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RNF2 (ring finger protein 2)

Identity

Alias_symbol (synonym)BAP-1
BAP1
DING
HIPI3
RING1B
RING2
Other alias
HGNC (Hugo) RNF2
LocusID (NCBI) 6045
Atlas_Id 45636
Location 1q25.3  [Link to chromosome band 1q25]
Location_base_pair Starts at 185014551 and ends at 185071740 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
HMCN1 (1q25.3) / RNF2 (1q25.3)NUP153 (6p22.3) / RNF2 (1q25.3)HMCN1 1q25.3 / RNF2 1q25.3
NUP153 6p22.3 / RNF2 1q25.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)RNF2   10061
Cards
Entrez_Gene (NCBI)RNF2  6045  ring finger protein 2
AliasesBAP-1; BAP1; DING; HIPI3; 
RING1B; RING2
GeneCards (Weizmann)RNF2
Ensembl hg19 (Hinxton)ENSG00000121481 [Gene_View]  chr1:185014551-185071740 [Contig_View]  RNF2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000121481 [Gene_View]  chr1:185014551-185071740 [Contig_View]  RNF2 [Vega]
ICGC DataPortalENSG00000121481
TCGA cBioPortalRNF2
AceView (NCBI)RNF2
Genatlas (Paris)RNF2
WikiGenes6045
SOURCE (Princeton)RNF2
Genetics Home Reference (NIH)RNF2
Genomic and cartography
GoldenPath hg19 (UCSC)RNF2  -     chr1:185014551-185071740 +  1q25.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)RNF2  -     1q25.3   [Description]    (hg38-Dec_2013)
EnsemblRNF2 - 1q25.3 [CytoView hg19]  RNF2 - 1q25.3 [CytoView hg38]
Mapping of homologs : NCBIRNF2 [Mapview hg19]  RNF2 [Mapview hg38]
OMIM608985   
Gene and transcription
Genbank (Entrez)AF075026 AF141327 AI242656 AK091574 AK314793
RefSeq transcript (Entrez)NM_007212
RefSeq genomic (Entrez)NC_000001 NC_018912 NT_004487 NW_004929293
Consensus coding sequences : CCDS (NCBI)RNF2
Cluster EST : UnigeneHs.591490 [ NCBI ]
CGAP (NCI)Hs.591490
Alternative Splicing GalleryENSG00000121481
Gene ExpressionRNF2 [ NCBI-GEO ]   RNF2 [ EBI - ARRAY_EXPRESS ]   RNF2 [ SEEK ]   RNF2 [ MEM ]
Gene Expression Viewer (FireBrowse)RNF2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6045
GTEX Portal (Tissue expression)RNF2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ99496   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ99496  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ99496
Splice isoforms : SwissVarQ99496
Catalytic activity : Enzyme6.3.2.- [ Enzyme-Expasy ]   6.3.2.-6.3.2.- [ IntEnz-EBI ]   6.3.2.- [ BRENDA ]   6.3.2.- [ KEGG ]   
PhosPhoSitePlusQ99496
Domaine pattern : Prosite (Expaxy)ZF_RING_1 (PS00518)    ZF_RING_2 (PS50089)   
Domains : Interpro (EBI)RAWUL    Znf_C3HC4_RING-type    Znf_RING    Znf_RING/FYVE/PHD    Znf_RING_CS   
Domain families : Pfam (Sanger)RAWUL (PF16207)    zf-C3HC4 (PF00097)   
Domain families : Pfam (NCBI)pfam16207    pfam00097   
Domain families : Smart (EMBL)RING (SM00184)  
Conserved Domain (NCBI)RNF2
DMDM Disease mutations6045
Blocks (Seattle)RNF2
PDB (SRS)2H0D    3GS2    3H8H    3IXS    3RPG    4R8P    4S3O   
PDB (PDBSum)2H0D    3GS2    3H8H    3IXS    3RPG    4R8P    4S3O   
PDB (IMB)2H0D    3GS2    3H8H    3IXS    3RPG    4R8P    4S3O   
PDB (RSDB)2H0D    3GS2    3H8H    3IXS    3RPG    4R8P    4S3O   
Structural Biology KnowledgeBase2H0D    3GS2    3H8H    3IXS    3RPG    4R8P    4S3O   
SCOP (Structural Classification of Proteins)2H0D    3GS2    3H8H    3IXS    3RPG    4R8P    4S3O   
CATH (Classification of proteins structures)2H0D    3GS2    3H8H    3IXS    3RPG    4R8P    4S3O   
SuperfamilyQ99496
Human Protein AtlasENSG00000121481
Peptide AtlasQ99496
HPRD07028
IPIIPI00026993   IPI00514074   IPI00643504   
Protein Interaction databases
DIP (DOE-UCLA)Q99496
IntAct (EBI)Q99496
FunCoupENSG00000121481
BioGRIDRNF2
STRING (EMBL)RNF2
ZODIACRNF2
Ontologies - Pathways
QuickGOQ99496
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  ubiquitin ligase complex  mitotic cell cycle  euchromatin  gastrulation with mouth forming second  sex chromatin  chromatin binding  ubiquitin-protein transferase activity  protein binding  nucleus  nucleoplasm  nucleoplasm  transcription, DNA-templated  germ cell development  zinc ion binding  anterior/posterior axis specification  nuclear body  ligase activity  protein sumoylation  spinal cord development  PcG protein complex  response to retinoic acid  PRC1 complex  histone H2A monoubiquitination  histone H2A-K119 monoubiquitination  negative regulation of sequence-specific DNA binding transcription factor activity  ubiquitin protein ligase activity  MLL1 complex  RING-like zinc finger domain binding  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  ubiquitin ligase complex  mitotic cell cycle  euchromatin  gastrulation with mouth forming second  sex chromatin  chromatin binding  ubiquitin-protein transferase activity  protein binding  nucleus  nucleoplasm  nucleoplasm  transcription, DNA-templated  germ cell development  zinc ion binding  anterior/posterior axis specification  nuclear body  ligase activity  protein sumoylation  spinal cord development  PcG protein complex  response to retinoic acid  PRC1 complex  histone H2A monoubiquitination  histone H2A-K119 monoubiquitination  negative regulation of sequence-specific DNA binding transcription factor activity  ubiquitin protein ligase activity  MLL1 complex  RING-like zinc finger domain binding  
NDEx NetworkRNF2
Atlas of Cancer Signalling NetworkRNF2
Wikipedia pathwaysRNF2
Orthology - Evolution
OrthoDB6045
GeneTree (enSembl)ENSG00000121481
Phylogenetic Trees/Animal Genes : TreeFamRNF2
HOVERGENQ99496
HOGENOMQ99496
Homologs : HomoloGeneRNF2
Homology/Alignments : Family Browser (UCSC)RNF2
Gene fusions - Rearrangements
Fusion : MitelmanHMCN1/RNF2 [1q25.3/1q25.3]  [t(1;1)(q25;q25)]  
Fusion : MitelmanNUP153/RNF2 [6p22.3/1q25.3]  [t(1;6)(q25;p22)]  
Fusion: TCGAHMCN1 1q25.3 RNF2 1q25.3 BRCA
Fusion: TCGANUP153 6p22.3 RNF2 1q25.3 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRNF2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RNF2
dbVarRNF2
ClinVarRNF2
1000_GenomesRNF2 
Exome Variant ServerRNF2
ExAC (Exome Aggregation Consortium)RNF2 (select the gene name)
Genetic variants : HAPMAP6045
Genomic Variants (DGV)RNF2 [DGVbeta]
DECIPHER (Syndromes)1:185014551-185071740  ENSG00000121481
CONAN: Copy Number AnalysisRNF2 
Mutations
ICGC Data PortalRNF2 
TCGA Data PortalRNF2 
Broad Tumor PortalRNF2
OASIS PortalRNF2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRNF2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDRNF2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RNF2
DgiDB (Drug Gene Interaction Database)RNF2
DoCM (Curated mutations)RNF2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RNF2 (select a term)
intoGenRNF2
Cancer3DRNF2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608985   
Orphanet
MedgenRNF2
Genetic Testing Registry RNF2
NextProtQ99496 [Medical]
TSGene6045
GENETestsRNF2
Huge Navigator RNF2 [HugePedia]
snp3D : Map Gene to Disease6045
BioCentury BCIQRNF2
ClinGenRNF2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6045
Chemical/Pharm GKB GenePA34426
Clinical trialRNF2
Miscellaneous
canSAR (ICR)RNF2 (select the gene name)
Probes
Litterature
PubMed110 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRNF2
EVEXRNF2
GoPubMedRNF2
iHOPRNF2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:25:22 CET 2017

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