Atlas of Genetics and Cytogenetics in Oncology and Haematology

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RPS6KA4 (ribosomal protein S6 kinase A4)

Identity

Alias_namesribosomal protein S6 kinase
Alias_symbol (synonym)RSK-B
MSK2
Other aliasS6K-alpha-4
HGNC (Hugo) RPS6KA4
LocusID (NCBI) 8986
Atlas_Id 43479
Location 11q13.1  [Link to chromosome band 11q13]
Location_base_pair Starts at 64359153 and ends at 64372215 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
AHNAK (11q12.3) / RPS6KA4 (11q13.1)AHNAK 11q12.3 / RPS6KA4 11q13.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(11;11)(q12;q13) AHNAK/RPS6KA4
RPS6KA4/CCDC88B (11q13)

External links

Nomenclature
HGNC (Hugo)RPS6KA4   10433
Cards
Entrez_Gene (NCBI)RPS6KA4  8986  ribosomal protein S6 kinase A4
AliasesMSK2; RSK-B; S6K-alpha-4
GeneCards (Weizmann)RPS6KA4
Ensembl hg19 (Hinxton)ENSG00000162302 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000162302 [Gene_View]  ENSG00000162302 [Sequence]  chr11:64359153-64372215 [Contig_View]  RPS6KA4 [Vega]
ICGC DataPortalENSG00000162302
TCGA cBioPortalRPS6KA4
AceView (NCBI)RPS6KA4
Genatlas (Paris)RPS6KA4
WikiGenes8986
SOURCE (Princeton)RPS6KA4
Genetics Home Reference (NIH)RPS6KA4
Genomic and cartography
GoldenPath hg38 (UCSC)RPS6KA4  -     chr11:64359153-64372215 +  11q13.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RPS6KA4  -     11q13.1   [Description]    (hg19-Feb_2009)
EnsemblRPS6KA4 - 11q13.1 [CytoView hg19]  RPS6KA4 - 11q13.1 [CytoView hg38]
Mapping of homologs : NCBIRPS6KA4 [Mapview hg19]  RPS6KA4 [Mapview hg38]
OMIM603606   
Gene and transcription
Genbank (Entrez)AF074715 AJ010119 AK223561 AK292163 AK298507
RefSeq transcript (Entrez)NM_001006944 NM_001300802 NM_001318361 NM_003942
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)RPS6KA4
Cluster EST : UnigeneHs.105584 [ NCBI ]
CGAP (NCI)Hs.105584
Alternative Splicing GalleryENSG00000162302
Gene ExpressionRPS6KA4 [ NCBI-GEO ]   RPS6KA4 [ EBI - ARRAY_EXPRESS ]   RPS6KA4 [ SEEK ]   RPS6KA4 [ MEM ]
Gene Expression Viewer (FireBrowse)RPS6KA4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8986
GTEX Portal (Tissue expression)RPS6KA4
Human Protein AtlasENSG00000162302-RPS6KA4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO75676   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO75676  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO75676
Splice isoforms : SwissVarO75676
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   
PhosPhoSitePlusO75676
Domaine pattern : Prosite (Expaxy)AGC_KINASE_CTER (PS51285)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)AGC-kinase_C    Kinase-like_dom_sf    MSK2_N_dom    Pkinase_C    Prot_kinase_dom    Protein_kinase_ATP_BS    Ribosomal_S6_kinase_II    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)    Pkinase_C (PF00433)   
Domain families : Pfam (NCBI)pfam00069    pfam00433   
Domain families : Smart (EMBL)S_TK_X (SM00133)  S_TKc (SM00220)  
Conserved Domain (NCBI)RPS6KA4
DMDM Disease mutations8986
Blocks (Seattle)RPS6KA4
SuperfamilyO75676
Human Protein Atlas [tissue]ENSG00000162302-RPS6KA4 [tissue]
Peptide AtlasO75676
HPRD04677
IPIIPI00022536   IPI00479926   IPI00745931   IPI00982822   IPI00978530   
Protein Interaction databases
DIP (DOE-UCLA)O75676
IntAct (EBI)O75676
FunCoupENSG00000162302
BioGRIDRPS6KA4
STRING (EMBL)RPS6KA4
ZODIACRPS6KA4
Ontologies - Pathways
QuickGOO75676
Ontology : AmiGOmagnesium ion binding  negative regulation of cytokine production  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  ribosomal protein S6 kinase activity  protein binding  ATP binding  nucleus  nucleus  nucleoplasm  cytoplasm  cytosol  regulation of transcription, DNA-templated  protein phosphorylation  protein phosphorylation  inflammatory response  histone phosphorylation  positive regulation of CREB transcription factor activity  positive regulation of histone phosphorylation  positive regulation of histone acetylation  intracellular signal transduction  intracellular signal transduction  histone H3-S10 phosphorylation  histone H3-S28 phosphorylation  positive regulation of transcription by RNA polymerase II  positive regulation of NF-kappaB transcription factor activity  interleukin-1-mediated signaling pathway  
Ontology : EGO-EBImagnesium ion binding  negative regulation of cytokine production  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  ribosomal protein S6 kinase activity  protein binding  ATP binding  nucleus  nucleus  nucleoplasm  cytoplasm  cytosol  regulation of transcription, DNA-templated  protein phosphorylation  protein phosphorylation  inflammatory response  histone phosphorylation  positive regulation of CREB transcription factor activity  positive regulation of histone phosphorylation  positive regulation of histone acetylation  intracellular signal transduction  intracellular signal transduction  histone H3-S10 phosphorylation  histone H3-S28 phosphorylation  positive regulation of transcription by RNA polymerase II  positive regulation of NF-kappaB transcription factor activity  interleukin-1-mediated signaling pathway  
Pathways : KEGGMAPK signaling pathway    TNF signaling pathway   
NDEx NetworkRPS6KA4
Atlas of Cancer Signalling NetworkRPS6KA4
Wikipedia pathwaysRPS6KA4
Orthology - Evolution
OrthoDB8986
GeneTree (enSembl)ENSG00000162302
Phylogenetic Trees/Animal Genes : TreeFamRPS6KA4
HOGENOMO75676
Homologs : HomoloGeneRPS6KA4
Homology/Alignments : Family Browser (UCSC)RPS6KA4
Gene fusions - Rearrangements
Fusion : MitelmanAHNAK/RPS6KA4 [11q12.3/11q13.1]  [t(11;11)(q12;q13)]  
Fusion PortalAHNAK 11q12.3 RPS6KA4 11q13.1 BRCA
Fusion : QuiverRPS6KA4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRPS6KA4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RPS6KA4
dbVarRPS6KA4
ClinVarRPS6KA4
1000_GenomesRPS6KA4 
Exome Variant ServerRPS6KA4
ExAC (Exome Aggregation Consortium)ENSG00000162302
GNOMAD BrowserENSG00000162302
Varsome BrowserRPS6KA4
Genetic variants : HAPMAP8986
Genomic Variants (DGV)RPS6KA4 [DGVbeta]
DECIPHERRPS6KA4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRPS6KA4 
Mutations
ICGC Data PortalRPS6KA4 
TCGA Data PortalRPS6KA4 
Broad Tumor PortalRPS6KA4
OASIS PortalRPS6KA4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRPS6KA4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDRPS6KA4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RPS6KA4
DgiDB (Drug Gene Interaction Database)RPS6KA4
DoCM (Curated mutations)RPS6KA4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RPS6KA4 (select a term)
intoGenRPS6KA4
Cancer3DRPS6KA4(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603606   
Orphanet
DisGeNETRPS6KA4
MedgenRPS6KA4
Genetic Testing Registry RPS6KA4
NextProtO75676 [Medical]
TSGene8986
GENETestsRPS6KA4
Target ValidationRPS6KA4
Huge Navigator RPS6KA4 [HugePedia]
snp3D : Map Gene to Disease8986
BioCentury BCIQRPS6KA4
ClinGenRPS6KA4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8986
Chemical/Pharm GKB GenePA34848
Clinical trialRPS6KA4
Miscellaneous
canSAR (ICR)RPS6KA4 (select the gene name)
DataMed IndexRPS6KA4
Probes
Litterature
PubMed42 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRPS6KA4
EVEXRPS6KA4
GoPubMedRPS6KA4
iHOPRPS6KA4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Feb 14 16:55:08 CET 2019
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