REV1 (REV1 DNA directed polymerase)

2003-12-01 Affiliation

Identity

HGNC

REV1

LOCATION

2q11.2

LOCUSID

51455

ALIAS

AIBP80,REV1L

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 51455
MIM: 606134
HGNC: 14060
Ensembl: ENSG00000135945

Variants:

dbSNP: 51455
ClinVar: 51455
TCGA: ENSG00000135945
COSMIC: REV1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000135945	ENST00000258428	Q9UBZ9
ENSG00000135945	ENST00000393445	Q9UBZ9
ENSG00000135945	ENST00000413697	F8WCR0
ENSG00000135945	ENST00000438366	H7C263
ENSG00000135945	ENST00000450415	C9JPS2

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Fanconi anemia pathway	KEGG	ko03460
Fanconi anemia pathway	KEGG	hsa03460
DNA Repair	REACTOME	R-HSA-73894
DNA Damage Bypass	REACTOME	R-HSA-73893
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	REACTOME	R-HSA-110313
Translesion synthesis by REV1	REACTOME	R-HSA-110312
Translesion synthesis by POLK	REACTOME	R-HSA-5655862
Translesion synthesis by POLI	REACTOME	R-HSA-5656121
Termination of translesion DNA synthesis	REACTOME	R-HSA-5656169

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PD	PMIDs
PA445601	Osteosarcoma	Disease	ClinicalAnnotation	associated		PD
PA449014	cisplatin	Chemical	ClinicalAnnotation	associated		PD

References

Pubmed ID	Year	Title	Citations
18498753	2008	PCNA ubiquitination and REV1 define temporally distinct mechanisms for controlling translesion synthesis in the avian cell line DT40.	113
15189446	2004	Interaction of hREV1 with three human Y-family DNA polymerases.	99
15380106	2004	Co-localization in replication foci and interaction of human Y-family members, DNA polymerase pol eta and REVl protein.	89
22266823	2012	Regulation of Rev1 by the Fanconi anemia core complex.	85
20028736	2010	Differential roles for DNA polymerases eta, zeta, and REV1 in lesion bypass of intrastrand versus interstrand DNA cross-links.	70
20164194	2010	Crystal structure of human REV7 in complex with a human REV3 fragment and structural implication of the interaction between DNA polymerase zeta and REV1.	58
21926160	2012	REV1 and polymerase ζ facilitate homologous recombination repair.	52
20888339	2010	Translesion synthesis across abasic lesions by human B-family and Y-family DNA polymerases α, δ, η, ι, κ, and REV1.	46
22761336	2012	MiR-96 downregulates REV1 and RAD51 to promote cellular sensitivity to cisplatin and PARP inhibition.	46
15609317	2005	Association of amino acid substitution polymorphisms in DNA repair genes TP53, POLI, REV1 and LIG4 with lung cancer risk.	45

Citation

Dessen P

REV1 (REV1 DNA directed polymerase)

Atlas Genet Cytogenet Oncol Haematol. 2003-12-01

Online version: http://atlasgeneticsoncology.org/gene/42085/rev1