RNF34 (ring finger protein 34)

2003-02-01 Affiliation

Identity

HGNC

RNF34

LOCATION

12q24.31

LOCUSID

80196

ALIAS

CARP-1,CARP1,RFI,RIF,RIFF,hRFI

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 80196
MIM: 608299
HGNC: 17297
Ensembl: ENSG00000170633

Variants:

dbSNP: 80196
ClinVar: 80196
TCGA: ENSG00000170633
COSMIC: RNF34

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000170633	ENST00000361234	Q969K3
ENSG00000170633	ENST00000392464	H7BYJ1
ENSG00000170633	ENST00000392465	Q969K3
ENSG00000170633	ENST00000554606	G3V504
ENSG00000170633	ENST00000554868	G3V5F1
ENSG00000170633	ENST00000555076	G3V566
ENSG00000170633	ENST00000557402	G3V4D1
ENSG00000170633	ENST00000613529	A0A087WTM5

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Immune System	REACTOME	R-HSA-168256
Adaptive Immune System	REACTOME	R-HSA-1280218
Class I MHC mediated antigen processing & presentation	REACTOME	R-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradation	REACTOME	R-HSA-983168
Gene Expression	REACTOME	R-HSA-74160
Generic Transcription Pathway	REACTOME	R-HSA-212436
Transcriptional Regulation by TP53	REACTOME	R-HSA-3700989
Regulation of TP53 Activity	REACTOME	R-HSA-5633007
Regulation of TP53 Expression and Degradation	REACTOME	R-HSA-6806003
Regulation of TP53 Degradation	REACTOME	R-HSA-6804757

References

Pubmed ID	Year	Title	Citations
18382127	2008	CARPs enhance p53 turnover by degrading 14-3-3sigma and stabilizing MDM2.	13
21308745	2011	Destabilization of CARP mRNAs by aloe-emodin contributes to caspase-8-mediated p53-independent apoptosis of human carcinoma cells.	8
31304625	2019	RNF34 functions in immunity and selective mitophagy by targeting MAVS for autophagic degradation.	7
12118383	2002	Isolation and characterization of a novel gene, hRFI, preferentially expressed in esophageal cancer.	5
25012219	2014	The E3 ligase RNF34 is a novel negative regulator of the NOD1 pathway.	4
15595643	2004	Effects of expression of hRFI on adenoma formation and tumor progression in colorectal adenoma-carcinoma sequence.	2
20564261	2010	Uncoupling of bait-protein expression from the prey protein environment adds versatility for cell and tissue interaction proteomics and reveals a complex of CARP-1 and the PKA Cbeta1 subunit.	2

Citation

Dessen P

RNF34 (ring finger protein 34)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42136/rnf34