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ROCK1 (Rho associated coiled-coil containing protein kinase 1)

Identity

Alias_symbol (synonym)p160ROCK
Other aliasP160ROCK
ROCK-I
HGNC (Hugo) ROCK1
LocusID (NCBI) 6093
Atlas_Id 42141
Location 18q11.1  [Link to chromosome band 18q11]
Location_base_pair Starts at 18529703 and ends at 18691812 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ROCK1 (18q11.1) / ABHD3 (18q11.2)ROCK1 (18q11.1) / B4GALT6 (18q12.1)ROCK1 (18q11.1) / CABYR (18q11.2)
ROCK1 (18q11.1) / CMKLR1 (12q23.3)ROCK1 (18q11.1) / DCC (18q21.2)ROCK1 (18q11.1) / GATA6 (18q11.2)
ROCK1 (18q11.1) / GUCA2B (1p34.2)ROCK1 (18q11.1) / LRIG3 (12q14.1)ROCK1 18q11.1 / ABHD3 18q11.2
ROCK1 18q11.1 / B4GALT6 18q12.1ROCK1 18q11.1 / CABYR 18q11.2ROCK1 18q11.1 / DCC 18q21.2
ROCK1 18q11.1 / GATA6 18q11.2ROCK1 18q11.1 / GUCA2B 1p34.2ROCK1 18q11.1 / LRIG3 12q14.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  dic(9;17)(p13;q11) PAX5/TAOK1


External links

Nomenclature
HGNC (Hugo)ROCK1   10251
Cards
Entrez_Gene (NCBI)ROCK1  6093  Rho associated coiled-coil containing protein kinase 1
AliasesP160ROCK; ROCK-I
GeneCards (Weizmann)ROCK1
Ensembl hg19 (Hinxton)ENSG00000067900 [Gene_View]  chr18:18529703-18691812 [Contig_View]  ROCK1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000067900 [Gene_View]  chr18:18529703-18691812 [Contig_View]  ROCK1 [Vega]
ICGC DataPortalENSG00000067900
TCGA cBioPortalROCK1
AceView (NCBI)ROCK1
Genatlas (Paris)ROCK1
WikiGenes6093
SOURCE (Princeton)ROCK1
Genetics Home Reference (NIH)ROCK1
Genomic and cartography
GoldenPath hg19 (UCSC)ROCK1  -     chr18:18529703-18691812 -  18q11.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)ROCK1  -     18q11.1   [Description]    (hg38-Dec_2013)
EnsemblROCK1 - 18q11.1 [CytoView hg19]  ROCK1 - 18q11.1 [CytoView hg38]
Mapping of homologs : NCBIROCK1 [Mapview hg19]  ROCK1 [Mapview hg38]
OMIM601702   
Gene and transcription
Genbank (Entrez)AB208965 AK057038 AK307388 AU121527 BC113114
RefSeq transcript (Entrez)NM_005406
RefSeq genomic (Entrez)NC_000018 NC_018929 NG_042178 NT_010966 NW_004929410
Consensus coding sequences : CCDS (NCBI)ROCK1
Cluster EST : UnigeneHs.306307 [ NCBI ]
CGAP (NCI)Hs.306307
Alternative Splicing GalleryENSG00000067900
Gene ExpressionROCK1 [ NCBI-GEO ]   ROCK1 [ EBI - ARRAY_EXPRESS ]   ROCK1 [ SEEK ]   ROCK1 [ MEM ]
Gene Expression Viewer (FireBrowse)ROCK1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6093
GTEX Portal (Tissue expression)ROCK1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13464   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ13464  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ13464
Splice isoforms : SwissVarQ13464
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   
PhosPhoSitePlusQ13464
Domaine pattern : Prosite (Expaxy)AGC_KINASE_CTER (PS51285)    PH_DOMAIN (PS50003)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)    ZF_DAG_PE_2 (PS50081)   
Domains : Interpro (EBI)AGC-kinase_C    Kinase-like_dom    PE/DAG-bd    PH_dom-like    PH_domain    Pkinase_C    Prot_kinase_dom    Protein_kinase_ATP_BS    Rho-bd_dom    ROCK1    ROCK1/ROCK2    Ser/Thr_dual-sp_kinase    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)    Pkinase_C (PF00433)    Rho_Binding (PF08912)   
Domain families : Pfam (NCBI)pfam00069    pfam00433    pfam08912   
Domain families : Smart (EMBL)C1 (SM00109)  PH (SM00233)  S_TK_X (SM00133)  S_TKc (SM00220)  
Conserved Domain (NCBI)ROCK1
DMDM Disease mutations6093
Blocks (Seattle)ROCK1
PDB (SRS)1S1C    2ESM    2ETK    2ETR    2V55    3D9V    3NCZ    3NDM    3O0Z    3TV7    3TWJ    3V8S    4L2W    4W7P    4YVC    4YVE    5BML   
PDB (PDBSum)1S1C    2ESM    2ETK    2ETR    2V55    3D9V    3NCZ    3NDM    3O0Z    3TV7    3TWJ    3V8S    4L2W    4W7P    4YVC    4YVE    5BML   
PDB (IMB)1S1C    2ESM    2ETK    2ETR    2V55    3D9V    3NCZ    3NDM    3O0Z    3TV7    3TWJ    3V8S    4L2W    4W7P    4YVC    4YVE    5BML   
PDB (RSDB)1S1C    2ESM    2ETK    2ETR    2V55    3D9V    3NCZ    3NDM    3O0Z    3TV7    3TWJ    3V8S    4L2W    4W7P    4YVC    4YVE    5BML   
Structural Biology KnowledgeBase1S1C    2ESM    2ETK    2ETR    2V55    3D9V    3NCZ    3NDM    3O0Z    3TV7    3TWJ    3V8S    4L2W    4W7P    4YVC    4YVE    5BML   
SCOP (Structural Classification of Proteins)1S1C    2ESM    2ETK    2ETR    2V55    3D9V    3NCZ    3NDM    3O0Z    3TV7    3TWJ    3V8S    4L2W    4W7P    4YVC    4YVE    5BML   
CATH (Classification of proteins structures)1S1C    2ESM    2ETK    2ETR    2V55    3D9V    3NCZ    3NDM    3O0Z    3TV7    3TWJ    3V8S    4L2W    4W7P    4YVC    4YVE    5BML   
SuperfamilyQ13464
Human Protein AtlasENSG00000067900
Peptide AtlasQ13464
HPRD03414
IPIIPI00022542   IPI01021624   IPI00023187   
Protein Interaction databases
DIP (DOE-UCLA)Q13464
IntAct (EBI)Q13464
FunCoupENSG00000067900
BioGRIDROCK1
STRING (EMBL)ROCK1
ZODIACROCK1
Ontologies - Pathways
QuickGOQ13464
Ontology : AmiGOGolgi membrane  ruffle  apical constriction  protein kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein binding  ATP binding  centriole  cytosol  cytoskeleton  plasma membrane  protein phosphorylation  cellular component disassembly involved in execution phase of apoptosis  smooth muscle contraction  leukocyte cell-cell adhesion  signal transduction  I-kappaB kinase/NF-kappaB signaling  Rho protein signal transduction  negative regulation of angiogenesis  GTP-Rho binding  membrane to membrane docking  lamellipodium  actin cytoskeleton organization  regulation of cell adhesion  cortical actin cytoskeleton organization  cortical actin cytoskeleton organization  bleb  bleb assembly  negative regulation of protein binding  regulation of actin cytoskeleton organization  regulation of actin cytoskeleton organization  negative regulation of myosin-light-chain-phosphatase activity  negative regulation of myosin-light-chain-phosphatase activity  negative regulation of neuron apoptotic process  regulation of keratinocyte differentiation  metal ion binding  vascular endothelial growth factor receptor signaling pathway  ephrin receptor signaling pathway  leukocyte migration  leukocyte tethering or rolling  myoblast migration  regulation of stress fiber assembly  regulation of focal adhesion assembly  positive regulation of focal adhesion assembly  establishment of protein localization to plasma membrane  establishment of protein localization to plasma membrane  regulation of establishment of endothelial barrier  regulation of establishment of endothelial barrier  negative regulation of bicellular tight junction assembly  regulation of establishment of cell polarity  regulation of cell motility  
Ontology : EGO-EBIGolgi membrane  ruffle  apical constriction  protein kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein binding  ATP binding  centriole  cytosol  cytoskeleton  plasma membrane  protein phosphorylation  cellular component disassembly involved in execution phase of apoptosis  smooth muscle contraction  leukocyte cell-cell adhesion  signal transduction  I-kappaB kinase/NF-kappaB signaling  Rho protein signal transduction  negative regulation of angiogenesis  GTP-Rho binding  membrane to membrane docking  lamellipodium  actin cytoskeleton organization  regulation of cell adhesion  cortical actin cytoskeleton organization  cortical actin cytoskeleton organization  bleb  bleb assembly  negative regulation of protein binding  regulation of actin cytoskeleton organization  regulation of actin cytoskeleton organization  negative regulation of myosin-light-chain-phosphatase activity  negative regulation of myosin-light-chain-phosphatase activity  negative regulation of neuron apoptotic process  regulation of keratinocyte differentiation  metal ion binding  vascular endothelial growth factor receptor signaling pathway  ephrin receptor signaling pathway  leukocyte migration  leukocyte tethering or rolling  myoblast migration  regulation of stress fiber assembly  regulation of focal adhesion assembly  positive regulation of focal adhesion assembly  establishment of protein localization to plasma membrane  establishment of protein localization to plasma membrane  regulation of establishment of endothelial barrier  regulation of establishment of endothelial barrier  negative regulation of bicellular tight junction assembly  regulation of establishment of cell polarity  regulation of cell motility  
Pathways : BIOCARTAIntegrin Signaling Pathway [Genes]    Erk and PI-3 Kinase Are Necessary for Collagen Binding in Corneal Epithelia [Genes]    Role of MAL in Rho-Mediated Activation of SRF [Genes]    PKC-catalyzed phosphorylation of inhibitory phosphoprotein of myosin phosphatase [Genes]    Thrombin signaling and protease-activated receptors [Genes]    Rho cell motility signaling pathway [Genes]   
Pathways : KEGGChemokine signaling pathway    Vascular smooth muscle contraction    TGF-beta signaling pathway    Axon guidance    Focal adhesion    Leukocyte transendothelial migration    Regulation of actin cytoskeleton    Pathogenic Escherichia coli infection    Shigellosis    Salmonella infection    Proteoglycans in cancer    MicroRNAs in cancer   
NDEx NetworkROCK1
Atlas of Cancer Signalling NetworkROCK1
Wikipedia pathwaysROCK1
Orthology - Evolution
OrthoDB6093
GeneTree (enSembl)ENSG00000067900
Phylogenetic Trees/Animal Genes : TreeFamROCK1
HOVERGENQ13464
HOGENOMQ13464
Homologs : HomoloGeneROCK1
Homology/Alignments : Family Browser (UCSC)ROCK1
Gene fusions - Rearrangements
Fusion : MitelmanROCK1/ABHD3 [18q11.1/18q11.2]  
Fusion : MitelmanROCK1/B4GALT6 [18q11.1/18q12.1]  [t(18;18)(q11;q12)]  
Fusion : MitelmanROCK1/CABYR [18q11.1/18q11.2]  [t(18;18)(q11;q11)]  
Fusion : MitelmanROCK1/CMKLR1 [18q11.1/12q23.3]  [t(12;18)(q23;q11)]  
Fusion : MitelmanROCK1/DCC [18q11.1/18q21.2]  [t(18;18)(q11;q21)]  
Fusion : MitelmanROCK1/GATA6 [18q11.1/18q11.2]  [t(18;18)(q11;q11)]  
Fusion : MitelmanROCK1/GUCA2B [18q11.1/1p34.2]  [t(1;18)(p34;q11)]  
Fusion : MitelmanROCK1/LRIG3 [18q11.1/12q14.1]  [t(12;18)(q14;q11)]  
Fusion: TCGAROCK1 18q11.1 ABHD3 18q11.2 BRCA
Fusion: TCGAROCK1 18q11.1 B4GALT6 18q12.1 HNSC
Fusion: TCGAROCK1 18q11.1 CABYR 18q11.2 LUAD
Fusion: TCGAROCK1 18q11.1 DCC 18q21.2 HNSC
Fusion: TCGAROCK1 18q11.1 GATA6 18q11.2 LUAD
Fusion: TCGAROCK1 18q11.1 GUCA2B 1p34.2 BLCA
Fusion: TCGAROCK1 18q11.1 LRIG3 12q14.1 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerROCK1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ROCK1
dbVarROCK1
ClinVarROCK1
1000_GenomesROCK1 
Exome Variant ServerROCK1
ExAC (Exome Aggregation Consortium)ROCK1 (select the gene name)
Genetic variants : HAPMAP6093
Genomic Variants (DGV)ROCK1 [DGVbeta]
DECIPHER (Syndromes)18:18529703-18691812  ENSG00000067900
CONAN: Copy Number AnalysisROCK1 
Mutations
ICGC Data PortalROCK1 
TCGA Data PortalROCK1 
Broad Tumor PortalROCK1
OASIS PortalROCK1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICROCK1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDROCK1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ROCK1
DgiDB (Drug Gene Interaction Database)ROCK1
DoCM (Curated mutations)ROCK1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ROCK1 (select a term)
intoGenROCK1
Cancer3DROCK1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601702   
Orphanet
MedgenROCK1
Genetic Testing Registry ROCK1
NextProtQ13464 [Medical]
TSGene6093
GENETestsROCK1
Huge Navigator ROCK1 [HugePedia]
snp3D : Map Gene to Disease6093
BioCentury BCIQROCK1
ClinGenROCK1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6093
Chemical/Pharm GKB GenePA34623
Clinical trialROCK1
Miscellaneous
canSAR (ICR)ROCK1 (select the gene name)
Probes
Litterature
PubMed309 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineROCK1
EVEXROCK1
GoPubMedROCK1
iHOPROCK1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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