RGS4 (regulator of G protein signaling 4)

2007-04-01  

Identity

HGNC
RGS4
LOCATION
1q23.3
LOCUSID
5999
ALIAS
RGP4,SCZD9
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 5999
MIM: 602516
HGNC: 10000
Ensembl: ENSG00000117152

Variants:

dbSNP: 5999
ClinVar: 5999
TCGA: ENSG00000117152
COSMIC: RGS4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000117152ENST00000367906P49798
ENSG00000117152ENST00000367908P49798
ENSG00000117152ENST00000367909P49798
ENSG00000117152ENST00000367909A0A024R909
ENSG00000117152ENST00000421743P49798
ENSG00000117152ENST00000527809P49798
ENSG00000117152ENST00000528938E9PS05
ENSG00000117152ENST00000531057E9PR32

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594
G alpha (z) signalling eventsREACTOMER-HSA-418597

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA447216SchizophreniaDiseaseClinicalAnnotation, VariantAnnotationassociatedPD18204343
PA450688olanzapineChemicalClinicalAnnotationassociatedPD
PA450882perphenazineChemicalClinicalAnnotationassociatedPD
PA451201quetiapineChemicalClinicalAnnotationassociatedPD
PA451257risperidoneChemicalClinicalAnnotation, VariantAnnotationassociatedPD18204343
PA451974ziprasidoneChemicalClinicalAnnotationassociatedPD
PA452233antipsychoticsChemicalClinicalAnnotationassociatedPD

References

Pubmed IDYearTitleCitations
185839792008Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database.395
163809052005Bipolar I disorder and schizophrenia: a 440-single-nucleotide polymorphism screen of 64 candidate genes among Ashkenazi Jewish case-parent trios.131
181982662008No significant association of 14 candidate genes with schizophrenia in a large European ancestry sample: implications for psychiatric genetics.111
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
120239792002Association and linkage analyses of RGS4 polymorphisms in schizophrenia.77
195499192009Breast cancer migration and invasion depend on proteasome degradation of regulator of G-protein signaling 4.57
172203562007N-terminal residues control proteasomal degradation of RGS2, RGS4, and RGS5 in human embryonic kidney 293 cells.48
210416082011Family-based analysis of genetic variation underlying psychosis-inducing effects of cannabis: sibling analysis and proband follow-up.48
170066722007Evidence for statistical epistasis between catechol-O-methyltransferase (COMT) and polymorphisms in RGS4, G72 (DAOA), GRM3, and DISC1: influence on risk of schizophrenia.46
170066722007Evidence for statistical epistasis between catechol-O-methyltransferase (COMT) and polymorphisms in RGS4, G72 (DAOA), GRM3, and DISC1: influence on risk of schizophrenia.46

Citation

Dessen P

RGS4 (regulator of G protein signaling 4)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47334/rgs4