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RAPGEF4 (Rap guanine nucleotide exchange factor 4)

Identity

Alias (NCBI)CAMP-GEFII
CGEF2
EPAC
EPAC 2
EPAC2
Nbla00496
HGNC (Hugo) RAPGEF4
HGNC Alias symbcAMP-GEFII
CGEF2
HGNC Alias namecAMP-regulated guanine nucleotide exchange factor II
  exchange protein directly activated by cAMP 2
HGNC Previous nameRAP guanine-nucleotide-exchange factor (GEF) 4
 Rap guanine nucleotide exchange factor (GEF) 4
LocusID (NCBI) 11069
Atlas_Id 51540
Location 2q31.1  [Link to chromosome band 2q31]
Location_base_pair Starts at 172735845 and ends at 173052892 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
AC013461.1 () / RAPGEF4 (2q31.1)ARID1B (6q25.3) / RAPGEF4 (2q31.1)DGKI (7q33) / RAPGEF4 (2q31.1)
RAPGEF4 (2q31.1) / PGA3 (11q12.2)RCAN2 (6p21.1) / RAPGEF4 (2q31.1)AC013461.1 RAPGEF4 2q31.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)RAPGEF4   16626
Cards
Entrez_Gene (NCBI)RAPGEF4    Rap guanine nucleotide exchange factor 4
AliasesCAMP-GEFII; CGEF2; EPAC; EPAC; 
EPAC2; Nbla00496
GeneCards (Weizmann)RAPGEF4
Ensembl hg19 (Hinxton)ENSG00000091428 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000091428 [Gene_View]  ENSG00000091428 [Sequence]  chr2:172735845-173052892 [Contig_View]  RAPGEF4 [Vega]
ICGC DataPortalENSG00000091428
TCGA cBioPortalRAPGEF4
AceView (NCBI)RAPGEF4
Genatlas (Paris)RAPGEF4
SOURCE (Princeton)RAPGEF4
Genetics Home Reference (NIH)RAPGEF4
Genomic and cartography
GoldenPath hg38 (UCSC)RAPGEF4  -     chr2:172735845-173052892 +  2q31.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RAPGEF4  -     2q31.1   [Description]    (hg19-Feb_2009)
GoldenPathRAPGEF4 - 2q31.1 [CytoView hg19]  RAPGEF4 - 2q31.1 [CytoView hg38]
ImmunoBaseENSG00000091428
Genome Data Viewer NCBIRAPGEF4 [Mapview hg19]  
OMIM606058   
Gene and transcription
Genbank (Entrez)AB027471 AB075513 AB209681 AK294433 AK294445
RefSeq transcript (Entrez)NM_001100397 NM_001282899 NM_001282900 NM_001282901 NM_001375864 NM_001375865 NM_001375866 NM_001375867 NM_001375868 NM_001375869 NM_001375870 NM_001375871 NM_001375872 NM_001375873 NM_001375874 NM_001375875 NM_001375876 NM_007023
Consensus coding sequences : CCDS (NCBI)RAPGEF4
Gene ExpressionRAPGEF4 [ NCBI-GEO ]   RAPGEF4 [ EBI - ARRAY_EXPRESS ]   RAPGEF4 [ SEEK ]   RAPGEF4 [ MEM ]
Gene Expression Viewer (FireBrowse)RAPGEF4 [ Firebrowse - Broad ]
GenevisibleExpression of RAPGEF4 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)11069
GTEX Portal (Tissue expression)RAPGEF4
Human Protein AtlasENSG00000091428-RAPGEF4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8WZA2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8WZA2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8WZA2
PhosPhoSitePlusQ8WZA2
Domaine pattern : Prosite (Expaxy)CNMP_BINDING_3 (PS50042)    DEP (PS50186)    RASGEF (PS00720)    RASGEF_CAT (PS50009)    RASGEF_NTER (PS50212)   
Domains : Interpro (EBI)cNMP-bd-like    cNMP-bd_dom    DEP_dom    Ras-like_GEF    Ras-like_Gua-exchang_fac_N    Ras_G-nucl-exch_fac_CS    Ras_GEF_dom_sf    RASGEF_cat_dom    RASGEF_cat_dom_sf    RmlC-like_jellyroll    Ubiquitin-like_domsf    WH-like_DNA-bd_sf    WH_DNA-bd_sf   
Domain families : Pfam (Sanger)cNMP_binding (PF00027)    DEP (PF00610)    RasGEF (PF00617)    RasGEF_N (PF00618)   
Domain families : Pfam (NCBI)pfam00027    pfam00610    pfam00617    pfam00618   
Domain families : Smart (EMBL)cNMP (SM00100)  DEP (SM00049)  RasGEF (SM00147)  RasGEFN (SM00229)  
Conserved Domain (NCBI)RAPGEF4
SuperfamilyQ8WZA2
AlphaFold pdb e-kbQ8WZA2   
Human Protein Atlas [tissue]ENSG00000091428-RAPGEF4 [tissue]
HPRD06929
Protein Interaction databases
DIP (DOE-UCLA)Q8WZA2
IntAct (EBI)Q8WZA2
BioGRIDRAPGEF4
STRING (EMBL)RAPGEF4
ZODIACRAPGEF4
Ontologies - Pathways
QuickGOQ8WZA2
Ontology : AmiGOadaptive immune response  guanyl-nucleotide exchange factor activity  protein binding  cytosol  plasma membrane  G protein-coupled receptor signaling pathway  small GTPase mediated signal transduction  membrane  calcium-ion regulated exocytosis  regulation of exocytosis  cAMP-mediated signaling  insulin secretion  cAMP binding  small GTPase binding  regulation of catalytic activity  regulation of insulin secretion  hippocampal mossy fiber to CA3 synapse  regulation of synaptic vesicle cycle  
Ontology : EGO-EBIadaptive immune response  guanyl-nucleotide exchange factor activity  protein binding  cytosol  plasma membrane  G protein-coupled receptor signaling pathway  small GTPase mediated signal transduction  membrane  calcium-ion regulated exocytosis  regulation of exocytosis  cAMP-mediated signaling  insulin secretion  cAMP binding  small GTPase binding  regulation of catalytic activity  regulation of insulin secretion  hippocampal mossy fiber to CA3 synapse  regulation of synaptic vesicle cycle  
Pathways : KEGGRap1 signaling pathway    Adrenergic signaling in cardiomyocytes    Leukocyte transendothelial migration    Insulin secretion   
NDEx NetworkRAPGEF4
Atlas of Cancer Signalling NetworkRAPGEF4
Wikipedia pathwaysRAPGEF4
Orthology - Evolution
OrthoDB11069
GeneTree (enSembl)ENSG00000091428
Phylogenetic Trees/Animal Genes : TreeFamRAPGEF4
Homologs : HomoloGeneRAPGEF4
Homology/Alignments : Family Browser (UCSC)RAPGEF4
Gene fusions - Rearrangements
Fusion : MitelmanRCAN2/RAPGEF4 [6p21.1/2q31.1]  
Fusion : QuiverRAPGEF4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRAPGEF4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RAPGEF4
dbVarRAPGEF4
ClinVarRAPGEF4
MonarchRAPGEF4
1000_GenomesRAPGEF4 
Exome Variant ServerRAPGEF4
GNOMAD BrowserENSG00000091428
Varsome BrowserRAPGEF4
ACMGRAPGEF4 variants
VarityQ8WZA2
Genomic Variants (DGV)RAPGEF4 [DGVbeta]
DECIPHERRAPGEF4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRAPGEF4 
Mutations
ICGC Data PortalRAPGEF4 
TCGA Data PortalRAPGEF4 
Broad Tumor PortalRAPGEF4
OASIS PortalRAPGEF4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRAPGEF4  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DRAPGEF4
Mutations and Diseases : HGMDRAPGEF4
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaRAPGEF4
DgiDB (Drug Gene Interaction Database)RAPGEF4
DoCM (Curated mutations)RAPGEF4
CIViC (Clinical Interpretations of Variants in Cancer)RAPGEF4
Cancer3DRAPGEF4
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606058   
Orphanet
DisGeNETRAPGEF4
MedgenRAPGEF4
Genetic Testing Registry RAPGEF4
NextProtQ8WZA2 [Medical]
GENETestsRAPGEF4
Target ValidationRAPGEF4
Huge Navigator RAPGEF4 [HugePedia]
ClinGenRAPGEF4
Clinical trials, drugs, therapy
MyCancerGenomeRAPGEF4
Protein Interactions : CTDRAPGEF4
Pharm GKB GenePA134861108
PharosQ8WZA2
Clinical trialRAPGEF4
Miscellaneous
canSAR (ICR)RAPGEF4
HarmonizomeRAPGEF4
DataMed IndexRAPGEF4
Probes
Litterature
PubMed57 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXRAPGEF4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:28:15 CEST 2021

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