RGS1 (regulator of G protein signaling 1)

2003-02-01  

Identity

HGNC
LOCATION
1q31.2
LOCUSID
ALIAS
1R20,BL34,HEL-S-87,IER1,IR20
FUSION GENES

Other Information

Locus ID:

NCBI: 5996
MIM: 600323
HGNC: 9991
Ensembl: ENSG00000090104

Variants:

dbSNP: 5996
ClinVar: 5996
TCGA: ENSG00000090104
COSMIC: RGS1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000090104ENST00000367459Q08116
ENSG00000090104ENST00000367459A0A024R945
ENSG00000090104ENST00000469578Q08116

Expression (GTEx)

0
50
100
150
200
250
300
350
400

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA172GNAI1GenePathwayassociated
PA173GNAI3GenePathwayassociated
PA175GNASGenePathwayassociated
PA24347GNAI2GenePathwayassociated

References

Pubmed IDYearTitleCitations
190739672008Shared and distinct genetic variants in type 1 diabetes and celiac disease.249
183111402008Newly identified genetic risk variants for celiac disease related to the immune response.231
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
198791942009Integration of genetic risk factors into a clinical algorithm for multiple sclerosis susceptibility: a weighted genetic risk score.80
198651022010Multiple sclerosis susceptibility alleles in African Americans.35
204680642010Association study of 182 candidate genes in anorexia nervosa.30
205553552010IL12A, MPHOSPH9/CDK2AP1 and RGS1 are novel multiple sclerosis susceptibility loci.28
200832282010Genome-wide analysis of chromosomal alterations in patients with esophageal squamous cell carcinoma exposed to tobacco and betel quid from high-risk area in India.27
217955952011Cutting Edge: Regulator of G protein signaling-1 selectively regulates gut T cell trafficking and colitic potential.27
165653222006RGS1 and RGS13 mRNA silencing in a human B lymphoma line enhances responsiveness to chemoattractants and impairs desensitization.24

Citation

Dessen P

RGS1 (regulator of G protein signaling 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42099/rgs1