ROCK1 (Rho-associated, coiled-coil containing protein kinase 1)

Identity

Other names	MGC131603
	MGC43611
	P160ROCK
	PRO0435
HGNC	ROCK1
Location	18q11.2
Location_base_pair	Starts at 16783701 and ends at 16945810 bp from pter ( according to hg18-March_2006).
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

External links

	Nomenclature
HGNC	ROCK1   10251
Entrez_Gene	ROCK1  6093  Rho-associated, coiled-coil containing protein kinase 1
	Cards
GeneCards	ROCK1
Ensembl	ENSG00000067900 [Gene_View]  ROCK1 [Vega]
Genatlas	ROCK1
	Genomic and cartography
GoldenPath	ROCK1  -  18q11.2   chr18:16783701-16945810 -  18q11.1   [Description]    (hg18-March_2006)
Ensembl	ROCK1 - 18q11.1 [CytoView]
NCBI	Mapview
OMIM	601702 Disease map [OMIM]
HomoloGene	ROCK1
	Gene and transcription
Genbank	AB208965 [ ENTREZ ]
Genbank	AK057038 [ ENTREZ ]
Genbank	AK307388 [ ENTREZ ]
Genbank	AU121527 [ ENTREZ ]
Genbank	BC041849 [ ENTREZ ]
RefSeq	NM_005406 [ SRS ]    NM_005406 [ ENTREZ ]
RefSeq	AC_000061 [ SRS ]    AC_000061 [ ENTREZ ]
RefSeq	AC_000150 [ SRS ]    AC_000150 [ ENTREZ ]
RefSeq	NC_000018 [ SRS ]    NC_000018 [ ENTREZ ]
RefSeq	NT_010966 [ SRS ]    NT_010966 [ ENTREZ ]
RefSeq	NW_001838467 [ SRS ]    NW_001838467 [ ENTREZ ]
RefSeq	NW_927095 [ SRS ]    NW_927095 [ ENTREZ ]
CCDS	ROCK1 CCDS - NCBI
AceView	ROCK1 AceView - NCBI
Unigene	Hs.714459 [ SRS ]    Hs.714459 [ NCBI ]
Fast-db	1960 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	Q13464 [ SRS]    Q13464 [ EXPASY ]     Q13464 [ INTERPRO ]     Q13464 [ UNIPROT ] Q13464 [ VarSplice FASTA ]
Prosite	PS51285 AGC_KINASE_CTER [ SRS ]    PS51285 AGC_KINASE_CTER [ Expasy ]
Prosite	PS50003 PH_DOMAIN [ SRS ]    PS50003 PH_DOMAIN [ Expasy ]
Prosite	PS00107 PROTEIN_KINASE_ATP [ SRS ]    PS00107 PROTEIN_KINASE_ATP [ Expasy ]
Prosite	PS50011 PROTEIN_KINASE_DOM [ SRS ]    PS50011 PROTEIN_KINASE_DOM [ Expasy ]
Prosite	PS00108 PROTEIN_KINASE_ST [ SRS ]    PS00108 PROTEIN_KINASE_ST [ Expasy ]
Prosite	PS00479 ZF_DAG_PE_1 [ SRS ]    PS00479 ZF_DAG_PE_1 [ Expasy ]
Prosite	PS50081 ZF_DAG_PE_2 [ SRS ]    PS50081 ZF_DAG_PE_2 [ Expasy ]
Interpro	IPR002219 DAG_PE_bd [ SRS ]    IPR002219 DAG_PE_bd [ EBI ]
Interpro	IPR000861 HR1-like_rho-bd [ SRS ]    IPR000861 HR1-like_rho-bd [ EBI ]
Interpro	IPR001849 PH [ SRS ]    IPR001849 PH [ EBI ]
Interpro	IPR000961 Pkinase_C [ SRS ]    IPR000961 Pkinase_C [ EBI ]
Interpro	IPR000719 Prot_kinase_core [ SRS ]    IPR000719 Prot_kinase_core [ EBI ]
Interpro	IPR017441 Protein_kinase_ATP_bd_CS [ SRS ]    IPR017441 Protein_kinase_ATP_bd_CS [ EBI ]
Interpro	IPR015008 Rho_bd [ SRS ]    IPR015008 Rho_bd [ EBI ]
Interpro	IPR015751 Rho_kinase [ SRS ]    IPR015751 Rho_kinase [ EBI ]
Interpro	IPR017442 Se/Thr_pkinase-rel [ SRS ]    IPR017442 Se/Thr_pkinase-rel [ EBI ]
Interpro	IPR008271 Ser_thr_pkin_AS [ SRS ]    IPR008271 Ser_thr_pkin_AS [ EBI ]
Interpro	IPR002290 Ser_thr_pkinase [ SRS ]    IPR002290 Ser_thr_pkinase [ EBI ]
CluSTr	Q13464
Pfam	PF00130 C1_1 [ SRS ]    PF00130 C1_1 [ Sanger ]    pfam00130 [ NCBI-CDD ]
Pfam	PF02185 HR1 [ SRS ]    PF02185 HR1 [ Sanger ]    pfam02185 [ NCBI-CDD ]
Pfam	PF00169 PH [ SRS ]    PF00169 PH [ Sanger ]    pfam00169 [ NCBI-CDD ]
Pfam	PF00069 Pkinase [ SRS ]    PF00069 Pkinase [ Sanger ]    pfam00069 [ NCBI-CDD ]
Pfam	PF00433 Pkinase_C [ SRS ]    PF00433 Pkinase_C [ Sanger ]    pfam00433 [ NCBI-CDD ]
Pfam	PF08912 Rho_Binding [ SRS ]    PF08912 Rho_Binding [ Sanger ]    pfam08912 [ NCBI-CDD ]
Smart	SM00109 C1 [EMBL]
Smart	SM00233 PH [EMBL]
Smart	SM00133 S_TK_X [EMBL]
Smart	SM00220 S_TKc [EMBL]
Prodom	PD000001 Prot_kinase[INRA-Toulouse]
Prodom	Q13464 ROCK1_HUMAN [ Domain structure ]   Q13464 ROCK1_HUMAN  [ sequences sharing at least 1 domain ]
Blocks	Q13464
PDB	1S1C [ SRS ]    1S1C [ PdbSum ],   1S1C [ IMB ]   1S1C [ RSDB ]
PDB	2ESM [ SRS ]    2ESM [ PdbSum ],   2ESM [ IMB ]   2ESM [ RSDB ]
PDB	2ETK [ SRS ]    2ETK [ PdbSum ],   2ETK [ IMB ]   2ETK [ RSDB ]
PDB	2ETO [ SRS ]    2ETO [ PdbSum ],   2ETO [ IMB ]   2ETO [ RSDB ]
PDB	2ETR [ SRS ]    2ETR [ PdbSum ],   2ETR [ IMB ]   2ETR [ RSDB ]
HPRD	03414
	Protein Interaction databases
DIP	Q13464
IntAct	Q13464
	Polymorphism : SNP, mutations, diseases
OMIM	601702    [ map ]
GENETests	601702
SNP	ROCK1 [dbSNP-NCBI]
SNP	NM_005406 [SNP-NCI]
SNP	ROCK1 [GeneSNPs - Utah]  ROCK1] [HGBASE - SRS]
HAPMAP	ROCK1 [HAPMAP]
COSMIC	ROCK1 [Somatic mutation (COSMIC-CGP-Sanger)]
HGMD	ROCK1
Genetic Association	ROCK1
CDC HuGE	ROCK1
	General knowledge
Family Browser	ROCK1 [UCSC Family Browser]
SOURCE	NM_005406
SMD	Hs.714459
SAGE	Hs.714459
Enzyme	2.7.11.1 [ Enzyme-Expasy ]   2.7.11.1 [ Enzyme-SRS ]   2.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]
GO	Golgi membrane [Amigo]  Golgi membrane
GO	nucleotide binding [Amigo]  nucleotide binding
GO	cytokinesis [Amigo]  cytokinesis
GO	protein serine/threonine kinase activity [Amigo]  protein serine/threonine kinase activity
GO	ATP binding [Amigo]  ATP binding
GO	intracellular [Amigo]  intracellular
GO	cytoplasm [Amigo]  cytoplasm
GO	Golgi apparatus [Amigo]  Golgi apparatus
GO	cytosol [Amigo]  cytosol
GO	protein amino acid phosphorylation [Amigo]  protein amino acid phosphorylation
GO	apoptosis [Amigo]  apoptosis
GO	intracellular signaling cascade [Amigo]  intracellular signaling cascade
GO	Rho protein signal transduction [Amigo]  Rho protein signal transduction
GO	zinc ion binding [Amigo]  zinc ion binding
GO	membrane [Amigo]  membrane
GO	transferase activity [Amigo]  transferase activity
GO	diacylglycerol binding [Amigo]  diacylglycerol binding
GO	membrane to membrane docking [Amigo]  membrane to membrane docking
GO	actin cytoskeleton organization and biogenesis [Amigo]  actin cytoskeleton organization and biogenesis
GO	identical protein binding [Amigo]  identical protein binding
GO	metal ion binding [Amigo]  metal ion binding
GO	leukocyte migration [Amigo]  leukocyte migration
GO	leukocyte tethering or rolling [Amigo]  leukocyte tethering or rolling
BIOCARTA	Thrombin signaling and protease-activated receptors    [Genes]
BIOCARTA	Erk and PI-3 Kinase Are Necessary for Collagen Binding in Corneal Epithelia    [Genes]
BIOCARTA	Integrin Signaling Pathway    [Genes]
BIOCARTA	Role of MAL in Rho-Mediated Activation of SRF    [Genes]
BIOCARTA	PKC-catalyzed phosphorylation of inhibitory phosphoprotein of myosin phosphatase    [Genes]
BIOCARTA	Rho cell motility signaling pathway    [Genes]
KEGG	Wnt signaling pathway
KEGG	TGF-beta signaling pathway
KEGG	Axon guidance
KEGG	Focal adhesion
KEGG	Leukocyte transendothelial migration
KEGG	Regulation of actin cytoskeleton
PubGene	ROCK1
TreeFam	ROCK1
CTD	6093 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	ROCK1 Related clones (RZPD - Berlin)
	PubMed
PubMed	110 Pubmed reference(s) in Entrez

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

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Contributor(s)

Written	09-2002	Dessen P, Le Minor S
Updated	03-2008	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Thu Nov 27 14:09:23 2008