RING    Znf_RING/FYVE/PHD    Znf_RING_CS   
Domain families : Pfam (Sanger)SAP (PF02037)    zf-C3HC4 (PF00097)   
Domain families : Pfam (NCBI)pfam02037    pfam00097   
Domain families : Smart (EMBL)RING (SM00184)  SAP (SM00513)  ZnF_Rad18 (SM00734)  
Conserved Domain (NCBI)RAD18
DMDM Disease mutations56852
Blocks (Seattle)RAD18
PDB (SRS)2MRE    2MRF    2Y43    2YBF   
PDB (PDBSum)2MRE    2MRF    2Y43    2YBF   
PDB (IMB)2MRE    2MRF    2Y43    2YBF   
PDB (RSDB)2MRE    2MRF    2Y43    2YBF   
Structural Biology KnowledgeBase2MRE    2MRF    2Y43    2YBF   
SCOP (Structural Classification of Proteins)2MRE    2MRF    2Y43    2YBF   
CATH (Classification of proteins structures)2MRE    2MRF    2Y43    2YBF   
SuperfamilyQ9NS91
Human Protein AtlasENSG00000070950
Peptide AtlasQ9NS91
HPRD09242
IPIIPI00024579   IPI00878498   IPI00879143   IPI00925575   IPI00925824   IPI00925169   IPI00878327   
Protein Interaction databases
DIP (DOE-UCLA)Q9NS91
IntAct (EBI)Q9NS91
FunCoupENSG00000070950
BioGRIDRAD18
STRING (EMBL)RAD18
ZODIACRAD18
Ontologies - Pathways
QuickGOQ9NS91
Ontology : AmiGOY-form DNA binding  damaged DNA binding  protein binding  nucleus  nucleus  nucleoplasm  nucleoplasm  replication fork  cytoplasm  centrosome  DNA repair  postreplication repair  protein monoubiquitination  cellular response to DNA damage stimulus  zinc ion binding  response to UV  ligase activity  polyubiquitin binding  ubiquitin protein ligase binding  protein complex binding  site of double-strand break  nuclear inclusion body  DNA damage response, detection of DNA damage  identical protein binding  single-stranded DNA-dependent ATPase activity  protein autoubiquitination  positive regulation of chromosome segregation  negative regulation of cell death  ubiquitin protein ligase activity  Rad6-Rad18 complex  
Ontology : EGO-EBIY-form DNA binding  damaged DNA binding  protein binding  nucleus  nucleus  nucleoplasm  nucleoplasm  replication fork  cytoplasm  centrosome  DNA repair  postreplication repair  protein monoubiquitination  cellular response to DNA damage stimulus  zinc ion binding  response to UV  ligase activity  polyubiquitin binding  ubiquitin protein ligase binding  protein complex binding  site of double-strand break  nuclear inclusion body  DNA damage response, detection of DNA damage  identical protein binding  single-stranded DNA-dependent ATPase activity  protein autoubiquitination  positive regulation of chromosome segregation  negative regulation of cell death  ubiquitin protein ligase activity  Rad6-Rad18 complex  
NDEx NetworkRAD18
Atlas of Cancer Signalling NetworkRAD18
Wikipedia pathwaysRAD18
Orthology - Evolution
OrthoDB56852
GeneTree (enSembl)ENSG00000070950
Phylogenetic Trees/Animal Genes : TreeFamRAD18
HOVERGENQ9NS91
HOGENOMQ9NS91
Homologs : HomoloGeneRAD18
Homology/Alignments : Family Browser (UCSC)RAD18
Gene fusions - Rearrangements
Fusion : MitelmanRAD18/CD86 [3p25.3/3q13.33]  
Fusion: TCGARAD18 3p25.3 CD86 3q13.33 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRAD18 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RAD18
dbVarRAD18
ClinVarRAD18
1000_GenomesRAD18 
Exome Variant ServerRAD18
ExAC (Exome Aggregation Consortium)RAD18 (select the gene name)
Genetic variants : HAPMAP56852
Genomic Variants (DGV)RAD18 [DGVbeta]
DECIPHER (Syndromes)3:8918880-9005159  ENSG00000070950
CONAN: Copy Number AnalysisRAD18 
Mutations
ICGC Data PortalRAD18 
TCGA Data PortalRAD18 
Broad Tumor PortalRAD18
OASIS PortalRAD18 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRAD18  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDRAD18
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RAD18
DgiDB (Drug Gene Interaction Database)RAD18
DoCM (Curated mutations)RAD18 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RAD18 (select a term)
intoGenRAD18
Cancer3DRAD18(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605256   
Orphanet
MedgenRAD18
Genetic Testing Registry RAD18
NextProtQ9NS91 [Medical]
TSGene56852
GENETestsRAD18
Huge Navigator RAD18 [HugePedia]
snp3D : Map Gene to Disease56852
BioCentury BCIQRAD18
ClinGenRAD18
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD56852
Chemical/Pharm GKB GenePA134912253
Clinical trialRAD18
Miscellaneous
canSAR (ICR)RAD18 (select the gene name)
Probes
Litterature
PubMed110 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRAD18
EVEXRAD18
GoPubMedRAD18
iHOPRAD18
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:24:10 CET 2017

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