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Taking over the Atlas
Dear Colleagues,
The Atlas, once more, is in great danger, and I will have to proceed to a collective economic lay-off of all the team involved in the Atlas before the begining of April 2015 (a foundation having suddenly withdrawn its commitment to support the Atlas). I ask you herein if any Scientific Society (a Society of Cytogenetics, of Clinical Genetics, of Hematology, or a Cancer Society, or any other...), any University and/or Hospital, any Charity, or any database would be interested in taking over the Atlas, in whole or in part. If taking charge of the whole lot is too big, a consortium of various actors could be the solution (I am myself trying to find partners). Could you please spread the information, contact the relevant authorities, and find partners.
Survival of the Atlas will be critically dependant upon your ability to find solutions (and urgently!).
Kind regards.
Jean-Loup Huret jlhuret@AtlasGeneticsOncology.org
Donations are also welcome
If each casual visitor gives 3 Euros or Dollars, the Atlas is saved in a week !
If each professional gives 100 Euros or Dollars once a year (now), the Atlas is saved in 2 weeks !
Don't let the Atlas imminent demise
Note: we send fiscal receipts for donations equal or above 50 Euros or Dollars

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RAD51C (RAD51 paralog C)

Identity

Other namesBROVCA3
FANCO
R51H3
RAD51L2
HGNC (Hugo) RAD51C
LocusID (NCBI) 5889
Location 17q22
Location_base_pair Starts at 56769934 and ends at 56772741 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)RAD51C   9820
Cards
Entrez_Gene (NCBI)RAD51C  5889  RAD51 paralog C
GeneCards (Weizmann)RAD51C
Ensembl hg19 (Hinxton)ENSG00000108384 [Gene_View]  chr17:56769934-56772741 [Contig_View]  RAD51C [Vega]
Ensembl hg38 (Hinxton)ENSG00000108384 [Gene_View]  chr17:56769934-56772741 [Contig_View]  RAD51C [Vega]
ICGC DataPortalENSG00000108384
cBioPortalRAD51C
AceView (NCBI)RAD51C
Genatlas (Paris)RAD51C
WikiGenes5889
SOURCE (Princeton)RAD51C
Genomic and cartography
GoldenPath hg19 (UCSC)RAD51C  -     chr17:56769934-56772741 +  17q22   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)RAD51C  -     17q22   [Description]    (hg38-Dec_2013)
EnsemblRAD51C - 17q22 [CytoView hg19]  RAD51C - 17q22 [CytoView hg38]
Mapping of homologs : NCBIRAD51C [Mapview hg19]  RAD51C [Mapview hg38]
OMIM189960   602774   613390   613399   
Gene and transcription
Genbank (Entrez)AA304618 AF029669 AF029670 AI424321 AI914449
RefSeq transcript (Entrez)NM_002876 NM_058216
RefSeq genomic (Entrez)NC_000017 NC_018928 NG_023199 NT_010783 NW_004929407
Consensus coding sequences : CCDS (NCBI)RAD51C
Cluster EST : UnigeneHs.412587 [ NCBI ]
CGAP (NCI)Hs.412587
Alternative Splicing : Fast-db (Paris)GSHG0012685
Alternative Splicing GalleryENSG00000108384
Gene ExpressionRAD51C [ NCBI-GEO ]     RAD51C [ SEEK ]   RAD51C [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO43502 (Uniprot)
NextProtO43502  [Medical]
With graphics : InterProO43502
Splice isoforms : SwissVarO43502 (Swissvar)
Domaine pattern : Prosite (Expaxy)RECA_2 (PS50162)   
Domains : Interpro (EBI)AAA+_ATPase    DNA_recomb/repair_Rad51_C    DNA_recomb/repair_RecA-like    P-loop_NTPase    RecA_ATP-bd   
Related proteins : CluSTrO43502
Domain families : Pfam (Sanger)Rad51 (PF08423)   
Domain families : Pfam (NCBI)pfam08423   
Domain families : Smart (EMBL)AAA (SM00382)  
DMDM Disease mutations5889
Blocks (Seattle)O43502
Human Protein AtlasENSG00000108384
Peptide AtlasO43502
HPRD04143
IPIIPI00012829   IPI00791660   IPI00792282   IPI00979421   IPI01013984   IPI00040453   
Protein Interaction databases
DIP (DOE-UCLA)O43502
IntAct (EBI)O43502
FunCoupENSG00000108384
BioGRIDRAD51C
IntegromeDBRAD51C
STRING (EMBL)RAD51C
Ontologies - Pathways
QuickGOO43502
Ontology : AmiGOfour-way junction DNA binding  double-strand break repair via homologous recombination  DNA catabolic process, endonucleolytic  DNA binding  protein binding  ATP binding  nucleus  nucleoplasm  replication fork  cytoplasm  mitochondrion  DNA repair  DNA recombination  sister chromatid cohesion  female meiosis sister chromatid cohesion  reciprocal meiotic recombination  male meiosis I  spermatogenesis  blood coagulation  DNA-dependent ATPase activity  crossover junction endodeoxyribonuclease activity  positive regulation of G2/M transition of mitotic cell cycle  Rad51B-Rad51C-Rad51D-XRCC2 complex  Rad51C-XRCC3 complex  perinuclear region of cytoplasm  Holliday junction resolvase complex  
Ontology : EGO-EBIfour-way junction DNA binding  double-strand break repair via homologous recombination  DNA catabolic process, endonucleolytic  DNA binding  protein binding  ATP binding  nucleus  nucleoplasm  replication fork  cytoplasm  mitochondrion  DNA repair  DNA recombination  sister chromatid cohesion  female meiosis sister chromatid cohesion  reciprocal meiotic recombination  male meiosis I  spermatogenesis  blood coagulation  DNA-dependent ATPase activity  crossover junction endodeoxyribonuclease activity  positive regulation of G2/M transition of mitotic cell cycle  Rad51B-Rad51C-Rad51D-XRCC2 complex  Rad51C-XRCC3 complex  perinuclear region of cytoplasm  Holliday junction resolvase complex  
Pathways : KEGGHomologous recombination    Fanconi anemia pathway   
Protein Interaction DatabaseRAD51C
DoCM (Curated mutations)RAD51C
Wikipedia pathwaysRAD51C
Gene fusion - rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerRAD51C [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RAD51C
dbVarRAD51C
ClinVarRAD51C
1000_GenomesRAD51C 
Exome Variant ServerRAD51C
SNP (GeneSNP Utah)RAD51C
SNP : HGBaseRAD51C
Genetic variants : HAPMAPRAD51C
Genomic Variants (DGV)RAD51C [DGVbeta]
Mutations
ICGC Data PortalENSG00000108384 
Somatic Mutations in Cancer : COSMICRAD51C 
CONAN: Copy Number AnalysisRAD51C 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)Zhejiang University Center for Genetic and Genomic Medicine (ZJU-CGGM)
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)**PUBLIC** CCHMC Molecular Genetics Laboratory Mutation Database
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)17:56769934-56772741
Mutations and Diseases : HGMDRAD51C
OMIM189960    602774    613390    613399   
MedgenRAD51C
NextProtO43502 [Medical]
GENETestsRAD51C
Disease Genetic AssociationRAD51C
Huge Navigator RAD51C [HugePedia]  RAD51C [HugeCancerGEM]
snp3D : Map Gene to Disease5889
DGIdb (Drug Gene Interaction db)RAD51C
General knowledge
Homologs : HomoloGeneRAD51C
Homology/Alignments : Family Browser (UCSC)RAD51C
Phylogenetic Trees/Animal Genes : TreeFamRAD51C
Chemical/Protein Interactions : CTD5889
Chemical/Pharm GKB GenePA34177
Clinical trialRAD51C
Cancer Resource (Charite)ENSG00000108384
Other databases
Probes
Litterature
PubMed80 Pubmed reference(s) in Entrez
CoreMineRAD51C
GoPubMedRAD51C
iHOPRAD51C
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated02-2015Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Mar 28 17:05:28 CET 2015

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For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.