Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

RAD51C (RAD51 paralog C)

Identity

Alias (NCBI)BROVCA3
FANCO
R51H3
RAD51L2
HGNC (Hugo) RAD51C
HGNC Alias symbRAD51L2
FANCO
HGNC Previous nameRAD51 (S. cerevisiae) homolog C
 RAD51 homolog C (S. cerevisiae)
LocusID (NCBI) 5889
Atlas_Id 346
Location 17q22  [Link to chromosome band 17q22]
Location_base_pair Starts at 58692602 and ends at 58735611 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
AHCYL1 (1p13.3) / RAD51C (17q22)BCAS3 (17q23.2) / RAD51C (17q22)LRP8 (1p32.3) / RAD51C (17q22)
LRRC37B (17q11.2) / RAD51C (17q22)MSI2 (17q22) / RAD51C (17q22)RAD51C (17q22) / ATXN7 (3p14.1)
RAD51C (17q22) / BCAS3 (17q23.2)USP32 (17q23.1) / RAD51C (17q22)BCAS3 17q23.2 / RAD51C 17q22
LRP8 1p32.3 / RAD51C 17q22LRRC37B 17q11.2 / RAD51C 17q22MSI2 17q22 / RAD51C 17q22
USP32 17q23.1 / RAD51C 17q22

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Cancer prone implicated (Data extracted from papers in the Atlas) [ 2 ]
  Fanconi anemia Familial Myeloproliferative Disorders


External links

Nomenclature
HGNC (Hugo)RAD51C   9820
LRG (Locus Reference Genomic)LRG_314
Cards
Entrez_Gene (NCBI)RAD51C    RAD51 paralog C
AliasesBROVCA3; FANCO; R51H3; RAD51L2
GeneCards (Weizmann)RAD51C
Ensembl hg19 (Hinxton)ENSG00000108384 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000108384 [Gene_View]  ENSG00000108384 [Sequence]  chr17:58692602-58735611 [Contig_View]  RAD51C [Vega]
ICGC DataPortalENSG00000108384
TCGA cBioPortalRAD51C
AceView (NCBI)RAD51C
Genatlas (Paris)RAD51C
SOURCE (Princeton)RAD51C
Genetics Home Reference (NIH)RAD51C
Genomic and cartography
GoldenPath hg38 (UCSC)RAD51C  -     chr17:58692602-58735611 +  17q22   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RAD51C  -     17q22   [Description]    (hg19-Feb_2009)
GoldenPathRAD51C - 17q22 [CytoView hg19]  RAD51C - 17q22 [CytoView hg38]
ImmunoBaseENSG00000108384
genome Data Viewer NCBIRAD51C [Mapview hg19]  
OMIM602774   613390   613399   
Gene and transcription
Genbank (Entrez)AA304618 AF029669 AF029670 AI424321 AI914449
RefSeq transcript (Entrez)NM_002876 NM_058216
Consensus coding sequences : CCDS (NCBI)RAD51C
Alternative Splicing GalleryENSG00000108384
Gene ExpressionRAD51C [ NCBI-GEO ]   RAD51C [ EBI - ARRAY_EXPRESS ]   RAD51C [ SEEK ]   RAD51C [ MEM ]
Gene Expression Viewer (FireBrowse)RAD51C [ Firebrowse - Broad ]
GenevisibleExpression of RAD51C in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5889
GTEX Portal (Tissue expression)RAD51C
Human Protein AtlasENSG00000108384-RAD51C [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO43502   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO43502  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO43502
PhosPhoSitePlusO43502
Domaine pattern : Prosite (Expaxy)RECA_2 (PS50162)   
Domains : Interpro (EBI)DNA_recomb/repair_Rad51_C    DNA_recomb/repair_RecA-like    P-loop_NTPase    Rad51_DMC1_RadA    RecA_ATP-bd   
Domain families : Pfam (Sanger)Rad51 (PF08423)   
Domain families : Pfam (NCBI)pfam08423   
Conserved Domain (NCBI)RAD51C
SuperfamilyO43502
AlphaFold pdb e-kbO43502   
Human Protein Atlas [tissue]ENSG00000108384-RAD51C [tissue]
HPRD04143
Protein Interaction databases
DIP (DOE-UCLA)O43502
IntAct (EBI)O43502
BioGRIDRAD51C
STRING (EMBL)RAD51C
ZODIACRAD51C
Ontologies - Pathways
QuickGOO43502
Ontology : AmiGOfour-way junction DNA binding  four-way junction DNA binding  meiotic DNA recombinase assembly  telomere maintenance via recombination  double-strand break repair via homologous recombination  DNA binding  protein binding  ATP binding  nucleus  nucleoplasm  nucleoplasm  replication fork  replication fork  cytoplasm  mitochondrion  cytosol  DNA repair  DNA recombination  sister chromatid cohesion  female meiosis sister chromatid cohesion  reciprocal meiotic recombination  male meiosis I  spermatogenesis  blood coagulation  ATPase, acting on DNA  crossover junction endodeoxyribonuclease activity  crossover junction endodeoxyribonuclease activity  positive regulation of G2/M transition of mitotic cell cycle  cell junction  Rad51B-Rad51C-Rad51D-XRCC2 complex  Rad51B-Rad51C-Rad51D-XRCC2 complex  Rad51C-XRCC3 complex  Rad51C-XRCC3 complex  intracellular membrane-bounded organelle  perinuclear region of cytoplasm  
Ontology : EGO-EBIfour-way junction DNA binding  four-way junction DNA binding  meiotic DNA recombinase assembly  telomere maintenance via recombination  double-strand break repair via homologous recombination  DNA binding  protein binding  ATP binding  nucleus  nucleoplasm  nucleoplasm  replication fork  replication fork  cytoplasm  mitochondrion  cytosol  DNA repair  DNA recombination  sister chromatid cohesion  female meiosis sister chromatid cohesion  reciprocal meiotic recombination  male meiosis I  spermatogenesis  blood coagulation  ATPase, acting on DNA  crossover junction endodeoxyribonuclease activity  crossover junction endodeoxyribonuclease activity  positive regulation of G2/M transition of mitotic cell cycle  cell junction  Rad51B-Rad51C-Rad51D-XRCC2 complex  Rad51B-Rad51C-Rad51D-XRCC2 complex  Rad51C-XRCC3 complex  Rad51C-XRCC3 complex  intracellular membrane-bounded organelle  perinuclear region of cytoplasm  
Pathways : KEGGHomologous recombination    Fanconi anemia pathway   
NDEx NetworkRAD51C
Atlas of Cancer Signalling NetworkRAD51C
Wikipedia pathwaysRAD51C
Orthology - Evolution
OrthoDB5889
GeneTree (enSembl)ENSG00000108384
Phylogenetic Trees/Animal Genes : TreeFamRAD51C
Homologs : HomoloGeneRAD51C
Homology/Alignments : Family Browser (UCSC)RAD51C
Gene fusions - Rearrangements
Fusion : MitelmanAHCYL1/RAD51C [1p13.3/17q22]  
Fusion : MitelmanBCAS3/RAD51C [17q23.2/17q22]  
Fusion : MitelmanLRP8/RAD51C [1p32.3/17q22]  
Fusion : MitelmanLRRC37B/RAD51C [17q11.2/17q22]  
Fusion : MitelmanRAD51C/ATXN7 [17q22/3p14.1]  
Fusion : MitelmanRAD51C/BCAS3 [17q22/17q23.2]  
Fusion : MitelmanUSP32/RAD51C [17q23.1/17q22]  
Fusion PortalBCAS3 17q23.2 RAD51C 17q22 BRCA
Fusion PortalLRP8 1p32.3 RAD51C 17q22 BRCA
Fusion PortalLRRC37B 17q11.2 RAD51C 17q22 BRCA
Fusion PortalMSI2 17q22 RAD51C 17q22 BRCA
Fusion PortalUSP32 17q23.1 RAD51C 17q22 BRCA
Fusion : QuiverRAD51C
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRAD51C [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RAD51C
dbVarRAD51C
ClinVarRAD51C
MonarchRAD51C
1000_GenomesRAD51C 
Exome Variant ServerRAD51C
GNOMAD BrowserENSG00000108384
Varsome BrowserRAD51C
Genomic Variants (DGV)RAD51C [DGVbeta]
DECIPHERRAD51C [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRAD51C 
Mutations
ICGC Data PortalRAD51C 
TCGA Data PortalRAD51C 
Broad Tumor PortalRAD51C
OASIS PortalRAD51C [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRAD51C  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DRAD51C
Mutations and Diseases : HGMDRAD51C
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutasearch RAD51C
DgiDB (Drug Gene Interaction Database)RAD51C
DoCM (Curated mutations)RAD51C (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RAD51C (select a term)
Cancer3DRAD51C(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602774    613390    613399   
Orphanet634    3384   
DisGeNETRAD51C
MedgenRAD51C
Genetic Testing Registry RAD51C
NextProtO43502 [Medical]
GENETestsRAD51C
Target ValidationRAD51C
Huge Navigator RAD51C [HugePedia]
ClinGenRAD51C (curated)
Clinical trials, drugs, therapy
MyCancerGenomeRAD51C
Protein Interactions : CTDRAD51C
Pharm GKB GenePA34177
PharosO43502
Clinical trialRAD51C
Miscellaneous
canSAR (ICR)RAD51C
HarmonizomeRAD51C
DataMed IndexRAD51C
Probes
Litterature
PubMed122 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXRAD51C
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Sep 15 22:33:29 CEST 2021

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.