Atlas of Genetics and Cytogenetics in Oncology and Haematology


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RAD51C (RAD51 paralog C)

Identity

Other namesBROVCA3
FANCO
R51H3
RAD51L2
HGNC (Hugo) RAD51C
LocusID (NCBI) 5889
Atlas_Id 346
Location 17q22
Location_base_pair Starts at 56769934 and ends at 56772741 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2015)
BCAS3 17q23.2 / RAD51C 17q22LRP8 1p32.3 / RAD51C 17q22LRRC37B 17q11.2 / RAD51C 17q22
MSI2 17q22 / RAD51C 17q22USP32 17q23.1 / RAD51C 17q22

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Cancer prone implicated (Data extracted from papers in the Atlas)
  Fanconi anaemia

External links

Nomenclature
HGNC (Hugo)RAD51C   9820
Cards
Entrez_Gene (NCBI)RAD51C  5889  RAD51 paralog C
GeneCards (Weizmann)RAD51C
Ensembl hg19 (Hinxton)ENSG00000108384 [Gene_View]  chr17:56769934-56772741 [Contig_View]  RAD51C [Vega]
Ensembl hg38 (Hinxton)ENSG00000108384 [Gene_View]  chr17:56769934-56772741 [Contig_View]  RAD51C [Vega]
ICGC DataPortalENSG00000108384
TCGA cBioPortalRAD51C
AceView (NCBI)RAD51C
Genatlas (Paris)RAD51C
WikiGenes5889
SOURCE (Princeton)RAD51C
Genomic and cartography
GoldenPath hg19 (UCSC)RAD51C  -     chr17:56769934-56772741 +  17q22   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)RAD51C  -     17q22   [Description]    (hg38-Dec_2013)
EnsemblRAD51C - 17q22 [CytoView hg19]  RAD51C - 17q22 [CytoView hg38]
Mapping of homologs : NCBIRAD51C [Mapview hg19]  RAD51C [Mapview hg38]
OMIM189960   602774   613390   613399   
Gene and transcription
Genbank (Entrez)AA304618 AF029669 AF029670 AI424321 AI914449
RefSeq transcript (Entrez)NM_002876 NM_058216
RefSeq genomic (Entrez)NC_000017 NC_018928 NG_023199 NT_010783 NW_004929407
Consensus coding sequences : CCDS (NCBI)RAD51C
Cluster EST : UnigeneHs.412587 [ NCBI ]
CGAP (NCI)Hs.412587
Alternative Splicing : Fast-db (Paris)GSHG0012685
Alternative Splicing GalleryENSG00000108384
Gene ExpressionRAD51C [ NCBI-GEO ]     RAD51C [ SEEK ]   RAD51C [ MEM ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
BioGPS (Tissue expression)5889
Protein : pattern, domain, 3D structure
UniProt/SwissProtO43502 (Uniprot)
NextProtO43502  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO43502
Splice isoforms : SwissVarO43502 (Swissvar)
PhosPhoSitePlusO43502
Domaine pattern : Prosite (Expaxy)RECA_2 (PS50162)   
Domains : Interpro (EBI)AAA+_ATPase    DNA_recomb/repair_Rad51_C    DNA_recomb/repair_RecA-like    P-loop_NTPase    RecA_ATP-bd   
Domain families : Pfam (Sanger)Rad51 (PF08423)   
Domain families : Pfam (NCBI)pfam08423   
Domain families : Smart (EMBL)AAA (SM00382)  
DMDM Disease mutations5889
Blocks (Seattle)RAD51C
Human Protein AtlasENSG00000108384
Peptide AtlasO43502
HPRD04143
IPIIPI00012829   IPI00791660   IPI00792282   IPI00979421   IPI01013984   IPI00040453   
Protein Interaction databases
DIP (DOE-UCLA)O43502
IntAct (EBI)O43502
FunCoupENSG00000108384
BioGRIDRAD51C
IntegromeDBRAD51C
STRING (EMBL)RAD51C
ZODIACRAD51C
Ontologies - Pathways
QuickGOO43502
Ontology : AmiGOrecombinase activity  four-way junction DNA binding  double-strand break repair via homologous recombination  double-strand break repair via homologous recombination  DNA recombinase assembly  condensed nuclear chromosome  DNA binding  double-stranded DNA binding  single-stranded DNA binding  protein binding  ATP binding  nucleus  nucleoplasm  nucleoplasm  replication fork  cytoplasm  mitochondrion  DNA repair  DNA repair  double-strand break repair  DNA recombination  mitotic recombination  sister chromatid cohesion  female meiosis sister chromatid cohesion  reciprocal meiotic recombination  male meiosis I  spermatogenesis  blood coagulation  DNA-dependent ATPase activity  crossover junction endodeoxyribonuclease activity  response to ionizing radiation  positive regulation of G2/M transition of mitotic cell cycle  Rad51B-Rad51C-Rad51D-XRCC2 complex  Rad51C-XRCC3 complex  strand invasion  double-strand break repair via synthesis-dependent strand annealing  perinuclear region of cytoplasm  Holliday junction resolvase complex  chromosome organization involved in meiotic cell cycle  
Ontology : EGO-EBIrecombinase activity  four-way junction DNA binding  double-strand break repair via homologous recombination  double-strand break repair via homologous recombination  DNA recombinase assembly  condensed nuclear chromosome  DNA binding  double-stranded DNA binding  single-stranded DNA binding  protein binding  ATP binding  nucleus  nucleoplasm  nucleoplasm  replication fork  cytoplasm  mitochondrion  DNA repair  DNA repair  double-strand break repair  DNA recombination  mitotic recombination  sister chromatid cohesion  female meiosis sister chromatid cohesion  reciprocal meiotic recombination  male meiosis I  spermatogenesis  blood coagulation  DNA-dependent ATPase activity  crossover junction endodeoxyribonuclease activity  response to ionizing radiation  positive regulation of G2/M transition of mitotic cell cycle  Rad51B-Rad51C-Rad51D-XRCC2 complex  Rad51C-XRCC3 complex  strand invasion  double-strand break repair via synthesis-dependent strand annealing  perinuclear region of cytoplasm  Holliday junction resolvase complex  chromosome organization involved in meiotic cell cycle  
Pathways : KEGGHomologous recombination    Fanconi anemia pathway   
Protein Interaction DatabaseRAD51C
Atlas of Cancer Signalling NetworkRAD51C
Wikipedia pathwaysRAD51C
Orthology - Evolution
OrthoDB5889
GeneTree (enSembl)ENSG00000108384
Phylogenetic Trees/Animal Genes : TreeFamRAD51C
Homologs : HomoloGeneRAD51C
Homology/Alignments : Family Browser (UCSC)RAD51C
Gene fusions - Rearrangements
Fusion: TCGABCAS3 17q23.2 RAD51C 17q22 BRCA
Fusion: TCGALRP8 1p32.3 RAD51C 17q22 BRCA
Fusion: TCGALRRC37B 17q11.2 RAD51C 17q22 BRCA
Fusion: TCGAMSI2 17q22 RAD51C 17q22 BRCA
Fusion: TCGAUSP32 17q23.1 RAD51C 17q22 BRCA
Polymorphisms : SNP, variants
NCBI Variation ViewerRAD51C [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RAD51C
dbVarRAD51C
ClinVarRAD51C
1000_GenomesRAD51C 
Exome Variant ServerRAD51C
Exome Aggregation Consortium (ExAC)ENSG00000108384
SNP (GeneSNP Utah)RAD51C
SNP : HGBaseRAD51C
Genetic variants : HAPMAPRAD51C
Genomic Variants (DGV)RAD51C [DGVbeta]
Mutations
ICGC Data PortalRAD51C 
TCGA Data PortalRAD51C 
Tumor PortalRAD51C
TCGA Copy Number PortalRAD51C
Somatic Mutations in Cancer : COSMICRAD51C 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)Zhejiang University Center for Genetic and Genomic Medicine (ZJU-CGGM)
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)**PUBLIC** CCHMC Molecular Genetics Laboratory Mutation Database
BioMutasearch RAD51C
DgiDB (Drug Gene Interaction Database)RAD51C
DoCM (Curated mutations)RAD51C (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RAD51C (select a term)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)17:56769934-56772741
CONAN: Copy Number AnalysisRAD51C 
Mutations and Diseases : HGMDRAD51C
OMIM189960    602774    613390    613399   
MedgenRAD51C
NextProtO43502 [Medical]
TSGene5889
GENETestsRAD51C
Huge Navigator RAD51C [HugePedia]  RAD51C [HugeCancerGEM]
snp3D : Map Gene to Disease5889
BioCentury BCIQRAD51C
General knowledge
Chemical/Protein Interactions : CTD5889
Chemical/Pharm GKB GenePA34177
Clinical trialRAD51C
Other databases
Probes
Litterature
PubMed81 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRAD51C
GoPubMedRAD51C
iHOPRAD51C
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Sat Jan 16 19:21:56 CET 2016

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