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RGS1 (regulator of G protein signaling 1)

Identity

Alias_namesIER1
regulator of G-protein signalling 1
Alias_symbol (synonym)1R20
IR20
BL34
Other aliasHEL-S-87
HGNC (Hugo) RGS1
LocusID (NCBI) 5996
Atlas_Id 42099
Location 1q31.2  [Link to chromosome band 1q31]
Location_base_pair Starts at 192575727 and ends at 192580029 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
GNB5 (15q21.2) / RGS1 (1q31.2)RGS1 (1q31.2) / RGS1 (1q31.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)RGS1   9991
Cards
Entrez_Gene (NCBI)RGS1  5996  regulator of G protein signaling 1
Aliases1R20; BL34; HEL-S-87; IER1; 
IR20
GeneCards (Weizmann)RGS1
Ensembl hg19 (Hinxton)ENSG00000090104 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000090104 [Gene_View]  chr1:192575727-192580029 [Contig_View]  RGS1 [Vega]
ICGC DataPortalENSG00000090104
TCGA cBioPortalRGS1
AceView (NCBI)RGS1
Genatlas (Paris)RGS1
WikiGenes5996
SOURCE (Princeton)RGS1
Genetics Home Reference (NIH)RGS1
Genomic and cartography
GoldenPath hg38 (UCSC)RGS1  -     chr1:192575727-192580029 +  1q31.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RGS1  -     1q31.2   [Description]    (hg19-Feb_2009)
EnsemblRGS1 - 1q31.2 [CytoView hg19]  RGS1 - 1q31.2 [CytoView hg38]
Mapping of homologs : NCBIRGS1 [Mapview hg19]  RGS1 [Mapview hg38]
OMIM600323   
Gene and transcription
Genbank (Entrez)AA962409 AF493925 AK093544 AK303138 AK315607
RefSeq transcript (Entrez)NM_002922
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)RGS1
Cluster EST : UnigeneHs.75256 [ NCBI ]
CGAP (NCI)Hs.75256
Alternative Splicing GalleryENSG00000090104
Gene ExpressionRGS1 [ NCBI-GEO ]   RGS1 [ EBI - ARRAY_EXPRESS ]   RGS1 [ SEEK ]   RGS1 [ MEM ]
Gene Expression Viewer (FireBrowse)RGS1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5996
GTEX Portal (Tissue expression)RGS1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ08116   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ08116  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ08116
Splice isoforms : SwissVarQ08116
PhosPhoSitePlusQ08116
Domaine pattern : Prosite (Expaxy)RGS (PS50132)   
Domains : Interpro (EBI)RGS    RGS1    RGS_subdom1   
Domain families : Pfam (Sanger)RGS (PF00615)   
Domain families : Pfam (NCBI)pfam00615   
Domain families : Smart (EMBL)RGS (SM00315)  
Conserved Domain (NCBI)RGS1
DMDM Disease mutations5996
Blocks (Seattle)RGS1
PDB (SRS)2BV1    2GTP   
PDB (PDBSum)2BV1    2GTP   
PDB (IMB)2BV1    2GTP   
PDB (RSDB)2BV1    2GTP   
Structural Biology KnowledgeBase2BV1    2GTP   
SCOP (Structural Classification of Proteins)2BV1    2GTP   
CATH (Classification of proteins structures)2BV1    2GTP   
SuperfamilyQ08116
Human Protein AtlasENSG00000090104
Peptide AtlasQ08116
HPRD15968
IPIIPI00873849   IPI00908845   
Protein Interaction databases
DIP (DOE-UCLA)Q08116
IntAct (EBI)Q08116
FunCoupENSG00000090104
BioGRIDRGS1
STRING (EMBL)RGS1
ZODIACRGS1
Ontologies - Pathways
QuickGOQ08116
Ontology : AmiGOG-protein alpha-subunit binding  GTPase activator activity  calmodulin binding  cytosol  plasma membrane  immune response  signal transduction  G-protein coupled receptor signaling pathway  adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway  regulation of G-protein coupled receptor protein signaling pathway  negative regulation of signal transduction  extrinsic component of cytoplasmic side of plasma membrane  positive regulation of GTPase activity  leukotriene signaling pathway  
Ontology : EGO-EBIG-protein alpha-subunit binding  GTPase activator activity  calmodulin binding  cytosol  plasma membrane  immune response  signal transduction  G-protein coupled receptor signaling pathway  adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway  regulation of G-protein coupled receptor protein signaling pathway  negative regulation of signal transduction  extrinsic component of cytoplasmic side of plasma membrane  positive regulation of GTPase activity  leukotriene signaling pathway  
NDEx NetworkRGS1
Atlas of Cancer Signalling NetworkRGS1
Wikipedia pathwaysRGS1
Orthology - Evolution
OrthoDB5996
GeneTree (enSembl)ENSG00000090104
Phylogenetic Trees/Animal Genes : TreeFamRGS1
HOVERGENQ08116
HOGENOMQ08116
Homologs : HomoloGeneRGS1
Homology/Alignments : Family Browser (UCSC)RGS1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRGS1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RGS1
dbVarRGS1
ClinVarRGS1
1000_GenomesRGS1 
Exome Variant ServerRGS1
ExAC (Exome Aggregation Consortium)RGS1 (select the gene name)
Genetic variants : HAPMAP5996
Genomic Variants (DGV)RGS1 [DGVbeta]
DECIPHERRGS1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRGS1 
Mutations
ICGC Data PortalRGS1 
TCGA Data PortalRGS1 
Broad Tumor PortalRGS1
OASIS PortalRGS1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRGS1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDRGS1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RGS1
DgiDB (Drug Gene Interaction Database)RGS1
DoCM (Curated mutations)RGS1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RGS1 (select a term)
intoGenRGS1
Cancer3DRGS1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600323   
Orphanet
MedgenRGS1
Genetic Testing Registry RGS1
NextProtQ08116 [Medical]
TSGene5996
GENETestsRGS1
Target ValidationRGS1
Huge Navigator RGS1 [HugePedia]
snp3D : Map Gene to Disease5996
BioCentury BCIQRGS1
ClinGenRGS1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5996
Chemical/Pharm GKB GenePA34361
Clinical trialRGS1
Miscellaneous
canSAR (ICR)RGS1 (select the gene name)
Probes
Litterature
PubMed51 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRGS1
EVEXRGS1
GoPubMedRGS1
iHOPRGS1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:53:08 CEST 2017

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