Atlas of Genetics and Cytogenetics in Oncology and Haematology


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RAD51C (RAD51 paralog C)

Identity

Other namesBROVCA3
FANCO
R51H3
RAD51L2
HGNC (Hugo) RAD51C
LocusID (NCBI) 5889
Location 17q22
Location_base_pair Starts at 56769934 and ends at 56772741 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)RAD51C   9820
Cards
Entrez_Gene (NCBI)RAD51C  5889  RAD51 paralog C
GeneCards (Weizmann)RAD51C
Ensembl (Hinxton)ENSG00000108384 [Gene_View]  chr17:56769934-56772741 [Contig_View]  RAD51C [Vega]
ICGC DataPortalENSG00000108384
cBioPortalRAD51C
AceView (NCBI)RAD51C
Genatlas (Paris)RAD51C
WikiGenes5889
SOURCE (Princeton)NM_002876 NM_058216
Genomic and cartography
GoldenPath (UCSC)RAD51C  -  17q22   chr17:56769934-56772741 +  17q22   [Description]    (hg19-Feb_2009)
EnsemblRAD51C - 17q22 [CytoView]
Mapping of homologs : NCBIRAD51C [Mapview]
OMIM602774   613390   613399   
Gene and transcription
Genbank (Entrez)AA304618 AF029669 AF029670 AI424321 AI914449
RefSeq transcript (Entrez)NM_002876 NM_058216
RefSeq genomic (Entrez)AC_000149 NC_000017 NC_018928 NG_023199 NT_010783 NW_001838448 NW_004929407
Consensus coding sequences : CCDS (NCBI)RAD51C
Cluster EST : UnigeneHs.412587 [ NCBI ]
CGAP (NCI)Hs.412587
Alternative Splicing : Fast-db (Paris)GSHG0012685
Alternative Splicing GalleryENSG00000108384
Gene ExpressionRAD51C [ NCBI-GEO ]     RAD51C [ SEEK ]   RAD51C [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO43502 (Uniprot)
NextProtO43502  [Medical]
With graphics : InterProO43502
Splice isoforms : SwissVarO43502 (Swissvar)
Domaine pattern : Prosite (Expaxy)RECA_2 (PS50162)   
Domains : Interpro (EBI)AAA+_ATPase [organisation]   DNA_recomb/repair_Rad51_C [organisation]   DNA_recomb/repair_RecA-like [organisation]   P-loop_NTPase [organisation]   RecA_ATP-bd [organisation]  
Related proteins : CluSTrO43502
Domain families : Pfam (Sanger)Rad51 (PF08423)   
Domain families : Pfam (NCBI)pfam08423   
Domain families : Smart (EMBL)AAA (SM00382)  
DMDM Disease mutations5889
Blocks (Seattle)O43502
Human Protein AtlasENSG00000108384 [gene] [tissue] [antibody] [cell] [cancer]
Peptide AtlasO43502
HPRD04143
IPIIPI00012829   IPI00791660   IPI00792282   IPI00979421   IPI01013984   IPI00040453   
Protein Interaction databases
DIP (DOE-UCLA)O43502
IntAct (EBI)O43502
FunCoupENSG00000108384
BioGRIDRAD51C
InParanoidO43502
Interologous Interaction database O43502
IntegromeDBRAD51C
STRING (EMBL)RAD51C
Ontologies - Pathways
Ontology : AmiGOfour-way junction DNA binding  double-strand break repair via homologous recombination  DNA catabolic process, endonucleolytic  DNA catabolic process, endonucleolytic  DNA binding  protein binding  ATP binding  nucleus  nucleoplasm  replication fork  cytoplasm  mitochondrion  ATP catabolic process  DNA repair  DNA recombination  sister chromatid cohesion  female meiosis sister chromatid cohesion  reciprocal meiotic recombination  male meiosis I  spermatogenesis  blood coagulation  DNA-dependent ATPase activity  crossover junction endodeoxyribonuclease activity  positive regulation of G2/M transition of mitotic cell cycle  Rad51B-Rad51C-Rad51D-XRCC2 complex  Rad51C-XRCC3 complex  perinuclear region of cytoplasm  Holliday junction resolvase complex  
Ontology : EGO-EBIfour-way junction DNA binding  double-strand break repair via homologous recombination  DNA catabolic process, endonucleolytic  DNA catabolic process, endonucleolytic  DNA binding  protein binding  ATP binding  nucleus  nucleoplasm  replication fork  cytoplasm  mitochondrion  ATP catabolic process  DNA repair  DNA recombination  sister chromatid cohesion  female meiosis sister chromatid cohesion  reciprocal meiotic recombination  male meiosis I  spermatogenesis  blood coagulation  DNA-dependent ATPase activity  crossover junction endodeoxyribonuclease activity  positive regulation of G2/M transition of mitotic cell cycle  Rad51B-Rad51C-Rad51D-XRCC2 complex  Rad51C-XRCC3 complex  perinuclear region of cytoplasm  Holliday junction resolvase complex  
Pathways : KEGGHomologous recombination    Fanconi anemia pathway   
Protein Interaction DatabaseRAD51C
Wikipedia pathwaysRAD51C
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)RAD51C
snp3D : Map Gene to Disease5889
SNP (GeneSNP Utah)RAD51C
SNP : HGBaseRAD51C
Genetic variants : HAPMAPRAD51C
Exome VariantRAD51C
1000_GenomesRAD51C 
ICGC programENSG00000108384 
Somatic Mutations in Cancer : COSMICRAD51C 
CONAN: Copy Number AnalysisRAD51C 
Mutations and Diseases : HGMDRAD51C
Mutations and Diseases : intOGenRAD51C
Genomic VariantsRAD51C  RAD51C [DGVbeta]
dbVarRAD51C
ClinVarRAD51C
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM602774    613390    613399   
MedgenRAD51C
GENETestsRAD51C
Disease Genetic AssociationRAD51C
Huge Navigator RAD51C [HugePedia]  RAD51C [HugeCancerGEM]
General knowledge
Homologs : HomoloGeneRAD51C
Homology/Alignments : Family Browser (UCSC)RAD51C
Phylogenetic Trees/Animal Genes : TreeFamRAD51C
Chemical/Protein Interactions : CTD5889
Chemical/Pharm GKB GenePA34177
Clinical trialRAD51C
Cancer Resource (Charite)ENSG00000108384
Other databases
Probes
Litterature
PubMed71 Pubmed reference(s) in Entrez
CoreMineRAD51C
iHOPRAD51C
OncoSearchRAD51C
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Aug 26 17:02:16 CEST 2014

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