ROCK1 (Rho associated coiled-coil containing protein kinase 1)

2003-05-01  

Identity

HGNC
LOCATION
18q11.1
LOCUSID
ALIAS
P160ROCK,ROCK-I
FUSION GENES

Other Information

Locus ID:

NCBI: 6093
MIM: 601702
HGNC: 10251
Ensembl: ENSG00000067900

Variants:

dbSNP: 6093
ClinVar: 6093
TCGA: ENSG00000067900
COSMIC: ROCK1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000067900ENST00000399799Q13464
ENSG00000067900ENST00000578051J3KRH6
ENSG00000067900ENST00000635540A0A0U1RQV4

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90

Pathways

PathwaySourceExternal ID
TGF-beta signaling pathwayKEGGko04350
Axon guidanceKEGGko04360
Focal adhesionKEGGko04510
Tight junctionKEGGko04530
Leukocyte transendothelial migrationKEGGko04670
Regulation of actin cytoskeletonKEGGko04810
Pathogenic Escherichia coli infectionKEGGko05130
TGF-beta signaling pathwayKEGGhsa04350
Axon guidanceKEGGhsa04360
Focal adhesionKEGGhsa04510
Tight junctionKEGGhsa04530
Leukocyte transendothelial migrationKEGGhsa04670
Regulation of actin cytoskeletonKEGGhsa04810
Pathogenic Escherichia coli infectionKEGGhsa05130
ShigellosisKEGGhsa05131
Pathways in cancerKEGGhsa05200
Vascular smooth muscle contractionKEGGhsa04270
Chemokine signaling pathwayKEGGko04062
Vascular smooth muscle contractionKEGGko04270
Chemokine signaling pathwayKEGGhsa04062
Salmonella infectionKEGGko05132
Salmonella infectionKEGGhsa05132
Proteoglycans in cancerKEGGhsa05205
Proteoglycans in cancerKEGGko05205
MicroRNAs in cancerKEGGhsa05206
MicroRNAs in cancerKEGGko05206
Platelet activationKEGGhsa04611
Oxytocin signaling pathwayKEGGhsa04921
Oxytocin signaling pathwayKEGGko04921
cGMP-PKG signaling pathwayKEGGhsa04022
cGMP-PKG signaling pathwayKEGGko04022
cAMP signaling pathwayKEGGhsa04024
cAMP signaling pathwayKEGGko04024
Sphingolipid signaling pathwayKEGGhsa04071
Sphingolipid signaling pathwayKEGGko04071
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Signal TransductionREACTOMER-HSA-162582
Signaling by VEGFREACTOMER-HSA-194138
VEGFA-VEGFR2 PathwayREACTOMER-HSA-4420097
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases Activate ROCKsREACTOMER-HSA-5627117
Signaling by GPCRREACTOMER-HSA-372790
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (12/13) signalling eventsREACTOMER-HSA-416482
Programmed Cell DeathREACTOMER-HSA-5357801
ApoptosisREACTOMER-HSA-109581
Apoptotic execution phaseREACTOMER-HSA-75153
Apoptotic cleavage of cellular proteinsREACTOMER-HSA-111465
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
Semaphorin interactionsREACTOMER-HSA-373755
Sema4D in semaphorin signalingREACTOMER-HSA-400685
Sema4D induced cell migration and growth-cone collapseREACTOMER-HSA-416572
EPH-Ephrin signalingREACTOMER-HSA-2682334
EPHA-mediated growth cone collapseREACTOMER-HSA-3928663
EPHB-mediated forward signalingREACTOMER-HSA-3928662
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
178538932007Human ESCRT and ALIX proteins interact with proteins of the midbody and function in cytokinesis.285
146100602003ROCK-generated contractility regulates breast epithelial cell differentiation in response to the physical properties of a three-dimensional collagen matrix.213
191600182009Rho signaling, ROCK and mDia1, in transformation, metastasis and invasion.212
119921122002ROCK and Dia have opposing effects on adherens junctions downstream of Rho.153
157230502005Cdc42-MRCK and Rho-ROCK signalling cooperate in myosin phosphorylation and cell invasion.147
173444172007Notch1 is a p53 target gene involved in human keratinocyte tumor suppression through negative regulation of ROCK1/2 and MRCKalpha kinases.125
218404872011ROCK and JAK1 signaling cooperate to control actomyosin contractility in tumor cells and stroma.124
161414222005Inhibition of Rho kinase (ROCK) leads to increased cerebral blood flow and stroke protection.111
219944192011MicroRNA-148a suppresses tumor cell invasion and metastasis by downregulating ROCK1 in gastric cancer.108
164134702006ERK-MAPK signaling opposes Rho-kinase to promote endothelial cell survival and sprouting during angiogenesis.103

Citation

Dessen P

ROCK1 (Rho associated coiled-coil containing protein kinase 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/42141/rock1