RAD51C (RAD51 paralog C)

2003-02-01  

Identity

HGNC
LOCATION
17q22
LOCUSID
ALIAS
BROVCA3,FANCO,R51H3,RAD51L2
FUSION GENES

Other Information

Locus ID:

NCBI: 5889
MIM: 602774
HGNC: 9820
Ensembl: ENSG00000108384

Variants:

dbSNP: 5889
ClinVar: 5889
TCGA: ENSG00000108384
COSMIC: RAD51C

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000108384ENST00000337432O43502
ENSG00000108384ENST00000413590H7C1R0
ENSG00000108384ENST00000421782O43502
ENSG00000108384ENST00000425173H7C2Q5
ENSG00000108384ENST00000461271J3QR58
ENSG00000108384ENST00000475762E9PI66
ENSG00000108384ENST00000482007Q7KZJ0
ENSG00000108384ENST00000486827E9PI66
ENSG00000108384ENST00000487525Q7KZJ0
ENSG00000108384ENST00000583539J3QKK3
ENSG00000108384ENST00000584617J3QLB5
ENSG00000108384ENST00000584804J3QLQ2
ENSG00000108384ENST00000622327A0A087WZ35

Expression (GTEx)

0
5
10
15

Pathways

PathwaySourceExternal ID
Homologous recombinationKEGGko03440
Homologous recombinationKEGGhsa03440
Fanconi anemia pathwayKEGGko03460
Fanconi anemia pathwayKEGGhsa03460
HemostasisREACTOMER-HSA-109582
Factors involved in megakaryocyte development and platelet productionREACTOMER-HSA-983231
Cell CycleREACTOMER-HSA-1640170
MeiosisREACTOMER-HSA-1500620
Meiotic recombinationREACTOMER-HSA-912446
DNA RepairREACTOMER-HSA-73894
DNA Double-Strand Break RepairREACTOMER-HSA-5693532
Homology Directed RepairREACTOMER-HSA-5693538
HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)REACTOMER-HSA-5693567
HDR through Homologous Recombination (HRR)REACTOMER-HSA-5685942
Homologous DNA Pairing and Strand ExchangeREACTOMER-HSA-5693579
Presynaptic phase of homologous DNA pairing and strand exchangeREACTOMER-HSA-5693616
Resolution of D-Loop StructuresREACTOMER-HSA-5693537
Resolution of D-loop Structures through Holliday Junction IntermediatesREACTOMER-HSA-5693568
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)REACTOMER-HSA-5693554

References

Pubmed IDYearTitleCitations
204009642010Germline mutations in breast and ovarian cancer pedigrees establish RAD51C as a human cancer susceptibility gene.242
204009632010Mutation of the RAD51C gene in a Fanconi anemia-like disorder.176
147160192004RAD51C is required for Holliday junction processing in mammalian cells.96
163953352006Interplay between human DNA repair proteins at a unique double-strand break in vivo.86
262612512015Contribution of Germline Mutations in the RAD51B, RAD51C, and RAD51D Genes to Ovarian Cancer in the Population.64
124277462003Complex formation by the human Rad51B and Rad51C DNA repair proteins and their activities in vitro.57
171147952007Role of RAD51C and XRCC3 in genetic recombination and DNA repair.50
216169382011RAD51C is a susceptibility gene for ovarian cancer.50
120369132002Effect of germ-line genetic variation on breast cancer survival in a population-based study.49
241417872014Breast cancer-associated missense mutants of the PALB2 WD40 domain, which directly binds RAD51C, RAD51 and BRCA2, disrupt DNA repair.45

Citation

Dessen P

RAD51C (RAD51 paralog C)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/346/rad51c